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    Hepatitis B Test: Serologic Test Result Interpretation: Clement Awuah Biomedical Lab Scientist

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    This document provides information about hepatitis B serologic test result interpretation. It discusses the types of viral hepatitis and outlines the hepatitis B virus. It also describes hepatitis B serology, including the structure of hepatitis B and the antigens and antibodies involved in hepatitis B testing. Finally, it provides a table interpreting the results of hepatitis B serological tests based on different combinations of antigens and antibodies being present or absent.

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    Hepatitis B Test: Serologic Test Result Interpretation: Clement Awuah Biomedical Lab Scientist

    Uploaded by

    Clement
    30 views20 pages
    This document provides information about hepatitis B serologic test result interpretation. It discusses the types of viral hepatitis and outlines the hepatitis B virus. It also describes hepatitis B serology, including the structure of hepatitis B and the antigens and antibodies involved in hepatitis B testing. Finally, it provides a table interpreting the results of hepatitis B serological tests based on different combinations of antigens and antibodies being present or absent.

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    Hepatitis b Sero Interpretations (222)

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    This document provides information about hepatitis B serologic test result interpretation. It discusses the types of viral hepatitis and outlines the hepatitis B virus. It also describes hepatitis B serology, including the structure of hepatitis B and the antigens and antibodies involved in hepatitis B testing. Finally, it provides a table interpreting the results of hepatitis B serological tests based on different combinations of antigens and antibodies being present or absent.

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    Download as pptx, pdf, or txt
    30 views20 pages

    Hepatitis B Test: Serologic Test Result Interpretation: Clement Awuah Biomedical Lab Scientist

    Uploaded by

    Clement
    This document provides information about hepatitis B serologic test result interpretation. It discusses the types of viral hepatitis and outlines the hepatitis B virus. It also describes hepatitis B serology, including the structure of hepatitis B and the antigens and antibodies involved in hepatitis B testing. Finally, it provides a table interpreting the results of hepatitis B serological tests based on different combinations of antigens and antibodies being present or absent.

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    HEPATITIS B TEST: SEROLOGIC TEST RESULT

    INTERPRETATION

    Clement Awuah
    Biomedical Lab Scientist

    03/06/2021 1
    Outlines
    • Introduction
    • Mode of transmission
    • Geographical distribution
    • Statistics
    • Natural history
    • Laboratory Diagnosis and interpretation
    • Complication
    • Prevention
    03/06/2021 2
    Hepatitis
     Inflammation of the liver

    Causes
     Viral ( Most common)
     Drugs(alcohol)
     Chemicals
     Autoimmune diseases
     Genetic disorders
     Metabolic abnormalities

    03/06/2021 3
    VIRAL HEPATITIS
    • TYPES OF VIRAL HEPATITIS
    –A
    –B
    –C
    –D
    –E

    03/06/2021 4
    Hepatitis B Virus (HBV)
    • What is it?

    • It’s a DNA virus that attacks the liver causing both acute and
    chronic liver diseases.

    • Silent Epidemic

    03/06/2021 5
    03/06/2021 6
    At-Risk Population
    • Health care and public safety workers
    • Household contact of chronically infected
    • Patients undergoing hemodialysis
    • Transplant recipients
    • MSM

    03/06/2021 7
    03/06/2021 8
     
    Hepatitis B in Pregnancy, KPC, 2020 (n = 352)

    80.00
    72.73
    70.00

    60.00

    50.00
    Percentage

    40.00 NUMBER TESTED


    TESTED +VE
    29.41
    30.00 PROFILE TEST

    20.00
    10.71 10.51
    10.00 7.95 8.52 6.64
    3.33 2.70
    0.28
    0.00
    15-17 18-20 21-35 36-49 50-55
    03/06/2021 Age Group 9
    Hepatitis B Replication

    03/06/2021 10
    Serology
    Antigens and Antibodies

    Antibodies Test for antibody

    Antibodies can bind Test for antigen


    to specific antigen

    Circulating protein
    03/06/2021 11
    Structure of Hepatitis B

    03/06/2021 12
    Hepatitis B Serology

    03/06/2021 13
    HEPATITIS ‘B’ SEROLOGICAL TEST INTERPRETATION

    HBsAg HBsAb HBeAg HBeAb HBcAb INTERPRETATION


    (Surface (Surface (Envelope (Envelope (Core
    Antigen) Antibody) Antigen) Antibody) Antibody)
    KEY: + = POSITIVE & - = NEGATIVE

    _ _ _ _ _ Susceptible
    Resolving acute infection or Resolved infection
    _ _ _ _ +
    + _ _ _ _ Exposure to hepatitis B virus

    _ + _ _ _ Immune due to Hepatitis B vaccination

    + _ _ _ + Chronic hepatitis B Infection or Carrier State

    + _ + _ + Chronic hepatitis B infection with active replicating virus

    Immune due to natural infection/Exposure to hepatitis B


    _ + _ _ + virus with recovery or Immunity

    + _ _ + + Chronic Hepatitis B infection with non-replicating virus

    + _ + + + Chronic Hepatitis B Infection with active replicating virus

    03/06/2021
    14
    03/06/2021 15
    03/06/2021 16
    Hepatitis B Complications
    • Hepatocellular carcinoma: it occurs most often in people with
    chronic liver diseases, such as cirrhosis caused by hepatitis B or
    hepatitis C infection.

    03/06/2021 17
    Prevention 1/2
    • Hepatitis B Immunoglobulin - HBIG may be used to protect
    persons who are exposed to hepatitis B within 48 hours.

    03/06/2021 18
    Prevention 2/2
    Vaccination - highly
    effective recombinant
    vaccines (Since 1982)

    03/06/2021 19
    MORTICE GRATIAS

    03/06/2021 20

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