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    Stem Cell

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    grace efilia
    Stem cells are uncommitted cells that can differentiate into specific tissues. They have two main characteristics: self-renewal to produce more stem cells and differentiation into specialized cell types. There are several types of stem cells including totipotent, pluripotent, multipotent, and differentiated cells. Mesenchymal stem cells found in tissues like bone marrow and adipose tissue have self-renewal and differentiation abilities and potential applications in regenerative medicine. Stem cell therapy shows promise for treating various conditions in neurology, surgery, internal medicine, and other fields.

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    Stem Cell

    Uploaded by

    grace efilia
    66 views19 pages
    Stem cells are uncommitted cells that can differentiate into specific tissues. They have two main characteristics: self-renewal to produce more stem cells and differentiation into specialized cell types. There are several types of stem cells including totipotent, pluripotent, multipotent, and differentiated cells. Mesenchymal stem cells found in tissues like bone marrow and adipose tissue have self-renewal and differentiation abilities and potential applications in regenerative medicine. Stem cell therapy shows promise for treating various conditions in neurology, surgery, internal medicine, and other fields.

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    STEM CELL

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    Stem cells are uncommitted cells that can differentiate into specific tissues. They have two main characteristics: self-renewal to produce more stem cells and differentiation into specialized cell types. There are several types of stem cells including totipotent, pluripotent, multipotent, and differentiated cells. Mesenchymal stem cells found in tissues like bone marrow and adipose tissue have self-renewal and differentiation abilities and potential applications in regenerative medicine. Stem cell therapy shows promise for treating various conditions in neurology, surgery, internal medicine, and other fields.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    66 views19 pages

    Stem Cell

    Uploaded by

    grace efilia
    Stem cells are uncommitted cells that can differentiate into specific tissues. They have two main characteristics: self-renewal to produce more stem cells and differentiation into specialized cell types. There are several types of stem cells including totipotent, pluripotent, multipotent, and differentiated cells. Mesenchymal stem cells found in tissues like bone marrow and adipose tissue have self-renewal and differentiation abilities and potential applications in regenerative medicine. Stem cell therapy shows promise for treating various conditions in neurology, surgery, internal medicine, and other fields.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 19

    STEM CELL

    Laboratory of Stem Cell and Cancer Research


    Islamic University of Sultan Agung Semarang
    Omnis cellula e cellula
    “All cells come from
    preexisting cells”
    STEM CELL
    ?
    What’s Stem Cell

    “ Stem cells are uncommitted cells with


    the potential to differentiate into cells of
    specific tissue “

    • all cells in the body come from stem cells


    • a stem cell is a cell that is not yet
    specialised/uncommited cell
    • the process of specialisation is called
    differentiation
    THE CHARACTERISTICS OF
    STEM CELLS
    Stem cells can:
    • Self-renewal to make more stem cells
    • Differentiate into a specialised cell
    type
    Self Renewal
    Self renewal is the process
    duplication without losing
    developmental potential.
    Stem cell
    Symetric devision
    Self-renewal

    Progentitor/
    multipotent
    Non-simetris Devision
    Differented cell
    THE POTENCY OF CELL
    1. Totipotent
    2. Pluripotent Embrionic Stem Cell
    3. Multipotent Adult Stem Cell
    4. Differentiated Matur Cell
    Stem cell
    type Description Examples
    Cells from early
    Each cell can develop
    Totipotent ( 5-7days)
    into a new individual
    embryos

    Cells can form any (over Some cells of


    Pluripotent
    200) cell types blastocyst

    Cells differentiated, but Fetal tissue, cord


    Multipotent can form a number of blood, and adult
    other tissues stem cells
    THE CLASSIFICATION OF
    STEM CELL
    • Embryonic stem cells come from a five to six-day-
    old embryo. They have the ability to form virtually
    any type of cell found in the human body.

    • Embryonic germ cells are derived from the part of


    a human embryo or foetus that will ultimately
    produce eggs or sperm (gametes).

    • Adult stem cells are undifferentiated cells found


    among specialised or differentiated cells in a
    tissue or organ after birth. Based on current
    research they appear to have a more restricted
    ability to produce different cell types and to self-
    renewal.
    Embryonic stem cells
    Adult stem cells

    The Most significant impact on stem cell research and


    therapeutic advancements to date
    MESENCHYMAL STEM CELL
    Mesenchymal stem cell for cell with self-renewal and differentiation
    characteristic.
    Resource of MSC :
    • Bone marrow,
    • Adipose tissue (Zuk et al., 2002)
    • Placenta (In ’t Anker et al., 2004),
    • Skin (Shih et al., 2005),
    • Umbilical cord blood (Erices et al., 2000),
    • Umbilical cord perivascular cells (Sarugaser et al., 2005),
    • Umbilical cord Wharton’s jelly (Wang et al., 2004),
    • Dental pulp (Gronthos et al., 2000),
    • Amniotic fluid (Nadri and Soleimani, 2007),
    • Synovial membrane (De Bari et al., 2001),
    • Etc
    MSC FOR CLINICAL CASES

    Potential source for regenerative


    medicine and tissue replacement
    after injury or disease
    Homing
    “ The progenitor could move through the body
    and migrate towards the tissue where they are
    needed”.
    The Potential Target of Stem
    Cell Therapy
    1. Neurologist Departement:
    1. Stroke
    2. Parkinson's and Alzheimer's disease
    3. Huntington’s disease
    2. Surgery Departement:
    1. Fracture Case
    2. Burns Case
    3. Repair tendon
    4. Spinal cord damage
    3. Internist Departement
    1. Heart disease--- Miocard Infarct
    2. Liver-- Fibrosis
    3. Renal Injury--Failure
    4. Diabetes Mellitus Type 1
    5. Peripheral vascular ischaemia--- Ulcus Diabeticum
    4. Endocrinologist Department
    1. Growth hormone deficiency and disorder

    5. Dermatologist Department
    1. Aging (Cosmetic)
    5. Opthalmologist Therapy
    1. Lesions in the cornea
    2. Ocular disorders: age-related macular degeneration
    THANK YOU

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