Case Study
Case Study
Case Study
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Acute Pyelonephritis
Definition
Pyelonephritis is an infection of the
kidney and the ureters, the ducts that
carry urine away from the kidney.
Alternative Names
a Urinary tract infection -
complicated;
a Infection - kidney;
a Complicated urinary tract infection;
a Kidney infection
Causes
Pyelonephritis most often occurs as a result of urinary tract
infection, particularly when there is occasional or persistent
backflow of urine from the bladder into the ureters or an area
called the kidney pelvis.
Pyelonephritis can be sudden (acute) or long-term (chronic).
-Acute uncomplicated pyelonephritis is the sudden
development of kidney inflammation.
-Chronic pyelonephritis is a long-standing infection that
does not go away.
Pyelonephritis occurs much less often than a bladder infection,
although a history of such an infection increases your risk.
You're also at increased risk for a kidney infection if you have
any of the following conditions:
-Backflow of urine into the ureters or kidney pelvis
-Kidney Stones
-Obstructive Urophaty
-Renal Papillary Necrosis
You are also more likely to get a kidney infection if you have a
history of chronic or recurrent UTI, especially if the infection
is caused by a particularly aggressive type of bacteria.
Acute pyelonephritis can be severe in the elderly and in people
who are immunosuppresed (for example, those
with cancer or AIDS).
Symptoms
a Back pain or flank
ºSkin changes
pain
-Flushed or reddened
a Chills with shaking skin
a Severe abdominal -Moist skin (diaphoresis)
pain (occurs -Warm skin
occasionally) ºUrination problems
a Fatigue -Blood in the urine
a Fever
-Cloudy or abnormal
urine color
-Higher than 102 -Foul or strong urine
degrees Fahrenheit odor
-Persists for more than -Increased urinary
2 days frequency or urgency
a General ill feeling -Need to urinate at
a Chills with shaking night (nocturia)
-Painful urination
Mental changes or
ºVomiting, nausea
confusion
°xams and Tests
A physical exam may show tenderness when the
health care provider presses (palpates) the area
of the kidney.
a Blood culture may show an infection.
a Urinalysis commonly reveals white or red blood
cells in the urine.
a Other urine tests may show bacteria in the
urine.
An intravenous pyelogram (IVP) or CT scan of the
abdomen may show swollen kidneys. These tests
can also help rule out underlying disorders.
Additional tests and procedures that may be done
include:
a Kidney biopsy
a Kidney scan
a Kidney ultrasound
a Voiding cystourethrogram
Treatment
The goals of treatment are to: If you have a severe
a Control the infection infection or cannot take
a Relieve symptoms antibiotics by mouth, you
Due to the high death rate in may be given antibiotics
the elderly population and through a vein
the risk of complications, (intravenously) at first.
prompt treatment is
Chronic pyelonephritis may
recommended. Sudden
require long-term
(acute) symptoms usually
antibiotic therapy. It is
go away within 48 to 72
very important that you
hours after appropriate
finish all the medicine.
treatment.
Your doctor will select the Commonly used antibiotics
appropriate antibiotics include the following:
after a urine culture a Amoxicillin
identifies the bacteria that a Cephalosporin
are causing the infection. a Levofloxacin and
In acute cases, you may ciprofloxacin
receive a 10- to 14-day a Sulfa drugs such as
course of antibiotics. sulfisoxazole/trimethoprim
Outlook (Prognosis)
With treatment, most kidney infections get better without
complications. However, the treatment may need to be
aggressive or prolonged.
Pregnant women and persons with diabetes or spinal
paralysis should have a urine culture after finishing
antibiotic therapy to make sure that the bacteria are no
longer present in the urine.
In rare cases, permanent kidney damage can result when:
a Chronic kidney infections occur in a transplanted kidney
a Many kidney infections occur during infancy or childhood
Acute kidney injury (acute renal failure) may occur if a
severe infection leads to significantly low blood pressure
(shock). The elderly, infants, and persons with a weakened
immune system have an increased risk for developing
shock and a severe blood infection called sepsis. Often, such
patients will be admitted to the hospital for frequent
monitoring and IV antibiotics, IV fluids, and other
medications as necessary.
Severe episodes of acute kidney injury may result in
permanent kidney damage and lead to chronic kidney
disease.
Possible Complications
Acute kidney failure
Kidney infection returns
Infection around the kidney (perinephric
abscess)
Severe blood infection (sepsis)
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