Swatilekha Das (RN, MSN)
Swatilekha Das (RN, MSN)
Swatilekha Das (RN, MSN)
(RN,MSN)
INTRODUCTION
Endometriosis is a condition in which cells similar
to those in the endometrium, the layer of tissue that
normally covers the inside of the uterus, grows
outside of it. Most often this is on the ovaries,
fallopian tubes, and tissue around the uterus and
ovaries; however, in rare cases it may also occur in
other parts of the body.
DEFINITION
The presence of functioning endometrium (glands &
Stroma) in sites other than uterine mucosa is called
endometriosis.
RISK FACTORS
Genetics- Genetic predisposition plays a role.
Daughters or sisters of women with endometriosis are at
higher risk of developing endometriosis themselves.
Low progesterone levels may be genetic, and may
contribute to a hormone imbalance.
There is an about six-fold increased incidence in women
with an affected first-degree relative.
It has been proposed that endometriosis results from a
series of multiple hits within target genes, in a
mechanism similar to the development of cancer. In this
case, the initial mutation may be either somatic or
heritable.
Environmental toxins- Some factors associated with
endometriosis include:
not having given birth (nulliparity)
prolonged exposure to estrogen; for example, in
late menopause or early menarche
obstruction of menstrual outflow; for example,
in Mülleriananomalies
PATHOPHYSIOLOGY
CLINICAL MANIFESTATIONS
Dysmenorrhea – painful, sometimes disabling cramps
during the menstrual period; pain may get worse over
time (progressive pain), also lower back pains linked to
the pelvis