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    Ekstravaskuler

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    priska ratrigis
    This document discusses drug absorption and elimination kinetics. It provides equations to model the rate of change of drug concentration in the body over time based on first-order absorption and elimination processes. It then describes two methods for determining the absorption rate constant (Ka): the residual method, which analyzes drug remaining in the gastrointestinal tract over time, and the Wagner-Nelson method, which analyzes the relationship between cumulative drug absorbed and drug concentration in the blood to determine Ka based on the slope of the log fraction of drug remaining over time. The document concludes by providing an example data set for determining Ka using one of these methods.

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    Ekstravaskuler

    Uploaded by

    priska ratrigis
    32 views13 pages
    This document discusses drug absorption and elimination kinetics. It provides equations to model the rate of change of drug concentration in the body over time based on first-order absorption and elimination processes. It then describes two methods for determining the absorption rate constant (Ka): the residual method, which analyzes drug remaining in the gastrointestinal tract over time, and the Wagner-Nelson method, which analyzes the relationship between cumulative drug absorbed and drug concentration in the blood to determine Ka based on the slope of the log fraction of drug remaining over time. The document concludes by providing an example data set for determining Ka using one of these methods.

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    This document discusses drug absorption and elimination kinetics. It provides equations to model the rate of change of drug concentration in the body over time based on first-order absorption and elimination processes. It then describes two methods for determining the absorption rate constant (Ka): the residual method, which analyzes drug remaining in the gastrointestinal tract over time, and the Wagner-Nelson method, which analyzes the relationship between cumulative drug absorbed and drug concentration in the blood to determine Ka based on the slope of the log fraction of drug remaining over time. The document concludes by providing an example data set for determining Ka using one of these methods.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    32 views13 pages

    Ekstravaskuler

    Uploaded by

    priska ratrigis
    This document discusses drug absorption and elimination kinetics. It provides equations to model the rate of change of drug concentration in the body over time based on first-order absorption and elimination processes. It then describes two methods for determining the absorption rate constant (Ka): the residual method, which analyzes drug remaining in the gastrointestinal tract over time, and the Wagner-Nelson method, which analyzes the relationship between cumulative drug absorbed and drug concentration in the blood to determine Ka based on the slope of the log fraction of drug remaining over time. The document concludes by providing an example data set for determining Ka using one of these methods.

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    Compartment 1, EV

    Compartment 1, EV
     Absorption processes, which Ka (absorption constant) should be
    larger than Ke (elimination constant).
     What do you think if Ka is lesser than Ke?
     Note: elimination rate  first order process
     While absorption  can be zero order, but most of drugs are
    absorbed based on first order process
    Kinetic processes

    dDB
     rate _ in  rate _ out
    Dt
    dDB
     FkaDGI  kDB
    dt
    dDB
     FkaD0e  kat  kDB
    dt
    FkaD0
    Cp  (e  kt  e  kat )
    Vd ( Ka  k )
    Cp  Ae  kt  Ae  kat

    FkaDo
    A int ercept  A = intercept
    Vd (ka  k )
    How to determine Ka?
    Two available methods:
    Residual method
    Wagner-Nelson method
    Residual method
    Wagner-Nelson method
    Amount drug absorbed = Drug in blood +
    Drug in urine  Ab = Db + Du
    Ab~ = amount of drug absorbed at t = ~
    Amount of unabsorbed drug = 1-(Ab/Ab~)

    Ab  CpVD  kVD[ AUC ]


    t
    0
    At t = ~, Cp~ = 0

    Ab ~  0  kVD[ AUC ]0~


    Fraction absorbed:

    Ab CpVD  kVD[ AUC ]0~


    ~

    Ab kVD[ AUC ]0~
    Ab Cp  k[ AUC ]t0
    ~

    Ab k[ AUC ]0~
    Fraction drug remaining in GIT
    Dgi/Do = fraction unabsorbed drug = 1-(Ab/Ab~)

    DGi
     e  kat
    D0

     kat
    log DGi / Do 
    2.3
    Wagner-Nelson method steps

    Slope =
    -ka/2.3
    Cont..
    Carilah ka
    Time hr Conc ug/mL Time hr Conc ug/mL
    0 0 10 4.66
    1 3.13 12 3.90
    2 4.93 14 3.24
    3 5.86 16 2.67
    4 6.25 18 2.19
    5 6.28 24 1.20
    6 6.11 28 0.81
    7 5.81 32 0.54
    8 5.45 36 0.36
    9 5.06 48 0.10
    Reflection
    When do you use one of the both explained
    method for determining Ka of drug kinetic?
    Pls explain..

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