Epidemiologic Transition
Epidemiologic Transition
Epidemiologic Transition
http://www.who.int/docstore/bulletin/pdf/2001/issue2/vol.79no.2.1
59-170.pdf
Lecture
■ Epidemiologic Transition
■ Geographic Studies, what do they tell us?
Abdel Omran
Evolution of Disease
Charles Darwin
Evolution of Species
Epidemiology
Psychiatric Epidemiologists
Diabetes Epidemiology
Cardiovascular Epidemiology
Cancer Epidemiology
Infectious Disease Epidemiology
Instead at looking at individual
diseases, we need to look at the
patterns of diseases
Mortality is the fundamental
factor in the dynamics of
population growth and causes of
death.
35 years
Increasing Life Expectancy and
Causes of Death
100
Other
80
60
Violence
40
CHD
20 CA
Infection
0
40 44 48 52 56 60 64 68 72 76
NCD
Epidemiologic Transition
Death Rates for TB in England
and Wales
4500
4000
3500
3000
2500
2000
1500
1000
500
0
1840 1855 1875 1895 1915 1935 1948 1958 1968
Death Rates for TB in England
and Wales
4500
4000 TB Bacillus
3500 Identified
3000
2500
2000
Chemotherapy
1500
BCG Vaccination
1000
500
0
1840 1855 1875 1895 1915 1935 1948 1958 1968
Death Rates for Measles in
Children in England and Wales
1400
1200
1000
800
600
400
200
0
1850 1870 1890 1910 1930 1950 1970
Death Rates for Measles in
Children in England and Wales
1400
1200
1000
800
600
400 Immunization begun
200
0
1850 1870 1890 1910 1930 1950 1970
NIDDM CHD
Trauma
Mortality Rates
CA
Epidemiologic Transition
Importance of
Geographic Patterns
Incidence of Stomach CA
Males
Japan
Columbia
Iceland
Finland
UK
US NW
US White
India
Nigeria
0 20 40 60 80 100
Breast Cancer Incidence
Females
US Whites
US NW
UK
Poland
Jamaica
Singapore
Brazil
Nigeria
Japan
0 5 10 15 20 25 30
CHD Death Rates
Males, aged 45-54
Finland
Scotland
UK
US
Bulgaria
Italy
Egypt
Japan
Guatamala
Thailand
Italy
Japan
US
Hong Kong
Scotland
UK
0 10 20 30 40 50 60 70 80 90
High Incidence of NCDs in
Developing Countries
✽ Possible Infectious Etiology
Macronodular Cirrhosis
Hepatocellular Carcinoma
Rheumatic Heart Disease
Iron deficiency anemia
✽ Related to Nutrition Deficiency
Endemic Goiter
Malnutrition Related Diabetes.
High Incidence of NCDs in Developed Countries
Cardiovascular
CHD
Deep Vein Thrombosis
Respiratory
Emphysema
Lung CA
Female Genital
Endometriosis
Endometrial CA
Breast
Breast CA
Fibrocystic Disease
Male Genital
Prostrate CA
Metabolic
NIDDM
Back to Nature
Nomads 45 yrs
Farmers 60 yrs
Urban 70 yrs
1960
Urban Rural
rural urban
USA Developing
Countries
2006
Urban Rural
urban
rural
USA Developing
Countries
Causes of Death
Developed Developing
■ Age 15-44 Age 15-44
Accidents Accidents
CA CHD
CHD CA
■ Age 45-54 Age 45-54
CHD CHD
CA CA
Accidents Accidents