Type Iii Hypersensitivity:: Localised (Arthus Reaction) or
Type Iii Hypersensitivity:: Localised (Arthus Reaction) or
Type Iii Hypersensitivity:: Localised (Arthus Reaction) or
Step-3
These antigen-antibody complexes activate the Step-4
classical complement pathway leading to The complement proteins and antigen-antibody
vasodilation complexes attract leukocytes to the area.
Type III-Mechanism of reaction
Step-5
The leukocytes discharge
their killing agents and
promote massive
inflammation. This can
lead to tissue death and
hemorrhage.
• Arthus Reaction: acute
Arthus Reaction antibody-mediated
hypersensitivity to soluble
Experimental antigens
model for
Immune Complex
disease • Comple
ment
activati
on
serum sickness
• A systemic type III reaction, can result from the injection of large
quantities of a poorly catabolized foreign antigen.
• frequently followed the administration of therapeutic horse
antiserum.
• Streptokinase (bacterial enzyme) .
• Antibiotics (penicillin or cephalosporin).
CONTACT DERMATITIS
• SYMPTOMS ARE
ERYTHEMA AND Poison Ivy
INDURATION -
SOMETIMES BLISTERING
EXAMPLES OF TYPE 4 HYPERSENSITIVITY:
CONTACT DERMATITIS
• TRIGGERED BY CERTAIN
MATERIALS
– METALS (e.g.: NICKEL IN Rubber in Brassiere
JEWELRY, WATCHES)
– CLOTHING
– RUBBER (e.g.: ELASTIC,
Nickel in Watch Strap
GLOVES, CONDOMS)
– LEATHER
– COSMETICS
– PLANTS (e.g.: POISON IVY)
Patch Testing
Hypersensitivity