Scribd Logo
Upload

Welcome to Scribd!

  • 25 views

    Pharmacology

    Uploaded by

    Michael Piduca
    The document discusses developing a hierarchy of clinical drug terms by mapping actual drugs to their dosage forms using data from multiple sources, finding there was a 72% match rate initially but numerous inconsistencies across sources. Examples are provided of comparing dosage forms for specific drugs across sources, looking for areas of both agreement and disagreement, and developing a preliminary hierarchy by classifying related dosage forms. Open questions remain around completing a full hierarchy and addressing editorial policies.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Pharmacology

    Uploaded by

    Michael Piduca
    25 views18 pages
    The document discusses developing a hierarchy of clinical drug terms by mapping actual drugs to their dosage forms using data from multiple sources, finding there was a 72% match rate initially but numerous inconsistencies across sources. Examples are provided of comparing dosage forms for specific drugs across sources, looking for areas of both agreement and disagreement, and developing a preliminary hierarchy by classifying related dosage forms. Open questions remain around completing a full hierarchy and addressing editorial policies.

    Original Description:

    Pharma

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses developing a hierarchy of clinical drug terms by mapping actual drugs to their dosage forms using data from multiple sources, finding there was a 72% match rate initially but numerous inconsistencies across sources. Examples are provided of comparing dosage forms for specific drugs across sources, looking for areas of both agreement and disagreement, and developing a preliminary hierarchy by classifying related dosage forms. Open questions remain around completing a full hierarchy and addressing editorial policies.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    25 views18 pages

    Pharmacology

    Uploaded by

    Michael Piduca
    The document discusses developing a hierarchy of clinical drug terms by mapping actual drugs to their dosage forms using data from multiple sources, finding there was a 72% match rate initially but numerous inconsistencies across sources. Examples are provided of comparing dosage forms for specific drugs across sources, looking for areas of both agreement and disagreement, and developing a preliminary hierarchy by classifying related dosage forms. Open questions remain around completing a full hierarchy and addressing editorial policies.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 18

    Drug Forms

    Jim Cimino
    A Modest Goal
    • Mapping actual drugs to Clinical Drug terms
    • Exchanging Clinical Drug terms sufficient for a
    variety of purposes
    • Question:
    – Will some loss of information be acceptable?
    – Does decision support care about pill vs. capsule?
    Clincial Drug Review
    • Active ingredients
    – Chemical
    – Form Strength
    • Strength amount
    • Strength units
    • Volume
    • Volume units
    • Dosage form
    Focus on Dosage Form

    • 3982 comparisons
    • 111 synonyms
    • 72% match rate
    • What went wrong?
    Examination of Dosage Forms
    • Compare use of each form, in each
    source, with use in other sources for
    corresponding medications
    • Look for irregularities in source
    • Look for 100% agreement
    • When not 100% agreement, look at
    hierarchical subsumption
    Irregularities in Sources
    NDC: 0000153144|FLUORITAB TABLETS CHEWABLE CHERRY|1.1|MG|
    TAB CHEW|100|BOT:
    A:: |FLUORITAB 0.5MG TABLET CHEW^SODIUM FLUORIDE|
    CHEWABLE TABLET|SODIUM FLUORIDE^00000000.500^MG
    ^0000.000^

    B: |FLUORITAB CHERRY TABS CHEW, 0.5MG|CHEWABLE TABLET|


    SODIUM FLUORIDE^1.100000^MG^^

    C: |SODIUM FLUORIDE CHEW TAB 1.1 MG (0.5MG F)|CHEWABLE


    TABLET|SODIUM FLUORIDE^1.1000^MG^^
    D: ||TABLET|SODIUM FLUORIDE^0.5^MG^^
    Near Misses and the Hierarchy
    Tablet
    is-a Sodium Fluoride
    1.1 MG D
    Chewable Tablet
    Tablet
    is-a

    A
    Sodium Fluoride
    1.1 MG
    B Chewable Tablet
    C
    Irregularities in Sources
    NDC: 0000014889|PROPRANOLOL HYDROCHLORIDE EXTENDED
    RELEASE CAPSULES|80|MG|CAP ER|100|BOT

    A: ||CAPSULE CR|PROPRANOLOL HYDROCHLORIDE^80^MG^^


    B: |PROPRANOLOL 80MG CAPSULE SA^PROPRANOLOL HCL|
    CAPSULE CR|PROPRANOLOL HCL^00000080.000^MG^0000.000^
    C:: |PROPRANOLOL HCL CAP CR 80 MG|CAPSULE CR|
    PROPRANOLOL HYDROCHLORIDE^80.0000^MG^^

    D:: |PROPRANOLOL HYDROCHLORIDE^80 MG|CAPSULE CR|


    PROPRANOLOL HYDROCHLORIDE^80^MILLIGRAM(S)^1^EACH

    E:: |PROPRANOLOL HCL TABS CR, 80MG|TABLET CR|PROPRANOLOL


    HYDROCHLORIDE^80.000000^MG^^
    Example of 100% Agreement

    A: LOTION: 1: LOTION|
    B: LOTION: 1: LOTION|
    C: LOTION: 1: LOTION|
    D: LOTION: 1: LOTION|
    E: LOTION: 1: LOTION|
    Example of 100% Agreement
    A: TABLET CR: 14: TAB E REL|TAB FC ER
    B: TABLET CR: 6: TAB FC ER|TAB SUG CO|
    C: TABLET CR: 9: TAB FC ER|TAB E REL|
    D: TABLET CR: 14: TAB E REL|TAB FC ER|TAB FC|
    E: TABLET CR: 7: TAB FC ER|TAB E REL|
    Example of <100% Agreement
    A: AEROSOL: 2: INHALANT|AEROSL SPR|
    B: AEROSOL: 1: INHALANT|
    C: AEROSOL: 1: INHALANT|
    SPRAY, TOPICAL, DERMAL: 1: AEROSL SPR|
    D: AEROSOL: 2: INHALANT|AEROSL SPR|
    E: AEROSOL: 1: INHALANT|
    Handling Ambiguity
    Aerosol
    Terbutaline Triamcinolone
    Sulfate is-a Acetonide
    A 0.2mg/ACT A
    Inhaled Dermal 0.147mg/GM
    Aerosol Aerosol
    D Aerosol Aerosol
    is-a is-a
    B
    Terbutaline Triamcinolone
    C Sulfate Acetonide
    0.2mg/ACT 0.147mg/GM C
    E
    Inhaled Aerosol Dermal Aerosol
    Example of Subsumption
    Aerosol ():
    A(AEROSOL) D(AEROSOL)

    Inhaled Aerosol (INHALENT):


    B(AEROSOL) C(AEROSOL) E(AEROSOL)

    Dermal Aerosol (AEROSL SPR):


    C(SPRAY TOPICAL, DERMAL)
    No Solution for Solution
    AMPUL ELIXIR DROPS, OPHTHALMIC
    DROPS INJ REPOSITORY (NON-SYSTEMIC)
    INFUS. BTL INJECTION INJECTION
    INJECTION INJECTION TYPE IRRIGATION
    IRRIGATION INJECTION IVPB SOLUTION
    SOLUTION KIT KIT, INJECTION
    IV SOLN. LIQUID (SYSTEMIC)
    KIT SOLUTION SOLUTION FOR
    PIGGYBACK SUSPENSION DROPS, OTIC
    PLAST. BAG SOLUTION FOR
    SKIN TEST INHALATION...
    SOLUTION CONCENTRATE SOLUTION
    SYRUP INJECTION OPHTMALMIC…
    VIAL KIT SOLUTION, ORAL
    NEBU (SYSTEMIC)
    OIL SOLUTION, OTIC
    SOLUTION SOLUTION, TOPICAL,
    SYRUP DERMAL
    SYRUP
    Hierarchy Thus Far
    Capsule (CAPSULE, CAP GEL CO) Aerosol ()
    Capsule EC (CAP DR PEL) Inhaled Aerosol (INHALENT)
    Capsule CR (CAP ER) Dermal Aerosol (AEROSL SPR)
    Capsule CR 12 HR (CAP ER) Cream (CREAM)
    Capsule CR 24 HR (CAP ER) Lotion (LOTION)
    Tablet (TABLET) Shampoo (SHAMPOO)
    Chewable Tablet (TAB CHEW) Ointment (OINTMENT)
    Sublingual Tablet (TABLET) Dressing (OINTMENT)
    Tablet Ultra MCR (TABLET) Patch ():
    Tablet CR (TAB FC, TAB FC ER, 24 Hour Patch TD24 (FILM ER)
    TAB E REL, TAB SUG CO) Biweekly Patch (PATCH ER)
    Tablet CR 12HR (TAB FC ER, Rectal Suppository (SUPP)
    TAB E REL) Topical Dermal Powder (POWDER)
    Tablet CR 24HR (TAB FC, TAB E REL,
    TAB SUG CO)
    Coated Tablet (TAB COAT)
    Enteric Coated Tablet (TAB D REL)
    Tablet SA OSM (TAB E REL)
    Liquid/Solution Hierarchy
    Oral (Systemic) Liquid/Solution Concentrate
    Oral Concentrate Oral Concentrate
    Oral Suspension Irrigation Solution
    Powder for Oral (Systemic) Suspension Drops
    Controlled Release Suspension Drops Suspension
    Syrup Suspension for Ophthalmic Drops
    Elixir Ophthalmic Drops
    Injection Solution for Otic Drops
    Ampule Dermal Topical Liquid/Solution
    Infusion Bottle Gel
    Repository Injection Oil
    Intravenous Solution Powder for Reconstitution
    IV Piggyback Solution for Oral Inhalation
    Intraperitoneal Solution Nebulizer
    Injection Kit Solution for Oral Mucous Membranes
    Plastic Bag Ophthalmic Solution
    Powder for Injection Ophthalmic Drops
    Skin Test Suspension for Ophthalmic Drops
    Suspension Otic Solution
    Oral Suspension Solution for Otic Drops
    Powder for Oral (Systemic) Suspension Vial
    Controlled Release Suspension
    12 Hour Controlled Release Suspension
    Drops Suspension
    Suspension for Ophthalmic Drops
    Suspension for Reconstitution
    Other Hierarchy
    Kit
    Injection Kit
    Miscellaneous Routes Kit
    Powder
    Powder for Injection
    Powder for Reconstitution
    Powder for Oral (Systemic) Suspension
    Where Do We Go From Here?
    • Work thus far is based on previous sample
    • Can a complete hierarchy be developed?
    • Will changes in editorial policy be needed?
    • If it should be done, who will do it?

    You might also like