Chronic Visual Loss: UBC Ophthalmology Club 2012

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Chronic Visual Loss

UBC Ophthalmology Club


2012
Approach
 History, physical, tests
 Patient population tends to be the elderly, but 2% of
adults in the US over age 40 have vision <20/40 (Congdon et
al. 2004. Arch Ophthalmol 122(4):477-85.)
 Prevalence increases with age
 Early detection may lead to early intervention and
preservation of vision
 Primary care is the first screen, know when to refer
Case 1
 55M comes to GP for  Exam:
routine physical  OD 20/30 OS 20/30
 Has HTN, currently on (both 20/25 2 years
thiazide ago)
 Denies visual loss, eye pain,  Pupils equal reactive
headaches  No RAPD
 Sister was taking an eye  EOM full
drop but not sure what  Confrontational VF
that’s for grossly intact
Case 1
 Management:
 A. This pt needs urgent
treatment to lower his IOP
 B. Refer pt to
ophthalmologist 1-2 weeks
 C. Reassess pt in 3 months
 D. Increase his thiazide
dose and consider adding a
second antihypertensive

Photo courtesy Dr. Fred Mikelberg


Transillumination defect. (Kuo &
Noecker, AAO 2009)

Pseudoexfoliation. (Shaw, AAO 2003)


Primary Open Angle Glaucoma
 Progressive optic neuropathy of unknown etiology with
persistent VF defect
 Risk factors incl. elevated IOP, family hx, race, age, myopia
 Sx incl. gradual loss of peripheral visual field
 Further tests:
 VF testing of this pt reveals nasal step defect
 IOP: OD 29mmHg, OS 23mmHg
 Retina tomography shows moderate thinning of nerve fibre
layer
 AAO recommends refer pt when:
 disc:cup >0.5 or one cup significantly larger than the other
 IOP > 21mmHg or >5mmHg difference between the eyes
 Sx of acute glaucoma
Common Rx for glaucoma
 The only pharmacological target is lowering IOP
 Alpha agonists(↑drain, ↓aq): clonidine, brimonidine
 Beta blocker (↓aq): timolol
 CA inhibitor (↓aq): acetazolamide (Diamox)
 Prostaglandin analog (↑drain): latanoprost (Xalatan)
 SE of PG analog- iris color change and longer eye lashes
Case 2
 70M c/o decreasing vision in both eyes over last 6 months
to GP
 This is particularly bothersome as he is having more
trouble reading and watching TV
 No eye conditions in the past
 Hx significant for obesity and 50 pkyr smoking, quit 5
years ago
 Family history unremarkable
Case 2
 OD 20/80, OS 20/100
 (last 2 years decreased)
 Pupils equal reactive
 EOM full
 CVF intact
 IOP within normal limits
 Fundoscopy:
 Amsler grid:

(Khanifar et al. Retinal Physician, 2007)


 What do you tell this patient?
 A. he has missed the window for effective intervention
 B. he needs immediate antioxidant and zinc supplement
 C. his children are at increased risk of this disease
 D. his condition probably won’t cause complete blindness
Age Related Macular Degeneration
 2 forms: atrophic (dry) and exudative (wet)
 Leading cause of blindness in adults >75 yr, mostly from
exudative form
 Multifactorial disease, see characteristic drusen
 Early diagnosis enables detection of exudative form, which
can be effectively treated with anti-VEGF agents
 Screening in primary care:
 Visual distortions, especially in central vision
 Presence of drusen in macula, retinal pigment breakdown
 Refer to ophthalmologist for full evaluation
Wet AMD

Monthly
injection,
$1600 per
shot
Case 3
 68F comes to GP with c/o decreased vision in her L eye
 She denies double vision or glares, in fact she said she can
read better with her L eye than her R eye now; she wants
to know if her reading glasses are still necessary
 No eye disease or trauma
 No family hx of eye diseases
 Meds include prednisone 20 mg daily for last 2 months
for RA flare
Case 3
 OD 20/30, OS 20/50
 Pupils equal reactive no
RAPD
 EOM full
 Confrontational VF full
 Fundus visualized,
unremarkable

(Espandar, AAO 2009)


Management
 What’s your course of action?
 A. Inform pt that her cataract is the result of her
prednisone use
 B. This pt needs to see an ophthalmologist STAT because
of risk of irreversible visual loss
 C. This pt’s presbyopia is improving so she should be
followed up in 6 months at your office
 D. Referral to ophthalmologist for evaluation and
treatment options
Cataract
 Etiology: opacified lens
 Most commonly associated with increasing age, but also
congenital, DM, steroid use, trauma, radiation
 Pt complain of painless gradual unilateral vision decrease
 “Second sight” refers to myopic shift as cataract increases
power of lens; this is temporary
 Referral to ophthalmologist when decrease in vision
becomes symptomatic and/or interfere with function
 Cataract removal+IOL implant is one of the most
frequently-performed and successful procedures in all of
surgery
Other types of cataracts

Cortical cataract Posterior subcapsular cataract

Implantable IOL
Case 4
 63M with 17 yr hx of Type 2 DM comes to GP to c/o
decrease in vision in both eyes
 Denies pain, distortions, double vision
 Hb A1c 7.5% despite being on metformin and gliclazide
 Also has dyslipidemia, on atorvastatin
 No previous eye complaints
Case 4
 OD 20/40, OS 20/60
 Pupils equal reactive, red
reflex present
 EOM full VF intact
 AC deep and quiet
 Fundoscopy:

(AAO, 2012)
Diagnosis
 What is the cause of this pt’s decreased vision?
 A. Non-proliferative diabetic retinopathy
 B. Age related macular degeneration
 C. Proliferative diabetic retinopathy
 D. Branch retinal vein occlusion
Diabetic retinopathy
 Microvascular complication of DM
 Most common cause of vision loss in adults 25-74 yr
 In NPDR, vision loss arise from macular edema
 In PDR, vision loss can be rapid, secondary to scarring
and vitreous hemorrhage
 Ophthalmologist referral when:
 Newly diagnosed DM patient
 Eye exam every 1-2 years after
 Patient who develop rapid vision change
 Glycemic control is the cornerstone of systemic
management. DR is managed with laser and anti-VEGF
PDR

Proliferative disease, characterized by Pan-retinal photocoagulation uses laser


formation of new and fragile vessels to destroy ischemic retina in order to
that form a tangle on the disc and prevent neovascularization and
elsewhere. preserve the macula.
Summary
 4 most common causes of chronic visual loss and their
features:
 Open angle glaucoma- insidious, treat IOP
 Age related macular degeneration- distortions, most common
 Cataract- often unilateral, good result with surgery
 Diabetic retinopathy- check in all DM pt, bilateral visual loss
 All are either reversible or can be managed well
(slow/stop vision loss) if detected early
 Therefore, primary care’s role is vital in screening of
chronic eye diseases
Questions?

 Edited by: Steven Schendel, PGY-4


 Reviewed by: Drs. Fred Mikelberg, David Maberley, Francis
Law

 Contact:
 R Tom Liu
[email protected]

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