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    Molecular Biology BT401: Biotechnology

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    Vivek Gupta
    This document is from the University of Engineering & Management, Kolkata and is about a lesson plan for a Molecular Biology module on DNA damage repair. It discusses how DNA damage is different from mutations, some common causes of DNA damage including reactive oxygen species, how DNA damage can prevent proper replication if unrepaired, and some models of DNA damage repair mechanisms including nucleotide excision repair, base excision repair, mismatch repair, and SOS repair. The document emphasizes that understanding DNA damage, its causes, effects, and repair mechanisms is important.

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    Molecular Biology BT401: Biotechnology

    Uploaded by

    Vivek Gupta
    21 views12 pages
    This document is from the University of Engineering & Management, Kolkata and is about a lesson plan for a Molecular Biology module on DNA damage repair. It discusses how DNA damage is different from mutations, some common causes of DNA damage including reactive oxygen species, how DNA damage can prevent proper replication if unrepaired, and some models of DNA damage repair mechanisms including nucleotide excision repair, base excision repair, mismatch repair, and SOS repair. The document emphasizes that understanding DNA damage, its causes, effects, and repair mechanisms is important.

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    Molecular Biology

    Original Title

    Teaching Template Presentation

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    This document is from the University of Engineering & Management, Kolkata and is about a lesson plan for a Molecular Biology module on DNA damage repair. It discusses how DNA damage is different from mutations, some common causes of DNA damage including reactive oxygen species, how DNA damage can prevent proper replication if unrepaired, and some models of DNA damage repair mechanisms including nucleotide excision repair, base excision repair, mismatch repair, and SOS repair. The document emphasizes that understanding DNA damage, its causes, effects, and repair mechanisms is important.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    21 views12 pages

    Molecular Biology BT401: Biotechnology

    Uploaded by

    Vivek Gupta
    This document is from the University of Engineering & Management, Kolkata and is about a lesson plan for a Molecular Biology module on DNA damage repair. It discusses how DNA damage is different from mutations, some common causes of DNA damage including reactive oxygen species, how DNA damage can prevent proper replication if unrepaired, and some models of DNA damage repair mechanisms including nucleotide excision repair, base excision repair, mismatch repair, and SOS repair. The document emphasizes that understanding DNA damage, its causes, effects, and repair mechanisms is important.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 12

    UNIVERSITY

    OF ENGINEERING & MANAGEMENT, KOLKATA

    Molecular Biology
    BT401

    Biotechnology
    UNIVERSITY
    OF ENGINEERING & MANAGEMENT, KOLKATA

    Lesson Plan
    Module 1

    DNA Damage Repair


    UNIVERSITY
    OF ENGINEERING & MANAGEMENT, KOLKATA

    Importance of the
    Modules
    DNA damage is an abnormal chemical structure in DNA
    DNA damages cause changes in the structure of the genetic
    material and prevents the replication mechanism from
    functioning and performing properly. It has got deleterious
    effect on gene expression , hence its important to understand
    its cause, mechanism and effects and the repair mechanism
    UNIVERSITY
    OF ENGINEERING & MANAGEMENT, KOLKATA
    • Damage to DNA that occurs naturally can
    result from metabolic or hydrolytic processes.
    Metabolism releases compounds that damage
    DNA including reactive oxygen species
    • Oxidative DNA damage can produce more
    than 20 types of altered bases as well as single
    strand breaks

    5
    • DNA damage is distinctly different
    from mutation, although both are types of
    error in DNA. DNA damage is an abnormal
    chemical structure in DNA, while a mutation is
    a change in the sequence of standard base
    pairs. DNA damages cause changes in the
    structure of the genetic material and prevents
    the replication mechanism from functioning
    and performing properly

    6
    DNA damage resulting in multiple broken
    chromosomes

    7
    • DNA damage and mutation have different
    biological consequences. While most DNA
    damages can undergo DNA repair, such repair
    is not 100% efficient. Un-repaired DNA
    damages accumulate in non-replicating cells,
    such as cells in the brains or muscles of adult
    mammals, and can cause aging

    8
    Models of Damage Repair
    • Nucleotide excision repair
    • base excision repair
    • mismatch repair
    • SOS repair

    9
    10
    UNIVERSITY
    OF ENGINEERING & MANAGEMENT, KOLKATA

    Questions
    Questions from the explained Portions of the module
    (multiple slides – as required)

    Text must be in Georgia / Cambria

    Font size must not be less than 24


    UNIVERSITY
    OF ENGINEERING & MANAGEMENT, KOLKATA

    Answers or Solutions
    Answers of the given questions...
    These need to be discussed after certain time gap
    (multiple slides – as required)

    Text must be in Georgia / Cambria

    Font size must not be less than 24

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