Alteration of Cellular Information

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ALTERATION OF CELLULAR

INFORMATION

CLIMACO, Lorraine
HIJE, Bea Kristine
PEREGRINO, Marie Christine
REYES, Gerica
SEPTIMO, Maria Andrea
INTRODUCTION
EVOLVING DESIRABLE BIOCHEMICAL ACTIVITIES
THROUGH MUTATIUON AND SELECTION
• Although the cell has a well-developed system to prevent errors in DNA replication and an active
repair system to correct damage to a DNA molecule, mistakes can still occur. These mistakes are
called mutations.
• The genotype is the set of genes in our DNA which is responsible for a particular trait. Genotypes
can only be determined by biological tests, not observations. Genotype is an inherited trait and
hereditary information passed by the parents determines genotype. The entire genetic
information about an organism is contained in a genotype - even those characteristics which are
not expressed visually.
• The phenotype is the physical expression, or characteristics, of that trait. Phenotype is what you
see the visible or observable expression of the results of genes, combined with the environmental
influence on an organism's appearance or behavior.
• A mutation is a genotypic change and is irreversible.
How Mutations Occur
• Most mutations occur because of mistakes in DNA synthesis. One common form is a point
mutation.
• Point mutation or substitution is a genetic mutation where a single nucleotide base is changed,
inserted or deleted from a sequence of DNA or RNA. Point mutations have a variety of effects on
the downstream protein product consequences that are moderately predictable based upon the
specifics of the mutation.
• SILENT MUTATION- are mutations in DNA that do not have an observable effect on the organism's phenotype.
• NONSENSE MUTATION- is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product.
• Deletion Mutation (also called gene deletion, deficiency, or deletion mutation) is a mutation (a
genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA
replication. Any number of nucleotides can be deleted, from a single base to an entire piece of
chromosome.

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