Scribd Logo
Upload

Welcome to Scribd!

  • 21 views

    Discoid Lupus Erythematosus Systemic Lupus Erythematosus

    Uploaded by

    Yeni Saputri
    This document discusses two types of lupus erythematosus: discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). DLE typically presents as red patches or sores on the face, scalp, and ears. Progression from DLE to SLE is uncommon. SLE most often affects young to middle-aged women and can involve the skin, joints, kidneys, brain, and other organs. Diagnosis of SLE requires meeting 4 of 11 specific clinical and laboratory criteria. Treatment involves avoiding sunlight, using sunscreen, and medications such as antimalarials, corticosteroids, and immunosuppressants.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Discoid Lupus Erythematosus Systemic Lupus Erythematosus

    Uploaded by

    Yeni Saputri
    21 views27 pages
    This document discusses two types of lupus erythematosus: discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). DLE typically presents as red patches or sores on the face, scalp, and ears. Progression from DLE to SLE is uncommon. SLE most often affects young to middle-aged women and can involve the skin, joints, kidneys, brain, and other organs. Diagnosis of SLE requires meeting 4 of 11 specific clinical and laboratory criteria. Treatment involves avoiding sunlight, using sunscreen, and medications such as antimalarials, corticosteroids, and immunosuppressants.

    Original Description:

    slide SLE

    Original Title

    Lupus Eritematous

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses two types of lupus erythematosus: discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). DLE typically presents as red patches or sores on the face, scalp, and ears. Progression from DLE to SLE is uncommon. SLE most often affects young to middle-aged women and can involve the skin, joints, kidneys, brain, and other organs. Diagnosis of SLE requires meeting 4 of 11 specific clinical and laboratory criteria. Treatment involves avoiding sunlight, using sunscreen, and medications such as antimalarials, corticosteroids, and immunosuppressants.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    21 views27 pages

    Discoid Lupus Erythematosus Systemic Lupus Erythematosus

    Uploaded by

    Yeni Saputri
    This document discusses two types of lupus erythematosus: discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). DLE typically presents as red patches or sores on the face, scalp, and ears. Progression from DLE to SLE is uncommon. SLE most often affects young to middle-aged women and can involve the skin, joints, kidneys, brain, and other organs. Diagnosis of SLE requires meeting 4 of 11 specific clinical and laboratory criteria. Treatment involves avoiding sunlight, using sunscreen, and medications such as antimalarials, corticosteroids, and immunosuppressants.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 27

    Lupus erythematosus

     Discoid lupus erythematosus


     Systemic lupus erythematosus
    Discoid Lupus erythematosus
     Young adult
     Women: men = 2:1
     Clinnical Findings :
     Dull red macule with adherent scale with
    follicular plugging, which heal with atrophy,
    scarring and pigemantary changing,
    telangiekatasis.
     Side: usually above the neck. Favorite are
    scalp, bridges of the nose, malar areas,
    lower lips and ears
     Generalized dle is less common than
    localized DLE and is usually
    suerimposed on alocallized discoid
    case.
     Progression from DLE to systemic
    lupus erythematosus (SLE) is
    uncommon.
     Differential diagnosis
    • Seborrheic dermatitis
    • Rosacea
    • Lupus vulagris
    • Sarcoid
    • Drug eruption
     Treatment
    • Avoid exposure to sunlight, excessive
    cold, to heat and trauma
    • Use a high SPF sun screen
    • Local:
     potent or super potent corticosteroid
     Intralesional triamsinolon acetonide 2,5 to
    10 mg/ml
     Systemic
    • Anti malarials. Hydroxychloroquine 6,5
    mg/kg/day. Chloroquine 250 mg/day
    • Quinacrine
    • Systemic corticosteroid for widespread
    or disfuguring lesion
    Systemic Lupus Erythematosus
     Young to middle aged women
     Skin involvement occurs in 80% of
    cases
     Diagnosis of SLE are based on four of
    the American Rheumatism
    Assosiation’s 11 criteria
     Cutaneus manifestation
    • Butterfly facial erythemmabullous lesion
    • Diffuse, non scarring hair loss
    • Mucous membrane lesion eq
    conjunctivitis, episcleritis, vaginal ulcer
    • Leg ulcer
    • Cutaneous angiitis
    • Calcinosis cutis
     Systemic manifestation
    • Arthralgia
    • Renal involvement
    • Myocarditis
    • CNS involvement
    • Vasculitis
    • Convulsion
    • Epilepsy
    • Retinitis
    • Idiopathic trombocytopenic purpura
     Etiology
    • Genetic
    • Altered immune respon
    • Drugs such as hydralazine, procainamid,
    sulfonamid, penicillin, anticonvulsan,
    minocycline and isoniazid
     Laboratory findings
    • Anemia hemolytic
    • Thrombocytopenia
    • Lymphopenia
    • Leukopenia
    • Erythrocyte sedimentation rate is
    elevated
    • Coombs tes positif
    • Rgeumatoid factor positif
     Immulogic findings
    • ANA test
    • LE cell test
    • Ds DNA
    • Anti SM antibody
    • Lupus band test
    • ANA pattern
     Differential diagnosis
    • Dermtaomyositis
    • Toxic erytema multiforme
    • Acute rheumatoid fever
    • Drug eruption
    • Sjogren’s syndrome
     Treatment
    • Avoid exposure to sunlight and use a high SPF
    sun screen
    • Antimalarial: hydroxychlotoquin or chloroquin
    • Corticosteroid: 1000 mg of prednisolone IV
    daily for 3 days , followed bt oraal prednisone
    0,5 to 1 mg/kg/dailly
    • Immunosuppressive therapy: azathiopreine,
    methotrexate and cyclophosphamide
    1982 ACR (Revised 1997) SLE
    Classification Criteria
    1. Malar (butterfly) rash
    2. Discoid lesions
    3. Photosensitivity
    4. Oral ulcers
    5. Non-deforming arthritis (non-erosive for the most part)
    6. Serositis: pleuropericarditis, aseptic peritonitis
    7. Renal: persistent proteinuria › 0.5 g/d or ›3+ or cellular
    casts
    8. Neurologic disorders: seizures, psychosis
    9. Heme: hemolytic anemia; leukopenia, thrombocytopenia
    10. Immune: anti-DNA, or anti-Sm, or APS (ACA IgG, IgM),
    or lupus anticoagulant (standard) or false + RPR
    11. Positive FANA (fluorescent antinuclear antibody)
    SLE-Clinical and Laboratory Features
     Musculoskeletal 90%
     Skin 80%
     Renal 50%
     CNS 15%
     Severe thrombocytopenia
    5-10%
     Positive ANA 95+%

    Also, cardiopulmonary involvement,


    thrombotic tendency (APS), and
    “premature” or accelerated
    atherosclerosis!
    Joint involvement in lupus mimics rheumatoid arthritis (RA) but milder
    Jaccoud’s arthropathy
    Arthritis in lupus can be
    deforming but is typically
    non-erosive!

    You might also like