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    Artificial Skin: P. Petchiammal Iii B.SC Chemistry, St. John'S College

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    Jim Livingston
    Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns.

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    © All Rights Reserved
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    Artificial Skin: P. Petchiammal Iii B.SC Chemistry, St. John'S College

    Uploaded by

    Jim Livingston
    285 views21 pages
    Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns.

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    Artificial Skin

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    Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    285 views21 pages

    Artificial Skin: P. Petchiammal Iii B.SC Chemistry, St. John'S College

    Uploaded by

    Jim Livingston
    Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 21

    ARTIFICIAL SKIN

    P. PETCHIAMMAL
    III B.Sc CHEMISTRY,
    St. JOHN’S COLLEGE
    SKIN
    It’s the human body’s largest organ
    it‘s helps to regulate the body temperature
    Helps preserve fluid balance
    It protects the body from disease & physical
    damage
    LAYERS OF SKIN
    • Epidermis
    It’s the outer layer,which is composed of cells
    keratinocytes,melanocytes and Langerhans.

    • Dermis
    The dermis composed of connective tissue fibres,such as Collagen
    and it supplies nourishment to the epidermis.
    It protect nurses,blood vessels,sweet gland,hair from harmful bacteria.
    ARTIFICIAL SKIN
    Artificial skin is a synthetic substitute for
    human skin.itshuman bodies largest
    organ.ato treat a burned skin,surgeons first
    removed the burned skin & then quickly
    cover the underlying tisdue,usually with the
    combination of laboratory grown skin cells.
    When skin is damaged or lost due to injury or
    burns,bacteria and other micro organism
    have essay access to warm,nutrient rich
    body fluids
    BRIEF HISTORY OF ARTIFICIAL SKIN

    • 3000-2500BC India : Skin is allegedly transplanted by Hindus from the buttocks to repairs
    mutilated ears and noses.
    • 1998 Unitated states: First tissue engeenared skin is approved by FDA.
    • 2002 Unitated states: Integra is FDA
    • approved for treatment of severe burns.
    John F.Burke(July 22 1922-2011) was an
    American medical researcher at Harvard
    university widely known for his co-invention
    of artificial skin In 1981 together with
    Dr.LoAnnie Y.yannas.
    POLYMERS USED IN ARTIFICIAL SKIN

    • Silicon polymers
    • Polyesters
    • Polylactic acid
    • Other conventional material
    • Scaffold
    • Collagen
    SCAFFOLD

    • Scaffold is a molecular microscopy smaller structure,which is made up


    of polymer fibres that guide the growth of cells.
    • The polymer used in a scaffolding consists of polylactic acid and
    polyglycolic acid
    • Artificial skin is a collagen scaffold that induces regeneration of
    skin(dermis) in mammals such as humans.
    COLLAGEN
    • Collagen is a protein made up of amino
    acids,which turn build up of carbon,oxygen,and
    hydrogen.
    • Collagen contains specific amino acids-
    glycine,proline,hydroxyproline and argeinine
    • Collagen is a tough,strong fibre,that provides
    tensile,elasticity, and compressive strength to your
    argans and tissue.
    COLLAGEN SCAFFOLD
    • Collagen is a main structural protein of most hard and soft tissues in animals
    and the human body’s.
    • Which plays role in maintaining the biological and structural integrity of ECM
    and provides physical support to tissues.
    • Collagen can be extracted and purified from the variety of sources.
    • It possess extensive sources(such as bone,tendons,ligament,blood
    vessel,nerve,skin) as it is the main structural protein of most hard and soft
    tissues.
    COLLAGEN SCAFFOLD
    • In addition immunogenicity,a porous structure,good
    permeability,biocompatiability and biodegradability.
    • It has functions to regulate the morphology,adhesion,migration,and
    differentiate of cells.
    COLLAGEN SCAFFOLD
    • Properties of collagen scaffold,it presents poor mechanical properties and
    structural stability.
    • Ultraviolet irradiation,gamma radiation and dehydrothermal treatment are
    the most commonly used physical treatment.
    • They could increase the mechanical properties of the collagen scaffold
    while reducing the solubility and absorption without toxicity.
    MANUFACTURING PROCESS
    DERMAGRAFT
    • Is indicated for use in the treatment of full-
    thickness diabetic foot ulcers.
    • The product was approved for sale in the
    Unitated states in 2001.
    • It’s a cryopreserved human fibroblast -
    derived dermal substitute.(HFDS)
    TRANSCYTE
    • Is indicated for use as a temporary wound covering for surgically excissed
    full-thickness and deep partial thickness thermal burn wounds.
    • The product of human fibroblast-derived temporary skin substitute.
    • It was approved for sale in the Unitated states in 1999 and is also approved
    and marketed in a number of other countries.
    INTEGRA
    • Is a bilayer artificial skin replacement with a dermal layer composed of a
    bovine collagen gel cross linked with shark chondroitin-6-sulphate.
    • The synthetic epidermal layer is composed of a polysiloxane polymer that
    was removed before use in this study.
    SHARK CHONDROITIN-6-SULPHATE
    ADVANTAGES & DISADVANTAGES

    Advantages
    Disadvantages

    • It looks real
    • Risks of infection and rejection by the
    • Chances of survival for burn patients patients
    • Artificial skin seals the wound • Loss of sensitivity
    preventing fluid loss and bacteria
    from entering through the wound. • Cut of blood supply
    • The fear of stigmatization of the • Artificial skins are very expensive
    patient is eliminated. • You skin may develop allergies to
    something artificial
    THANK YOU
    😊

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