Referat - Sindrom Serotonin Dalam Kehamilan - Oca
Referat - Sindrom Serotonin Dalam Kehamilan - Oca
Referat - Sindrom Serotonin Dalam Kehamilan - Oca
MUHAMMAD ROSAMANILLAH
20174011135
“ Serotonin syndrome (SS) is a life-
threatening condition, usually
precipitated by a combination of
serotonergic agents. Data
regarding the incidence and
management of SS in obstetrics
are limited.
2
This study presents a case of SS
provoked by an atypical antipsychotic
in :
▪ a second trimester
▪ singleton gestation
▪ reviews the management of SS in an
obstetric patient
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CASE REPORT
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Patient ID:
▪ The patient is a 21-year-old
▪ gravida 1 at 24 wk gestation
▪ schizophreniform disorder
5
intravenous
she had taken
labetalol
two additional
And
tablets of
Monitoring in
lurasidone
ICU
6
EXAMINATION
Vital Sign:
Laboratory: all unremarkable
Heart Rate : 180x
▪ Complete Blood Count
Blood Pleasure : 18/89 mmHg
▪ Comprehesive metabolic panel
▪ Creatinine kinase
Physical Exam:
▪ Troponins
Neuromuscular excitability
▪ Urinalysis
Hyperreflexia in the L2–L4
▪ Urine drug screen
Inducible clonus
FHR : 130x
Electrocardiogram: sinus tachycardia
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MANAGEMENT IN
EMERGENCY DEPARTMENT
▪ intravenous labetalol
8
MANAGEMENT IN
INTENSIVE CARE UNIT
▪ Telemetry
▪ Pulse oxymetri
▪ Supplemental O2
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ETIOLOGY
Serotonin syndrome is most oft en triggered by the initiation
of:
▪ Autonomic stimulation
▪ Neuromuscular hyperactivity
17
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▪ The onset of symptoms usually occurs within 24 h
of an increase in dosage, overdose or withdrawal of
a serotonergic agent.
24
RECOMMENDATION
▪ having a high clinical suspicion of serotonin syndrome in
any obstetric patient who is taking psychiatric
medications and presents with altered mental status and
signs of autonomic dysfunction.
▪ seeking early engagement of a multidisciplinary team.
25
THANKS!
Any questions?
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