Scribd Logo
Upload

Welcome to Scribd!

  • 45 views

    Penggunaan Obat Pada Ibu Hamil Dan Menyusui

    Uploaded by

    elza nurrifqah
    The document discusses the effects of drug use during pregnancy and breastfeeding, noting changes in organ systems during pregnancy and FDA drug categories. It provides examples of specific drugs and their safety classification or known risks to the fetus or infant, such as ACE inhibitors posing risks of renal damage to the fetus and tetracycline risking tooth staining in breastfed infants. The effects of various common drugs for conditions like hypertension, dyspepsia, and nausea are outlined.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Penggunaan Obat Pada Ibu Hamil Dan Menyusui

    Uploaded by

    elza nurrifqah
    45 views19 pages
    The document discusses the effects of drug use during pregnancy and breastfeeding, noting changes in organ systems during pregnancy and FDA drug categories. It provides examples of specific drugs and their safety classification or known risks to the fetus or infant, such as ACE inhibitors posing risks of renal damage to the fetus and tetracycline risking tooth staining in breastfed infants. The effects of various common drugs for conditions like hypertension, dyspepsia, and nausea are outlined.

    Original Description:

    penggunaan obat

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses the effects of drug use during pregnancy and breastfeeding, noting changes in organ systems during pregnancy and FDA drug categories. It provides examples of specific drugs and their safety classification or known risks to the fetus or infant, such as ACE inhibitors posing risks of renal damage to the fetus and tetracycline risking tooth staining in breastfed infants. The effects of various common drugs for conditions like hypertension, dyspepsia, and nausea are outlined.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    45 views19 pages

    Penggunaan Obat Pada Ibu Hamil Dan Menyusui

    Uploaded by

    elza nurrifqah
    The document discusses the effects of drug use during pregnancy and breastfeeding, noting changes in organ systems during pregnancy and FDA drug categories. It provides examples of specific drugs and their safety classification or known risks to the fetus or infant, such as ACE inhibitors posing risks of renal damage to the fetus and tetracycline risking tooth staining in breastfed infants. The effects of various common drugs for conditions like hypertension, dyspepsia, and nausea are outlined.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    You are on page 1of 19

    PENGGUNAAN OBAT

    PADA IBU HAMIL DAN


    MENYUSUI
    Changes in pregnancy
    CARDIOVASCU
    LAR

    GASTROINTES
    GYNECOLOGI
    TINAL

    KIDNEY
    Cardiovascular
    > Increased blood volume by 30-50%
    > Increased cardiac output by 30-50%
    > Decreased systemic vascular resistance
    Gastrointestinal
    > IncreasedpH of intestinal secretion
    > Increased gastric emptying time
    > Decreased gastric acid secretion
    > Decreased intestinal motility
    KIDNEY
    > Increased renal blood flow rate
    > Increased glomerular filtration rate
    GYNECOLOGI
    • > Increased uterine blood flow
    FDA DRUGS CATEGORIES IN
    PREGNANCY
    CATEGORY
    A

    CATEGORY CATEGORY
    X B

    CATEGORY CATEGORY
    D C
    CATEGORY A
    • Adequate and well-controlled studies
    have failed to demonstrate a risk to the
    fetus in the first trimester of pregnancy (no
    risk in the later trimester)
    Example: levothyroxine, folic acid,
    MgSO4, liothyronine
    CATEGORY B
    • Animal reproductive studies have failed
    to demonstrate a risk to the fetus and
    there are no adequate and well-
    controlled studies in pregnant women
    Example: metformin, hydrocholorthiazide,
    amoxicillin, pantoprazole
    CATEGORY C
    • Animal reproduction studies have shown
    an adverse effect on the fetus and there
    are no adequate and well-controlled
    studies in humans, but potential benefits
    may warrant use of the drug in pregnant
    women despite potential risks.
    Example: tramadol, gabapentin,
    amlodipine, prednisone
    CATEGORY D
    • Positive evidence of human fetal risk
    based on adverse reaction data from
    investigational or marketing experience
    studies in humans but potential benefits
    may warrant use of the drug in pregnant
    women despite potential risks
    Example: lisinopril, alprazolam, losartan,
    clonazepam, lorazepam
    CATEGORY X
    • Studies in animals or humans have
    demonstrated fetal abnormalities and/or
    there is positive evidence of human fetal
    risk based on adverse reaction data
    from investigational or marketing
    experience and the risks involved in use
    of the drug in pregnant women clearlu
    outweigh potential benefits
    Example: atorvastatin, simvastatin,
    warfarin, methothrexate, finasteride.
    EFEK PENGGUNAAN OBAT
    PADA KEHAMIAN
    Drug Trimester Effect
    ACEI All Renal damage
    Barbiturates All Chronic use: neonatal
    dependence
    Carbamazepine First Neural tube defects
    Cocaine, tamoxifen All Risk of spontaneous abortion
    Ethanol All Fetal alcohol syndrome
    Tobacco All Intrauterine growth retardation
    Tetracycline All Discolorisation of teeth and
    altered bone growth
    Thalidomide First Limb malformation
    Warfarin First Alter respiratory tract formation
    Second CNS malformation
    Third Risk of bleeding
    Antiemetics drugs in pregnancy
    • Metoclopramide – B
    • Ondancentron – B
    • Domperidon – B
    • Phenothiazine – C
    Analgesics drugs in pregnancy
    • Paracetamol – B
    • Aspirin – C
    • NSAID – C & D
    Dyspepsia in pregnancy
    • Antasida – safe in 2nd and 3rd trimester
    • H2 antagonist (cimetidine/ranitidine) – safe
    in sectio
    • Sucralfat – safe in pregnancy because no
    absorptions
    Antihypertensive drugs in
    pregnancy
    • ACEI (captopril, lisinopril) – C & D
    • Beta blockers (propanolol, bisoprolol) – C
    &D
    • Diuretics (Furosemide) – C & D
    • ARB (candesartan) – C & D
    Antibiotics in pregnancy

    AMAN TIDAK AMAN


    Penicillin Tetracyclin

    Ampicillin Aminoglicoside

    Amoxicillin Gentamycin

    Cephalosporin Quinolon

    Cotrimoxazole Vancomycin

    Erithromycin

    Antifungal

    * Beware of allergic reaction in some antibiotics


    EFEK PENGGUNAAN OBAT
    PADA IBU MENYUSUI
    Drug Comments
    Tetracycline Risk of Permanent tooth staining in
    infant

    Isoniazide Risk of Pyridoxine deficiency in infant


    Barbiturate Lethargy, sedation and Poor suck
    reflexes

    Diazepam Drug accumulation and sedation


    Methadone Risk of withdrawal if breast feeding stop
    Iodine Thyroid suppression and risk of cancer
    Propylthiouracil Can suppress thyroid function in infant

    You might also like