Hoarseness—Causes and

Treatments
 SUMMARY
Background

• Hoarseness (dysphonia) is the reason for

about 1% of all consultations in primary care. It has many
causes, ranging from self-limited laryngitis to malignant
tumors of the vocal cords.

Methods

• This review is based on literature retrieved by a selective search

in PubMed employing the terms “hoarseness,” “hoarse voice,”
and “dysphonia,” on the relevant guideline of the American
Academy of Otolaryngology—Head and Neck Surgery, and on
Cochrane reviews.
Results

• Hoarseness can be caused by acute (42.1%) and chronic laryngitis

(9.7%), functional vocal disturbances (30%), and benign (10.7–31%)
and malignant tumors (2.2–3%), as well as by neurogenic
disturbances such as vocal cord paresis (2.8–8%), physiologic aging of
the voice (2%), and psychogenic factors (2–2.2 %). Hoarseness is very
rarely a manifestation of internal medical illness. Voice therapy is
often successful in the treatment of functional and organic vocal
disturbances . Surgery on the vocal cords is indicated to treat tumors
and inadequate vocal cord closure. The only entity causing
hoarseness that can be treated pharmacologically is chronic
laryngitis associated with gastro-esophageal reflux, which responds
to treatment of the reflux disorder. The empirical treatment of
hoarseness with antibiotics or corticosteroids is not recommended.
Conclusion

• Voice therapy, vocal cord surgery, and

drug therapy for appropriate groups of
patients with hoarseness are well
documented as effective by the available
evidence. In patients with risk factors,
especially smokers, hoarseness should be
immediately evaluated by laryngoscopy.
 The pathophysiology of hoarseness is
The term dysphonia is used to characterized by muscle tone– related
describe any impairment of the irregularity in the oscillation of the
voice—alteration in the sound of the vocal cords owing to hypertonic
voice with hoarseness, restriction of dysphonia, incomplete closure of the
vocal performance, or strained glottis on vocalization, or an increase
vocalization. in vocal cord bulk, perhaps due to a
tumor (Figure 1a, b).
The causes of hoarseness are diverse:

• Acute and chronic laryngitis (accounting for 42.1% and 9.7% of cases
respectively)
• Functional dysphonia (30%)
• Benign and malignant tumors (10.7 to 31.0% and 2.2 to 3.0% respectively)
• Neurogenic factors such as vocal cord paralysis (2.8 to 8%)
• Physiological aging (2%)
• Psychogenic factors (2.0 to 2.2%) (1, e5).

Very occasionally hoarseness can be attributed to

manifestations of laryngeal disease other than tumors(Table 1).
 Suspicion of a serious
underlying disease (Box, Figure
2) or persistence of hoarseness
for more than3 months ,should
prompt immediate investi gation
by means of indirect
laryngoscopy.
 Functional dysphonia

- In the absence of a specific anatomic correlate such as a

tumor, patients with hyperfunctional dysphonia, i.e., a non-
physiological increase in tone of the vocal cords on
phonation, in speaking or breathing, develop marked
difficulties in speaking, with accompanying hoarseness.
-The stroboscopic oscillation of the vocal cords is impaired or
irregular due to abnormal muscle tone. The measure of
choice is conservative treatment to counteract the damaging
strain on the voice. Various procedures are available to
improve vocal and respiratory technique and vocal hygiene
(evidence level 1a, recommendation grade A) (2, e4).
 Secondary manifestation of functional
dysphonia

-The vocal cord changes are a secondary manifestation of untreated

hyperfunctional dysphonia. Initially, there is reactive phonation
hyperplasia of the medial margin of the vocal cord—at the junction of the
anterior third and middle third, the site of greatest stress on phonation.
The tissue swells reversibly and edema arises. With the passage of time,
the soft swellings undergo fibrosis and turn into hard nodules, preventing
complete closure of the vocal cords in the affected area.
- The treatment of choice is voice therapy. Only infrequently is
microsurgical excision necessary in adults. In over 80% of patients the
voice is restored to normal by voice therapy alone. Recurrence rates of
30% after voice therapy and 13% after phonosurgery have been reported.
 Organic dysphonia

Acute laryngitis

Organic
Chronic laryngitis
dysphonia

Benign and
malignant
tumors
 Acute laryngitis

Acute laryngitis is the most common cause of hoarseness, and is

almost always viral in origin. It occurs in infections of the upper
respiratory tract and is self-limiting, subsiding after 1 to 2
weeks. Patients are counseled to limit how much they talk, but
absolute voice rest is not advised in order to avoid the risk of
overcompensation to the point of aphonia. Routine antibiotic
treatment is discouraged ,antibiotics are prescribed only in
exceptional circumstances, e.g., in the presence of bacterial
superinfection or laryngeal tuberculosis (Table 1). Indirect or
direct laryngoscopy is indicated in such severe cases (Figure 2).
Corticosteroids should not be administered in acute laryngitis.
 Chronic laryngitis

Chronic laryngitis is a precursor of vocal cord

cancer.

The following have been proposed as important

etiological factors:
• Nicotine abuse
• Inhaled corticoid treatment
• Inhaled environmental noxae
• Gastroesophageal reflux with laryngopharyngeal involvement.
Not infrequently leukoplakia
arises (Figure 3). Possible
clinical signs of chronic
laryngitis are dysphonia,
sensations in the throat, and a
constant urge to clear the
throat.The principal therapeutic
measures are avoidance of
noxae and regular laryngeal
stroboscopy for early detection
of malignancy (4, 6).
 Benign and malignant tumors
Vocal cord polyps/vocal cord cysts – Vocal cord
• polyps are unilateral tissue proliferations on the free margin of
the vocal cord and thus hamper phonation. The factors
promoting the formation of vocal cord polyps include smoking,
chronic laryngitis, and phonation trauma, i.e., microvascular
trauma with local edematous remodeling processes and
accompanying inflammation as a result of misuse of the voice.
Retention cysts arise when the excretory ducts of the mucous
glands are obstructed. The symptoms are hoarseness together
with reduced volume and fatigue of the voice. The treatment
of choice for polyps is phonosurgical excision at the base. Cysts
must be removed in toto with the capsule.
Reinke edema
• Reinke edema is caused predominantly by tobacco smoke
and mainly affects women (80%) between the ages of 40
and 60 years .Phonosurgical removal of the edema results
in improvement of the pitch, resonance, and also
resilience of the voice. It is essential to stop smoking,
although this does not always achieve marked
amelioration of the edema. As with polyps and cysts,
additional voice therapy may be required to correct a
reactive vocal dysfunction that has arisen preoperatively.
Recurring papillomatosis
• Juvenile (RJP) and adult (RAP) forms of recurring papillomatosis
are distinguished. RJP usually arises between the ages of 2 and
4 years and is a major cause of hoarseness and also dyspnea in
childhood . In children, infection with HPV 11 has a severe
course and may even lead to obstruction of the respiratory
tract.Hoarseness is the cardinal symptom of RAP, the
occurrence of which peaks between the ages of 20 and 40
years. The primarily benign, cauliflower-like neoplasms are
found mostly in the area of the vocal cords or extralaryngeally
in the trachea, bronchi, or lungs. Papillomas are excised
microsurgically.
Vocal cord malignancies
• Around two thirds of laryngeal cancers are located in the area
of the vocal cords. Squamous epithelial carcinoma accounts for
more than 90% of cases. Dysphonia is considered an early
symptom. In microlaryngostroboscopy, the term phonatory
standstill is used to describe the state in which the fine
vibrations of the tumor-infiltrated vocal cords are abolished.
The treatment comprises transoral (laser) resection or primary
low- volume radiotherapy. Treatment may be followed by
hoarseness owing to scarring or, in the case of tissue loss,
incomplete glottic closure. In this event, voice therapy often
has a successful result.
Vocal cord scarring
• Scarring of the sulcus between the vocal cord epi thelium and the
vocal muscle may be congenital, but in most cases occurs following
severe laryngitis or (phono)surgical interventions. Laryngoscopy of
the area around the sulcus shows abolition of the fine vibrations or,
in the event of significant tissue loss, incomplete glottic closure. The
voice is constantly hoarse and may be breathy and poorly audible.
Voice therapy usually only corrects the dysfunction, failing to achieve
any relevant improvement in resonance, and surgery to release the
scars or deal with the incomplete closure of the glottis is also
challenging. Reported results mostly describe the authors’ own
experience; there are no prospective studies from which evidence-
based treatment recommendations could be derived.
 Presbyphonia

Presbyphonia, the physiological hoarseness of old age. The vocal

cord musculature atrophies in the course of the physiological
aging process, giving rise to a more oval shape of the vocal cord
fissure during phonation. Furthermore, the mucus-producing
cells of the vocal cord also atrophy with age, so the surface film
increases in viscosity, negatively influencing the sound of the
voice. The leading symptom is a weak, less intense voice
produced at the cost of pronounced strain. Treatments that can
be considered are voice therapy, which may help to regulate the
tone and improve the subglottic air pressure, and phonosurgical
measures to reinforce glottis closure.
 Manifestation of internal diseases
Laryngopharyngeal reflux
• Nine to 26% of the population suffer from reflux-related mucosal irritation of
the larynx and pharynx with chronic laryngitis. Moreover, reflux is an
important trigger factor for laryngospasm or vocal cord dysfunction (VCD). Up
to 92% of these patients mention hoarseness, chronic urge to cough, throat
clearing, a lump in the throat, and unspecific swallowing difficulties .
Laryngoscopy reveals vocal cord edema, mucosal erythema, or gastric
laryngitis, i.e., mucosal hyperplasia with plication of the interarytenoid region
in the posterior part of the larynx. Trial treatment with proton pump
inhibitors is important in establishing the diagnosis. Another treatment
option is antireflux therapy, if hoarseness occurs in chronic laryngitis with
signs of reflux disease . In the absence of reflux this treatment is
inappropriate. Overall, the diagnosis of laryngopharyngeal reflux (LPR) is
assigned uncritically and too often among patients with dysphonia.
Accordingly, the symptomatic measures remain ineffective.
 Internal diseases with occasional laryngeal
manifestations

Tuberculosis

rheumatoid diseases such as :

• rheumatoid arthritis
• systemic lupus erythematosus
• Wegener disease
• and laryngeal sarcoidosis
amyloidosis

and manifestations of lymphoma

are among the internal diseases with occasional laryngeal involvement. In all these diseases
interdisciplinary management is mandatory. The treatment is usually based on experience from case
series.
 Neurogenic causes
Vocal cord paralysis
• Vocal cord paralysis may be partial (reduced mobility) or
complete, caused by damage to the recurrent laryngeal nerve; a
dysphonia arises from the incomplete glottic closure or irregular
vibration of the vocal cords. Vocal cord paresis may be the first
symptom of malignancy. The treatment should begin with speech.
If voice quality has shown no decisive improvement after 2
months and incomplete vocal cord closure persists, temporary
vocal cord filling (injection glottoplasty/ augmentation) is
recommended, e.g., with hyaluronic acid. Once the paresis has
persisted for 12 months, recovery is unlikely. In this case
autologous fat (less resorbable) should be used for injection
glottoplasty, or external thyroplasty can be performed.
Spasmodic dysphonia
• Spasmodic dysphonia (SD) is one of the focal
dystonias. This severe dysphonia leads to
involuntary spasms of the laryngeal
musculature with increased adduction or
abduction of the vocal cords, depending on
subtype. comprises injection of the neurotoxic
protein botulinum toxin into the affected vocal
cord muscles.
 Vocal cord dysfunction

VCD, sometimes called “laryngeal asthma,” is an intermittent, functional

laryngeal obstruction causing dyspnea. It occurs due to laryngeal
hyperreactivity on inspiration. A multifactorial etiology is assumed. Proposed
trigger mechanisms include repeated exposure of the larynx to irritative
inhaled stimuli such as perfumes or allergens and microaspiration in the
presence of laryngopharyngeal reflux. The episodic dyspnea with stridor is
accompanied by further symptoms such as dysphonia or aphonia. VCD may
occur in isolation but is also found in 3 to 5% of asthmatics. In contrast to the
classical bronchial asthma, medicinal therapy is ineffective. The episodes of
respiratory distress can usually be controlled well by means of special
breathing techniques. Psychotherapy is sometimes also recommended,
particularly for patients with secondary anxiety and panic attacks, but the fact
that predominantly case series have been published means there is no
sufficient evidence of its effect (e79).
 Psychogenic dysphonia

Psychogenic dysphonia preferentially affects women between

the ages of 20 and 40 years The patients complain of sudden
extreme hoarseness or even acute aphonia. By contrast, loud
coughing or throat clearing is still possible, i.e. vocal function is
impaired only in communicative contexts. Laryngoscopy shows
no inflammation, but sometimes there is muscle tone-related
limitation of adduction of the vocal cords during phonation. Our
investigation of 40 patients showed that psychogenic dysphonia
is often an acute manifestation preceded by severe
psychological stress. Behavioral psychotherapy is helpful ,
whereas voice therapy is completely ineffective.