MANUFACTURE OF MONOSODIUM

GLUTAMATE FROM CASSAVA ROOT CROPS

PRESENTED BY:
ANASTACIO, VAN CALVIN
BALANE, LAWRENCE BENZ
BRIONES, NEIL RYAN
DIAZ, GRAZIELLE ANNE
HERNANDEZ, LISA ANTOINETTE
IRINGAN, KAREN DEE
MODINA, MA. BETINA ISABEL
TURIJA, JOANNE PAULA
PROCESS FLOW DIAGRAM
BLOCK DIAGRAM
 EQUIPMENT DESIGN

• FERMENTOR
• FIXED BED ADSORBER
• CRYSTALLIZER
• TRAY DRYER
 FERMENTOR
LIST OF ASSUMPTIONS
• BATCH AEROBIC FERMENTER WILL BE USED IN THE FERMENTATION PROCESS.

• TWO DAYS WILL BE USED AS A FERMENTATION TIME FOR A CONVERSION OF 70% WITH TWENTY-
HOURS OPERATION A DAY.
• SS316 WILL BE THE MATERIAL OF CONSTRUCTION TO BE USED IN VESSEL DESIGN.
• 4 UNITS OF REACTOR PER BATCH.

• HEIGHT OF LIQUID TO DIAMETER OF THE TANK RATIO IS 1.5 FOR STABILITY PURPOSES.
• 20% OF THE TOTAL VOLUME OF FEED IS ALLOTTED AS AN ALLOWANCE FOR VAPOR SPACE.
• IMPELLER TYPE THAT WILL BE USED IS SIX-BLADE DISK

• API-ASME VESSEL DESIGN CODE WILL BE USED.

• MOTOR EFFICIENCY OF THE AGITATOR IS AROUND 80%
• ASSUME MAXIMUM TIME FOR CHARGE FEED TO THE REACTOR, HEAT TO REACTION TEMP, AND EMPTY
AND CLEAN REACTOR TIME.
 SPECIFICATION SHEET
IDENTIFICATION
Name of Equipment Steam Jacketed Fermenter

Equipment Code J-4

Type Aerobic

Mode of Operation Batch

Number of Units 5 units

Fermentation Time 36 hours

Function To produce glutamic acid

 BASIC DESIGN DATA
Materials Handled Glucose, Water, Inoculum, Aqueous NH3
Density 1,035.25 kg/m3
Viscosity 1.22 x 10-3 kg/m3
Maximum Temperature 30 ℃
Pressure 1.00 atm
VESSEL DESIGN
Material of Construction SS316
Volume 85.84 m3
Height 4.13 m
Diameter 2.30 m
Shell Thickness 6 mm
Head Thickness 6 mm
Bottom Thickness 6 mm
Head Type Ellipsoidal Head
Weld Type Single-butt welded joints
Welding Efficiency 0.6
 IMPELLER DESIGN

Impeller Type Rushton Impeller (6-Disk flat blades)

Number of Impellers 3

Impeller Diameter 0.767 m

Impeller Height 0.153 m

Impeller Width 1.15 m

Impeller Clearance at the 0.767 m

Bottom
Number of Baffles 4

Width of Baffles 0.23 m

Distance between Impellers 1.15 m

Speed of Rotation 180 rpm

Power Requirement 72 hp
 HEATING SYSTEM DESIGN

Area of Jacket 0.58 m2

Height of Jacket 0.08 m

Diameter of Jacket 3m

Material of Construction SS 316

Thickness of Jacket 6 mm

Heating Medium Steam

Heating Temperature 150 ℃ - 100 ℃

 DESIGN COMPUTATION FOR FERMENTOR
COMPONENT Mass (kg) Density Flow Rate (m3)
Glucose 5,930.60 1,540 3.85
Maltose 174.25 1,540 0.11
Water 54,415.73 1,000 54.42
Alpha-amylase 3.66 1,250 0.003
Protein 275.25 1,350 0.204
Fats 100.09 896.3601 0.11
Glucoamylase 2.13 1,892.6 0.001
Pullulanase 1.83 1,250 0.001
Inoculum 1,253.13 1,000 1.25
NH3 538.2 880 0.61
TOTAL 62,694.87 60.56

Average Density
𝑀𝑇𝑂𝑇𝐴𝐿
𝜌𝐴𝑉𝐸 =
𝑉𝑇𝑂𝑇𝐴𝐿
62,694.87 𝑘𝑔
𝜌𝐴𝑉𝐸 =
60.56 𝑚3
𝜌𝐴𝑉𝐸 = 1,035.25 𝑘𝑔Τ𝑚3 = 64.63 𝑙𝑏𝑚ൗ𝑓𝑡 3
 FIXED BED ADSORBER
SUMMARY OF ASSUMPTIONS
• GRANULAR ACTIVATED CARBON WILL BE USED TO REMOVE IMPURITIES.
• 100% OF THE IMPURITIES WILL BE ADSORBED BY THE GAC
• CARBON STEEL ASME CODE PRESSURE VESSEL WILL BE USED FOR THE DESIGN OF VESSEL.
• THE ALLOWANCE FOR VAPOR SPACE IS AROUND 20% OF THE HEIGHT OF LIQUID.
• MAXIMUM USABLE TIME OF ADSORBENT IS 1 DAY (20 HRS).
• UNS K03005 CARBON STEEL WILL BE THE MATERIAL OF CONSTRUCTION TO BE USED IN VESSEL
DESIGN.
 SPECIFICATION SHEET

Name of Equipment Fixed Bed Adsorber

Code J-6

Type Fixed Bed

Function To remove impurities in MSG solution

Number of Units 1 unit

Operation Batch

Operating Hours 20 hrs

No. of Batch 1

MSG, Glucose, Maltose, Oligosaccharides, Water, α- amylase, Glucoamylase,

Material Handled
Pullulanase, NaOH, Proteins, Fats, Fibre, HCl, C. Glutamicum
 CONSTRUCTION DETAILS
VESSEL
Material of Construction UNS K03005 Carbon Steel
Orientation Vertical
Type Cylindrical
Type of Joint Double v-butt joint
Joint Efficiency 0.85
Welding efficiency 1.0
Diameter 4.267 m
Height 8.20 m
Shell Thickness 5 mm
Head Thickness 4 mm
Pressure Drop 0.496 inH2O
 OPERATING CONDITION
Temperature 20-30 °C
Pressure 14.7 psi
Feed Flow rate 6.5016 m3/hr
ADSORBER DESIGN
Adsorbent Type Granular Activated Carbon
Bed Length 2.13 m
Contact Time 4.7 hrs
Adsorbent Replacement 1 day

Adsorbent Weight 16,771.11 kg

Adsorbent Support Two succession metal screens with sizes 8 and 30 mesh

Adsorption System Piping 4” Schedule 40 Carbon Steel Pipe

 DESIGN COMPUTATION FOR FIXED BED ADSORBER
• FEED :
Xi Density (kg/m3) Mass(kg) Volume(m3)
MSG 0.03048 1620 2182.27 1.347080247
Glucose 0.02435 1540 1743.6 1.132207792
Maltose 0.00159 1540 113.84 0.073922078
Oligo 0.0008 1540 56.93 0.036967532
Water 0.9418 1000 67438.38 67.43838
C. Glutamicum 0.00076 100 54.38 0.5438
Amylase 0.000001 1250 0.07 0.000056
Glucoamylase 0.0000006 1892.6 0.04 2.11349E-05
Pullulanase 0.0000006 1250 0.04 0.000032
NaOH 0.00011 2130 7.89 0.003704225
Protein 0.00008 1350 5.51 0.004081481
Fats 0.00003 0 2 0
Fibre 0.00001 0 0.85 0
1N HCl 0.000001 1490 0.01 6.71141E-06

1.0000132 71605.81 70.5802592

 DESIGN COMPUTATION FOR FIXED BED ADSORBER
• EFFLUENT Xi Density(kg/m3) mass (kg) volume(m3)
MSG 0.01486 1620 56.06 0.034604938
Glucose 0.46204 1540 1743.6 1.132207792
Maltose 0.03017 1540 113.84 0.073922078
Oligo 0.01509 1540 56.93 0.036967532
Water 0.4591 1000 1732.49 1.73249
Amylase 0.00002 1250 0.07 0.000056
Glucoamylase 0.00001 1892.6 0.04 2.11349E-05
Pullulanase 0.00001 1250 0.04 0.000032
CaCl2 0 0 0 0
NaOH 0.00209 2130 7.89 0.003704225
Lysine 0 0 0 0
Protein 0.00146 1350 5.51 0.004081481
Fats 0.00053 0 2 0
Fibre 0.00023 0 0.85 0
1N HCl 0 1490 0 0
Coryne 0.01441 100 54.38 0.5438
1 3773.7 3.561887183
• TECHNICAL SPECIFICATION OF ADSORBENT
(REF: S.R. FINE CHEMICALS / GRANULAR ACTIVATED CARBON MANAGEMENT AT WATER TREATMENT PLANT. ABSTRACT)
• TYPE : GRANULAR ACTIVATED CARBON
• BULK DENSITY : 550 KG/M3
• POROSITY : 0.66
• USING ADSORBENT USAGE RATE • VOLUME OF ADSORBENT NEEDED
CO − CE V (REF: ADSORPTION DESIGN GUIDE BY U.S. ARMY
AUR =
WSAT CORPS OF ENGINEERS, PAGE 3-3)
(100% OF IMPURITIES WILL BE ADSORB) AUR·T∗
• VADSORBENT =
ΡBULK
• V = 70.5803 M3
REF: (EMIS.VITO.BE)
0.225𝑔 • MAXIMUM USABLE TIME OF ADSORBENT PER
WSAT = UNIT IN 1 DAY.
G ADSORBENT

• 𝐴𝑈𝑅 =
3,773.5 𝑘𝑔 KG
16,771.11 · 1DAY
0.225
VADSORBENT = DAY
KG KG
• 𝐴𝑈𝑅 = 16,771.11 550 3
DAY M
VADSORBENT = 30.4929 M3 (1076.02 FT 3 )
• MASS OF ADSORBENT NEEDED • ADSORBER DIAMETER AND BED LENGTH
MADSORBENT = VADSORBENT ΡB BASED ON THE AVAILABLE DIAMETER OF THE
KG ADSORBER WITH A CAPACITY OF CARBON
3
MADSORBENT = 30.4929M 550 3 ADSORBER 60,000 LBS (27,240 KG)
M
MADSORBENT
= 16,771.1 KG (36,973.9329 LB) • DADSORBER = 14 FT (4.267M) FOR MODEL 14
(MODULAR CARBON ADSORPTION VESSEL)
MASSADSORBENT NEEDED
NO OF UNIT REQUIRED =
MASSADSORBENT PER UNIT
36,973.9329 LBS
NO OF UNITS REQUIRED =
60,000 LBS
NO OF UNITS REQUIRED = 0.616 ≈ 1 UNIT
 30.4929 M3 • LINEAR FLOW VELOCITY/HYDRAULIC LOADING, UO
• VADSORBENT = = 30.4929 M 3 /UNIT
1 UNIT • (REF: UNIT OPERATIONS OF CHEMICAL ENGINEERING BY MCCABE
ET. AL., EQ.25.3, P.847)
• VADSORBENT = ABED LBED
LΡT (WSAT −WO )
• T∗ =
UO CO
ΠD2ADSORBER
• VADSORBENT = LBED • WO =
4
0; SINCE FRESH ADSORBENT IS INTRODUCED TO THE UNIT

3 Π 4.267 2 KG
• 30.4929M = LBED • UO =
2.13M 1014.53 3 (0.225−0)
M
4 KG
53.47 3 1DAY X 20
HR
M DAY

• LBED = 2.13M (7 FT) • UO = 0.45466

M
≈ 4.1435X10−4
FT
HR S
 CRYSTALLIZER
LIST OF ASSUMPTIONS

• BATCH CRYSTALLIZATION PROCESS WILL BE EMPLOYED.

• 3 BATCHES PER DAY WILL BE USED.

• 20% OF THE TOTAL VOLUME OF THE FEED IS ALLOTTED AS ALLOWANCE FOR SAFETY.

• USING 30% OF THE CONICAL VESSEL VOLUME FOR THE EXTENSION OF THE CONICAL VESSEL ON THE FORM OF A
CYLINDER TO PROVIDE FOR VAPOR SPACE.

• SS – 316 WILL BE USED AS MATERIAL OF CONSTRUCTION FOR THE VESSEL DESIGN OF THE CRYSTALLIZER.

• USING DOUBLE WELD V – BUTT WITH EFFICIENCY OF 0.8 FOR THE WELDING TYPE.

• APA – ASME VESSEL DESIGN CODE WILL BE USED FOR THE DESIGN OF THE COLLECTING VESSEL.

• BASCO TYPE 500 MODEL 08072 HEAT EXCHANGER WITH TUBE DIAMETER OF 5/8” WILL BE USED.

• 1 TUBE PASS WILL BE USED WITH A ROTATED SQUARE PITCH ARRANGEMENT.

• USING 70% PUMP EFFICIENCY FOR THE TUBE SIDE FLUID.

 SPECIFICATION SHEET
IDENTIFICATION
Name of Equipment Crystallizer
Equipment Code T-1
Number Required 3 Unit
Capacity 31.25𝑚3

Function To crystallize Monosodium Glutamate from clear Monosodium

Glutamate solution

Operation Batch
Type Forced-Circulation Crystallizer
Material Handled Monosodium Glutamate Crystals
Monosodium Glutamate Solution
DESIGN DATA
Operating Pressure 1 atm
Temperature 30°C
Residence Time 2.35 hr
Density 1056 m3/kg
VESSEL DESIGN
Design Pressure 1.73 𝑎𝑡𝑚
Material of Construction SS – 316
Vessel Volume 37.5 𝑚3
Diameter 3.73 m
Height 37.5 m
Shell Thickness 5.0 mm
Head Thickness 5.0 mm
Recirculation Rate 𝑚3
8,371.05
ℎ𝑟
Insulation Material Mineral Wool
Insulation Thickness 0.43 m
EVAPORATING SYSTEM DESIGN
1 – 1 Shell and Tube Heat Exchanger BASCO TYPE 500 HEAT EXCHANGERS MODEL 08072
Tube Design Shell Design
Fluid Handled Concentrated MSG Fluid Handled Water
Solution
Mass Flow Rate 66,026.10 kg/day Mass Flow Rate 65,705.89 kg/day
Temperature 28°C 30°C Temperature 150°C 100°C
Number of Tubes 76 Shell Diameter 2.45 m
Length 6.63 m Baffle Diameter 2.45 m
Outside Diameter 15.88 mm Baffle Spacing 491 mm
Inside Diameter 14.10 mm Insulation Material Polyurethane
Pitch 19.85 Insulation Thickness 0.50 m
Clearance 3.97
PUMP DESIGN
Pump Type Massecuite Pump
Power Requirement 2.63 hp
 DESIGN COMPUTATION FOR CRYSTALLIZER

• FEED • Average Density

Component Mass (kg/day) Density (kg/m3) Volume (m3/day) 𝑚𝑡𝑜𝑡𝑎𝑙 66,026.10 kg
𝜌𝑎𝑣𝑒 = =
MSG Crystals 4919.61 1618 3.04
𝑉𝑡𝑜𝑡𝑎𝑙 62.52 𝑚3
kg 𝑙𝑏𝑚
= 1056.08 3 (70.55 3 )
MSG liquid 725.02 680 1.06 𝑚 𝑓𝑡
• For batch Process
Water 58313.09 998.23 58.42
𝐿𝑎
Ʈ=
3.76𝐺
Total 66,026.10 62.52 248 µm
Ʈ= −2 𝑚
= 8453.196 =2.35
3.67(7.99×10 µ )
s
• OPERATING TIME • VESSEL DIAMETER AND HEIGHT

NUMBER OF BATCH PER DAY: 2 FOR CONICAL VESSEL,

𝐻 = 1.5𝐷
RESIDENCE TIME: 2.35 HOURS
𝐷
ℎ = ℎ𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑐𝑜𝑛𝑖𝑐𝑎𝑙 𝑏𝑜𝑡𝑡𝑜𝑚, × TAN 600 ℎ
2 𝐵𝑎𝑡𝑐ℎ 2.35 HOURS 2
𝑂𝑝𝑒𝑟𝑎𝑡𝑖𝑛𝑔 𝑇𝑖𝑚𝑒 = × 𝐷
𝑑𝑎𝑦 1 𝑏𝑎𝑡𝑐ℎ × TAN 600
= ℎ𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑐𝑜𝑛𝑖𝑐𝑎𝑙 𝑏𝑜𝑡𝑡𝑜𝑚,
2
= 4.70 ℎ𝑜𝑢𝑟𝑠
1 𝜋 × 𝐷 × ℎ 𝜋 × 𝐷2
2
𝑉 = 𝑉𝐶𝑜𝑛𝑒 + 𝑉𝐶𝑦𝑙𝑖𝑛𝑑𝑒𝑟 = × + 𝐻−ℎ
3 4 4
= 0.230699 × 𝜋 × 𝐷 3
𝑘𝑔 𝑉 = 0.230699 × 𝜋 × 𝐷 3 = 75.024 𝑚3
• 𝑉𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝐶𝑟𝑦𝑠𝑡𝑎𝑙 𝑆𝑙𝑢𝑟𝑟𝑦 = 𝟔𝟔, 𝟎𝟐𝟔. 𝟏𝟎 ×
𝑑𝑎𝑦
1 𝑑𝑎𝑦 𝑚3 𝑚3
× = 31.25
2 𝑏𝑎𝑡𝑐ℎ 1056.26𝑘𝑔 𝑏𝑎𝑡𝑐ℎ 3 37.5 𝑚3
• 𝐷=
𝜋 × 0.230699

•
• VESSEL CAPACITY
• 𝐷𝑉= 3.73 𝑚 (12.23 𝑓𝑡) (146.70 IN)
USING 20% ALLOWANCE FOR SAFETY FACTOR,
• 𝐻𝑉= 1.5 3.73 = 5.60 𝑚 (18.36 𝑓𝑡)
3
VOLUME OF THE VESSEL = 1.2(31.25) = 37.5 𝑚
 TRAY DRYER

LIST OF ASSUMPTIONS
• 48 TRAYS IS USED BASED ON THE COMMERCIALLY AVAILABLE TRAY DRIER 48 TRAY DRIER GMP
MODEL MACHINE (REF: RIDDHI PHARMA MACHINERY LTD).
• 0.7% FINAL MOISTURE CONTENT OF THE PRODUCT (REF: PERRY’S HANDBOOK 8TH ED. PAGE
12-62, TABLE 12-19).
 SPECIFICATION SHEET
Identification
Name of Equipment Tray Dryer
Equipment Code E-4
Operation Batch
Mode of Heat Transfer Convection
Heating Medium Air
Materials Handled Monosodium Glutamate Crystals
Function To reduce moisture content of MSG.
Operating Conditions
Feed Temperature 30°C
Drying Rate 532.8 kg/hr
Air Inlet Temperature 150°C
Wet Bulb Temperature 44°C
Air Outlet Temperature 55°C
Drying Time 11 hours
Tray Design
Material of Construction SS-304
Finish Mirror Polished
Width 0.84 m
Length 1.68 m
Height 0.05 m
Drying Area 68.21 m2
Number of Trays 48
Door Design
Material of Construction Inside – SS-316
Outside – SS-304
No. of Door 1
Insulation Type Rock Wool
Finish Inside – Mirror Polished
Outside – Matte Polished
Dryer Design
Material of Construction Inside - SS-316
Outside – SS-304
Construction Double Walled Type
Type of Insulation Rock Wool
Insulation Thickness 0.075 m
Airflow Inside Dryer 2.73 m3/s
Width 2.00 m
Length 2.00 m
Height 2.45 m

Power of Blower 5.34 KW

Power of Exhaust Fan 3.97 KW

DESIGN COMPUTATION FOR TRAY DRYER