Scribd Logo
Upload

Welcome to Scribd!

  • 38 views

    Radang Kronik: Rino Pattiata Dept. Patologi Anatomik Fkui

    Uploaded by

    abbi
    Chronic inflammation is characterized by long-term inflammation where tissue damage and repair occur simultaneously driven by mononuclear cell infiltration. It can be caused by persistent viral or microbial infections, long-term toxic agents, or autoimmune diseases. Key cells involved include macrophages, lymphocytes, and plasma cells which secrete inflammatory mediators and cytokines perpetuating the inflammatory response and leading to tissue necrosis and fibrosis over time.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Radang Kronik: Rino Pattiata Dept. Patologi Anatomik Fkui

    Uploaded by

    abbi
    38 views29 pages
    Chronic inflammation is characterized by long-term inflammation where tissue damage and repair occur simultaneously driven by mononuclear cell infiltration. It can be caused by persistent viral or microbial infections, long-term toxic agents, or autoimmune diseases. Key cells involved include macrophages, lymphocytes, and plasma cells which secrete inflammatory mediators and cytokines perpetuating the inflammatory response and leading to tissue necrosis and fibrosis over time.

    Original Description:

    Lecture 22B Radang Kronik

    Original Title

    Lecture 22B Radang Kronik

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Chronic inflammation is characterized by long-term inflammation where tissue damage and repair occur simultaneously driven by mononuclear cell infiltration. It can be caused by persistent viral or microbial infections, long-term toxic agents, or autoimmune diseases. Key cells involved include macrophages, lymphocytes, and plasma cells which secrete inflammatory mediators and cytokines perpetuating the inflammatory response and leading to tissue necrosis and fibrosis over time.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    38 views29 pages

    Radang Kronik: Rino Pattiata Dept. Patologi Anatomik Fkui

    Uploaded by

    abbi
    Chronic inflammation is characterized by long-term inflammation where tissue damage and repair occur simultaneously driven by mononuclear cell infiltration. It can be caused by persistent viral or microbial infections, long-term toxic agents, or autoimmune diseases. Key cells involved include macrophages, lymphocytes, and plasma cells which secrete inflammatory mediators and cytokines perpetuating the inflammatory response and leading to tissue necrosis and fibrosis over time.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    You are on page 1of 29

    Radang Kronik

    Rino Pattiata
    Dept. Patologi Anatomik
    FKUI
    DEFINITION

    Long-term inflammation where the


    inflammation process is active, while
    tissue damage and repair was done
    simultaneously
    Chronic inflammation

    Mononuclear cell infiltration such as :


    macrophage, lymphocyte and plasma
    cell
    Tissue damage
    Repair: angiogenesis and fibrosis
    Causes of chronic
    inflammation
    Viral infection
    Persistent microbes infection
    Long term toxic agent
    Autoimmune disease
    Cells in chronic inflammation

    Macrophage
    Lymphocyte
    Plasma cell
    Eosinophyl
    Mast cell
    Makrofag (1)

    Monocyte half-time is 1 day, under influence of


    adhesion molecule and chemotactic factor will
    go to inflammation area
    Change into macrophage in tissue
    Activated into epitheloid cells
    Activated signal:
    Sitokin (IFN-)
    Endotoksin
    Mediators produce during acute inflammation
    Extracellular matrix such as fibronectin
    Makrophage (2)

    Activated macrophage could produce


    certain producr that will lead tissue into
    necrotic and fibrosis
    Acid and basic proteases
    Complement Komponen komplemen dan
    faktor pembekuan
    Oksigen reaktif dan NO
    Metabolit asam arakhidonat (eikosanoid)
    Sitokin : IL-1, TNF dan berbagai growth
    factor
    Cellular co-operation

    Macrophage in the inflammation area cause by


    MIF, while MAF will stimulate phagocytosis
    Production of several inflammation mediators
    Lymphocytes attracted
    Target cell destruction
    Interferon production, by activated T-cell
    which has antiviral role and will attracted
    macrophage. While interferon and will
    activated NK-cell and macrophage
    Granulomatosa inflammation

    Chronic inflammation showed aggregate


    of activated histiocyte (epitheloid)
    Could be caused by persisten T-cell
    response
    Activated T-cell will produce cytokine
    which will caused persistent macrophage
    activation
    Serous inflammation

    Efussion
    A few protein
    Injury against pleural mesotel pleura,
    peritoneum and pericardium
    Burnt or viral infection at skin epidermis
    Fibrinosa inflammation

    More severe injury, so bigger molecules


    can pass by including fibrin
    fibrin exudate will be degraded by
    fibrynolisis resolution
    Failed: organisation
    Resolusi
    Organisation

    Scar formation
    Started with granulation tissue consisted of
    endothelial cell proliferation and myofibroblast
    Myofibroblas : collagen secretion and othe
    matrix component; also have muscle filament
    and ability to bind to surrounding cell
    Granulation tissue will be change into mature
    fibrous tissue
    Suppurative/purulent
    inflammation
    Contain pus/purulent exudate consisted
    of necrotic tissue, neutrophyl and
    edematous solution
    Caused by pyogenic bacteria
    Could be formed as abscess
    Ulcer

    Loss of the entire surface


    mucosal/epithelium
    Base of ulcer is granulation tissues

    You might also like