For Breast Cancer: A Program of The UAMS College of Pharmacy
For Breast Cancer: A Program of The UAMS College of Pharmacy
For Breast Cancer: A Program of The UAMS College of Pharmacy
A program of the
UAMS College of Pharmacy
Child birth
After the age of 30
Exogenous Estrogen
Hormonal replacement
therapy(HRT)
30% increased risk
with long term use
Oral Contraceptives(OC)
risk slight
risk returns to normal
once the use of OCs
has been discontinued
Risk Factors for Breast Cancer
Radiation exposure
Breast disease
Atpyical Hyperplasia
Intraductal carcinoma in situ
Intralobular carcinoma in situ
Obesity
Diet
Fat
Alcohol
Genetics
BRCA-1
BRCA-2
P53, Rb-1
Her-2/neu, c-erB2,
c-myc
Staging of Breast Cancer
The American Joint Committee on
Cancer (AJCC) has designated staging by
TNM
T= tumor size
N = lymph node involvement
M = metastasis
Stage 1
Tumor < 2.0 cm in
greatest dimension
No nodal
involvement (N0)
No metastases (M0)
Stage II
Tumor > 2.0 < 5 cm
or
Ipsilateral axillary
lymph node (N1)
No Metastasis (M0)
Stage III
Tumor > 5 cm (T3)
or ipsilateral axillary lymph nodes fixed
to each other or other structures (N2)
involvement of ipsilateral internal
mammary nodes (N3)
Inflammatory carcinoma (T4d)
Stage IV (Metastatic breast
cancer)
Any T
Any N
Metastasis (M1)
Types of breast cancer
In situ
Intraductal (DCIS)
Intralobular (LCIS)
Invasive
Infiltrating
ductal carcinoma
Tubular carcinoma
Medullary carcinoma
Mucinous carcinoma
Symptoms and Screening
Normal breast physiology and
anatomy
Symmetry and balance
Size
weight
menstrualcycle
pregnancy and lactation
Texture
Shape
age
Abnormal signs and symptoms
Puckering
Dimpling
Retraction
Nipple discharge
Thickening of skin or lump or knot
Retracted nipple
Abnormal signs and symptoms
Change in breast size
Pain or tenderness
Redness
Change in nipple position
Scaling around nipples
Sore on breast that does not heal
Methods of Detection
Clinical
exam by MD or nurse
Mammography
Monthly breast self-exam
(BSE)
Clinical examination
Performed by doctor or
trained nurse practitioner
Annually for women over 40
At least every 3 years for
women between 20 and 40
More frequent examination
for high risk patients
Mammography
X-ray of the breast
Has been shown to
save lives in patients
50-69
Data mixed on
usefulness for patients
40-49
Normal mammogram
does not rule out
possibility of cancer
completely
Mammography
American Cancer Society recommends:
Pharmacists have a
responsibility as
patient advocates for
breast cancer
awareness