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    Lymphocytic Leukemia in A Golden Retriever Dog - A Case

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    Ganesh Dasara
    This document presents a case report of lymphocytic leukemia in a 7-year old male Golden Retriever dog. The dog presented with fever, anorexia, exercise intolerance, edema of the hind limbs and scrotum, tachycardia, and pale mucous membranes. Diagnostic tests revealed severe anemia, leukocytosis with lymphocytosis, elevated BUN and alkaline phosphatase levels, and hypoproteinemia. Cytological examination of blood and bone marrow showed large numbers of lymphocytes with irregular nuclei and prominent nucleoli. Based on these findings, the dog was diagnosed with acute lymphocytic leukemia.

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    Lymphocytic Leukemia in A Golden Retriever Dog - A Case

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    Ganesh Dasara
    73 views14 pages
    This document presents a case report of lymphocytic leukemia in a 7-year old male Golden Retriever dog. The dog presented with fever, anorexia, exercise intolerance, edema of the hind limbs and scrotum, tachycardia, and pale mucous membranes. Diagnostic tests revealed severe anemia, leukocytosis with lymphocytosis, elevated BUN and alkaline phosphatase levels, and hypoproteinemia. Cytological examination of blood and bone marrow showed large numbers of lymphocytes with irregular nuclei and prominent nucleoli. Based on these findings, the dog was diagnosed with acute lymphocytic leukemia.

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    LYmphocytic Leukemia

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    This document presents a case report of lymphocytic leukemia in a 7-year old male Golden Retriever dog. The dog presented with fever, anorexia, exercise intolerance, edema of the hind limbs and scrotum, tachycardia, and pale mucous membranes. Diagnostic tests revealed severe anemia, leukocytosis with lymphocytosis, elevated BUN and alkaline phosphatase levels, and hypoproteinemia. Cytological examination of blood and bone marrow showed large numbers of lymphocytes with irregular nuclei and prominent nucleoli. Based on these findings, the dog was diagnosed with acute lymphocytic leukemia.

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    73 views14 pages

    Lymphocytic Leukemia in A Golden Retriever Dog - A Case

    Uploaded by

    Ganesh Dasara
    This document presents a case report of lymphocytic leukemia in a 7-year old male Golden Retriever dog. The dog presented with fever, anorexia, exercise intolerance, edema of the hind limbs and scrotum, tachycardia, and pale mucous membranes. Diagnostic tests revealed severe anemia, leukocytosis with lymphocytosis, elevated BUN and alkaline phosphatase levels, and hypoproteinemia. Cytological examination of blood and bone marrow showed large numbers of lymphocytes with irregular nuclei and prominent nucleoli. Based on these findings, the dog was diagnosed with acute lymphocytic leukemia.

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    of 14

    LYMPHOCYTIC LEUKEMIA IN A

    GOLDEN RETRIEVER DOG A CASE


    REPORT

    Sudha Rani Chowdary. CH*, K. Rajesh, M. Raghunath


    and K. Sai Krishna

    Department of Teaching Veterinary Clinical Complex,


    NTR college of Veterinary Science, Gannavaram,
    Andhra Pradesh.
    Introduction
    Leukemia is the presence of malignant cells of
    hemolymphatic origin in the blood and bone
    marrow.

    In general, leukemia in animals is clinically recognized


    in later stages, once there is extensive marrow
    involvement by tumor cells, when the consequences
    of cytopenias require veterinary assistance.
    (Jacobs et al., 2002 )
    Anamnesis:

    Species: Dog

    Age: 7 years

    Breed: Golden retriever

    Sex: Male
    History / Clinical signs
    Fever since 10 days
    Anorexia
    Exercise intolerance
    Edema of hind limbs
    Edema of scrotum
    Tachycardia
    Pale mucus membranes
    Recumbent since previous day
    Diagnostic Imaging
    Radiography and ultrasonography of the
    thorax and abdomen revealed mild

    Cardiomegaly
    Spleenomegaly
    Hepatomegaly
    Hematology
    S.No. Parameter Result Normal value Remarks

    1 Hb (g%) 2 12-18

    2 PCV (%) 6 37-55 Severe anaemia

    3 TEC (x 106/cmm) 0.8 5.5-9.5

    4 TLC (x 103/cmm) 192 6-17 Severe


    leukocytosis
    5 DLC (%)

    Neutrophils,Eosinophils, 0 N: 60-77
    Monocytes, Basophils E: 2-10
    M: 3-10 Severe
    B: Rare lymphocytosis,
    Lymphocytes 100 L: 12-30 neutropenia,
    eosinopenia
    Serum Biochemistry
    S.No. Parameter Result Normal Remarks
    value
    1 BUN (mg/dl) 81.25 8-28 Elevated

    2 Creatinine (mg/dl) 1.7 0.5-1.7 Within normal range

    3 SGPT (U/l) 32 10-109 Within normal range

    4 SGOT (U/l) 13.08 13-15 Within normal range

    5 Total protein (g/dl) 3.6 5.4-7.5 Hypoproteinemia

    6 Albumin (g/dl) 1.2 2.3-3.1 Hypoalbuminemia

    7 Alkaline Phosphatase (U/l) 325.24 1-114 Elevated

    8 Calcium (mg/dl) 11 9.1-11.7 Within normal range


    No evidence of blood parasites.

    All the peripheral lymphnodes were normal in


    size.

    Aspirate of popliteal LN revealed large number


    of lymphocytes, few lymphoblasts and plasma
    cells. There was no evidence of abnormal
    nuclear changes.
    Cytology Blood Smear
    Photomicrograph: Blood smear showing large number of
    lymphocytes with moderate degree of pleiomorphism, irregular
    shaped nuclei with densely clumped chromatin and prominent
    nucleoli (Prolymphocytes). There is almost complete absence of RBCs,
    platelets and other leukocytes.
    Leishmans stain, 1000X
    Cytology Buffy coat
    Photomicrograph: Smear of buffy coat showing large number of
    lymphocytes with prominent nucleoli (arrow). There is complete
    absence of other leukocytes.
    Wrights stain, 1000X
    Diagnosis
    Based on the history, clinical, hematological and
    cytological findings, the case is diagnosed as
    lymphocytic leukemia.

    Further, it is classified under acute lymphocytic


    leukemia (ALL) which is attributed by the acute clinical
    signs since 10 days, presence of pleiomorphic
    lymphocytes with heterogenous chromatin pattern
    and prominent nucleoli (prolymphocytes/
    lymphoblasts).
    Differential Diagnosis

    Lymphoma:
    characterized by severe lymphadenopathy and It is associated
    with hypercalcemia.

    A pronounced lymphocytosis on the complete blood count is


    most consistent with CLL or ALL. This degree of lymphocytosis is
    occasionally seen in dogs with stage V lymphoma with circulating
    neoplastic cells.

    Lymphocytic leukemia patients usually have mild or no


    lymphnode enlargement .
    Ehrlichiosis:

    Persistent mature lymphocytosis with less than


    30,000 cells/L. is common.

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