Embryo Eye
Embryo Eye
Embryo Eye
Neuroepithelium
Lens
Placode
Prosencephalon
[diencephalon]
Optic
Vesicle
Mandibular Arch
B
View B
References
Moore & Persaud, Chapter 19, pages 492 - 503
Nolte: Chapter 17, pages 411 - 412
Dr. Downings Histology of the Eye
Learning Objectives
Optic Cup: Relationship to diencephalon &
to lens placode during development
Origin and Formation of the:
Optic Nerve & Retina
Iris & Ciliary Body
Lens
Choroid, Sclera & Cornea
Neuroepithelium
[AKA Neuroectoderm]
Neuroectoderm of the
Prosencephalon
Prosencephalon
[diencephalon]
Lens
Placode
(Diencephalon)
Optic
Vesicle
Optic Grooves
Optic Vesicles
Optic Cups
Mandibular Arch
Retina
Optic Nerve
Ciliary Body
Iris
Eye Development
Optic Grooves
Optic Vesicles
22 days
Optic Cups
Neuroepithelium
Prosencephalon
[diencephalon]
28 days
Lens
Placode
Optic
Vesicle
Mandibular Arch
32 days
M & P 19 - 1
Eye Development
Optic Nerve, Optic or
Choroid Fissure & Lens
22 days
Neuroepithelium
Prosencephalon
[diencephalon]
28 days
Lens
Placode
Optic
Vesicle
Mandibular Arch
32 days
M & P 19 - 1
Eye Development
Optic Nerve & Optic or
Choroid Fissure cont.
22 days
Neuroepithelium
Next slide
Prosencephalon
[diencephalon]
28 days
Lens
Placode
Optic
Vesicle
Mandibular Arch
32 days
M & P 19 - 1
Optic Fissure
Pupil
Hyaloid vessels
Optic Nerve (ON)
Sheath of ON
Edges of the
pupil
M & P 19 - 3
M & P 19 - 8
Developing pigment
epithelium of the
retina [from outer
layer of optic cup]
Intraretinal
space
A
Hyaloid
artery of
retina
Neural layer
of the retina
Mesenchyme
Pigment
epithelium of
the retina
Central
artery of
retina
D
Note: Intraretinal space is eliminated by fusion of the
pigment layer with the neural layer of the retina.
Retina
Outer layer
of optic cup
Optic
Cup
Mesenchyme
Lens
Pit
Optic Vesicle
Lens
Vesicle
Diencephalon
Inner layer of
optic cup
Intraretinal
space
3.5 wks
5 wks
4 wks
Neural layer
of the retina
Lens
6 wks
Lens
6.5 wks
Lens
Pigment
epithelium
layer of the
retina
8 wks
Lens
Lens
Ciliary Body
Iris
Lens
Lens
Iris
Central artery
of retina
D
NEXT
SLIDE
Ciliary Body
[= processes + muscle]
se
me
From
mesenchyme
e
ym
nch
Anterior chamber
Primary
(posterior)
lens fibers
Posterior
chamber
Ciliary
epithelium
[pigmented &
non-pigmented
Anterior lens
fibers
Pigmented & non-pigmented layers of ciliary epithelium that cover the ciliary processes
develop from the outer & inner layers, respectively, of the optic cup.
Iris
e
hym
c
n
se
me
From
neuroectoderm
Anterior chamber
Primary
(posterior)
lens fibers
Anterior lens
fibers
Posterior
chamber
STROMAL
LAYER OF IRIS
Epithelial layer forms from the most rostral aspect of optic cup; 2 cell layers thick; posterior side of iris;
blue pigment
Stromal or connective tissue layer forms from mesenchyme; anterior side of iris; brown pigment
Sphincter & Dilator muscles of the pupil develop within the stromal layer of the iris from neuroectoderm of
the optic cup.
Lumen
within the
Lens
Vesicle
Mesenchyme
Lens
Pit
Optic Vesicle
Diencephalon
Area of the
Lens
Placode
3.5 wks
Anterior
layer of
the Lens
5 wks
4 wks
Lens
Lens
Remnants of
hyaloid
vessels
Posterior
layer of
the Lens
6 wks
6.5 wks
Note that
lumen
disappears
8 wks
Future Anterior
chamber
Anterior
chamber
[aqueous
humor]
Irido-pupillary
membrane
Posterior
chamber
[aqueous
humor]
Posterior
chamber
[aqueous
humor]
Irido-pupillary
membrane
Anterior
chamber
[aqueous
humor]
Central artery
of retina
Hyaloid
artery
Vitreous
body
Hyaloid
canal
Vascular plexus
of the choroid
layer
Sclera
Sheath of the
optic nerve
Outer layer is the tough SCLERA. Comparable to dura. Continuous with the sheath of the
optic nerve, posteriorly.
Surface
Ectoderm
3 layers of the
cornea
Epithelium
Stroma
Endothelium
Three layers of the cornea & conjunctiva form at the most anterior aspect of the eye.
SURFACE ECTODERM induced by lens to form the EPITHELIUM of the cornea & conjunctivum.
STROMA is derived from mesenchyme.
ENDOTHELIUM forms from the mesenchymal lining of the anteior chamber.
Cornea
Epithelium
Stroma
Endothelium
Mesenchyme
Eyelids
Surface
Ectoderm
Eyelids fused
by Wk 10
Eyelids re-opened
by ~26 wks.
Congenital Cataract
Detached Retina
Iris of right eye
Retina
Disruption of the adhesion between the neural and pigmented layers of the retina.
These examples in the adult.
During development, congenital detached retina appears to be:
due to failure of the retinal layers to fuse and obliterate the intraretinal space.
caused by unequal growth of the eye.
Congenital Ptosis
Iris of right eye
Retina
A.
B.
Surgically corrected
C.
Congenital Coloboma
Retina of right eye
Iris of right eye