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    Metabolisme Lysine 2

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    Denok Risky Ayu Paramita
    1) Lysine is an essential amino acid in humans that plays important roles in protein synthesis, energy production, bone growth, and muscle formation. It is also a precursor for carnitine. 2) The biosynthesis pathways for lysine involve multiple enzymatic steps and differ between prokaryotes and eukaryotes. In bacteria, lysine is synthesized through aspartate and the diaminopimelate pathway, while eukaryotes and algae use the dihydrodipicolinate pathway. 3) Lysine degradation in humans and other organisms occurs primarily through the saccharopine pathway in the liver and mitochondria, forming acetyl-CoA. This pathway exists in reverse in plants and some bacteria

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    Metabolisme Lysine 2

    Uploaded by

    Denok Risky Ayu Paramita
    336 views26 pages
    1) Lysine is an essential amino acid in humans that plays important roles in protein synthesis, energy production, bone growth, and muscle formation. It is also a precursor for carnitine. 2) The biosynthesis pathways for lysine involve multiple enzymatic steps and differ between prokaryotes and eukaryotes. In bacteria, lysine is synthesized through aspartate and the diaminopimelate pathway, while eukaryotes and algae use the dihydrodipicolinate pathway. 3) Lysine degradation in humans and other organisms occurs primarily through the saccharopine pathway in the liver and mitochondria, forming acetyl-CoA. This pathway exists in reverse in plants and some bacteria

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    1) Lysine is an essential amino acid in humans that plays important roles in protein synthesis, energy production, bone growth, and muscle formation. It is also a precursor for carnitine. 2) The biosynthesis pathways for lysine involve multiple enzymatic steps and differ between prokaryotes and eukaryotes. In bacteria, lysine is synthesized through aspartate and the diaminopimelate pathway, while eukaryotes and algae use the dihydrodipicolinate pathway. 3) Lysine degradation in humans and other organisms occurs primarily through the saccharopine pathway in the liver and mitochondria, forming acetyl-CoA. This pathway exists in reverse in plants and some bacteria

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    336 views26 pages

    Metabolisme Lysine 2

    Uploaded by

    Denok Risky Ayu Paramita
    1) Lysine is an essential amino acid in humans that plays important roles in protein synthesis, energy production, bone growth, and muscle formation. It is also a precursor for carnitine. 2) The biosynthesis pathways for lysine involve multiple enzymatic steps and differ between prokaryotes and eukaryotes. In bacteria, lysine is synthesized through aspartate and the diaminopimelate pathway, while eukaryotes and algae use the dihydrodipicolinate pathway. 3) Lysine degradation in humans and other organisms occurs primarily through the saccharopine pathway in the liver and mitochondria, forming acetyl-CoA. This pathway exists in reverse in plants and some bacteria

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 26

    METABOLISME

    LYSINE
    Oleh :
    Helda Dwi H

    081524253003

    Denok Risky A.P

    081524253007

    Gambaran Umum

    Asam amino: asam


    organik yang mengandung:
    gugus amino
    gugus karboksil.
    atom hidrogen dan
    gugus R (rantai
    samping) pembeda

    Asam amino esensial

    Biosintesis Lisin

    Sumber : JOURNAL OF B ACTERIOLOGY , July 2010, p. 33043310

    Biosintesis Lisin pada


    eukaryotic algae

    Piruva
    t+
    1. aspartate kinase
    2. Aspartate semialdehyde
    dehydrogenase
    9. dihydrodipicolinate synthase
    10.Dihydrodipicolinate reductase
    11.LL-diaminopimelate
    aminotransferase

    +
    glutama
    t

    12.diaminopimelate epimerase
    13.diaminopimelate epimerase

    Sumber : Review Metabolites 2013, 3, 294-311; doi:10.3390/metabo3020294

    Phaeodactylum tricornutum

    Amino Acid Biosynthesis


    Pathways in Diatoms
    Metabolites 2013, 3, 294-311;
    doi:10.3390/metabo3020294

    Semua enzim yang berperan


    dalam
    jalur
    biosintesis
    lysine
    merupakan single copy dari masingmasing gen yang ditemukan dalam
    genom Thalassiosira pseudonana dan
    Phaeodactum tricomutum.
    Thalassiosira pseudonana

    Biosintesis Lisin pada


    bakteri

    Sumber : JOURNAL OF B ACTERIOLOGY , July 2010, p. 33043310

    Lanjutan Biosintesis
    Lisin pada bakteri

    Sumber : JOURNAL OF B ACTERIOLOGY , July 2010, p. 33043310

    Enzyme DHDPS

    Mekanisme katalitik Enzim


    DHDPS

    Kontrol Regulasi Biosintesis AA


    Lisin

    Kontrol Regulasi Biosintesis AA Lisin

    Feedback
    Inhibition

    Fungsi Lisin

    untuk sintesis protein

    berperan penting dalam penyediaan energi,


    pertumbuhan tulang, dan pembentukan otot

    Sebagai precursor pembentukan karnitin

    Carnitine

    Digestion of
    Proteins

    Degradasi Lisin dalam Tubuh Manusia

    In humans, Lysine is an essential amino acid, and


    there is no Lysine biosynthetic machinery. However,
    humans do degrade Lysine.

    The main catabolic pathway for Lysine, via


    Saccharopine (e-N-(L-Glutaryl-2)-L-lysine), is a
    mitochondrial pathway leading to the formation of
    Acetyl-CoA (Acetyl-Coenzyme-A).

    Lysine Catabolism
    Saccharopine pathway in Liver Human

    Sumber : Thesis. 2011. Published Karen


    Patricia Chapman.

    Protein and lysine requirements of


    infants, children, adolescents, and
    adults
    The lysine
    requirement is
    higher in infants
    than in adults, and
    recent
    recommendations
    indicated a lysine
    requirement that
    ranges from 64
    mg/kg d to 30 mg/kg
    d for 0.5 y infant
    and adult (>18 y).

    Sumber : The Journal of Nutrition. 2007. Published by American Society for Nutrition.

    Katabolisme Lysine

    Sumber :

    1
    2

    JOURNAL OF B ACTERIOLOGY , Nov. 2005, p. 75007510. American Society for Microbiology.


    JOURNAL OF B ACTERIOLOGY , Nov. 2005, p. 75007510. American Society for Microbiology.

    Lysine Catabolism pathway

    Sumber : The ISME Journal (2013) 7, 24002410 & 2013 International Society for Microbial Ecology All rights
    reserved

    Lysine Catabolism AMV pathway

    Sumber : JOURNAL OF B ACTERIOLOGY , Nov. 2005, p. 75007510. American Society for Microbiology.

    Lysine Catabolism
    Saccharopine pathway in bacteria

    Sumber : Federation of European Biochemical Societies. 2012. Published by Elsevier B.V. All rights

    Lysine
    Catabolism
    Saccharopine
    pathway in Plant
    1) lysineketoglutaric
    acid reductase (LKR)
    (2) saccharopine
    dehydrogenase (SDH)
    (3) aminoadipic acid
    semialdehyde
    dehydrogenase
    (AADH)
    (4) aminoadipic acid
    aminotransferase
    (AAA)
    (5) general a-amino
    acid transaminase.

    Sumber : Review. 2000. Published by


    Elsevier B.V. All rights reserved.

    Summary of degradation
    lysine in plant and animal

    The saccharopine pathway also exists in plants and


    animals, but instead of functioning in lysine
    synthesis, it works in the reverse reaction, leading
    to lysine degradation. In the direction of
    degradation, the first two enzymatic steps can be
    viewed as an atypical transamination reaction in
    which the a-amino group of lysine is transferred to
    a-ketoglutarate to form glutamic acid.

    TERIMA KASIH
    By : Helda dan Denok

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