Stomach: Name: Fizzatin Nisha Binti Mohd Uzir Gosigan Servai Group: 32A

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Stomach

NAME: FIZZATIN NISHA BINTI MOHD UZIR


GOSIGAN SERVAI
GROUP: 32A

Gross
Anatomy of
Stomach

J-shaped muscular organ with lesser and greater curvatures.


- nearly vertical in tall people, and horizontal in short
people
- divided into four regions;
cardiac region (cardia) small area within about 3 cm of the
cardiac orifice
fundic region (fundus) dome-shaped portion superior to
esophageal attachment
body (corpus) makes up the greatest part of the stomach
pyloric region narrower pouch at the inferior end
subdivided into the funnel-like antrum
and narrower pyloric canal that terminates
at
pylorus
pylorus narrow passage to duodenum
- pyloric sphincter (gastroduodenal) regulates the passage of
chyme into the duodenum

stomach is a muscular sac in upper left


abdominal cavity immediately inferior to the
diaphragm
primarily functions as a food storage organ
designed to release small volumes into
duodenum
internal volume of about 50 mL when empty
1.0 1.5 L after a typical meal
up to 4 L when extremely full and extend nearly as
far as the pelvis
takes approximately 4 hours to clear meal!
Antrum hold 30 ml
3 ml of chyme released into duodenum per
contraction

Mechanical digestion breaks up bolus, turns


solid food into a liquid, and begins chemical
digestion of protein and fat

Chemical digestion
Salivary amilase / deactivated by gastric acid
Lingual and gastric lipase / activated by gastric acid
Gastric HCl denatures protein
Gastric Pepsinogen converted by gastric HCl into
active pepsin

most digestion occurs after the chyme


passes on to the small intestine

Pathological of
stomach
Peptic

Ulcer Disease

Gastric

cancer

Peptic ulcer disease


(PUD)
Definition : Peptic ulcer disease refers to painful sores or ulcers
in the lining of the stomach or first part of the small intestine,
called the duodenum
An ulcer is the end result of an imbalance between digestive
fluids in the stomach and duodenum. Ulcers can be caused by:
* Infection with a type of bacteria called Helicobacter pylori (H. pylori)
* Excess acid production from gastrinomas, tumors of the acid
producing cells of the stomach that increases acid output (seen in
Zollinger-Ellison syndrome)
An ulcer may or may not have symptoms. When symptoms occur,
they may include:
* A gnawing or burning pain in the middle or upper stomach between
meals or at night
* Bloating
* heartburn
* nausea or vomiting

Gastric cancer
Stomach cancer, also called gastric cancer, is a
malignant tumor arising from the lining of the
stomach.
Stomach cancers are classified according to the
type of tissue where they originate.
The most common type of stomach cancer is
adenocarcinoma, which starts in the glandular
tissue of the stomach and accounts for 90% to
95% of all stomach cancers.
Stomach cancer may often be cured if it is found
and treated at an early stage. Unfortunately, the
outlook is poor if the cancer is already at an
advanced stage when discovered. In most cases,
stomach cancer is found at later stages

What Causes Stomach Cancer?


The

exact cause of stomach cancer is


unknown, but a number of factors can
increase the risk of the disease, including:

- Gender -- men have more than double therisk of getting


stomach cancer
than women.
- Lifestyle factors such as smoking, drinking alcohol, and eating a
diet low in
fruits and vegetables or high in salted, smoked,
or nitrate
preserved foods may increase your risk
- Helicobacter pylori (H. pylori) infection of the stomach. H. pylori
is a
bacterium that infects the lining of the
stomach and

Type of
diagnosis

Upper

endoscopy

-During this test, the doctor passes an endoscope, which is a


thin, flexible,
lighted tube with a small video camera on the end, down your
throat. This
lets the doctor see the lining of your esophagus, stomach, and
first part of
the small intestine.
- When seen through an endoscope, stomach cancer can look
like an
ulcer, a mushroom-shaped or protruding mass, or diffuse, flat,
thickened
areas of mucosa known aslinitis plastica.

Imaging

tests

-Imaging tests use x-rays, magnetic fields, sound waves,


or
radioactive substances to create pictures of the inside
of your
body. Imaging tests may be done for a number of
reasons,
including;
1.
2.
3.

To help find out whether a suspicious area might be cancerous


To learn how far cancer may have spread
To help determine if treatment has been effective

- Upper gastrointestinal (GI) series


- Computed tomography (CT or CAT) scan
- Magnetic resonance imaging (MRI) scan
- Positron emission tomography (PET) scan

~THE
END~

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