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    Mumps

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    Amri Rizal
    This document summarizes information about mumps and the mumps vaccine. It describes mumps as a viral illness that causes parotitis and orchitis. The mumps virus is an RNA paramyxovirus. The mumps vaccine contains the live Jeryl Lynn mump virus strain, is 95% effective, and provides lifelong immunity when administered as part of the MMR vaccine for all infants over 12 months and susceptible adults. The vaccine has a good safety profile, though rare adverse reactions can include fever, rash, or encephalitis.

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    Mumps

    Uploaded by

    Amri Rizal
    111 views19 pages
    This document summarizes information about mumps and the mumps vaccine. It describes mumps as a viral illness that causes parotitis and orchitis. The mumps virus is an RNA paramyxovirus. The mumps vaccine contains the live Jeryl Lynn mump virus strain, is 95% effective, and provides lifelong immunity when administered as part of the MMR vaccine for all infants over 12 months and susceptible adults. The vaccine has a good safety profile, though rare adverse reactions can include fever, rash, or encephalitis.

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    This document summarizes information about mumps and the mumps vaccine. It describes mumps as a viral illness that causes parotitis and orchitis. The mumps virus is an RNA paramyxovirus. The mumps vaccine contains the live Jeryl Lynn mump virus strain, is 95% effective, and provides lifelong immunity when administered as part of the MMR vaccine for all infants over 12 months and susceptible adults. The vaccine has a good safety profile, though rare adverse reactions can include fever, rash, or encephalitis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    111 views19 pages

    Mumps

    Uploaded by

    Amri Rizal
    This document summarizes information about mumps and the mumps vaccine. It describes mumps as a viral illness that causes parotitis and orchitis. The mumps virus is an RNA paramyxovirus. The mumps vaccine contains the live Jeryl Lynn mump virus strain, is 95% effective, and provides lifelong immunity when administered as part of the MMR vaccine for all infants over 12 months and susceptible adults. The vaccine has a good safety profile, though rare adverse reactions can include fever, rash, or encephalitis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 19

    Mumps and Mumps Vaccine

    Epidemiology and Prevention of VaccinePreventable Diseases

    National Immunization Program Centers for Disease Control and Prevention


    Revised March 2002

    Mumps
    Acute viral illness Parotitis and orchitis described by Hippocrates in 5th century B.C. Viral etiology described by Johnson and Goodpasture in 1934 Frequent cause of outbreaks among military personnel in prevaccine era

    Mumps Virus
    Paramyxovirus RNA virus One antigenic type

    Rapidly inactivated by chemical agents, heat and ultraviolet light

    Mumps Pathogenesis
    Respiratory transmission of virus Replication in nasopharynx and regional lymph nodes Viremia 12-25 days after exposure with spread to tissues Multiple tissues infected during viremia

    Mumps Clinical Features


    Incubation period 14-18 days Nonspecific prodrome of low-grade fever, headache, malaise, myalgias

    Parotitis in 30%-40%
    Up to 20% of infections asymptomatic May present as lower respiratory illness, particularly in preschool-aged children

    Mumps Complications
    CNS involvement Orchitis 15% of clinical cases 20%-50% in postpubertal males 2%-5%

    Pancreatitis Deafness Death

    1/20,000
    1-3/10,000

    Mumps Laboratory Diagnosis


    Isolation of mumps virus Serologic testing positive IgM antibody significant increase in IgG antibody between acute and convalescent specimens

    Mumps Epidemiology
    Reservoir Transmission Human Respiratory drop nuclei Subclinical infections may transmit

    Temporal pattern Peak in late winter and spring Communicability Three days before to four days onset of active disease

    Mumps United States, 1968- 2001*


    160 140 120

    Cases

    100 80 60 40 20 0 1968 1972 1976 1980 1984 1988 1992 1996 2000

    *2001 provisional data

    Mumps United States, 1980-2001*


    14000 12000 10000

    Cases

    8000 6000 4000 2000 0 1980

    1984

    1988

    1992

    1996

    2000

    *2001 provisional data

    Mumps - United States, 1980-2000 Age Distribution of Reported Cases


    <5 70 60 50 5-14 15-39 40+

    Percent

    40 30 20 10 0
    1980 1985 1990 1995 2000

    Mumps Clinical Case Definition


    Acute onset of unilateral or bilateral swelling of parotid or salivary gland lasting >2 days without other apparent cause.

    Mumps Vaccine
    Composition Efficacy Duration of Immunity Schedule Live virus (Jeryl Lynn strain) 95% (Range, 90%-97%)

    Lifelong
    1 Dose

    Should be administered with measles and rubella (MMR)

    Mumps (MMR) Vaccine Indications


    All infants >12 months of age Susceptible adolescents and adults without documented evidence of immunity

    Mumps Immunity
    Born before 1957 Documentation of physiciandiagnosed mumps Serologic evidence of mumps immunity Documentation of adequate vaccination

    MMR Adverse Reactions


    Fever 5%-15%

    Rash
    Joint symptoms Parotitis Deafness Encephalopathy

    5%
    25% rare rare <1/1,000,000 doses

    Thrombocytopenia <1/30,000 doses

    MMR Vaccine Contraindications and Precautions Severe allergic reaction to prior dose or vaccine component Pregnancy

    Immunosuppression
    Moderate or severe acute illness Recent blood product

    Measles and Mumps Vaccines and Egg Allergy


    Measles and mumps viruses grown in chick embryo fibroblast culture

    Studies have demonstrated safety of MMR in egg allergic children


    Vaccinate without testing

    National Immunization Program


    Hotline Email Website 800.232.2522 [email protected] www.cdc.gov/nip

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