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    Crestor (Rosuvastatin Calcium) : Abbreviations Abbrev Definitions Dictionary ICD9 Codes Equipment Hospitals Drugs More.

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    Aidi Rahman
    Crestor (rosuvastatin calcium) is a synthetic lipid-lowering agent approved as a treatment for hypercholesterolemia. The drug is classified as a Statin, a type of agent that inhibits cholesterol production in the liver. Crestor is indicated as an adjunct to diet to reduce elevated cholesterol levels in the blood.

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    Crestor (Rosuvastatin Calcium) : Abbreviations Abbrev Definitions Dictionary ICD9 Codes Equipment Hospitals Drugs More.

    Uploaded by

    Aidi Rahman
    291 views2 pages
    Crestor (rosuvastatin calcium) is a synthetic lipid-lowering agent approved as a treatment for hypercholesterolemia. The drug is classified as a Statin, a type of agent that inhibits cholesterol production in the liver. Crestor is indicated as an adjunct to diet to reduce elevated cholesterol levels in the blood.

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    Cholesterol Drugs Crestor

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    Crestor (rosuvastatin calcium) is a synthetic lipid-lowering agent approved as a treatment for hypercholesterolemia. The drug is classified as a Statin, a type of agent that inhibits cholesterol production in the liver. Crestor is indicated as an adjunct to diet to reduce elevated cholesterol levels in the blood.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    291 views2 pages

    Crestor (Rosuvastatin Calcium) : Abbreviations Abbrev Definitions Dictionary ICD9 Codes Equipment Hospitals Drugs More.

    Uploaded by

    Aidi Rahman
    Crestor (rosuvastatin calcium) is a synthetic lipid-lowering agent approved as a treatment for hypercholesterolemia. The drug is classified as a Statin, a type of agent that inhibits cholesterol production in the liver. Crestor is indicated as an adjunct to diet to reduce elevated cholesterol levels in the blood.

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    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
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    Crestor (rosuvastatin calcium) - Drug information from MediLexicon

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    Crestor (rosuvastatin calcium)


    Company: AstraZeneca Approval Status: Approved August 2003 Treatment for: Hypercholesterolemia Areas: Cardiovascular / Cardiology

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    Crestor
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    | General Information | Clinical Results | Side Effects | Mechanism of Action | Literature References | Additional Information |

    General Information
    Crestor (rosuvastatin calcium) is a synthetic lipid-lowering agent approved as a treatment for hypercholesterolemia. The drug is classified as a Statin, a type of agent that inhibits cholesterol production in the liver. Crestor is indicated as an adjunct to diet to reduce elevated cholesterol levels in the blood. It is indicated for primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Type IIa and IIb). It is also indicated as an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV) and in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments. The dose range for Crestor is 5 to 40 mg once daily. Therapy should be individualized according to goal of therapy and response.

    Clinical Results
    FDA approval of Crestor was based a double-blind, placebo-controlled, dose-ranging study and a open-label study of 2,240 subjects with type IIa and IIb hypercholesterolemia. Results demonstrated that Crestor reduced total-C, LDL-C, ApoB, nonHDL-C, and TG, and increases HDL-C, in patients with hypercholesterolemia and mixed dyslipidemia.

    Side Effects
    Adverse events associated with the use of Crestor may include (but are not limited to) the following:

    Pharyngitis Headache Diarrhea Dyspepsia Myalgia Asthenia Back Pain Flu syndrome Urinary tract infection

    Mechanism of Action
    Rosuvastatin is an inhibitor of HMG-CoA reductase, an enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. Rosuvastatin reduces cholesterol by increasing the number of low-density lipoprotein (LDL) receptors on the cellsurface to enhance uptake and catabolism of LDL. It also inhibits hepatic synthesis of hepatic very-low-density lipoprotein (VLDL), which reduces the total number of VLDL and LDL particles. The treatment reduces triglycerides (TG) and produces increases in high-density lipoprotein cholesterol (HDL-C.)

    Literature References
    Davidson MH.. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. Expert Opin Investig Drugs. 2002 Mar;11(3):125-41. Review. McTaggart F. Comparative pharmacology of rosuvastatin. Atheroscler Suppl.. 2003 Mar; 4(1): 9-14.

    http://www.medilexicon.com/drugs/crestor.php

    2/11/2011

    Crestor (rosuvastatin calcium) - Drug information from MediLexicon

    Page 2 of 2

    Nezasa K, Higaki K, Takeuchi M, Nakano M, Koike M. Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin. Xenobiotica. 2003 Apr; 33(4): 379-88. Stein EA. The power of statins: aggressive lipid lowering. Clin Cardiol. 2003 Apr; 26(4 Suppl 3): III25-31. Review.

    Additional Information
    For additional information on Hypercholesterolemia or Crestor, please visit The Crestor Home Page

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    Crestor Drug Information


    The Crestor drug information shown above is licensed from Thomson CenterWatch. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

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