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    You are on page 1of 3

    LIST OF FIGURES

    Figure No. Subject Page No.

    1. Absorbing Species Containing σ, π , n Electrons 6

    2. Transition State Of Electrons 6

    3. Modern UV–Visible Spectrophotometer 7

    4. Fecl3 and O-Phenanthroline complex formation 12

    Structure of oxethazaine 13

    5. Absorption Spectrum of standard Oxethazaine 27

    6. Specificity- Spectrum of Ferric Phenanthroline complex in 29

    Glacial acetic acid

    7. Oxethazaine linearity- 48 µg/ml to 72 µg/ml 34

    x
    LIST OF ABBREVIATIONS AND SYMBOLS

    % - Percentage

    %RSD - Percentage Relative Standard Deviation


    °
    C - Degree Celsius

    AUC - Area under Curve

    OXE - Oxethazaine

    Gms - Grams

    ICH - International Conference on Harmonisation

    IR - InfraRed

    nm - Nanometer

    S.D. - Standard Deviation

    UV-VIS - Ultraviolet-Visible

    v/v - Volume/Volume

    λ - Lambda

    μg/ ml - Microgram Per Millilitre

    xi
    ABSTRACT

    A simple, specific, accurate and precise Phenanthroline derivatized Oxethazaine by

    Visible spectrophotometry in Suspension dosage form has been developed. The method is

    based on the measurement of absorbance of Oxethazaine at wavelength of 495nm in

    Glacialacetic acid using Ferric phenanthroline reagent. Oxethazaine obeyed Beer's law in the

    concentration range 48-72µg/ml with correlation coefficient 0.9941. The results have been

    validated statistically as per ICH guidelines. This sensitive method was capable to recover

    accurately and precisely from 80 %, 100 % and 120 % level of target concentration. The

    proposed method suitably applied for the analysis of Oxethazaine in bulk and in

    Pharmaceutical formulation for routine analysis.

    Keywords: Visible spectroscopy, Oxethazaine,Oxetacaine, Derivatisation,Ferric

    phenanthroline reagent.

    xii

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