Bariatric Surgery
Bariatric Surgery
Bariatric Surgery
surgery
Dr ch. Anjani
Gs Pg
Introduction:
Recent meta-analysis studying all-cause mortality reported that relative to normal weight, all grades
of obesity were associated with significantly higher all-cause mortality.
Multiple modalities have been used to treat this disease. Various interventions include lifestyle
changes, specific diets, medications, devices and surgery.
Bariatric surgery is an established and integral part of the comprehensive management of morbidly
obese patients. Recent long-term studies have clearly demonstrated substantial reduction in
mortality in bariatric surgery patients as well as decreased risk of developing comorbidities
associated with obesity; thereby, leading to drop in direct health care costs.
DEFINITION & RATIONALE
Bariatric surgery is the branch of surgery involving manipulation of the
stomach and/or small bowel to achieve weight loss and control of obesity-
related disease.
Because of the tendency for basal metabolic rate to decrease with dieting, most people will
regain all their weight, returning to the previous homeostatic set point
Bariatric surgery appears to alter this mechanism and ‘reset’ this point, with 15–25% weight
loss maintenance for up to 20 years
Bariatric surgery leads to long-term survival benefit and improves obesity-related disease and
quality of life
The phrases ‘metabolic’ or ‘diabetes’ surgery are increasingly being used in conjunction with,
or instead of, ‘bariatric surgery’ owing to the highly efective way that surgery improves the
metabolic syndrome, with weight loss being a welcome additional efect.
Type 2 diabetes is part of the ‘metabolic syndrome’, which includes high blood pressure,
dyslipidaemia and polycystic ovary syndrome.
Bariatric surgery indications:
The 2013 European Congress on Obesity at Liverpool and American Association of Metabolic
and Bariatric Surgery (AAMBS) in 2013 has come up with the following indications for
bariatric surgery:
BMI >40
BMI >35 with co-morbidities (Hyperlipidemia, OSA, Metabolic syndrome, HTN, DM, raised
TG, reduced HDL cholesterol
Failed less invasive methods like dietary therapy and
at high risk for obesity-associated morbidity and mortality
NICE guidance on bariatric surgery, 2014
Bariatric surgery is a treatment option for anyone with BMI ≥40 kg/m2
Offer an expedited assessment for people with BMI ≥35 kg/m2 with onset of
type 2 diabetes in past 10 years
Consider an assessment for people with BMI of 30–34.9 kg/m2 with onset of type
2 diabetes within 10 years
Consider an assessment for people of Asian origin with onset of type 2 diabetes
at a lower BMI than other populations
Bariatric surgery is the option of choice for adults with BMI >50 kg/m2 when other
interventions have not been effective
People fitting the above criteria are also required to be receiving or to receive assessment in a
specialist weight management service before referral to a surgical team
Bariatric surgery & type 2 DM:
Bariatric surgery contributes to improved beta cell function, thereby, clearly proving beneficial in type 2 diabetes mellitus.
Surgically induced improvement of type 2 may be considered effective if: Postoperative insulin dose less than or equal to
25% of the preoperative.
Postoperative oral antidiabetic treatment dose less than or equal to 50% of the preoperative one.
Postoperative reduction in glycosylated haemoglobin (HbA1c) more than 0.5% within 3 months or reaching less than 7.0%.
In 2012, Food and Drug Administration (FDA) approved the use of laparoscopic adjustable gastric banding (LAGB) for
patients with BMI 30-34.9 kg/m2 with type 2 diabetes mellitus or other obesity related comorbidities.
International Diabetes Federation also proposed the eligibility for bariatric procedures for subset of patients with type 2
diabetes mellitus and BMI of 30 kg/m2 with inadequate glyceamic control despite the optimal management.
However, bariatric surgery is not recommended as the treatment of type 2 diabetes mellitus without morbid obesity.
Bariatric surgery & class 1 obesity:
The American Society of Metabolic and Bariatric Surgery (ASMBS) in 2012 came up with the
position statement recommending bariatric surgery for patients with BMI 30-35 kg/m2 who do
not achieve substantial and durable weight and comorbidity improvement with nonsurgical
methods.
Class I obesity was recognized as a well-defined disease that causes or exacerbates multiple
other diseases, decreases the duration of life and decreases the quality of life. There is no
current justification on grounds of evidence of clinical effectiveness, cost effectiveness ethics, or
equity that this group should be excluded from bariatric surgery.
Bariatric procedures, such as gastric banding, sleeve gastrectomy and gastric bypass, have been
shown in various randomized controlled trials to be well- tolerated and effective treatment for
patients with BMI 30-35 kg/m2 in the short and medium term.
Bariatric surgery & age:
IN ADOLESCENTS:
Has a BMI more than 40 kg/m2 and at least one comorbidity.
Has followed at least 6 months of organized weight reducing attempts in a specialized center.
Shows skeletal and developmental maturity.
Is capable to commit to comprehensive medical and psychological evaluation before and
after surgery.
Is willing to participate in a postoperative multidisciplinary treatment program in a unit with
specialist pediatric support
IN ELDERLY:
The primary objective of bariatric surgery in elderly is to improve quality of life rather than
increasing life span.
Contraindications:
As per European guidelines for metabolic and bariatric
surgery, following should not be considered for bariatric Other clinical contraindications include:
surgery:
Cirrhosis with portal hypertension
Absence of a period of identifiable medical management.
Active cancer
Patient who is unable to participate in prolonged
medical follow up. Prader-Willi syndrome
Non-stabilized psychotic disorders, severe depression, Pregnancy
personality and eating disorders, unless specifically
advised by a psychiatrist experienced in obesity. It has been recommended that women
Alcohol abuse and/or drug dependencies. should avoid pregnancy for at least 12-18
months after bariatric surgery.
Diseases threatening life in the short-term.
Patients who are unable to care for themselves and have
no long-term family or social support that will warrant
such care.
Specific exclusion criteria for bariatric surgery in the treatment of type 2 diabetes mellitus are as follows:
Secondary diabetes
Antibodies positive [anti-glutamic acid decarboxylase (anti-GAD) or islet cell antibody (ICA)] or C-peptide <1
ng/mL or unresponsive to mixed meal challenge.
Types of bariatric surgery:
Malabsorptive procedures: They aim to bypass a segment
of the small bowel so that less food is absorbed. They are not only
associated with severe nutritional deficiencies but are technically
demanding as well. They do have some restrictive component, but it is
secondary to the mal- absorptive aspect of the procedure. They
include biliopancreatic diversion (BPD) biliopancreatic diversion with
duodenal switch (BPD-DS).
Restrictive procedures: They aim to restrict the amount of
food ingested by surgically reducing the size of the stomach. They do
have minimal malabsorptive component. The restrictive procedures
most commonly performed are vertical banded gastroplasty, LAGB and
sleeve gastrectomy.
Hybrid procedure: They aim to restrict food intake by creating a
small gastric pouch as well as limit the absorption by bypassing the
proximal small bowel. It leaves 95% of the small bowel intact and so
avoids many of the unwanted malabsorptive side effects such as
diarrhea and nutritional deficiencies. It is among the most common
surgical bariatric procedure performed
The Roux-en-Y gastric bypass (RYGB) and upcoming omega-loop gastric
bypass fall under this category.
Adjustable gastric banding:
Laparoscopic adjustable gastric banding is a popular
weight loss procedure in Australia and Europe,
although its use is waning after success of sleeve
gastrectomy.
It is essentially a restrictive and reversible procedure. It
involves placing an inflatable band in the upper part of
the stomach so as to create a small proximal pouch.
The band is connected to a port implanted in the
abdominal wall through a tube. The size of this pouch
can be adjusted by instilling or aspirating saline from
the gastric band through this port.
Laparoscopic adjustable gastric banding seems to be a
safer procedure as it is less invasive.
LAGB requires intensive postoperative follow-up to
achieve good results
ADVANTAGES: DISADVANTAGES:
It does not alter anatomy of It is associated with frequent, though less severe,
gastrointestinal tract and can be long-term complications including band slippage,
reversed easily. band erosion and port-site problems.
It does not lead to major
nutritional problems. Recent long-term data with mean follow-up of 14
years published by Aarts et al. (2014) reported
The adjustable restriction is an revisional surgery in 53% patients either due to
added attraction for those who insufficient weight loss or complications. Only 22%
want freedom to eat more on patients had functioning band with good result after
some occasions such as the follow-up period.
vacations. Moreover, patients who were lost to follow up did
The weight loss is gradual and almost twice as bad in terms of excess weight loss
can be tailored to one's compared to those who had regular follow-up.
requirements.
Laparoscopic Sleeve gastrectomy:
It has become the most common bariatric surgery
worldwide.
Based on substantial comparative and long-term data
for sleeve gastrectomy, the American Society for
Metabolic and Bariatric Surgery in 2012 recognized LSG
as an acceptable option as a primary bariatric
procedure and as a first stage
procedure in high-risk patients as a
part of a planned staged approach.
The procedure of sleeve gastrectomy involves a
longitudinal resection of the stomach starting from the
antrum 5-6 cm from the pylorus and finishing at the
fundus close to the angle of His over a bougie
Most surgeons prefer to use a bougie about 36-40
French to calibrate the size of the sleeve. The average
size of the stomach that remains after the procedure is
about 150 mL. It is a relatively shorter and technically
straight forward procedure
The advantage of LSG over RYGB include absence of any anastomosis, maintenance of
normal food pathway, absence of dumping, marginal ulceration and no risk
of late internal hernias, fewer nutritional complications.
Sleeve gastrectomy has a better impact on weight loss and diabetes than gastric banding while its impact is
similar to the results achieved by RYGB.
The disadvantages include difficulty in managing suture line leaks, absence of long-
term results, propensity for de novo GERD and a possible inferior impact on
type 2 diabetes mellitus. Staple line leak , bleeding , stricture formation and
a mortality of 0.1% were among major complications.
Mean follow-up of greater than 5 years have clearly showed a weight loss of more than 50%.
The weight loss is due to multiple factors. Sleeve gastrectomy is a restrictive procedure involving
removal of over 80% of the stomach including the distensible portion. This decrease in capacity permits
intake of only a small amount of food, imparting a feeling of early satiety.
Moreover, sleeve gastrectomy has a major impact on metabolic pathways involving glucose metabolism.
Decrease in ghrelin levels, decrease in gastric emptying time and increase in incretins like glucagon like
peptide 1(GLP 1) due to early presentation of food to ileum improve glycemic control and render
positive impact on type 2 diabetes mellitus.
Owing to the above benefits or risk profile, Laparoscopic Sleeve Gastrectomy (LSG) has recently been
argued as the rightful gold standard weight loss surgery procedure.
Roux-en-Y gastric bypass:
Introduced by Mason and Ito in mid-1960s, this procedure is most
well studied in the field of bariatric surgery. The major feature of this
surgery is creation of a proximal gastric pouch of small
size (<20 cm) that is totally separated from the remaining
stomach.
The size of the proximal gastric pouch must be small to create
adequate restriction and it should be based on
lesser curvature of the stomach to prevent dilation of over
time. The small pouch is anastomosed to a Roux loop of
jejunum creating a gastrojejunostomy of about 2 cm
in diameter. This adds to restriction component as well.
The malabsorptive component is created by anastomosing
biliopancreatic limb to the alimentary limb
carrying food, thereby, bypassing major portion of
stomach and 150-200 cm of small bowel.
No Standard length for The limbs.
The length of biliopancreatic limb from ligament of Treitz is usually
20-50 cm and length of the Roux limb is 75-150 cm depending on the
BMI and presence or absence of diabetes.
Longer length of Roux limb is associated with higher short-term
weight loss but on long-term follow-up, this difference becomes less
significant.
Another technical aspect of this surgery is the pathway of the Roux limb for gastrojejunostomy.
The pathway of Roux limb of proximal jejunum can be
anterior to the colon and stomach or
posterior to both or
posterior to colon and anterior to stomach.
The antecolic position is associated with lower incidence of internal hernia.
The RYGB is very efficacious in weight loss leading to 60-70% of excess weight loss in the first
year. Not only it has positive impact on obesity associated comorbidities, long term results are
also encouraging. Recent studies have shown 50-60% excess weight loss at 10-year follow-up.
Gastric bypass is considered as the "gold standard" of weight loss surgery.
Bilio pancreatic diversion
Bleeding is one of the life-threatening complications after bariatric surgery, particularly after gastric
bypass and sleeve gastrectomy.
Hematemesis in the first few hours after gastric bypass implies bleeding from gastrojejunostomy
unless proven otherwise.
Tachycardia, hypotension, sanguineous drain output and a drop in hematocrit are early signs.
Bleeding after sleeve gastrectomy can be extraluminal or intraluminal. Extraluminal causes
include bleeding from staple line, omental vessel, injury to spleen, liver laceration or trocar sites.
Intraluminal bleed, less common, may result from staple line bleed. An urgent re-look surgery
and control of hemorrhage is warranted.
Leak is another most feared complication, especially after gastric bypass and sleeve
gastrectomy. The most common site of leak after sleeve gastrectomy is proximal
third of stomach, near gastroesophageal junction due to high intra- gastric
pressure with impaired peristaltic activity and ischemia.
Tachycardia, tachypnea, fever and oliguria are most common alarming signs.
Leak can be early or late.
Early leak is defined as leak diagnosed within 72 hours of surgery. Pulse rate is single
most reliable parameter to diagnose it; however, tachypnea and fever may also occur.
Computed tomography (CT) scan or gastrograffin study study is imaging of choice. Re-
look surgery, repair of leak, drain placement and feeding jejunostomy are standard of
care.
Late leaks are those diagnosed after 72 hours. Repair of leak is not recommended due to
extensive inflammatory reaction. Conservative management with image guided drainage
of infected collection, parenteral antibiotics, nasojejunal feeding and insertion of stents
should be considered. Operative intervention is mandatory in case of toxemia or
peritonitis.
Stricture formation after sleeve gastrectomy and stenosis of anastomotic site after gastric bypass is
other major issue in bariatric surgery. The most common site of stricture is incisura
angularis due to luminal narrowing or kink.