DR J S Yadav
DR J S Yadav
DR J S Yadav
OF
DR.J.S.YADAV, FNA,FTWAS
CSIR Bhatnagar Fellow
(former Director, CSIR-IICT),
INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY
HYDERABAD – 500 007
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CURRICULUM VITAE
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Research Interests:
To develop methodologies for preparation of insect pheromones and
Popularize ecofriendly pheromone application technology (PAT) for pest control
strategies
To sharpen and advocate the acquired expertise in synthesizing enantiomerically
pure compounds from Natural Products via asymmetric Synthesis.
To contribute and develop modern Synthetic methods and reagents for the ease of
synthesis of complex organic molecules
To develop unique and viable affordable routes for the synthesis of common
drugs/agrochemicals
Fellowships of Academies:
Fellow, Third World Academy of Sciences (FTWAS) (2005)
Fellow, Indian Academy of Sciences ( FASc) (2010)
Fellow, Andhra Pradesh Akademi of Sciences (FAPASc) (2002)
Fellow, Indian National Science Academy (FNASc) (1998)
Fellow, National Academy of Sciences (FNA) (1993)
Fellow, Young Associate, Indian Academy of Sciences, Bangalore (1984)
Awards:
Shanti Swarup Bhatnagar Award in Chemical Sciences (1991)
22nd Khwarizmi International Award, IROST-UNESCO, Iran
Ranbaxy Research Award in Pharmaceutical Sciences (2000)
Jagadish Chandra Bose Fellowship Award (2008-Continuing)
Pandit Jawaharlal Nehru National Award from Madhya Pradesh Department of
Science & Technology, Madhya Pradesh (2009)
Prof.S.Swaminathan Commemorative Lecture Award (2002)
Vasvik Award for Chemical Sciences & Technology (1999)
Goyal Award for Chemical Sciences (2003)
Vigyan Ratna Award, Uttar Pradesh (2003)
Vigyan Gaurav Samman Award, Uttar Pradesh (2004)
Dr. S Hussain Zaheer Young Scientist Award (1990)
CRSI Silver Medal (2003)
Andhra Pradesh Scientist Award (2003)
FAPCCI Award by Federation of Andhra Pradesh Chamber of Commerce and
Industry (1987)
Banaras Hindu University Alumnus Award (2010)
Honors and Professorships:
Visiting Professor and Elite Advisor, King Saud University, Saudi Arabia
Visiting Professor, Royal Melbourne Institute of Technology (RMIT), Australia
Distinguished Professor, Banaras Hindu University,
Rajadhyaksha Memorial Lecture
Prof A B Kulkarni Endowment Lectureship for Basic Research Contributions by
Bombay University
Prof K Venkatraman Lectureship (UDCT, Mumbai)
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Membership of Various Committees:
Steering Committee Member for the 12th Five Year Plan on Environment, Forest &
Wildlife, Planning Commission, Govt. of India
Task Force Member, Ministry of Chemicals and Fertilizers, Department of Chemicals
and Petrochemicals, Govt. of India
Member, Oversight Committee, Ministry of Environment and Forests, Govt. of India
Task Force Member, Green Chemistry, Department of Science and Technology, Govt.
of India
Member, Working Groups of Planning Commission, Ministry of Environment and
Forests.
Member, Supreme Court Monitoring Committee, Hazardous Waste Management,
Ministry of Environment and Forests, GOI
Member, Expert Committee Pharmaceutical Research & Development Support Fund
(PRDSF) Ministry of Science & Technology, GOI
Member Central Council for Research in Ayurveda and Siddha
Member Centre for High Technology, Ministry of Petroleum, GOI
Member Central Insecticide Board Ministry of Agriculture GOI (2003 – 2006)
Member Research Council National Chemical Laboratory, Pune , CSIR (2004 –2007)
National Representative for India to IUPAC Commission on Agro-chem. and
Environment
Former Member of Project Advisory Commission of University Grant Committee of
Hong Kong
Member of the Project Advisory Committee (PAC) for Scientific Engineering
Research Council (S E R C) of DST for identifying thrust areas of Research and their
funding
Member, International Collaboration Committees, PAC, DST
Member of the Committee of Drugs & Pharmaceuticals for the IX Five Year Plan
constituted by the Ministry of Chemicals & Fertilizers
Member of the Technical Advisory Board (TAB) of C S I R
Member of the Committee constituted by DST to prepare “Vision - 2005” documents
in Chemical Sci.
Member of Research Council of REC Warangal, A.P.
Member of the Andhra Pradesh Department of Higher Education
Key Member of the Modernization and Upgradation of Chemical Laboratories under
Central Board of Excise & Customs.
Member of the Editorial Board, Journal of Medicinal and Aromatic Plant Sciences.
Member of the Editorial Board, Proceedings of Indian Academy of Science
(Chemical)
Sectional President, Chemical Sciences Section, Indian Science Congress 2010
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Original Contributions to Industrial Research:
Dr.Yadav is one of the most distinguished organic chemists of the country. He always
believes that any outstanding achievement in science needs to be in direct relationship
for the betterment of a common man and thus society.
He was the first person to develop an unique method to resolve an acid by using half
mole of chiral base and other half being inorganic base. His process not only saves
expensive resolving agent but also provides high yields of first crop with high purity.
Many patents were taken by multinational for different biomolecules using his novel
findings (Patent No.PCT-122, No.6130352).
The other major industries that are associated are: GSK-Smithkline Beecham- UK, Arqule-
USA, Evolva-Switzerland, Dupont-USA, Bayer, Givaudaun, Loreal-France, Colgate
Palmolive-USA, Alkali Metals-Hyderabad, Ogene Systems-Hyderabad, AVRA Laboratories-
Hyderabad, Bio-con Laboratories-Bangalore, Bharat Biotech-Hyderabad , Ranbaxy-New
Delhi etc.,
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Agrochemicals:
In order to develop alternative eco-friendly and environmentally safe pest control strategies
and to address the indiscriminate use of harmful pesticides Dr.Yadav has pioneered
pheromone application technology (PAT) through the utility of insect pheromones (the
chemicals released by insect kingdom for certain communication and behavioral response
purpose). The field demonstrations and the work covered under this area are depicted in the
following table:
TECHNOLOGY RELEASED
Pheromones:
Yellow Stem borer for rice Pest Control India
American Boll worm for cotton Pest Control India & Pheromones India Limited
Muscalure (Z9 – Tricosene) for Astec Chemicals Mumbai
mosquito
Ground Nut Leaf Miner (GLM) Asian Herbex (Alkali Metals)
for ground nut
Sugarcane Internode Borer Rajshree Sugars & Asian Herbex (Alkali Metals)
Brinjal shoot and fruit borer Asian Herbex (Alkali Metals)
Pyrethroids:
S-Fenevelrate Virchow Laboratories, Bharat Rasayan and Isagro Asia
Cypermethrin FMC
Lambda Cyhalothrin FMC & Isagro Asia
The efforts of Dr.Yadav on PAT for GLM are recognized by Commissioner of Agriculture,
Andhra Pradesh and included in the subsidized IPM program of AP State which may benefit
nearly one lakh small farm holders in the near future.
From the beginning of his research career, he has been at the forefront of research in
new areas and has tackled the most difficult problems with the deepest insight. His
pioneering work on the development of first ever highly enantioselective synthesis
of propargyl alcohol derivative from epoxy alcohol as well as carbohydrates and
subsequent investigations over nearly one decade mark a milestone in his prolific
career that has resulted in fundamental contribution in asymmetric chemistry in India.
During the said period it was elusive to achieve the total synthesis of a number of long
chain fatty acid such as lipoxin A, Coriolic acid, Octadecanoic acid, Sphingenine,
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Strongylodiol, Panaxytriol etc.,. which are achieved easily applying his
methodologies.
He and his group developed a very new novel reaction for the asymmetric synthesis
of allylic alcohol in one step in presence of titanocene reagent (cyclopentyl titanocene
chloride) without compromising the stereocenter which has brought the attention of
synthetic organic chemists worldwide. He has also developed a methodology to form
trans-3-hydroxyvinyl chloride, which are very useful reagents for coupling reactions,
by treatment of epoxychlorides with lithium amide. He has employed all the above
strategies very elegantly for the total synthesis of complex natural products and has
received maximum citations.
Dr. Yadav was the first to develop directed-Prins cyclization protocol for the synthesis
of 2,4,6-syntrisubstituted tetrahydropyran derivatives under environmentally benign
conditions and further transformations for the formation of anti-1,3-diol, that lead to
the total synthesis of a number of highly complex natural products (Leucascandrolide
A, Crocacin A, Pironetin, Apicularen A, Salicylihalamide A, Tetrahydrolipstatin etc.),
which amply demonstrated the value of this approach.
The research investigations dealing with the iodine catalyzed carbon-carbon bond
formation reaction starting from δ-hydroxy, α,β-unsaturated aldehyde leading to 2,6-
trans-disubstituted dihydropyran as a single diastereomer have added new dimensions
to synthetic organic chemistry and have made it possible to prepare many
tetrahydropyran/ dihydropyran containing complex macrolides in a highly concise and
convergent manner.
His research with metal salts catalyzed transformations to generate a variety of
novel heterocycles through multi-component reactions, diversity oriented synthesis,
and combinatorial chemistry which have great potential for medicinal chemistry and
new drug discovery program.
The research group of Dr. Yadav deals with the synthesis and biological functions of
carbohydrates and glycol-conjugates. His group has significantly contributed include
the development of new and better methods for synthesizing exceptionally complex
molecules starting from carbohydrate, the use of new methods in the synthesis and
study of properties of complex carbohydrates of increasing size and complexity, the
design and synthesis of glycosidase inhibitors and the use of synthetic compounds for
the study of innate immunity.
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Natural Products:
Dr. Yadav has created state-of-art and world class facilities in natural products and
new bioactive molecule research through the network and sponsored projects, which
placed IICT in world map as a source of new bioactive molecules especially from the
Indian Medicinal Plants. Herbal Drug industry using these facilities for the
standardization of their products for regulatory purposes.
Through his vast expertise in Chemistry of Natural Products, many programmes and
projects were explored on the utility of Natural products for human health care at
different CSIR laboratories under project head “Bioactives from Natural Products”.
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Academic Achievements:
Dr.Yadav while working at CSIR-IICT has excelled in the academics and his
outstanding findings have been published in very reputed international journals. To
the best of information, he is the only scientist in the entire CSIR and in all
disciplines so far, who could publish over 1000 reputed research papers during his
career and still going strong. In fact, this academic zeal of him could attract so many
young and enthusiastic and budding researchers to get themselves associated with
Dr.Yadav for their PhD degrees and which has brought him an identification and
recognition as the human resources person in the field of organic chemistry. And
he is also been identified as the best productive chemist of India by an
independent Scopus survey.
No of Publications:1030
No of Patents: 70
No of PhDs awarded: 16 (more to come)
Sum of
the
Times
Cited 1618
[?] : 3
Sum of
Times
Cited
without
self-
citation 1322
s [?] : 4
Citing
Articles
[?] : 9571
The latest 20 years are displayed. The latest 20 years are displayed. Citing
View a graph with all years. View a graph with all years. Articles
without
self-
citation
s [?] : 8839
Average
Citation
s per
Item [?] 15.8
: 8
h-index
[?] : 53
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Scientific Contributions as Director, IICT:
Dr.Yadav strongly believes that any sustainability in development will be possible only
when the second line of leadership is available and established. Dr.Yadav in toto
executed and implemented the same meticulously because of which many potential
young scientific leaders are emerged in IICT and bringing many laurels to IICT. In fact,
the present Directors Dr.T.K.Chakraborty, Central Drug Research Institute (CDRI),
Lucknow and Dr.Ahmed Kamal, National Institute for Pharmaceutical and Educational
Research (NIPER), Hyderabad are the products from IICT. The Prestigious CSIR-
Shanti Swarup Bhatnagar Award 2011 is bestowed upon Dr.G.N.Sastry, Sr.Scientist,
IICT.
In turn the support and encouragement given by Dr.Yadav has culminated into many
prestigious awards. They include Ranbaxy Award (2009-10, 2010-11 and 2011-12),
NASI-Young Scientist Awards (2010-11 and 2011-12), OPPI Young Scientist Awards
(2009-10 and 2010-11). Various other awards are received by 24 scientists of IICT. In
addition IICT lifted CSIR Technology Award for the year 2005 and the DST National
Technology Award for the year 2009.
Dr.J.S.Yadav is a recipient of the most prestigious Jagadish Chandra Bose award. The
world class infrastructure facilities created under his dynamic leadership are made
available at IICT lure enthusiastic scientists from abroad to establish their own schools
of expertise in India.
Dr.Yadav always aimed for the over all development of IICT. If today, IICT is
considered as a Centre of Excellence for many disciplines and also for interdisciplinary
activities, the entire credit should go to Dr.Yadav who has whole heartedly supported
and encouraged his scientists to establish themselves.
Dr.Yadav has taken all pains in sowing the seeds of inculcation amongst the scientists to
take up challenging tasks which are delivering the fruits today.
The institute hosts nearly 800 research students in various disciplines of science which
itself is the hall mark of respect given to science in IICT under the able and dynamic
leadership of Dr.J.S.Yadav.
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IICT is recognized for Prohibition of Chemical Weapons (OPCW) designated
status by Chemical Weapons Convention (CWC).
A “Biotechnology Incubator Centre” with the support from DBT, and
Government of AP.
Pilot plant facility for Synthetic Aviation Lubricants (SVS) supported by Centre
for High Technology (CHT) and in collaboration with IOC (R&D), NAL, HAL,
GTRE, CEMILAC.
IICT has acclaimed the name of human resources. Many young talented researchers
have taken up their PhD programs at the Institute.
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ECF bar graph & publications bar graph:
ECF from Govt. 13.33 16.88 22.63 17.43 13.97 19.44 20.00 21.31
Departments
ECF / Scientist (Rs.in lakhs) 8.51 10.95 14.45 11.97 10.69 12.33 13.90 13.24
Budgetary Support / Scientist 21.89 23.43 26.82 26.23 38.04 42.63 51.25 62.50
(Rs.in lakhs)
ECF / Budgetary Support 39% 47% 54% 45% 28% 29% 27% 22%
(%)
Patent (Filed) – India 26 29 9 21 17 10 19 12
Patent (Filed) – Abroad 36 82 34 21 55 29 54 33
Patent (Granted) – India 15 31 18 20 74 11 17 7
Patent (Granted) – Abroad 43 33 28 24 35 34 27 41
Patent / Scientist (Filed) 0.28 0.48 0.19 0.20 0.34 0.19 0.36 0.43
Patent / Scientist (Granted) 0.26 0.19 0.20 0.21 0.52 0.21 0.21 0.24
No. of Papers (SCI) 414 430 551 603 513 486 489 -
Total IF 865 837 1131 1274 1124 1231 1252 -
IF / Paper 2.09 1.947 2.05 2.11 2.19 2.61 2.56 -
Paper/ Scientist 1.87 1.87 2.43 2.86 2.44 2.34 2.43 -
Ph.D thesis submitted 56 57 77 79 85 76 92 91
Deputations abroad 30 38 42 56 47 44 44 56
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Contributions made as member of CSIR family:
Being one of the leading and productive contemporary organic chemists of the country and a
Shanti Swarup Bhatnagar Awardee (1991) in Chemical Sciences, he has become an
automatic choice to be the member of many prestigious scientific committees. They
include:
IICT richly possesses the world class state of art facilities worth of Rs.210.00
crores out of which 45 crores have been added during the last 3 ½ years, and
requisite expertise to tackle, face and solve any eventual R&D challenges of any
magnitude in a shortest span of time
IICT has a working strength of 1900 staff members which include scientists (194
nos) technical staff (137 nos), administration (174 nos), the other paraphernalia
staff and temporary staff (600 nos) and research scholars (700 nos). With the
unstinted support of the staff IICT has always created itself a position as ever
shining jewel in the crown of CSIR.
The National Mol Bank (NMB), a unique facility, jointly funded by DST and
CSIR, has been setup at IICT.
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In January 2010, the P C Ray Building for exploring collaborations and networks
at IICT was inaugurated by our Hon’ble Director General Prof.Samir K
Brahmachari.
The three new Centres of excellence equipped with latest facilities are ready for
inauguration.
Centre for Chemical Biology
Centre for Lipid Science & Technology
Centre for Pheromone Research
Construction of additional three floors on the existing IICT Hostel.
Construction of world class main entrance gate.
Facelift of main building and renovation of interior of the first floor of the main
building and guest houses.
Construction of seminar hall –cum-dining hall is under way.
As a step towards estate management a portion of land leased to NMDC has been
retrieved recently. A piece of prime land situated in the heart of the city is being
constantly monitored.
Under the leadership of Dr. Yadav, the general Administration, Finance &
Accounts and Stores & Purchase has been working as one unit in tandem. The
Director has accorded free hand in discharging their functions in accordance with
rules & regulations and guidelines of CSIR.
Under the dynamic leadership of Dr. Yadav, health aspect of employee and their
families has been taken care of by providing periodical health checkups. IICT
Dispensary is equipped with all facilities viz. pathological, X-ray, ECG, etc. and
recently a new physiotherapy unit has been set up and functioning well. Good
health is the essence for quality output for the institute and as well as for
individual.
Under the guidance of Dr. Yadav, CSIR Purchase Rules 2008 have been
successfully implemented in IICT. Considering the past pattern of procurements
of high turnover, common user items, the base of Rate Contracts were increased
to 67 firms which were processed online through the Software developed
internally. The systems in S&P Division were geared up to expand the entire
allocation made during the financial year 2011-12 without any surrender of funds.
Dr. Yadav always encouraged sporting activities. IICT has become an automatic
choice for holding CSIR-SSBMT, Nayudamma Tournament, etc.
Dr. Yadav has evinced interest for healthy atmosphere of the staff colony. In the
colony a Children Park has been set up with all the facilities which is well
maintained.
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Towards Societal Service:
Council of Scientific and Industrial Research (CSIR) has strived with zeal in building the
nation by developing relevant technologies that have immense value to the society and
people at large. It is this zeal that has driven Dr.J.S.Yadav, a leading scientist of CSIR, to
concentrate all his research and development efforts for the benefit of the nation, society
and its people.
Realizing early that science and technology inputs alone can bring succor to the
woos of “Aam Aadmi”, he focused all his scientific pursuits to Food and
Healthcare. Recognizing the stupendous task of enhancing the agricultural
production to feed the nation on one hand and the harmful effects of
indiscriminate use of pesticides to increase agricultural produce on the other has
led him to pursue Integrated Pest Management through Pheromone Application
Technology (PAT), which he pioneered in India
He has remarkable abilities in developing new methodologies to synthesize most
complex and important Active Pharmaceutical Ingredients (APIs). His
understanding of mechanisms of various organic reactions and imaginary skills in
building and designing the molecules are very unique. These versatile strengths
have allowed him to develop cost effective technologies for drug molecules,
making them affordable to a common man and easy availability in the market. It
is pertinent to say that several pharmaceutical companies in India want to have
him as their Research Advisor for his high caliber chemistry inputs to develop
technologies that are relevant to the nation.
Moved by the dreaded impairment caused by Fluorosis, specially on the growing
children Dr.Yadav decided to put all his efforts to find an answer to it. This
determined zeal of him could make him come out with a highly economical,
feasible and easily manageable Reverse Osmosis (RO) process for defluoridation
of ground water in affected areas of Andhra Pradesh. In 8 villages these plants
are commissioned and nearly 25 villagers are benefitted by these plants. The
major advantage of this technology is the low operating cost (6 paise) per liter of
water and removal of all impurities in a single step.
Dr.Yadav always believed that the development of rural areas in particular the
training community reflects the over all growth and development of that country.
Considering the value added deliverables from Samadhan Centre, Dr.Yadav
encouraged his staff to establish Samadhan kendras at strategic rural locations for
the over all development.
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Countries Visited:
U.S.A, UK, USSR, FRANCE, SOUTH KOREA, JAPAN, CHINA, THE
NETHERLANDS, JORDAN, SENEGAL, GERMANY, SINGAPORE,
SWITZERLAND, AUSTRALIA, SAUDI ARABIA, IRAN & BELGIUM.
Nominated by Govt of India as one of the expert member to represent along with
the Hon’ble Minister of Science & Technology to attend JCM and WG meeting
scheduled to be held at Washington DC during 8-11th June, 2012 under Indo-US
Forum.
Collaborations Extended:
The scientific collaborations which Dr.Yadav has established with the world
renowned schools of chemistry and expertise are highly vision based for the
overall development and recognition of the Institute. They include:
ArQule, USA, Aisin Cosmos, Japan, Glaxo Smithkline, ArQule, Evolva, Dupont,
Bayer, Givaudaun, Loreal, Colgate Palmolive, NIMS-Japan, RMIT-Australia,
King Saud University, Saudi Arabia.
Many Plenary and Invited lectures (>400) have been delivered at various National
and International Seminars and Symposiums both in India and Abroad
Chaired many Sessions on several occasions in International and National
Conferences.
The aura of Dr.Yadav in chemistry is such that the Institute has taken up highly
inspirational projects which address the needs of our society. They include the energy
sector, affordable health care, agriculture, supply of safe drinking water supply etc., In
fact, almost all the projects proposed in the XII FYP have some direct or indirect
significance for the benefit of society with their expected outputs. Every project has been
meticulously scrutinized and is being projected with a desirable output. The following are
the major ongoing project activities:
OSDD: Open Source Drug Discovery:
CSIR has an ambitious program on discovering drugs by openly inviting and
indulging the innovative and intellectual blend of ideas together on a single
platform and then come out with a possible lead to develop an affordable
ingredient to address a given ailment. CSIR has coined this strategic plan as Open
Source Drug Discovery program. Dr.J.S.Yadav has been asked by CSIR to
shoulder the responsibility and implement this unique program of OSDD. The
visionary skills of Dr.Yadav has transformed the entire program into individually
based approach for a given activity. Dr.J.S.Yadav feels that by sharpening each
individual brain pool will have a definite advantage to achieve a desirable and
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deliverable goal. With this versatile thinking Dr.Yadav and all the members of the
group are confident that certainly there will be a brighter output for OSDD, the
most ambitious program of CSIR.
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