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    CADD Question Papers

    Uploaded by

    Ammu Mahi

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    CADD Question Papers

    Uploaded by

    Ammu Mahi
    12 views6 pages

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    CADD question papers

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    12 views6 pages

    CADD Question Papers

    Uploaded by

    Ammu Mahi

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 6

    Rajiv Gandhi University of Health Sciences, Karnataka

    VIII Semester B. Pharm Degree Examination – 24-Jun-2022

    Time: Three Hours Max. Marks: 75 Marks

    COMPUTER AIDED DRUG DESIGN


    Q.P. CODE: 5039
    Your answers should be specific to the questions asked
    Draw neat labeled diagrams wherever necessary
    All the Questions are compulsory

    LONG ESSAYS 2 x 10 = 20 Marks


    1. Classify bio-isosterism approach with examples. Discuss of bio-isosterism replacement
    strategy with one case study.
    OR
    Describe the theoretical determination of partition coefficient and electronic parameters in
    QSAR.

    2. Define the term pharmacophore. Explain about the pharmacophore mapping suitable
    example.

    SHORT ESSAYS 7 x 5 = 35 Marks


    3. Write a note on Random and non-random screening.
    OR
    Differentiate molecular mechanics and Quantum mechanics.

    4. Define the term virtual screening. Explain the concept.


    OR
    Define Chemoinformatics? Explain steps involved in chemical data curation.

    5. Write a note on different stages of drug discovery.


    6. Discuss the parameters of Hansch and Free Wilson analysis.
    7. Discuss various methods for determination of energy minimization.
    8. Define molecular docking. Explain rigid docking.
    9. Write note on ADME databases.

    SHORT ANSWERS 10 x 2 = 20 Marks


    10. Define lead molecule.
    11. Give two methods of lead optimization
    12. Taft’s steric constant.
    13. Expand COMFA and COMSIA.
    14. Define global minima.
    15. Enumerate the applications of QSAR
    16. List out the various chemical database.
    17. Lipinski’s rule of five.
    18. What is bio-informatics?
    19. Enlist any two biochemical database’.
    ******
    Rajiv Gandhi University of Health Sciences, Karnataka
    VIII Semester B. Pharm Degree Examination – 09-Jun-2023

    Time: Three Hours Max. Marks: 75 Marks

    COMPUTER AIDED DRUG DESIGN


    Q.P. CODE: 5039
    Your answers should be specific to the questions asked
    Draw neat labeled diagrams wherever necessary
    All the Questions are compulsory

    LONG ESSAYS 2 x 10 = 20 Marks


    1. What is docking? Explain the different types of docking and their applications.
    OR
    Explain in detail the lead discovery based on drug metabolism and clinical observation with
    examples and structures.

    2. Explain the concept of Quantitative – structure activity relationship (QSAR). Enlist the
    different QSAR parameters.

    SHORT ESSAYS 7 x 5 = 35 Marks


    3. Write a note on Chemeinformatics.
    OR
    Explain serendipitous drug discovery with examples.

    4. Explain about the molecular mechanics principles.


    OR
    Explain the approaches for de novo drug design.

    5. Explain different methods in determination of energy minimization.


    6. Explain Hansch analysis and give its applications.
    7. Explain the pharmacophore based screening.
    8. Write a note ADME database’s.
    9. Discuss in brief various parameters of quantum mechanics.

    SHORT ANSWERS 10 x 2 = 20 Marks


    10. Write the application of molecular modelling.
    11. Expand COMFA and COMSIA.
    12. Define Lipinski’s rule of 5.
    13. Enlist the various databases used in drug design.
    14. What is CADD? Enlist the applications.
    15. Define global and local minima.
    16. Importance of partition coefficient in the drug action.
    17. Applications of Free Wilson analysis.
    18. Give the importance of biochemical database.
    19. What is lead optimization?

    ******
    Rajiv Gandhi University of Health Sciences, Karnataka
    VIII Semester B. Pharm Degree Examination – 25-Nov-2021

    Time: Three Hours Max. Marks: 75 Marks

    COMPUTER AIDED DRUG DESIGN


    Q.P. CODE: 5039
    Your answers should be specific to the questions asked
    Draw neat labeled diagrams wherever necessary
    All the Questions are compulsory

    LONG ESSAYS 2 x 10 = 20 Marks


    1. What is a lead molecule? Discuss the various stages involved in identification of a lead
    molecule.
    OR
    What is QSAR? Explain the Hansch analysis and Free Wilson analysis.

    2. Define and classify Molecular docking and discuss various steps involved in the flexible
    docking.

    SHORT ESSAYS 7 x 5 = 35 Marks


    3. What is analog Based Drug Design? Explain with suitable examples.
    OR
    Discuss about similarity based methods used in virtual screening.

    4. Discuss Comparative Molecular Field Analysis (CoMFA).


    OR
    Discuss the important aspect of pharmacophore mapping.

    5. Discuss the importance of prediction and analysis of ADME properties in drug design.
    6. Briefly explain the importance of various databases in drug design?
    7. Write a note on various energy minimization techniques used in molecular modeling study.
    8. Briefly explain quantum mechanical approach in drug design.
    9. Explain in brief about the molecular mechanics in drug design.

    SHORT ANSWERS 10 x 2 = 20 Marks


    10. Enlist various stages of drug design.
    11. Define Random screening and Non-random screening.
    12. Define partition coefficient and log P.
    13. Enlist electronic and steric descriptors of QSAR
    14. Compare SAR versus QSAR.
    15. Define pharmacophore and De novo drug design.
    16. Define the terms Bioinformatics and chemoinformatics.
    17. List out the various chemical databases.
    18. Write a note on importance of biochemical databases.
    19. What is Conformational Analysis and give its applications

    ******
    Rajiv Gandhi University of Health Sciences, Karnataka
    VIII Semester B. Pharm Degree Examination – 21-Nov-2023

    Time: Three Hours Max. Marks: 75 Marks

    COMPUTER AIDED DRUG DESIGN


    Q.P. CODE: 5039
    Your answers should be specific to the questions asked
    Draw neat labeled diagrams wherever necessary
    All the Questions are compulsory

    LONG ESSAYS 2 x 10 = 20 Marks


    1. Explain various physicochemical parameters of QSAR with examples.
    OR
    Elaborate De Novo drug designing giving emphasis on various approaches involved.

    2. Elaborate Analog based drug designing giving emphasis on objectives and categories of
    analog designing.

    SHORT ESSAYS 7 x 5 = 35 Marks


    3. What properties a lead compound should possess to develop as an orally active compound.
    OR
    Discuss Hammett’s substituent constant and Taft’s steric constant and its role in predicting
    biological activity.

    4. Explain the role of Pharmacophore.


    OR
    Discuss various databases used in drug design and discovery.

    5. What is molecular docking? Explain rigid docking.


    6. Write a short note on energy minimization.
    7. Discuss global minima.
    8. Write a note on the role of bioinformatics in the drug discovery process.
    9. Explain various parameters of molecular mechanics.

    SHORT ANSWERS 10 x 2 = 20 Marks


    10. Mention any two advantages of free Wilson analysis.
    11. Define COMFA
    12. Explain Hansch analysis.
    13. Compare SAR and QSAR.
    14. Define COMSIA with its two applications.
    15. Explain Lipinski rule of 5.
    16. Define cheminformatics and mention its two applications.
    17. Give Examples of drugs discovered through serendipity.
    18. How are ADME databases are obtained?
    19. Define Local minima.

    ******
    Rajiv Gandhi University of Health Sciences, Karnataka
    VIII Semester B. Pharm Degree Examination – 29-Nov-2022

    Time: Three Hours Max. Marks: 75 Marks

    COMPUTER AIDED DRUG DESIGN


    Q.P. CODE: 5039
    Your answers should be specific to the questions asked
    Draw neat labeled diagrams wherever necessary
    All the Questions are compulsory

    LONG ESSAYS 2 x 10 = 20 Marks


    1. Explain Hansch analysis and Free Wilson analysis along with its advantages and
    disadvantages.
    OR
    Explain the stages of drug discovery and development.

    2. Discuss the different types of lead discovery. Explain and discovery based on clinical
    observation with examples.

    SHORT ESSAYS 7 x 5 = 35 Marks


    3. Explain Hammett’s and Taft’s constants of QSAR.
    OR
    Explain de novo drug design.

    4. Discuss concept of pharmacophore mapping.


    OR
    Write note on ADME databases.

    5. Discuss importance of quantum mechanics in drug design.


    6. Define bio-isosterism? Classify bio-isosterism with examples.
    7. Write a note on Conformational analysis.
    8. Explain different methods in determination of energy minimization.
    9. Define bioinformatics? Explain its application in drug discovery.

    SHORT ANSWERS 10 x 2 = 20 Marks


    10. Mention the electronic parameters used in QSAR studies
    11. Mention the steric parameters used in QSAR.
    12. Expand COMFA and COMSIA.
    13. Define random and non-random screening.
    14. Define global and local minima.
    15. Lipinski’s rule of five.
    16. Define lead optimization.
    17. Define Chemeinformatics.
    18. Enlist biochemical database’s.
    19. Application of chemical database’s.

    ******

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