Red Flags in Spinal Conditions - Physiopedia
Red Flags in Spinal Conditions - Physiopedia
Red Flags in Spinal Conditions - Physiopedia
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Contents
1 Introduction
2 History of Red Flags
3 Epidemiology of Red Flags
4 Subjective Assessment
4.1 Age
4.2 History of Cancer
4.3 Unexplained Weight Loss
4.4 Pain[8]
4.5 Responsiveness to Previous Therapy
4.6 Other[8]
5 Objective History
5.1 Physical Appearance
5.2 Deformity of the spine
5.3 Muscle Spasm
5.4 Neurological Assessment
6 Diagnostic Tests
6.1 Fracture
6.1.1 Lumbar Spine
6.1.2 Cervical Spine
6.2 Cancer
6.3 Ankylosing Spondylitis
6.4 Cauda Equina
7 Clinical Reasoning
8 Management of Red Flags
9 Documentation
10 References
Online Course: An Introduction to Red Flags Online Course: Spinal Malignancy Online Course: Differential Diagnosis Progra…
An Introduction to Red Flags Learn how to use red flags Spinal Malignancy Introducing a framework to enhance a Differential Diagnosis Programme How to effectively screen
effectively when considering serious pathologies as a clinician's ability to screen for serious spinal pathology Start a patient for a serious pathology Start course 12-14 hours -
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Physiopedia Course instructor Laura Finucane Consultant physiotherapist, specialist interest in red flags, Vice President of IFOMPT •
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Online Course: Spinal Malignancy
Spinal Malignancy Introducing a framework to enhance a clinician's ability to screen for serious spinal pathology Start course 1-1.5 hours - - - - Powered by Physiopedia Course
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Introduction
This article is currently under review and may not be up to date. Please come back soon to see the finished work! (18/08/2022)
Clinical findings that increase the level of suspicion that there is a serious medical condition presenting as common, non-serious,
musculoskeletal conditions, are commonly described as red flags.[1]
International guidelines, for example the assessment of lower back pain[2] and neck pain,[3] recommend using red flags to identify
serious pathology. Red flags are features from a patient's subjective and objective assessment which are thought to put them at a
higher risk of serious pathology and warrant referral for further diagnostic testing[4]. They often highlight non-mechanical conditions
or pathologies of visceral origin and can be contraindications to many Physiotherapy treatments.
Although red flags have a valid role to play in assessment and diagnosis they should also be used with caution as they have poor
diagnostic accuracy[5] and red flag questions are not used consistently across guidelines[5]. Some guidelines even recommend
immediate referral to imaging if any red flag is present, which could lead to many unnecessary referrals if clinicians did not clinically
reason their referral[6]. The International Framework for Red Flags for Potential Serious Spinal Pathologies was developed to create
some consensus amongst healthcare workers identifying possible red flags in patients presenting with musculoskeletal complaints.
Table showing breakdown of the conditions lower back pain patients present with
Figures in brackets indicate estimated percentages of patients with these conditions among all adult patients with signs and
symptoms of low back pain. Percentages may vary substantially according to demographic.[10]
Subjective Assessment
Clinicians must be aware of the key signs and symptoms associated with serious medical conditions that cause spinal pain and
develop a system to continually screen for the presence of these conditions.[11] They should also consider the context of the red
flag.[1] It is important to communicate clearly and effectively the reasons for asking these questions with the patient. Provide
reassurance to the patient if they are likely at low risk for a serious pathology.
Age
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In the UK, age above 55 years is considered a red flag, this is because above this age, particularly above 65, the chances of being
diagnosed with many serious pathologies, such as cancers, increase[8].
History of Cancer
A patient history of cancer and also family history of cancer should be established, particularly in a first degree relative, such as a
parent or sibling[8]. The most common forms of metastatic cancer are: breast, lung and prostate.
Pain[8]
1. Constant Pain - This needs to be true constant pain that does not vary within a 24 hour period.
2. Thoracic Pain - The thoracic region is the most common region for metastases.
3. Severe Night Pain - This can be linked to be objective history if the patient's symptoms are brought on when they are lying down
or non weight bearing.
4. Abdominal pain and changed bowel habits but with no change of medication - A change is bowel habits can be a red flag for
cauda equina.
Other[8]
Systemically unwell
Bilateral pins and needles
Trauma , fall from height, road traffic accident or combat
Past medical history of tuberculosis or osteoporosis
Smoking - Has adverse effects on circulation, therefore decreasing the nutritional supply getting to the intervertebral disk and
vertebrae. Over time this leads to degeneration of these structures and therefore instability which can cause lower back pain. It
has also been suggested that regular coughing, which if often associated with smoking, can also lead to increased mechanical
stress on the spine
Cauda Equina Symptoms: urinary retention, fecal incontinence, unilateral or bilateral sciatica, reduced straight leg raise
and saddle anaesthesia
Objective History
The subjective assessment will provide the therapist with the majority of the information needed to clarify cause of symptoms.
[12]
The objective assessment needs to be sufficiently thorough to ensure that if present, red flags are managed appropriately[13]. It
is suggests that a total of 44 items in the objective examination can be considered as red flags[13]
Physical Appearance
The therapist should determine if the patient is unwell objectively however this is a very subjective concept. The following signs may
indicate that the patient has a systemic serious pathology[8].
Pallor/flushing
Sweating
Altered complexion: sallow/jaundiced
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Tremor/shaking
Tired
Disheveled/unkempt
Halitosis
Poorly fitting clothes
Muscle Spasm
This is suggested to be synonymous with spinal pain and is therefore difficult to determine if it is associated with a red flag
pathology. If a serious spinal pathology is present, the muscle spasm may be severe enough to be a cause of scoliosis in the spine.[8]
The correlation between muscle spasm, pain and other objective clinical measurements however, are poorly supported by strong
evidence.[8]
Neurological Assessment
Patients who report neurological signs in the subjective assessment require a neurological assessment.[14] A neurological deficit is
rarely the first presenting symptom in a patient with serious spinal pathology however 70% of patients will have a neurological deficit
at the time of diagnosis.[8] Dermatomes, myotomes and reflexes should be examined. The upper motor neuron pathways should also
be examined via extensor plantar reflex (Babinski), clonus and hoffmans. If brisk, it may indicate a upper motor neuron pathology.[8]
Diagnostic Tests
In differential diagnosing serious spinal conditions we should understand the best tests for each spinal pathology and/or clusters of
tests. The best tests are: reliable, low cost, have validated findings and high diagnostic accuracy i.e. specifictit and sensitivity).
Specificity - Is the percentage of people who test negative for a specific disease among a group of people who do not have the
disease [15]
Sensitivity - Is the percentage of people who test positive for a specific disease among a group of people who have the disease
[15]
Likelihood ratio = The Likelihood Ratio (LR) is the likelihood that a given test result would be expected in a patient with the
target disorder compared to the likelihood that that same result would be expected in a patient without the target disorder [16]
High sensitivity and LOW LR = RULE OUT people who don’t have the disease
High specificity and HIGH LR = RULE IN people who have the disease
Fracture
Lumbar Spine
Table to show sensitivity, specificity, and likelihood ratios of subjective information in the diagnosis of lumbar
fracture[17][18][19][20][21][22][23]
Subjective Index Sensitivity Specificity Positive likelihood Ratios Negative likelihood Ratios
(%) (%) (%) (%)
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Clustered Results Sensitivity (%) Specificity (%) Positive likelihood Ratio (%) Negative likelihood ratio (%)
To objectively test for a compression fracture in the lumbar spine the examiner stands behind the patient. The patient stands facing a
mirror so that the examiner can gauge their reaction. The entire length of the spine is examined using firm, closed-fist percussion. It
is positive when the patient complains of a sharp, sudden pain.
Diagnostic Test Sensitivity (%) Specificity (%) Positive Likelihood ratio (%) Negative Likelihood Ratio (%)
Cervical Spine
In the cervical spine the Canadian C-Spine Rule can be used to identify when people should be sent for radiography.
Cancer
Shows sensitivity, specificity and likelihood ratios for signs and symptoms that could indicate cancer [24][25][26][27][28][29]
Subjective Index Sensitivity Specificity Positive likelihood ratio Negative likelihood ratio
(%) (%) (%) (%)
0.55 0.35
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1 0.97
0.50 0.81
Ankylosing Spondylitis
Shows sensitivity and specificity of information from subjective assessment in regards to Ankylosing Spondylitis [25]
Cauda Equina
Shows sensitivity and specificity of the signs and symptoms associated with cauda equina[30][31].
Urinary Retention 90
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Clinical Reasoning
The use of red flags should not replace clinical reasoning but used as an adjunct to the process.[32] A lone red flag would not
necessarily provide a strong indication of serious pathology. It should be considered in the context of a person's history and the
findings on examination.[33][34]
Patients’ inappropriate misattribution of insidious symptoms to a traumatic event is common and can be misleading. Clinical
reasoning is only as good as the information on which it is based indicating the importance of thorough questioning in the subjective
assessment.
The three types of errors that can occur in clinical reasoning include:
Within the clinical reasoning process, the therapist should determine if there are logical inferences in regards to the information they
are receiving from the patient. The therapist should not be reassured by previous investigations being reported on as normal. In the
early stages, serious spinal pathology is difficult to detect and weight loss will not always be evident in these early stages.[35]
Red Herrings for serious spinal pathology may include spinal stenosis, lower limb edema, nerve root compression, peripheral
neuropathy, cervical myelopathy, alcoholism, diabetes, MS and UMND.[13] Due to the abundance of red herrings that can be present,
it is important the therapist interprets the red flags in the context of the patient's current presenting condition and not singularly.[13]
Failure to improve after one month is a red flag and the patient can be referred back to the GP for continued management and further
diagnostic tests as required.[8] The GP will be able to refer the patient on to have x-rays, CT/MRI, blood tests or nerve conduction
studies.[39] It has been suggested that to reduce the rate of false alarms, the patient should be referred back to the GP in the first
instance to undertake further investigations as required before more advanced imaging is undertaken[40].
Documentation
After onward referral red flags must be acknowledged in the notes as this will indicate contraindication to physiotherapy.
Physiotherapist documentation of red flags in the USA has demonstrated that 8 of 11 red flags were documented 98% of the time as
seen below:
Age over 50
Bladder dysfunction
History of cancer
Immunosuppression
Night pain
History of trauma
Saddle anaesthesia
Lower extremity neurological deficit
Weight loss
Recent infection
Fever/chills
In comparison to this data in the USA, Scotland undertook a review of the documentation of red flags on 2147 episodes of care. The
investigation took place in two phases, between May and June 2008 and January and February 2009). The therapists were given an
online tool to prompt them in respect to the most common red flags [32] Results reported that in the first phase, 33% of red flags
were documented and of those 33%, 54% were cauda equina symptoms. In comparison, within phase two, the rate of
documentation rose to 65% for red flags and within those, 84% recorded cauda equina [32]. Despite documentation improving, this
still left 1 in 5 therapists not documenting red flags. Of all the red flag questions investigated, HIV/drug abuse was the least
documented red flag [32]
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Related articles
10. Deyo, R and Diehl, A. Cancer as a cause of back pain – fequencey, clinical presentation and diagnostic strategies.Journal of
General Internal Medicine. 1988;3(3):230-8.
11. Anthony Delitto, Steven Z. George, Linda Van Dillen, Julie M. Whitman, Gwendolyn Sowa, Paul Shekelle, Thomas R. Denninger,
Joseph J. Godges. Low Back Pain: Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability,
and Health from the Orthopaedic Section of the American Physical Therapy Association (http://www.jospt.org/doi/full/10.2519/jos
pt.2012.42.4.A1). Journal of Orthopaedic and Sports Physical Therapy, 2012, 42(4)
12. Eveleigh, C. Red Flags and Spinal Masquereders. [online]. Available at : www.nspine.co.uk/.../09-nspine2013-red-flags-
masqueraders.ppt. Accessed 13/01/14. 2013.
13. Greenhalgh, S. and Selfe, J. A qualitative investigation of Red Flags for serious spinal pathology. Physiotherapy. 95, pp: 223 –
226. 2009.
14. Petty, N. J. and Moore, A. P. Neuromuscular examination and assessment: a handbook for therapists. Edingburgh: Churchill
Livingstone. 2001.
15. Sackett, D.L., Straws, S.E., Richardson, W.S., et al. (2000) Evidence-based medicine: How to practice and teach EBM.(2nd ed.)
London: Harcourt Publishers Limited.
16. Centre for evidence based medicine, Critical appraisal, Likelihood ratios, August 2012, (accessed January 2014)
17. Van den Bosch MAAJ, Hollingworth W, Kinmonth AL, Dixon AK. Evidence against the use of lumbar spine radiography for low
back pain. Clinical Radiology 2004;59:69-76.
18. Roman M, Brown C, Richardson W,Isaacs R, Howes C, Cook C. The development of a clinical decision making algorithm for
detection of osteoporotic vertebral compression fracture or wedge deformity. Journal Manipulative Physiological Therapeutics
2010;18:44-9.
19. Patrick JD, Doris PE, Mills ML, Friedman J, Johnston C. Lumbar spine x-rays: a multihospital study. Annals Emergency Medicine
1983;12:84-7.
20. Scavone JG, Latshaw RF, Rohrer GV. Use of lumbar spine films. Statistical evaluation at a university teaching hospital. JAMA
1981;246:1105-8.
21. Gibson M, Zoltie N. Radiography for back pain presenting to accident and emergency departments. Archives Emergency
Medicine 1992;9:28-31.
22. Deyo RA, Diehl AK. Lumbar spine films in primary care: current use and effects of selective ordering criteria. Journal General
Internal Medicine 1986;1:20-5.
23. Langdon J, Way A, Heaton S, Bernard J, Molloy S. Vertebral compression fractures: new clinical signs to aid diagnosis. Annals
Royal College Surgeons England 2009 Dec 7.
24. Reinus WR, Strome G, Zwemer FL. Use of lumbosacral spine radiographs in a level II emergency department. AJR American
Journal Roentgenology 1998;170:443-7.
25. Deyo RA, Jarvik JG. Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med. 2002;137:586-97.
26. Jacobson AF. Musculoskeletal pain as an indicator of occult malignancy. Yield of bone scintigraphy. Archives of International
Medicine 1997;157:105-9.
27. Frazier LM, Carey TS, Lyles MF, Khayrallah MA, McGaghie WC. Selective criteria may increase lumbosacral spine roentgenogram
use in acute low-back pain. Archives of International Medicine 1989;149:47-50.
28. Deyo RA, Diehl AK. Cancer as a cause of back pain: frequency, clinical presentation, and diagnostic strategies. Journal General
Internal Medicnie 1988;3:230-8.
29. Cook C, Ross MD, Isaacs R, Hegedus E. Investigation of nonmechanical findings during spinal movement screening for
identifying and/or ruling out metastatic cancer. Pain Practice 2012;12:426-33.
30. Jalloh and Minhas. Emergency Medicine. 2007;24:33-4
31. N.A. Johnson and S. Grannum. Accuracy of clinical signs and symptoms in predicting the presence of cauda equine syndrome
The Bone and Joint Journal. 2012 vol. 94-B no. SUPP X 058
32. Ferguson, F. Holdsworth, L. and Rafferty, D. Low back pain and physiotherapy use of red flags: the evidence from Scotland.
Physiotherapy. 96, pp: 282 – 288. 2010
33. Finucane L, Selfe J, Mercer C, Greenhalgh S, Downie A, Pool A et al. An evidence informed clinical reasoning framework for
clinicians in the face of serious pathology in the spine course slide. Plus2020.
34. Mercer, C., Jackson, A., Hettinga, D., Barlos, P., Ferguson, S., Greenhalgh, S., Harding, V., Hurley Osing, D., Klaber Moffett, J.,
Martin, D., May, S., Monteath, J., Roberts, L., Talyor, N. and Woby, S. Clinical guidelines for the physiotherapy management of
persistent low back pain, part 1: exercise. Chatered Society of Physiotherapy. [online]. Available at:
http://www.csp.org.uk/publications/low-back-pain. Accessed 13/01/14. 2006.
35. Greenhalgh, S. and Selfe, J. Malignant Myeloma of the spine: Case Report. Physiotherapy. 89 (8), pp: 486 – 488.
36. Moffett, J. K., McLean, S. and Roberts, L. Red flags need more evalutation: reply. Rheumatology. 45, pp: 922. 2006
37. Chau, A. M. T., Xu, L. L., Pelzer, N. R. and Gragnaniello, C. (2013). Timing of surgical intervention in cauda equine syndrome – a
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37. Chau, A. M. T., Xu, L. L., Pelzer, N. R. and Gragnaniello, C. (2013). Timing of surgical intervention in cauda equine syndrome – a
systematic critical review. World Neurosurgery. 12
38. Carvalho, A. Red Alert: How useful are flags for identifying the origins of pain and barriers to rehabilitation? Frontline. 13 (17).
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39. Chartered Society of Physiotherapy. The Clinical Guidelines for the physiotherapy management of perisistent low back pain.
[online]. Available at: www.csp.org.uk/publications/low-back-pain. Accessed 14/01/2014. 2006
40. Hensche, N. and Maker, C. Red flags need more evaluation. Rheumatology. 45, pp: 921. 2006.
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