Joachim Frank

Joachim Frank
Joachim Frank (German pronunciation: [ˈjoːaxɪm ˈfʁaŋk]

) HonFRMS; born September 12, 1940) is a German- Joachim Frank
American biophysicist at Columbia University and a
Nobel laureate. He is regarded as the founder of single-
particle cryo-electron microscopy (cryo-EM), for
which he shared the Nobel Prize in Chemistry in 2017
with Jacques Dubochet and Richard Henderson.[2] He
also made significant contributions to structure and
function of the ribosome from bacteria and eukaryotes.
Life and career

Frank was born in Siegen in the borough of Weidenau.
After completing his Vordiplom (B.S.) degree in
physics at the University of Freiburg (1963)[3] and his
Diplom under Walter Rollwagen's mentorship at the
Ludwig Maximilian University of Munich with the Joachim Frank under Nobel Prize press
thesis "Untersuchung der Sekundärelektronen- conference in Stockholm, December 2017
Emission von Gold am Schmelzpunkt" (Investigation Born September 12, 1940
of secondary electron emission of gold at its melting Siegen, Germany
point) (1967), Frank obtained his Ph.D. from the Citizenship United States, Germany[1]
Technical University of Munich for graduate studies in
Education University of Freiburg (BS)
Walter Hoppe's lab at the Max Planck Institut für
University of Munich (MS)
Eiweiss- und Lederforschung (now Max Planck
Max Planck Society
Institute of Biochemistry) with the dissertation
Technical University of
Untersuchungen von elektronenmikroskopischen
Munich (PhD) Cornell
Aufnahmen hoher Auflösung mit Bilddifferenz- und
University
Rekonstruktionsverfahren[4] (Investigations of high-
resolution electron micrographs using image difference Known for Single-particle cryo-electron
and reconstruction methods) (1970). The thesis microscopy
explores the use of digital image processing and Ribosome structure and
optical diffraction in the analysis of electron dynamics
micrographs, and alignment of images using the cross- Spouse Carol Saginaw (m. 1983)
correlation function. Children Ze Frank & Mariel Frank
As a Harkness postdoctoral fellow, he had the Awards

Benjamin Franklin Medal
opportunity to study for two years in the United States: in Life Science (2014)
with Robert Nathan at the Jet Propulsion Laboratory,
Wiley Prize in Biomedical
California Institute of Technology; with Robert M.
Sciences (2017)
Glaeser at Donner Lab, University of California,
Berkeley and with Benjamin M. Siegel at Cornell Nobel Prize in Chemistry
University, Ithaca, New York.[5][6][7] In the fall of 1972 (2017)
he returned briefly to the Max Planck Institute of Honorary Fellow of the
Biochemistry in Martinsried as research assistant, Royal Microscopical
working on the theory of partial coherence in electron Society (2018)
microscopy,[8] then, in 1973, he joined the Cavendish
Scientific career
Laboratory, University of Cambridge as Senior
Research Assistant under Vernon Ellis Cosslett. Fields Structural biology
Cryo-electron microscopy
In 1975 Frank was offered a position of senior research Institutions University at Albany,
scientist in the Division of Laboratories and Research Department of Biomedical
(now Wadsworth Center), New York State Department Sciences
of Health,[6][9] where he started working on single- Columbia University College
particle approaches in electron microscopy. [10] In 1985 of Physicians and Surgeons,
he was appointed associate and then (1986) full Department of Biochemistry
professor at the newly formed Department of and Molecular Biophysics
Biomedical Sciences of the University at Albany, State
Thesis Untersuchungen von
University of New York. In 1987 and 1994, he went on
elektronenmikroskopischen
sabbaticals in Europe, one to work with Richard
Aufnahmen hoher Auflösung
Henderson, Laboratory of Molecular Biology Medical
mit Bilddifferenz- und
Research Council in Cambridge and the other as a Rekonstruktionsverfahren
Humboldt Research Award winner with Kenneth C. (1970)
Holmes, Max Planck Institute for Medical Research in
Doctoral Walter Hoppe
Heidelberg.[6] In 1998 Frank was appointed
advisor
investigator of the Howard Hughes Medical Institute
(HHMI). Since 2003 he was also lecturer at Columbia Other academic Robert Glaeser, Robert
University, and he joined Columbia University in 2008 advisors Nathan
as professor of Biochemistry and Molecular
Biophysics (http://www.wikicu.com/Biochemistry_and_Molecular_Biophysics_Department) and of
biological sciences.
Awards (selection)
1994 Humboldt Research Award of the Alexander von Humboldt Foundation[7]
2006 Fellow of the American Academy of Arts and Sciences[11]
2006 Member of the National Academy of Sciences[12]
2014 Benjamin Franklin Medal in Life Science of the Franklin Institute[13]
2017 Wiley Prize in Biomedical Sciences[14]
2017 Nobel Prize in Chemistry[15]
2018 Honorary Doctorate, University of Siegen (Germany)[16]
2018 Honorary Fellow of the Royal Microscopical Society
Selected publications
Books
Frank, Joachim (2014), Found in Translation – Collection of Original Articles on Single-
Particle Reconstruction and the Structural Basis of Protein Synthesis, Singapore: World
Scientific Press, ISBN 978-981-4522-80-9.
Herman, Gabor T.; Frank, Joachim (2014), Computational Methods for Three-Dimensional
Microscopy Reconstruction, springer, ISBN 978-1-4614-9520-8.
Frank, Joachim (2011), Molecular Machines in Biology: Workshop of the Cell, Cambridge:
Cambridge University Press, ISBN 978-0-521-19428-0.
Glaeser, Robert M.; Downing, Ken; Chiu, Wah; Frank, Joachim; DeRosier, David (2007),
Electron Crystallography of Biological Macromolecules, Oxford: Oxford University Press,
ISBN 978-0-19-508871-7.
Frank, Joachim (2006), Electron Tomography (2nd ed.), New York: Springer, ISBN 978-0-
387-31234-7.
Frank, Joachim (2006), Three-Dimensional Electron Microscopy of Macromolecular
Assemblies (2nd ed.), Oxford: Oxford University Press, ISBN 978-0-19-518218-7.
Articles
Frank, Joachim (2015). "Generalized single-particle cryo-EM – a historical perspective" (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749046). Microscopy. 65 (1): 3–8.
doi:10.1093/jmicro/dfv358 (https://doi.org/10.1093%2Fjmicro%2Fdfv358). PMC 4749046 (htt
ps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749046). PMID 26566976 (https://pubmed.ncb
i.nlm.nih.gov/26566976).
Frank, Joachim; Gonzalez, Jr., Ruben L. (2010). "Structure and dynamics of a processive
Brownian motor: the translating ribosome" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2
917226). Annu. Rev. Biochem. 79: 381–412. doi:10.1146/annurev-biochem-060408-173330
(https://doi.org/10.1146%2Fannurev-biochem-060408-173330). PMC 2917226 (https://www.
ncbi.nlm.nih.gov/pmc/articles/PMC2917226). PMID 20235828 (https://pubmed.ncbi.nlm.nih.
gov/20235828).
Frank, Joachim; Spahn, Christian M.T. (2010). "The ribosome and the mechanism of protein
synthesis". Rep. Prog. Phys. 69 (5): 1383–1417. doi:10.1088/0034-4885/69/5/R03 (https://d
oi.org/10.1088%2F0034-4885%2F69%2F5%2FR03). S2CID 121917680 (https://api.semanti
cscholar.org/CorpusID:121917680).
Frank, Joachim (2009). "Single-particle reconstruction of biological macromolecules in
electron microscopy -- 30 years" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844734).
Q. Rev. Biophys. 42 (3): 139–158. doi:10.1017/S0033583509990059 (https://doi.org/10.101
7%2FS0033583509990059). PMC 2844734 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC
2844734). PMID 20025794 (https://pubmed.ncbi.nlm.nih.gov/20025794).
References
1. Frank, Joachim (2017), Curriculum Vitae (http://franklab.cpmc.columbia.edu/franklab/wp-con
tent/uploads/2016/09/Joachim-Frank-Long-CV-Sep-2016_complete1.pdf) Archived (https://w
eb.archive.org/web/20171009143354/http://franklab.cpmc.columbia.edu/franklab/wp-conten
t/uploads/2016/09/Joachim-Frank-Long-CV-Sep-2016_complete1.pdf) October 9, 2017, at
the Wayback Machine. Retrieved October 4, 2017.
2. "The Nobel Prize in Chemistry 2017" (https://www.nobelprize.org/nobel_prizes/chemistry/lau
reates/2017/). The Nobel Foundation. October 4, 2017. Retrieved October 6, 2017.
3. Entry in the University Archive Freiburg, Prüfungsausschuss für Diplom-Physiker B 11/593
4. Entry in the catalogue of the Deutsche Nationalbibliothek: DNB 482124628 (http://d-nb.info/
482124628)
5. "Joachim Frank, PhD | P&S; Research" (https://web.archive.org/web/20171009143354/http
s://www.ps.columbia.edu/research/profile/joachim-frank-phd). Archived from the original (htt
ps://www.ps.columbia.edu/research/profile/joachim-frank-phd) on October 9, 2017.
Retrieved October 5, 2017.
6. Mossman, Kaspar (December 11, 2007). "Profile of Joachim Frank" (https://www.ncbi.nlm.ni
h.gov/pmc/articles/PMC2148354). Proc. Natl. Acad. Sci. U.S.A. 104 (50): 19668–70.
Bibcode:2007PNAS..10419668M (https://ui.adsabs.harvard.edu/abs/2007PNAS..10419668
M). doi:10.1073/pnas.0710323105 (https://doi.org/10.1073%2Fpnas.0710323105).
PMC 2148354 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148354). PMID 18056798
(https://pubmed.ncbi.nlm.nih.gov/18056798).
7. "Archived copy" (https://web.archive.org/web/20171009143354/http://franklab.cpmc.columbi
a.edu/franklab/wp-content/uploads/2016/09/Joachim-Frank-Long-CV-Sep-2016_complete1.
pdf) (PDF). Archived from the original (http://franklab.cpmc.columbia.edu/franklab/wp-conten
t/uploads/2016/09/Joachim-Frank-Long-CV-Sep-2016_complete1.pdf) (PDF) on October 9,
2017. Retrieved October 4, 2017.
8. Frank, Joachim (1973), "The envelope of electron microscopic transfer functions for partially
coherent illumination", Optik, 38: 519–539.
9. Wicher, Konrad (2006). History of the electron microscope: the high voltage electron
microscope and beyond at the Division of Laboratories and Research/Wadsworth Center.
Albany, New York: Wadsworth Center, New York State Department of Health. p. 149.
10. Frank, Joachim (1975). "Averaging of low-exposure electron micrographs of non-periodic
objects". Ultramicroscopy. 1 (2): 159–162. doi:10.1016/s0304-3991(75)80020-9 (https://doi.
org/10.1016%2Fs0304-3991%2875%2980020-9). PMID 1236029 (https://pubmed.ncbi.nlm.
nih.gov/1236029).
11. Book of Members 1780–present (https://www.amacad.org/multimedia/pdfs/publications/book
ofmembers/ChapterF.pdf) (PDF, 878 kB) at American Academy of Arts and Sciences
(amacad.org); Retrieved February 23, 2017.
12. "Joachim Frank" (http://www.nasonline.org/member-directory/members/20012446.html).
nasonline.org. January 12, 2006. Retrieved February 23, 2017.
13. "Joachim Frank" (https://www.fi.edu/laureates/joachim-frank). fi.edu. December 12, 2014.
Retrieved February 23, 2017.
14. "The 16th Annual Wiley Prize in Biomedical Sciences Awarded for Pioneering Developments
in Electron Microscopy" (https://web.archive.org/web/20171004135815/http://newsroom.wile
y.com/press-release/all-corporate-news/16th-annual-wiley-prize-biomedical-sciences-award
ed-pioneering-deve). newsroom.wiley.com. February 22, 2017. Archived from the original (ht
tp://newsroom.wiley.com/press-release/all-corporate-news/16th-annual-wiley-prize-biomedic
al-sciences-awarded-pioneering-deve) on October 4, 2017. Retrieved February 23, 2017.
15. "Nobel Prize in Chemistry Awarded for Cryo-Electron Microscopy" (https://www.nytimes.co
m/2017/10/04/science/nobel-prize-chemistry.html). The New York Times. October 4, 2017.
Retrieved October 4, 2017.
16. "Respect and Recognition" (http://www.uni-siegen.de/presse/relaunch/en/releases/2017/817
947.html). uni-siegen.de. April 17, 2018. Retrieved October 2, 2018.
Further reading
Mossman, Kaspar (December 11, 2007). "Profile of Joachim Frank" (https://www.ncbi.nlm.ni
h.gov/pmc/articles/PMC2148354). Proceedings of the National Academy of Sciences of the
USA. 104 (50): 19668–19670. Bibcode:2007PNAS..10419668M (https://ui.adsabs.harvard.e
du/abs/2007PNAS..10419668M). doi:10.1073/pnas.0710323105 (https://doi.org/10.1073%2
Fpnas.0710323105). PMC 2148354 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC214835
4). PMID 18056798 (https://pubmed.ncbi.nlm.nih.gov/18056798).
External links
Frank Lab (http://franklab.cpmc.columbia.edu/franklab/) Archived (https://web.archive.org/w
eb/20210325104252/https://franklab.cpmc.columbia.edu/franklab/) March 25, 2021, at the
Wayback Machine website
List of Publications (http://franklab.cpmc.columbia.edu/franklab/publications) Archived (http
s://web.archive.org/web/20201224092056/http://franklab.cpmc.columbia.edu/franklab/public
ations) December 24, 2020, at the Wayback Machine
Joachim Frank (https://scholar.google.com/citations?user=a7LHl00AAAAJ) publications
indexed by Google Scholar
Joachim Frank (https://www.nobelprize.org/laureate/945) on Nobelprize.org including the
Nobel Lecture on December 8, 2017 Single-Particle Reconstruction – Story in a Sample
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Joachim Frank

Joachim Frank (German pronunciation: [ˈjoːaxɪm ˈfʁaŋk]

Life and career

As a Harkness postdoctoral fellow, he had the Awards

Retrieved from "https://en.wikipedia.org/w/index.php?title=Joachim_Frank&oldid=1241390651"

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