Gene Interactions Lecture Note

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BIO 301 Class: Gene Interactions

Instructor: Mr. Mathew

Introduction
In this session, we will examine gene interactions, understanding how they differ
from Mendelian inheritance, and explore interallelic gene interactions along with
the various types of gene interactions.

Gene Interactions: An Overview


Gene interaction refers to a type of non-Mendelian inheritance. Unlike Mendelian
inheritance, where characters are governed by a single gene, gene interactions
involve two or more genes influencing a single trait. This concept emerged when it
was realized that many characters are governed by multiple genes, leading to non-
Mendelian inheritance patterns.

Mendelian vs. Non-Mendelian Inheritance


Mendelian Inheritance:
Characters are governed by a single gene.

Non-Mendelian Inheritance:
Many characters are governed by two or more genes.

Dihybrid Ratio and Gene Interaction


Gene interaction modifies the typical dihybrid ratio of 9:3:3:1 observed in
Mendelian inheritance. This modification occurs because multiple genes interact to
influence the expression of a single trait.

Definition of Gene Interaction


Gene interaction is the phenomenon where two or more genes interact and affect
each other's expression in the development of a single character in an organism. In
simple terms, two or more genes contribute to a single phenotype.
Types of Gene Interactions
There are two main types of gene interactions:
1. Intra-allelic Gene Interaction: Interactions between alleles of the same gene.
2. Inter-allelic Gene Interaction: Interactions between alleles of different genes.

Intra-allelic Gene Interaction:

Intra-allelic gene interaction refers to the interaction between the alleles of a single
gene.

Inter-allelic Gene Interaction:

Inter-allelic gene interaction involves the genetic interaction between the alleles of
one gene with the alleles of another gene.

Types of Inter-allelic Gene Interactions:

1. Complementary Gene Interaction:

- The phenotypic ratio is 9:7.

2. Supplementary Gene Interaction:

- The phenotypic ratio is 9:3:4.

3. Epistasis:

- Can be dominant or recessive.

- Dominant Epistasis: The phenotypic ratio is 12:3:1.

- Recessive Epistasis: The phenotypic ratio is 9:3:4.

Key Points
Gene interaction is a non-Mendelian inheritance pattern.
It involves the interaction of two or more genes to influence a single trait.
This leads to modifications in the typical dihybrid ratio.
There are two types of gene interactions: intra-allelic and inter-allelic.
Conclusion
In summary, gene interactions represent a complex form of inheritance where
multiple genes work together to determine a single trait. Understanding these
interactions provides insight into the complexity of genetic traits beyond the
simpler Mendelian patterns.

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