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ROLE OF AYURVEDA IN DOWN SYNDROME

Article in World Journal of Pharmaceutical Research · May 2020

DOI: 10.20959/wjpr20207-17834

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Ashwini Zadpe Renu Rathi

Datta Meghe Institute of Medical Sciences (Deemed University) MGACHRC,Salod Wardha
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 World Journal of Pharmaceutical Research
Ashwini et al. SJIF Research
World Journal of Pharmaceutical Impact Factor 8.084

Volume 9, Issue 7, 2202-2208. Case Study ISSN 2277– 7105

ROLE OF AYURVEDA IN DOWN SYNDROME

Dr. Ashwini B. Zadpe*1, Dr. Renu rathi2, Dr. Bharat Rathi3, Dr. Jyoti Rani4,
Dr. Prachi Sharma5 and Dr. Rakesh khatana6

1
P.G Scholar, Deptt. of Kaumarbhritya Mahatma Gandhi Ayurvedic College & Research
Centre, Wardha, India.
2
Prof. Deptt. of Kaumarbhritya, Mahatma Gandhi Ayurvedic College & Research Centre,
Wardha, India.
3
Professor in Deptt. of Rasashastra & Bhaishajya Kalpana, Mahatma Gandhi Ayurvedic
College & Research Centre, Wardha, India.
4
P.G Scholar, Deptt. of Panchkarma, Gurukul Campus, UAU, Haridwar P.G Scholar, Deptt.
of kaumarbhritya, Mahatma Gandhi.
5
Ayurvedic College & Research Centre, Wardha, India P.G Scholar, Deptt. of Kaumarbhritya
Mahatma Gandhi.
6
Ayurvedic College & Research Centre, Wardha, India.

ABSTRACT
Article Received on
20 May 2020 Down syndrome is a genetic disorder caused when abnormal cell
Revised on 10 June 2020 division results in extra genetic material from chromosome 21. This
Accepted on 30 June 2020
DOI: 10.20959/wjpr20207-17834 extra genetic causes developmental changes and physical features of
Down syndrome. It is usually associated with physical features of
Down syndrome. It is usually associated with physical growth delays,
*Corresponding Author
Dr. Ashwini B. Zadpe mild to moderate Intellectual disability and characteristic facial
P.G Scholar, Deptt. of features. Approximately 1 in 800 to 1000 children are born with Down
Kaumarbhritya Mahatma syndrome. Its occurrence is affected by age of mother and other
Gandhi Ayurvedic College
different factors.[1] According to Ayurveda, Down syndrome can be
& Research Centre, Wardha,
occurs due to Vata dosha and Beeja dosha abnormality. This case
India.
study deals with Ayurvedic management of Down syndrome with
Shirodhara, Abhyanga, Matra basti, Utsadana. Patient showed impressive improvement in
presenting symptoms. Aim- To study role of ayurveda in down syndrome. Material and
Method-A child 1 year 8 months old with symptoms of drooling of saliva, delayed
milestones, delayed speech brought by their parents in opd. Medhya drugs orally with

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Ashwini et al. World Journal of Pharmaceutical Research

panchkarma procedures like shirodhara, matra basti, sarvanng abhyanga given. Observations
And Results- Appetite of child got improved. The activity of child gets mildly increase.
Without sitting with support achieved, Supportive standing and walking, Supportive
crawling, Can speak bisyllabus words. Conclusion: Case study reveals Ayurvedic treatment
has positive effects on child improvement.

KEYWORDS: Down syndrome, Abhyanga, Matra Basti, Shirodhara.

INTRODUCTION
Down syndrome is one of the most prevalent genetic disease. It is among leading causes of
Intellectual disability.[2]

Incidence increases with Increasing maternal age.

Age of mother Risk factor
20 years 1:2000
30 years 2:1000
40 years 3:100

The Chromosomal abnormalities associated with Down syndrome manifest in variety of

physical and mental symptoms such as flat appearing face, upward slanting of eyes, short
neck, deep crease across centre of palm (simian crease), Short stature.[3] Children with Down
syndrome develop more slowly than normal. They experience delay in speech, mild to
moderate mental retardation having varies health issues including heart defects, GIT
anomalies, weak neuromuscular tone, dysmorphic features of head, neck, airways, visual,
audiovascular anomalies. Its condition can be suspected at the time of birth when baby
displays dysmorphic physical features confirmed diagnosis made with the help of
investigation like karyotype, maternal serum markers (triple test), short femur, CHD,
Clinodactyly, Thick nuchal fold. In Ayurveda, It can be understood as Sahaja beeja- beeja
bhaga, beeja-bhaga avayva janya vikara(Disorder of germ cell, chromosome).[4]

CASE REPORT
Basic information of patient
Name-XYZ
Age- 1 year 8 months OPD No.-1808300121
Sex- Female IPD No.-1808310006
Informant- Mother Address- Nachangaon

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Ashwini et al. World Journal of Pharmaceutical Research

Chief Complaint- Drooling of saliva since age of 6 months, delayed speech since age of 7-8
months, Unable to sit, stand and walk without support since 1 year.

Associated complaints- Cough and cold since 3 days, Lack of appetite since 7-8 months (on
and off), Irregular bowel since age of 1 year.

Present History- Patient came to OPD with complaint of drooling of saliva, delayed speech
and unable to sit and stand without support, unable to walk without supporting even after
completing 1.8 years of age. Mother noticed that child has not recognized parents as well as
other milestones are delay, not able to speak, crawls, walk, sit at the 16 months of age.

Past History-Not significant.

Birth History
 Antenatal- Mother was having history of stress in work, place and no history other
medical illness.
 Natal history- Full term vaginal delivery with birth weight 2.7 kg, cried soon after birth.
 Post natal- Child had given NICU care just after delivery for hyperbilirubinemia and
observation due to syndromic features.

Immunization History- All vaccines according to schedule till age.

Family history- Nothing significant
Personal history
Appetite Average
Bowel Irregular with hard stool
Urine normal, 10-12 /day
Sleep- Disturbed,
Habits History of teeth grinding

General Examination
Built- Lean
Appearance Lethargic
Eyes Pallor+,
Tongue Coated with protuberance
P/R 110/min
R.R 24/min
B.p 90/50 mm of hg
Temp Normal

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Ashwini et al. World Journal of Pharmaceutical Research

Systemic Examination
Cns Conscious, but not oriented about time and place.
Plantar –flexion, knee jerk – sluggish, ankle jerk- sluggish, biceps and triceps-
Reflexes
n
Muscle power Grade 4/5, b/l ul and ll
Muscle tone Hypotonic,
Cvs N
R.s N
P/a Soft, no distension or organomegaly

Anthropometry
Wt 7 kg,
Ht 62 cm,
Head circumference- 42 cm
Mid arm circumference 14 cm
chest circumference- 41cm

Developmental History
S. NO Parameters Milestones Attained age Normal limit
1. GROSS MOTOR Neck holding 7 months 7 months
Sitting with support 20 months 5 months
Sitting without support 22 months 9 months
Stand without support 24 months 12 months
Walk without support 28 months 13 months
2 FINE MOTOR Pincer grasp 18 months 8 months
3 LANGUAGE Cooin delayed 3 months
Monosyllabus (ma,ba) 10 months 6 months
4 PERSONAL-SOCIAL Eye contact 7 months 7 months
Recognised mother 6 months 3 months
Social smile &
Delayed 3 months
Recognizing relatives

Treatment Protocol
Deepan, Pachana, Snehapana, Abhyanga, Swedana, Basti

Date of admission 31/8/18, Treatment is given for total 5 sittings each of 7 days It includes
panchkarma procedures and shaman aoushadhis.

Panchkarma Procedures-Ist Sitting

S. No Therapy Medicine used
Shirodhara followed by
1 Brahmi tail
shiroabhyanga
2 Utsadan Dashmool tail +Triphala churna for 3 days
3 Sarvang abhyanga Dashmool oil (after 3 days)
4 Nadi swedana With Dashmool Kshaya for 3 days

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Ashwini et al. World Journal of Pharmaceutical Research

5 Pinda sweda Shashtishali panda sweda

Dashmool oil
6 Matra basti
Ist day -10 ml,2nd day-15 ml,3rd day-20 ml,4th day- 25 ml

Second sitting
Shirodhara followed by
1 Brahmi tail
shiroabhyanga
2 Sarvang abhyanga Dashmool oil (after 3 days)
3 Pinda sweda Shashtishali panda sweda
Dashmool oil
4 Matra basti Ist day -10 ml,2nd day-15 ml,3rd day-20 ml,4th day- 25
ml,5TH DAY 30 ml,3o ml for next 2 days
Third Sitting
1 Shiropichu Brahmi tail
2 Sarvang abhyanga Dashmool oil (after 3 days)
3 Pinda sweda Shashtishali panda sweda
Ksheerbala oil
4 Matra basti Ist day -10 ml,2nd day-15 ml,3rd day-20 ml,4th day- 25
ml,5TH DAY 30 ml,3o ml for next 2 days
Fourth Sitting
1 Shirodhara Brahmi tail
2 Sarvang abhyanga Dashmool oil (after 3 days)
3 Pinda sweda Shashtishali panda sweda
Dashmool oil
4 Matra basti Ist day -10 ml,2nd day-15 ml,3rd day-20 ml,4th day- 25
ml,5TH DAY 30 ml,3o ml for next 2 days
3 Nasya Brahmi oil
4 Utsadan Triphala churna+Dashmool tail (for 3 days)
Fifth Sitting
1 Shirodhara Brahmi tail
2 Sarvang abhyanga Dashmool oil (after 3 days)
3 Pinda sweda Shashtishali panda sweda
Dashmool oil
4 Matra basti Ist day -10 ml,2nd day-15 ml,3rd day-20 ml,4th day- 25
ml,5TH DAY 30 ml,3o ml for next 2 days
5 Nasya Brahmi oil

Shaman Aoushad
churna+Vacha churna
4 Brahmi Vati 1/2tab Bd after food Water
3rd Sitting
1 Neurocare drops 10 drop Bd(after food) Milk
2 Ashwagandha churna ½ tab Bd(after food) honey
Sitopladi
churna+trikatu+Guduchi
3 ¼ each 4 times a day Honey
churna+Yashtimadhu
churna+Vacha churna
4 Saptamrit louh 1/3tab Bd after food Water

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Ashwini et al. World Journal of Pharmaceutical Research

5 Samvardhan ghrit 10 mlBd after food Milk

4th Sitting
1 Orofer XT drops 1 ml od(after food) Water
Ashwagandha
2 ½ tab Bd(after food) Honey
churna+Brahmi churna
Sitopladi
churna+trikatu+Guduchi
3 ¼ each 4 times a day Honey
churna+Yashtimadhu
churna+Vacha churna
4 Saptamrit louh 1/3tab Bd after food Water
5 Samvardhan ghrit 10 mlBd after food Milk
5 Saptamrit loha ¼ tab Bd before food Water
5th Sitting
1 Cognium syruo 3ml tds(after food) Water
2 Ashwagandha churna ½ tab Bd(after food) Honey
Sitopladi
churna+trikatu+Guduchi
3 ¼ each 4 times a day Honey
churna+Yashtimadhu
churna+Vacha churna
4 Samvardhan ghrit 10 mlBd after food Milk
5 Krimikutha rasa ¼ tab Bd before food for 3days Water

RESULTS AND DISCUSSION

As per Ayurvedic aspects, Down syndrome can be understood as beejabhagaavayava janya
vikara by vata dushti. Since vata vitiation is the primary cause of Down syndrome the
treatment protocol should be strengthening and building to increase the prana (life energy)
present. Hence vatahara and medhya dravya treatment and symptomatic treatment according
to condition is followed. The oil therapy of shirodhara strengthens the mind, building ojas to
contain the prana and tejas. The combination of abhyanga, shirodhara, and swedhna is
known as bliss therapy.[6]

After the first sitting the appetite of child got improved. The activity of child gets mildly
increase but mother also complaints for irregular bowel movements and easy distractibility.

After 2nd sitting Without sitting with support achieved- for 10min, Supportive standing and
walking, Supportive crawling, Can speak bisyllabus words.

After completion of course child is able to sit without support, able to walk without,
understand natural calls support (urine, stool urge),Run with walker, Improved gross, fine
language, social milestone improved.

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 Ashwini et al. World Journal of Pharmaceutical Research

CONCLUSION
As in today era ,late age marriage are preferred, so conceiving age is also going increasing,
that leads to risk factor of down syndrome Case study reveals Ayurvedic treatment has
positive effects on child improvement. Since root cause of disease can not be treated, but it
can lead patient to better lives mentally and socially.

REFERENCES
1. National Institute of child health and human development, NIH, Facts about Down
syndrome <http;//www.nichd.nih.gov/publications/pubs/downsyndrome.>
2. wahab AA Bener a, Teebi as, The incidence patterns of down syndrome, clin genet, 2006;
69: 360-362.
3. ”Signs and Symptoms of Down Syndrome “Medicine Net, 21/12/18
http;//www.medicinenet.com/down_ syndrome/>.
4. Dhiman K, Kumar A, Dhiman KS, Shad, Garbhakar Bhavas ,Congenital and genetic
disorders ayu, 2010; 3192: 175-184.
5. Douillard, John. “Attention Deficit Disorders: An Ayurvedic Perspective.” Light on
Ayurveda Journal 1.1 (Fall2002<http://www.loaj.com/articles/ayurvedic_ treatment.html.
6. Marc Halpern, Principles of Ayurvedic Medicine. Vol 2. 9th ed. (Grass Valley: California
College of Ayurveda, 2007.

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