DENGUE

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DENGUE

Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and
subtropical areas. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14
days after infection. These may include a high fever, headache, vomiting, muscle and joint pains,
and a characteristic skin itching and skin rash. Recovery generally takes two to seven days. In a
small proportion of cases, the disease develops into severe dengue (previously known as dengue
hemorrhagic fever or dengue shock syndrome)[8] with bleeding, low levels of blood platelets,
blood plasma leakage, and dangerously low blood pressure.[1][2]

Dengue virus has four confirmed serotypes; infection with one type usually gives lifelong
immunity to that type, but only short-term immunity to the others. Subsequent infection with a
different type increases the risk of severe complications.[9] The symptoms of dengue resemble
many other diseases including malaria, influenza, and Zika.[10] Blood tests are available to
confirm the diagnosis including detecting viral RNA, or antibodies to the virus.[11]

There is no specific treatment for dengue fever. In mild cases, treatment is focused on treating
pain symptoms. Severe cases of dengue require hospitalisation; treatment of acute dengue is
supportive and includes giving fluid either by mouth or intravenously.[1][2]

Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes
aegypti.[1] Infection can be prevented by mosquito elimination and the prevention of bites.[12] Two
types of dengue vaccine have been approved and are commercially available. Dengvaxia became
available in 2016 but it is only recommended to prevent re-infection in individuals who have
been previously infected.[13] The second vaccine, Qdenga, became available in 2022 and is
suitable for adults, adolescents and children from four years of age.[14]

The earliest descriptions of a dengue outbreak date from 1779; its viral cause and spread were
understood by the early 20th century.[15] Already endemic in more than one hundred countries,
dengue is spreading from tropical and subtropical regions to the Iberian Peninsula and the
southern states of the US, partly attributed to climate change.[7][16] It is classified as a neglected
tropical disease.[17] During 2023, more than 5 million infections were reported, with more than
5,000 dengue-related deaths.[7] As most cases are asymptomatic or mild, the actual numbers of
dengue cases and deaths are under-reported.[7]

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