Experiment No 5

NASAL PREPARATIONS
DEFINITION:
Nasal preparations are products applied in the nose to treat the symptoms of
hay fever, congestion or infection usually. They include preparations such
as Nasal steroids, Lubricants, Antihistamines, Decongestants, and Anti-
infective to treat the conditions of nose or nasal symptoms.
METHOD OF ADMINISTRATION:
Nasal preparations are usually solutions or suspensions administered by

drops or as a fine mist from a nasal spray container, which could include an
aerosol with a metered valve.
INHALATION PREPARATIONS:
Inhalation solution of medicament administered by nasal or oral respiratory

route for local or systemic effect. Nebulizer is suitable for
administration of inhalation solution orally. If they give
droplets sufficiently fine and uniform in size so they must
stick the bronchitis. Particle size is one of the important
parameter for inhalation the max particles size for
penetration into pulmonary cavity is 0.5 to 7 micrometre.
TYPES OF NASAL PREPARATIONS:
1. Nasal Antihistamines and Decongestants

2. Nasal Lubrications and Irrigations
3. Nasal Steroids
DOSAGE FORM AVAILABLE:
1. Nasal Drops 3. Nasal Powders

2. Nasal Sprays 4. Nasal Gels
APPLICATIONS:
Delivery of non-peptide pharmaceuticals with extensive pre-systemic metabolism, such as
1. Progesterone 4. Nitroglycerin
2. Estradiol 5. Sodium Chromoglyate
3. Propranolol
can be rapidly absorbed through the nasal mucosa with a systemic bioavailability of
approximately 100%
DELIVERY OF DIAGNOSTIC DRUGS DIAGNOSTIC AGENTS:
1. Phenolsulfonphthalein – kidney function.

2. Secretin – pancreatic disSorders.
3. Pentagastrin – secretory function of gastric acid
ADVANTAGES:
1. It’s easy and convenient

2. Can be easily administered to the unconscious patients
3. Compared to oral medications, intranasal medication delivery
results in faster delivery to the blood stream and higher blood
levels
4. No destruction by stomach acid and intestinal enzymes
5. No destruction by hepatic first pass metabolism
6. Compared to IV medications, intranasal medication delivery
results in comparable blood levels depending on the drug and dose.
PREPRATION METHODS:
1. Wet gum method
2. Dry gum method
3. Bottle’s methods
4. Auxillary method
STORAGE:
1. Keep the bottle away from sunlight

2. Don’t share your nasal spray with anyone else
3. Keep them away from children
EXPERIMENT NO. 05
Object:
To prepare and dispense 25ml of aqueous inhalation solution.
Apparatus and materials:

Mortar and pestle, dispensing bottle, volumetric flask, eucalyptus oil, menthol, magnesium
carbonate, purified water.
Formula for 1000 ml:

Eucalyptus oil ---------------------------------100ml
Menthol -----------------------------------------20gm
Magnesium carbonate-------------------------70g
Purified water ----------------------------------Q.S to produce1000ml
Formula for 25 ml:

Eucalyptus oil --------------------------------- ____ml
Menthol ----------------------------------------- ____gm
Magnesium carbonate------------------------- ____gm
Purified water ---------------------------------- Q.S to produce ______ml
Procedure:
 Firstly weigh the menthol, magnesium carbonate and eucalyptus oil.
 Add menthol in a mortar and pestle and triturate it to convert in powder form.
 Now add eucalyptus oil in mortar and pestle and keep on triturating.
 Now add magnesium carbonate in the mixture previously prepared.
 Then pour the solution in measuring cylinder and make up the volume with purified water up
to 25ml.
 Dispense it into a dispensing bottle and place the label over it.
Uses:
 Used as a bronchodilator.
 Used for relief the symptom of cough, cold and blocked noses and nasal congestion.
Role of ingredient:
Eucalyptus oil
 Eucalyptus oil use in the treatment of sinus infection.
 Eucalyptus oil has antimicrobial and antiseptic properties that are effective at treating
wounds, burns, cuts, abrasions, sores and scrapes.
 Eucalyptus oil use for hair nourishment and use as an excellent cleanser to remove grease
and grime.
Menthol
 Menthol is used to relieve symptoms of bronchitis, sinusitis and similar conditions.
Magnesium carbonate
 It has anti-inflammatory benefits.
 It is used in cosmetic industries especially in talcum powder, face powder, baby powder.
 It is a mineral supplement used to prevent and treat low amounts of magnesium in the
blood. Magnesium is very important for the normal functioning of cells, nerves, muscles,
bones, and the heart.
REMARKS:

Experiment No 5

Uploaded by

Copyright:

Available Formats

Experiment No 5

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Experiment No 5

Uploaded by

Copyright:

Available Formats

NASAL PREPARATIONS

Nasal preparations are usually solutions or suspensions administered by

Inhalation solution of medicament administered by nasal or oral respiratory

TYPES OF NASAL PREPARATIONS:

1. Nasal Antihistamines and Decongestants

DOSAGE FORM AVAILABLE:

1. Nasal Drops 3. Nasal Powders

Delivery of non-peptide pharmaceuticals with extensive pre-systemic metabolism, such as

1. Phenolsulfonphthalein – kidney function.

1. It’s easy and convenient

1. Keep the bottle away from sunlight

Apparatus and materials:

Formula for 1000 ml:

Purified water ----------------------------------Q.S to produce1000ml

Formula for 25 ml:

Menthol ----------------------------------------- ____gm

Magnesium carbonate------------------------- ____gm

Purified water ---------------------------------- Q.S to produce ______ml

You might also like