SAFETY DATA SHEET

Revision date 19-Dec-2023 Version 5

1. Identification
Product identifier

Product name Factor Xa Protease

Other means of identification

Product No P8010

Synonyms None

Recommended use of the chemical and restrictions on use

Recommended use This product is for research and development only

Restrictions on use No information available

Details of the supplier of the safety data sheet

Supplier Address
New England BioLabs
240 County Road
Ipswich, MA 01938
USA

Emergency telephone number

Company Phone Number 978-927-5054, 800-632-5227 (toll free)

Telefax 978-921-1350

E-mail address [email protected]

24 Hour Emergency Phone Number Chemtrec +1 703-741-5970

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2. Hazard(s) identification
Classification

Label elements

Hazard statements

0 % of the mixture consists of ingredient(s) of unknown acute oral toxicity.

0 % of the mixture consists of ingredient(s) of unknown acute dermal toxicity.
52.922 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (gas).
52.922 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (vapor).
52.922 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (dust/mist).

Other information
No information available.

3. Composition/information on ingredients
Substance

Not applicable.

Mixture

4. First-aid measures
Description of first aid measures

Inhalation Remove to fresh air.

Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids.
Consult a physician.

Skin contact Wash skin with soap and water.

Ingestion Rinse mouth.

Most important symptoms and effects, both acute and delayed

Symptoms No information available.

Effects of Exposure No information available.

Indication of any immediate medical attention and special treatment needed

Note to physicians Treat symptomatically.

5. Fire-fighting measures

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Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.

Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.

Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.

Specific hazards arising from the No information available.

chemical

Explosion data
Sensitivity to mechanical impact None.
Sensitivity to static discharge None.

Special protective equipment and Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear.
precautions for fire-fighters Use personal protection equipment.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal precautions Ensure adequate ventilation.

Methods and material for containment and cleaning up

Methods for containment Prevent further leakage or spillage if safe to do so.

Methods for cleaning up Pick up and transfer to properly labeled containers.

7. Handling and storage

Precautions for safe handling

Advice on safe handling Handle in accordance with good industrial hygiene and safety practice.

Conditions for safe storage, including any incompatibilities

Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place.

8. Exposure controls/personal protection

Control parameters
Exposure Limits

Appropriate engineering controls

Engineering controls Showers

Eyewash stations
Ventilation systems.

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Individual protection measures, such as personal protective equipment

Eye/face protection No special protective equipment required.

Hand protection No special protective equipment required.

Skin and body protection No special protective equipment required.

Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are
exceeded or irritation is experienced, ventilation and evacuation may be required.

General hygiene considerations Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties

Information on basic physical and chemical properties
Physical state Liquid
Appearance Colorless
Color No information available
Odor Mild
Odor threshold No information available

Property Values Remarks • Method

pH No data available None known
Melting point / freezing point No data available None known
Initial boiling point and boiling rangeNo data available None known
Flash point No data available None known
Evaporation rate No data available None known
Flammability (solid, gas) No data available None known
Flammability Limit in Air None known
Upper flammability or explosive No data available
limits
Lower flammability or explosive No data available
limits
Vapor pressure No data available None known
Vapor density No data available None known
Relative density No data available None known
Water solubility No data available None known
Solubility(ies) No data available None known
Partition coefficient No data available None known
Autoignition temperature 392.78 °C / 739 °F
Decomposition temperature No data available None known
Kinematic viscosity No data available None known
Dynamic viscosity No data available None known

Other information
Explosive properties No information available
Oxidizing properties No information available
Softening point No information available
Molecular weight No information available
VOC content No information available
Liquid Density No information available
Bulk density No information available

10. Stability and reactivity

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Reactivity No information available.

Chemical stability Stable under normal conditions.

Possibility of hazardous reactions None under normal processing.

Conditions to avoid None known based on information supplied.

Incompatible materials None known based on information supplied.

Hazardous decomposition products None known based on information supplied.

11. Toxicological information

Information on likely routes of exposure

Inhalation Specific test data for the substance or mixture is not available.

Eye contact Specific test data for the substance or mixture is not available.

Skin contact Specific test data for the substance or mixture is not available.

Ingestion Specific test data for the substance or mixture is not available.

Symptoms related to the physical, chemical and toxicological characteristics

Symptoms No information available.

Acute toxicity .

Numerical measures of toxicity

The following values are calculated based on chapter 3.1 of the GHS document
ATEmix (oral) 20,233.70 mg/kg
ATEmix (dermal) 18,895.70 mg/kg
ATEmix (inhalation-gas) 99,999.00 ppm
ATEmix (inhalation-vapor) 99,999.00 mg/l
ATEmix (inhalation-dust/mist) 99,999.00 mg/l

0 % of the mixture consists of ingredient(s) of unknown acute oral toxicity

0 % of the mixture consists of ingredient(s) of unknown acute dermal toxicity
52.922 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (gas)
52.922 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (vapor)
52.922 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (dust/mist)

Component Information

Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation No information available.

Serious eye damage/eye irritation No information available.

Respiratory or skin sensitization No information available.

Germ cell mutagenicity No information available.

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Carcinogenicity No information available.

Reproductive toxicity No information available.

STOT - single exposure No information available.

STOT - repeated exposure No information available.

Aspiration hazard No information available.

12. Ecological information

Ecotoxicity

Persistence and degradability No information available.

Bioaccumulation

Component Information

Mobility in soil No information available.

Other adverse effects No information available.

13. Disposal considerations

Waste treatment methods

Waste from residues/unused Dispose of in accordance with local regulations. Dispose of waste in accordance with
products environmental legislation.

Contaminated packaging Do not reuse empty containers.

14. Transport information

DOT Not regulated

TDG Not regulated

MEX Not regulated

ICAO (air) Not regulated

IATA Not regulated

IMDG Not regulated

RID Not regulated

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ADR Not regulated

ADN Not regulated

15. Regulatory information

Regulatory information

International Regulations

The Montreal Protocol on Substances that Deplete the Ozone Layer Not applicable

The Stockholm Convention on Persistent Organic Pollutants Not applicable

The Rotterdam Convention Not applicable

International Inventories

DSL/NDSL Contact supplier for inventory compliance status.

EINECS/ELINCS Contact supplier for inventory compliance status.
ENCS Contact supplier for inventory compliance status.
IECSC Contact supplier for inventory compliance status.
KECL Contact supplier for inventory compliance status.
PICCS Contact supplier for inventory compliance status.
AIIC Contact supplier for inventory compliance status.
NZIoC Contact supplier for inventory compliance status.

Legend:
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
NZIoC - New Zealand Inventory of Chemicals

US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any
chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

SARA 311/312 Hazard Categories

Should this product meet EPCRA 311/312 Tier reporting criteria at 40 CFR 370, refer to Section 2 of this SDS for appropriate
classifications.
CWA (Clean Water Act)
This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42).

CERCLA
This material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive
Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and
Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level
pertaining to releases of this material.

US State Regulations
California Proposition 65

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This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know Regulations

This product does not contain any substances regulated under applicable state right-to-know regulations

U.S. EPA Label Information

EPA Pesticide Registration Number Not applicable

16. Other information

NFPA Health hazards 0 Flammability 1 Instability 0 Special hazards -
HMIS Health hazards 0 Flammability 1 Physical hazards 0 Personal protection X

Key or legend to abbreviations and acronyms used in the safety data sheet

Legend Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

TWA TWA (time-weighted average) STEL STEL (Short Term Exposure Limit)
Ceiling Maximum limit value * Skin designation

Key literature references and sources for data used to compile the SDS
Agency for Toxic Substances and Disease Registry (ATSDR)
U.S. Environmental Protection Agency ChemView Database
European Food Safety Authority (EFSA)
EPA (Environmental Protection Agency)
Acute Exposure Guideline Level(s) (AEGL(s))
U.S. Environmental Protection Agency Federal Insecticide, Fungicide, and Rodenticide Act
U.S. Environmental Protection Agency High Production Volume Chemicals
Food Research Journal
Hazardous Substance Database
International Uniform Chemical Information Database (IUCLID)
National Institute of Technology and Evaluation (NITE)
Australia National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
NIOSH (National Institute for Occupational Safety and Health)
National Library of Medicine's ChemID Plus (NLM CIP)
National Library of Medicine’s PubMed database (NLM PUBMED)
National Toxicology Program (NTP)
New Zealand's Chemical Classification and Information Database (CCID)
Organization for Economic Co-operation and Development Environment, Health, and Safety Publications
Organization for Economic Co-operation and Development High Production Volume Chemicals Program
Organization for Economic Co-operation and Development Screening Information Data Set
World Health Organization

Prepared by Environmental, Health and Safety, 978-927-5054

Revision date 19-Dec-2023

Revision note No information available.

Disclaimer
IMPORTANT: The information in this SDS is provided in good faith based on our knowledge as of the issue date (or
subsequent revision date, if any), and is to be used only as a guide. This SDS does not constitute a guarantee (express
or implied) of any kind and we make no warranties or merchantability or fitness for a particular purpose. This information
relates only to the designated product as shipped and may not be valid if the product is used in combination with any
other materials or is not used in accordance with our instructions. It is the responsibility of the buyer/user to ensure that
its activities comply with all applicable governmental requirements. Since conditions of use of the product are not under
the control of New England Biolabs, it is the duty of the buyer/user to determine the necessary conditions for the safe use
of the product. New England Biolabs will not be liable for any damages resulting from handling or contact with the
product.
End of Safety Data Sheet

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