Uso de Sustancias
Uso de Sustancias
Uso de Sustancias
Summary
Background Autistic individuals might be more likely to misuse substances than non-autistic individuals. Better Lancet Psychiatry 2021;
understanding of these patterns can help clinicians identify strategies to reduce substance use, protecting physical 8: 673–85
and mental health. The aim of this study was to compare the experiences of substance use between autistic and non- Published Online
July 1, 2021
autistic adolescents and adults.
https://doi.org/10.1016/
S2215-0366(21)00160-7
Methods This study is a mixed-methods study, including both quantitative (closed-ended questions) and qualitative See Comment page 641
(one open-ended question) online assessments. Data were collected as part of a larger study, the Autism and Physical Autism Research Centre,
Health Survey, in which we administered an anonymised, online questionnaire to autistic and non-autistic individuals Department of Psychiatry,
aged 16–90 years. In the present study, we investigated data on substance use or misuse, using two overlapping but University of Cambridge,
separate samples from the survey (one sample with complete quantitative responses and one sample with complete Cambridge, UK (E Weir BA,
C Allison PhD,
qualitative responses). Binary measures of substance use were investigated using unadjusted and adjusted binomial Prof S Baron-Cohen PhD)
logistic regression models. Content analysis was used to compare experiences of autistic and non-autistic adolescents Correspondence to:
and adults. We used Fisher’s exact tests to assess differences in frequency of reporting particular qualitative themes Elizabeth Weir, Autism Research
and subthemes. Centre, University of Cambridge,
Cambridge CB2 8AH, UK
[email protected]
Findings Survey recruitment was done between Feb 7, 2018, and Aug 26, 2019. At the end of the recruitment,
3657 individuals had accessed the survey. After excluding duplicates as well as participants with missing or incomplete
responses, we had data from 2386 participants (1183 autistic and 1203 non-autistic participants; 1571 female and
815 male participants) for the quantitative analyses and data from 919 participants (429 autistic and 490 non-autistic
participants; 569 female and 350 male participants) in the qualitative analyses. The samples for the quantitative and
qualitative analyses were predominantly composed of female individuals, White individuals, UK residents, and those
without intellectual disability. Autistic individuals were less likely than non-autistic individuals to report consuming
alcohol regularly (16·0% of autistic individuals vs 22·2% of non-autistic individuals; adjusted model: odds ratio
[OR] 0·69, 95% CI 0·55–0·86; p=0·0022) or binge-drinking (3·8% vs 8·2%; adjusted model: OR 0·38, 0·26–0·56;
p<0·0001). Autistic male participants were less likely than non-autistic male participants to report ever having smoked
(50·8% of autistic male participants vs 64·6% of non-autistic male participants; adjusted OR 0·50; 0·32–0·76;
p=0·0022) or ever using drugs (35·4% vs 52·7%; adjusted OR 0·53; 0·35–0·80; p=0·0022). Regarding our qualitative
analyses, among participants who reported a specific motivation for drug use, compared with non-autistic individuals,
autistic individuals were nearly nine times more likely to report using recreational substances to manage behaviour
(OR 8·89, 2·05–81·12; p=0·0017) and more likely to report using recreational substances to manage mental health
symptoms (OR 3·08, 1·18–9·08; p=0·032). Autistic individuals were also more likely to report vulnerability associated
with substance use (OR 4·16, 1·90–10·05; p=0·00027), including childhood use of drugs and being forced or tricked
into using drugs.
Interpretation Autistic individuals might be less likely than non-autistic individuals to report engaging in substance
misuse. They also report using drugs to self-medicate. Clinicians should be aware of vulnerability linked to substance
use among autistic patients and should work cooperatively with patients to effectively manage autistic and comorbid
symptoms.
Funding Autism Research Trust, Rosetrees Trust, Cambridge and Peterborough NHS Foundation Trust.
Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Research in context
Evidence before this study key information about sex differences, highlighting that
We searched PubMed and Google Scholar using various autistic male individuals were less likely to ever have smoked or
combinations of the search terms “autis*”, “substance use”, engaged in recreational drug use than non-autistic male
“substance misuse”, “dependence”, “addiction”, “quantitative”, individuals, whereas there were no significant differences
“qualitative”, and “adult” with no language restrictions for all between autistic and non-autistic female groups. Qualitatively,
studies from database inception until Nov 1, 2017, before our results suggest that autistic individuals were more likely to
beginning the study, and again from database inception until report using substances to manage behavioural symptoms
Feb 11, 2021, after study completion. Existing studies vary (including autism symptoms) and using them to manage
greatly in size and scope. Multiple large population-based mental health symptoms than were non-autistic individuals.
studies suggest that autistic individuals have an increased risk The findings also provide evidence for the reduced likelihood of
of substance misuse or misuse. Several qualitative studies with reporting social motivations for drug use among autistic
small sample sizes have been collectively described in reviews individuals compared with non-autistic individuals. New areas
and meta-analyses. They have identified motivations, of self-reported vulnerability have been identified by this study,
protective factors, and risk factors for substance use or misuse including childhood use of drugs and being forced or tricked
among autistic individuals; however, none of these studies into using drugs.
have attempted to quantify the relative likelihood of autistic
Implications of all the available evidence
and non-autistic adolescents and adults reporting these
Health-care providers should work with autistic people to
behaviours or experiences.
identify and effectively manage the autistic symptoms as well
Added value of this study as the comorbid behavioural, mental, and physical health
This mixed-methods study provides new evidence of symptoms that require additional support, to prevent
differences in smoking and alcohol use, as well as differences in self-medication and possible substance misuse. Clinicians
motivations for substance use, among autistic and non-autistic should be aware of increased risk of adverse life events for
adolescents and adults. This analysis includes large samples of autistic individuals, some of which might be connected to
autistic female individuals and older autistic adults, which are substance use. This study reaffirms the importance of early
groups that remain neglected in research. Our findings show autism diagnosis and supportive health care across the lifespan.
of camouflaging.4–7 Camouflaging can be defined as (including 7528 autistic individuals), autistic individuals
altering one’s behaviour or personality traits to align with were twice as likely to have substance use problems than
social norms; and compensation (a related but distinct non-autistic indi viduals; and even their non-autistic
concept) can be understood as conscious or subconscious siblings and parents were at increased risk of substance
processes that allow individuals with neurodevelopmental use problems compared with controls, suggesting that
conditions (eg, autism) to reduce the presentation of their genetic or environmental factors might contribute to
symptoms to others, despite ongoing difficulties. Autistic risks.17,19 Additional diagnoses of ADHD and intellectual
individuals might attempt to use strategies of cam disability seem to moderate the risk of substance misuse,
ouflaging or compensation to minimise or obscure their with an ADHD diagnosis increasing the risk and a
autism symptoms to align with societal expectations of diagnosis of intellectual disability decreasing the risk.17–19
behaviour;5,8 however, this behaviour can come at huge Existing studies indicate that participants with ADHD,
cost, worsening mental health problems and even ADHD and autism, as well as those with other
increasing risk of suicidality.4,5,8,9 Please note that we use developmental disorders were all at greater risk of
identity-first language (eg, autistic individual) throughout substance use problems than the autistic participants,
the manuscript, as this terminology is preferred by the making it difficult to quantify the risk of substance use
majority of the autistic community in the UK.10 or misuse that is specific to autism—even in large,
Several studies taken from both clinical and general population-based samples.17,19,20
population samples (with sample sizes ranging from Several population-based studies of neurotypical adults
89 to 4123 autistic participants) suggest that autistic suggest that substance use or misuse (including alcohol,
individuals are less likely to smoke, use tobacco, use tobacco, prescription and recreational drugs) is associated
nicotine,11–13 or misuse substances (including alcohol) with many physical health risks, including respiratory
than non-autistic individuals.12–16 By contrast, results from problems, cancer, heart disease, hypertension, heart attack,
larger studies and one systematic review indicate that stroke, reproductive morbidity, diabetes, liver damage or
autistic individuals might have an increased likelihood disease, and sleep conditions.21 In a previous study that we
of developing substance use-related problems.17–20 did with the same sample as the current study, we found
Specifically, in large population-based studies in Sweden that substance use was not associated with increased
(including 26 986 autistic individuals) and Norway health risks among the autistic individuals;22 however, this
study only used current alcohol consumption and greatest website Qualtrics to collect data regarding demographics,
smoking frequency as covariates, which does not capture autistic traits (we used a short version of the Autism
all aspects of substance use. In addition to physical health Spectrum Quotient, AQ-10, administered to non-autistic
risks, substance misuse might negatively affect the quality participants only), lifestyle-related factors (including both
of life of autistic individuals and exacerbate existing quantitative and qualitative substance use information),
difficulties with functional outcomes, such as maintenance personal medical history, and family medical history. We
of employment and education.18 used a convenience sampling framework to recruit
Six studies have attempted to establish motivations, participants via the Cambridge Autism Research Database,
protective factors, and risk factors for substance use or Autistica’s Discover Network, autism support groups and
misuse using qualitative methods;18,23 however, these charities, as well as social media (especially Twitter and
studies included small samples of autistic individuals Facebook). Because of our recruitment strategies, our
(n<50) and even fewer autistic females (n≤16). Autistic control sample might have been biased towards
individuals were more likely to use substances to individuals with an interest in autism or those with
compensate for comorbid mental health conditions undiagnosed autism. In an attempt to recruit a general
(as well as psychological distress) and perceived social population sample, we advertised the study via Facebook
difficulties; weak executive functioning, maladaptive and did not target specific autism groups or forums. All
coping style, late autism diagnosis, few social resources, advertisements encouraged participation from both
lack of structure in daily life or leisure activities, family autistic and non-autistic adolescents and adults.
history of substance misuse, early smoking onset, and All questions related to substance use were developed
adverse childhood experiences were additional risk by our research team by consulting publicly available
factors for substance use or misuse.18,23 information and questions from surveys from the UK
Only two studies considered sex or gender differences National Health Service, UK National Institute for Health
in substance misuse.14,19 In the general population, male and Care Excellence, US National Institutes of Health,
individuals are far more likely to use and misuse and WHO. All substance use data were collected as part
substances than female individuals;24 yet, this pattern of APHS, with the dual purposes of describing the
appears more complex among autistic individuals, with substance use or misuse of autistic individuals directly,
smaller differences between male and female while also con sidering the relationships between
individuals.14,19 Crucially, none of these studies consider substance use and risk of physical health conditions
sex or gender differences in substance use patterns or in among autistic individuals.22 The present analyses used
qualitative studies when considering motivations, binary measures of smoking and alcohol use (the
protective factors, or risk factors for substance use or binarisation was done before looking at the results).
misuse. These analyses also incorporated measures of
Research into the substance use of autistic individuals recreational drug use and second-hand smoke exposure
is limited in sample size and scope; however, it is clear (which were originally measured as binary [yes or no]
that differences in substance use might leave autistic responses). Analysing the data in this binarised structure
individuals susceptible to wide-ranging negative con allowed us to establish cutoff points for possible
sequences regarding daily functioning and physical substance misuse (eg, ≥5 alcoholic drinks per average
health. The present study attempts to explore whether session, consumption of alcohol on ≥3 days per week)
there are quantitative or qualitative differences in rather than describing substance use more generally, as
substance use between autistic and non-autistic the binarised data might have greater clinical relevance.
adolescents and adults. As questions relating to substance use might be
considered sensitive to some participants, we made all
Methods questions optional, and participants were informed of
Study design and participants this at the beginning of this section of the survey. We had
This study is a mixed-methods study, including both high response rates (>98·99%) to all quantitative
quantitative (closed-ended questions) and qualitative questions. The specific phrasing of all relevant questions
(one open-ended question) online assessments. Data were have been provided in the appendix (pp 5–8). See Online for appendix
collected as part of a larger study, the Autism and Physical This study obtained ethics approval from the University
Health Survey (APHS). Any consenting individual of at of Cambridge Human Biology Research Ethics committee
least 16 years of age was eligible to participate in the (HBREC.2017.28). Written, online informed consent was
APHS. To include as many relevant participant records as obtained from all participants. The study protocol has
possible, the quantitative and qualitative analyses of our been included in the appendix (pp 12–21).
study include two different but overlapping samples—
one sample with complete quantitative responses and Procedures
one sample with complete qualitative responses—both The qualitative section of the survey relied on responses to
taken from the APHS dataset. We used an anonymous, a single question related to substance use. All participant
self-report, cross-sectional survey in English via the records without a response to this question were excluded
vulnerability (OR 4·16, 1·90–10·05; p=0·00027), inclu between these patterns for autistic female individuals. To
ding being forced or tricked to use substances, childhood our knowledge, this finding is the first evidence that
use of substances, suicidality, trauma, and addiction or autistic male individuals are par ticularly unlikely to
dependence (table 3). engage in substance use compared with non-autistic
Among those who reported a specific motivation for male individuals; it might also suggest that the sex-
using drugs, autistic individuals were more likely to specific pattern of substance use in the general population
report using substances to manage mental health (eg, male individuals are more likely than female
symptoms and behaviour, but were less likely to report individuals to engage in substance use) might be different
social motivations for drug use (table 3). Among to that of autistic individuals,24 although two previous
participants who reported a specific motivation for drug studies showed small or non-significant sex differences.14,19
use, autistic individuals were nearly nine times more Cross-sectional convenience samples (as used in the
likely to report using recreational substances to manage present study) provide a unique opportunity for rec
behaviour than non-autistic individuals (OR 8·89; ruitment of large samples of diagnosed autistic female
95% CI 2·05–81·12; p=0·0017) and over three times individuals,3–7 without which analyses on sex differences
more likely to reporting using recreational substances would not be possible. This work emphasises the
to manage mental health symptoms than were non- importance of recruiting autistic female individuals in
autistic individuals (OR 3·08; 95% CI 1·18–9·08; research, as they might have unique risk factors and are
p=0·032). Autistic individuals also reported using now widely reported to have worse outcomes regarding
substances as a form of self-medication for physical physical health, mental health, and mortality.14,22,30
health symptoms (including sleep, digestion or eating, Among those who provided any information regarding
and pain) but the frequency of this reporting was their motivations for using drugs, autistic individuals
not different from that of non-autistic individuals. were nearly nine times more likely than non-autistic
Five individuals specifically reported that receiving their individuals to report using them to manage behaviour
autism diagnosis was relevant to reducing or ending specifically. Although the terms masking, compensation,
their substance use. and camouflaging were not directly used by participants
and might not apply to all instances of descriptions of
Discussion managing behaviour, the descriptions provided frequently
Autistic individuals were less likely to report consuming correspond to existing literature and definitions of these
alcohol regularly or binge-drinking than non-autistic concepts;4–8 individuals described using drugs to
individuals; however, our mixed-methods approach eliminate, control, or reduce autism or symptoms of
revealed possible points of concern regarding the autism (eg, sensory overload, stimming behaviour,
substance use of autistic individuals, including wide- improving overall function, improving perception) and
ranging sex differences and qualitative differences in other comorbid symptoms (eg, ADHD). One autistic
motivations for drug use. Autistic male individuals were individual noted “I smoke pot to make my anxiety and
far less likely to report ever having smoked or having ever autism go away. It’s the only time I fell on the same wave
used recreational substances than non-autistic male length as everyone else”). Although causal links have not
individuals, whereas there were no significant differences yet been established, compensation and camouflaging
Figure 2: Selected codes, subthemes, and themes of substance use among autistic and non-autistic individuals
The blue boxes represent the themes. The green boxes represent the subthemes for the theme called motivations for using. The red boxes represent the subthemes
for the theme called motivations to stop use. The white boxes provide selected codes for each theme or subtheme; a list of all codes can be found in the appendix
(p 1). OCD=obsessive-compulsive disorder.
have been linked to high rates of mental health conditions Understanding the complex relationships among
and increased risk of suicidality.4,5,8,9 Future research substance use, physical health, and mental health is
should investigate the role of com pensatory and essential, as several studies now indicate that autistic
camouflaging strategies in motivating substance use of individuals are at increased risk of a wide variety of
autistic individuals more specifically. chronic physical and mental health conditions,12–14,16,20,22
Autistic individuals reported using substances as a and substance use can have deleterious effects on physical
form of self-medication for both mental and physical and mental health.21 A previous study from our research
health symptoms, although only mental health symptoms group at the Autism Research Centre, University of
showed a significant increase in reporting among autistic Cambridge, UK, has shown that alcohol use and smoking
compared with non-autistic individuals. Many individuals do not fully explain differences in prevalence of physical
did not view this self-medication as negative, instead health conditions between autistic and non-autistic
indicating that use of marijuana (or more rarely other individuals;22 yet, it is possible that substance use operates
substances) provided them with a higher quality of life, as in a positive feedback loop by worsening physical and
proposed previously by the self-medication hypothesis.18,31 mental health conditions.
This study bolsters previous findings by supporting not be receiving appropriate management of behavioural,
greater likelihood of self-reported vulnerability associated physical, or mental health symptoms from medical
with substance use among autistic compared with non- providers. Third, marijuana and other substances
autistic individuals.32,33 Five autistic participants in this currently used for recreational drug use should be
study specifically noted that their autism diagnosis was investigated as possible medical interventions for
crucial to discontinuing their use or misuse of substances, managing physical and mental health symptoms fre
emphasising the importance of timely diagnosis of quently comorbid to autism. Fourth, unwanted symp
autism. In addition, we have identified new areas of risk toms of autism, mental health, and physical health
among autistic individuals, including forced or accidental conditions (identified by patients themselves) might
use of drugs and childhood use of drugs. This study serve as key targets for intervention for reducing
provides preliminary evidence that substance use substance use. Fifth, approaching sensitive topics
or misuse might have a complex association with vul (eg, substance use) is essential to ensure appropriate
nerability, with substances being used both to cope with safeguarding, particularly in light of evidence that
symptoms (eg, to deal with trauma, suicidality) and to substance use might be associated with risk of
serve as a vehicle to exacerbate other forms of vulnerability vulnerability among autistic individuals. As differences
(eg, eating disorders). with social communication are a core feature of autism,
Previous qualitative studies have suggested that autistic autistic individuals have previously endorsed that taking
adults might be motivated to use substances for the extra time within appointments and honouring alter
reasons such as compensatory or camouflaging strat native forms of communication (such as written or
egies, mental health, physical health, and adverse life online communication) might improve patient–provider
events or vulnerability.18,23 However, our findings are, to communication;34 however, the efficacy of these strategies
the best of our knowledge, the first to clarify that autistic has not been tested directly.
adults were far more likely than non-autistic adults to Although the study includes a large sample of
report substance use for these reasons. These findings qualitative responses, several limitations should be
have clinical implications. First, adverse life events, noted. First, the study might be subject to the so-called
autism symptoms causing difficulty, mental health winner’s curse, meaning that it might include artificially
symptoms, and physical health symptoms might all inflated point estimates for group differences.
serve as possible risk factors for substance use among Second, our study is subject to sampling and recruitment
autistic individuals. Second, autistic individuals might biases, as advertisements were circulated via social
and the Cambridge and Peterborough NHS Foundation Trust 14 Croen LA, Zerbo O, Qian Y, et al. The health status of adults on the
(grant G102307). EW is supported by funding from the Corbin autism spectrum. Autism 2015; 19: 814–23.
Charitable Trust. SBC received funding from the Wellcome Trust 15 McLeod JD, Hawbaker A, Meanwell E. The health of college
(214322\Z\18\Z). SBC received funding from Innovative Medicines students on the autism spectrum as compared to their neurotypical
Initiative 2 Joint Undertaking under grant agreement number 777394. peers. Autism 2020; 25: 719–30.
The Joint Undertaking receives support from the European Union’s 16 Vohra R, Madhavan S, Sambamoorthi U. Comorbidity prevalence,
Horizon 2020 research and innovation programme as well as the healthcare utilization, and expenditures of Medicaid enrolled adults
European Federation of Pharmaceutical Industries and Associations, with autism spectrum disorders. Autism 2017; 21: 995–1009.
AUTISM SPEAKS, Autistica, and Simons Foundation Autism Research 17 Butwicka A, Långström N, Larsson H, et al. Increased risk for
Initiative. SBC and CA received funding from the Autism Research substance use-related problems in autism spectrum disorders:
Trust, Autistica, the Medical Research Council, and the UK National a population-based cohort study. J Autism Dev Disord 2017;
47: 80–89.
Institute for Health Research (NIHR) Cambridge Biomedical Research
Centre. The research was supported by the NIHR Collaboration for 18 Ressel M, Thompson B, Poulin M-H, et al. Systematic review of risk
and protective factors associated with substance use and abuse in
Leadership in Applied Health Research and Care East of England at
individuals with autism spectrum disorders. Autism 2020;
Cambridgeshire and Peterborough NHS Foundation Trust. The views 24: 899–918.
expressed are those of the authors and not necessarily those of the NHS,
19 Solberg BS, Zayats T, Posserud M-B, et al. Patterns of psychiatric
NIHR, or Department of Health and Social Care. We are grateful to comorbidity and genetic correlations provide new insights into
Paula Smith and Rosemary Holt for assistance with advertisement and differences between attention-deficit/hyperactivity disorder and
Varun Warrier for helpful input in developing our analysis plan. autism spectrum disorder. Biol Psychiatry 2019; 86: 587–98.
In particular, we wish to thank Simon R White for his statistical advice 20 Weiss JA, Isaacs B, Diepstra H, et al. Health concerns and health
and support. Thanks also to all our participants, as well as the service utilization in a population cohort of young adults with
Cambridge Autism Research Database, Autistica’s Discover Network, autism spectrum disorder. J Autism Dev Disord 2018; 48: 36–44.
and various autism support groups and charities for assisting our 21 Schulte MT, Hser Y-I. Substance use and associated health
recruitment. conditions throughout the lifespan. Public Health Rev 2014; 35.
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