Cold storage technology

for the pharmaceutical industry and for research



ANGELANTONI:
a name, a story...
Giuseppe Angelantoni

c When Giuseppe Angelantoni founded his business in the cold

storage technique in 1932, he probably could not even have
imagined that, years later, his very surname would have become a
synonym for “cold storage engineering”.

His ingenious work has passed through significant cold

technology applications, some of which are patented, such as:
the first test chamber at -60°C in 1954; the first autonomous
vehicle-driven food transport system in 1956; the first freezer in
Europe at -104°C in 1961 with mechanical cooling, without LN2.
Double stage refrigeration compressor
patented in 1949 The story of his life coincides with that of the companies founded
as a result of his prolific activities, which today are present in 3
business fields under Angelantoni Industrie (Holding).

1) Refrigeration equipment and installations for hospitals,

universities, research laboratories and chemical-
pharmaceutical industry (Angelantoni Life Science - ALS);
2) Environmental simulation chambers and thin-film coating
technology (Angelantoni Test Technologies - ATT and
Kenosistec);
3) Renewable energy and energy efficiency (Archimede Solar
Energy and Turboalgor).

Refrigerated Truck, 1957 Refrigerator -104° C, 1962

...a reality, a future
The quality system of Angelantoni Industrie is certified in
accordance with standards ISO 9001, ISO 14001, ISO 13485.

This brochure is intended to briefly outline the activity of cold

technology applied to various industrial sectors, in particular the
pharmaceutical industry, by means of the following illustrations.
In this sector, processes pose technological challenges due to
the extremely low temperatures involved and the ensuing design
choices, together with a need for extreme reliability due to the
critical nature of the values of those processes.

Angelantoni Life Science has collected the heritage of the AG

Division of Milan, today merged into the site in Massa Martana,
taking advantage of the experience they have gained over 80
years of work with the related developed skills.
Therefore ALS is capable of offering the best solutions with a
high degree of reliability proven by the many references with
major national and international companies in the industry.

“Lab Automation” production area for robotic refrigerators

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 Cold technologies for industry
Process cooling

Custom design
chilling units
The competences and experience which the AG Division
of Milan has given us allow us to design and manufacture
custom-made chilling units, according to the specific
requirements of the Customer. Safe, eco-friendly and
efficient installations, equipped with modern safety
systems, low environmental impact and considerably higher
efficiency than old generation installations (R507/R404A).

Main features
• Heat output: from 10 to 2,000 kW
• Working temperature: from 20°C to -80°C
• Executions for classified or safe area
• Compliance with the main international design and construction
principles (PED - GMP - ASME - ANSI, etc.)
• Multidisciplinary design (mechanical, electric and instrumental) both
in the preliminary design stage and in the execution stage
• Project management, supplier control and testing during installation

Refrigeration system for the production of antibiotics

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 Cold technologies for industry
Process cooling

Brine package chilling units down to -75°C

cascade system, equipped with pumps
and liquid tank.
Refrigeration system for
the production of antibiotics.

Package units for cascade system, 40 kW

capacity at -80°C,
condensing with glycol water at-25°C,
3 independent circuits.
Refrigeration system for
the production of antibiotics.

Brine package chilling units

down to 30°C with 3 independent circuits
equipped with pumps and liquid tank.
Refrigeration system for
the production of blood-derivative drugs.
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 Cold technologies for industry
Multi use monobloc chilling units

For over 80 years, Angelantoni has All installations are equipped with automatic
been designing and building a large control and monitoring systems of the operating
conditions. Alarm systems, with possible
variety of refrigeration systems,
redundancy, to meet the strictest reliability
especially intended for the chemical requirements.
and pharmaceutical industry, with The alarms triggered by the system can be
the support of professionals with transmitted to the control room via text messages
longtime experience in the design and or e-mail.
supply of refrigeration systems for
Italian and international customers.

The AG Division of Milan in particular has

provided us with competences for the
standardised production of monobloc brine
chilling units (mixture of water and ethylene or
NaCl2 glycol) down to -30°C.
The standard chilling units can also be
supplied in versions for temperatures
down to -50°C with double stage or screw
compressors using suitable brine liquids.

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 Cold technologies for industry
Prefabricated refrigerated warehouses for the chemical and pharmaceutical industry

Prefabricated cold storage room

with 150 mm thick panels
plasticised inside and outside.
Outer dimensions:
m 40.50 (L) x 8.00 (W) x 10.20 (H)
Sliding doors 2m (W) x 3m (H)
net clearance, automatic opening,
with safety closure.
Operating temperature -20°C.

Prefabricated cold storage

room with 100 mm thick
panels plasticised inside and
outside.
Outer dimensions:
m 28.00 (L) x 11.6 (W) x 8.5 (H)
Sliding doors
2.00m (W) x 2.5m (H)
net clearance, automatic
opening, with safety closure.
Operating temperature +2°C.

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 Cold technologies for industry
Cold storage rooms

PE Series Prefabricated
cold rooms
Angelantoni Life Science manufactures a wide range of cold storage rooms
used to preserve vaccines, drugs and other products for the pharmaceutical
healthcare industry.
The main features of the products in this range are their high reliability and
the option of offering customised solutions. Our cold storage rooms are
manufactured in compliance with the standards in force.

Characteristics of the range

• Quick and easy assembly
• Rounded inside corners
• Precise temperature control (luminous intensity and humidity on demand)
• Insulation material: polyurethane, polystyrene and mineral wool
• Direct and indirect cooling systems
• ATEX execution on demand
• Maximum fire resistance rating: A2s1d0.

Pre-painted sheet-metal (RAL at your choice) internal

cladding
Internal cladding made of
embossed diamond aluminium (no-slip)

Internal cladding made of

stainless steel (no-slip)

Polyurethane, polystyrene and mineral wool

insulated core (for every fire resistance rating)

Pre-painted sheet-metal
or stainless steel external cladding

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Cold technologies for industry
Prefabricated cold storage room

How a PE series prefabricated room There is a door on the outside with a handle with
is made a key closing system, which can be opened in any
case from the inside. Internal emergency button.
Insulated floors cladded in pre-painted sheetmetal
or embossed diamond aluminium or no-slip Manually or automatically opened sliding doors
stainless steel. can be supplied on demand, complete with air
Our floors can bear even heavy loads such as wave safety devices.
those carried by lift trucks and forklifts. The floor
is provided with a draining device to simplify The door frame is heated by a specific built-in
cleaning and drain off fluid spills. The inside electric heating element.
corners are rounded to easily remove filth. On demand, protective curtains in PVC can be
installed on the doors to limit heat loss when opened.

The walls are made of modular panels with the

Assembly examples

following technical features:

• Core in expanded polyurethane, polystyrene or
mineral wool.
• Pre-painted steel or stainless steel cladding
(AISI 304 or 316). Panel thickness from 50 to
200 mm.

The service door is fitted with high-quality

rubber or silicon gaskets and equipped with a
microswitch to automatically switch off the fan
when the door is opened.

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 Tecnologie del freddo per l’industria
Cold storage rooms

REACH-IN PREFABRICATED
Modular freezers Temperature range: -20°C / -75°C

Dedicated customized solutions when medium storage capacity is required,

with single capacity up to 10,000 liters.
Reach-in freezers available from -20°C to -75°C to be installed inside
warehouses, wholesalers and pharmaceutical sites.
Properly designed for vaccine storage e
completely customizable in terms of shape and modularity.

Characteristics of the range

• Redundant refrigeration systems
• Available volumes 4000 (3 doors) and 6000 liters (4 doors)
• Temperature uniformity: +/- 5°C
• ACP7 controller
• Security and traceability in Bioguard access control
- Only authorized users have access to the device
- All accesses are tracked in terms of username, door open duration and door open event
• Connection to Cloud / Local monitoring software

Reach-in 6000 litres

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 Tecnologie del freddo per l’industria
Prefabricated cold storage room

ELECTRICAL PANEL
REFRIGERATING UNIT

WALK-IN Prefabricated Chambers down to -75°C

The central corridor is served COLD ROOM -75°C
10 modules, 5 on each side.
Each module is equipped with 3 ports of

ENTRANCE
access, each of which allows
the entrance of a trolley. CORRIDOR -20°C TROLLEY

The total capacity

of the plant is 30 trolleys.
The useful height of each module is 280 cm.
Each trolley has 4 shelves.

Two climatic chamber complex with

photoperiod for controlled growth of insects
Construction of the prefabricated complex
through self-supporting modular type panels,
assemblable, without welding having the
following technical features:
- Temperature range + 10 / + 45°C
- Uniformity gradient of humidity values: +/- 5%
- Dew point: + 5°C.
- Internal insulation with polyurethane injection
(70 mm)
- Three swing doors, two of which with portholes
- Mechanical door interlock system for
prevent simultaneous opening
- Common corridor between the two chambers

Ultra 3-Door Freezers

Temperature range:
-20°C / - 40°C
Temperature uniformity:
± 5°C
Ambient temperature of
exercise:
+ 5°C
Remote unit
condensing unit.

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 Cold technologies for industry
Temperature controllers

An advanced and reliable controller to make your work easier

ACP7: FULL CONTROL AT A GLANCE

N
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The last generation controller ACP7, developed by Angelantoni after years of experience and leveraging
the latest technologies, guarantees high-performance, maximum safety and easy use.
The control electronics has three separate processors: one for the control system, one for the alarm
section and one for communicating the detected data. Access to the parameters is password-protected
with 3 privilege levels: users, service, administrator.
The 7-inch display displays all key data on a single screen, allowing you to assess the operating
status in real time. The ACP7 controller has innovative functions to optimise consumption and
continuously monitor parameters.
The REAL-TIME function is used to display the daily temperature. This feature includes the events
list and the record of the temperatures and operational variables sampled every 30 sec. for 10
years. All values are stored and the event log files can be uploaded onto a local PC by means of the
built-in USB port in the controller. The ECOMODE function enables the machine to an energysaving
operating mode.
The PERSONAL PASSWORD allows you to regulate access to the controller and enable the editing
functions of the user parameters.

MICROPLC TOUCH SCREEN

This PLC electronic programmer and touch screen user interface designed in ALS
gives you the maximum flexibility in meeting the customer’s requests. Able to
program up to 1000 (one-thousand) cycles of 350 segments for temperature
ramps (humidity and light on demand).
Unlimited possibility of recording temperature (and humidity) variations over time.
Alarm log on table with date and time and total number of times triggered. The
stored cycles, the records and alarm logs can be exported from Compact Flash to
Pen Drive directly through the USB port on the control panel.
There is a buffer battery which allows you to store data even in case of a power
failure.

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Cold technologies for industry
Units with controlled environmental parameters

Application examples
Stability test chamber

Fitotrone: controlled environment room, temperature and relative humidity adjustment, and photoperiod for quick agronomic screening 13
 Cold technologies for industry
Analytical devices for industrial application

Angelantoni Life Science is a world leader in the market for

refrigeration and biomedical equipment for use in labo-
ratory and industrial processes, in particular for applica-
tions in healthcare, scientific and industrial research and

LAMINAR FLOW HOODS

STERIL LINE
Safety, reliability and comfort

Steril designs, manufactures and sells a wide range

of LAMINAR FLOW CABINETS, CONTAINMENT
SOLUTIONS for operator and product protection,
including biological safety cabinets, cytotoxic
cabinets, horizontal and vertical laminar flow and
Isolators.

CYTOBOX

THERMOSTATIC, CLIMATE AND PLANT GROWTH CABINETS

EKOC LINE
Temperature range: -10°C / +60°C

The EKOC series chambers are designed to control

temperature in the range -10°C to +60°C and relative
humidity between 20 and 90% (in the range +10°C/+50°C)
Three volumes available: 700, 900 and 1500 litres.

The EKOCHL series chambers are dedicated to stability

and growth tests of plant species with controlled
temperature, light and humidity.

14 14 EKOCHL 1500
Cold technologies for industry
Analytical devices for industrial application

the main industrial sectors. The aim is to produce innovative,

quality systems that meet and exceed customer expecta-
tions in terms of performance and technical and design spe-
cifications.

FREEZERS AND ULTRA-LOW TEMPERATURE FREEZERS

NEXUSgreen LINE
Temperature range: -40°C / -80°C

In this regard, the Nexus green line is a natural evolution in the field
of extremely low temperatures, which combines technological
development and environmental sustainability.
• Natural refrigerants (HC)
• Inverter technology
• Energy savings (up to 30%) compared to fixed speed systems.
• Noiseless operation.
• High temperature stability.

NEXUS green 810

THERMOSTATIC CHAMBERS
BULKFROST LINE
Temperature range: -75°C / +180°C

The thermostatic chamber allows the temperature

inside the test chamber to be controlled. It delivers high
performance, with a generous standard configuration
and a large number of accessories to suit all our
customers’ requirements.

BENEFITS
The key feature, i.e. the main functionality of this range of
models, is to allow the customer to set the temperature
curve in a custom way, namely by modulate the rate of
temperature descent and ascent with respect to the
starting value, in order to optimise biological material
freezing. As the biological world is highly diversified, the
temperature curves for various types of sample will be
equally diverse: with this line we are able to offer this
essential quality.

BULKFROST 1200 FH-EL 15

 Cold technologies for industry
Application examples

Clean room:
cold storage room at -5°C
classified in class C.

Liquid nitrogen freezers,

for temperatures down to
-180°C,
horizontal and vertical
versions.

Temperature, humidity and

photoperiod climatic room
for the
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growth of entomological
strains.
Cold technologies for industry
Application examples

The iceman
The archaeological remains known as “The Iceman”, also called “The Similaun Man”, is definitely
one of the most sensational and important archaeological discoveries of last century which UNESCO
inserted in the World Heritage list.

It is the mummified body of a man who lived over 5,000 years ago. The age was determined with the
carbon 14 test in OXFORD, U.K., and ZURICH, Switzerland laboratories.

The importance of this discovery is that the body of a man who lived in the past, between the Neolithic
period and the Copper Age, was preserved until today with his organism practically intact, since it was
protected by ice. Many museums worldwide preserve human remains of different ages, even older
than those of the Similaun Man. But it was a first time that a man was
discovered with all his organs intact - skin, muscles, the brain, the face with blue eyes, the respiratory
and digestive tracts and everything else.

The Similaun Man (also called “The Mummy” or “ÖTZI”, from the ÖTZ valley near the place of
discovery) is anatomically complete and substantially intact.

He was discovered casually in September 1991 by two German hikers, at an altitude of 3200 m, in the
Alps between Austria and Italy.

One of the primary problems to be resolved after the discovery was how to preserve the remains.
The system which we made was designed and installed by our AG division in Milan and is located in
the new South Tyrol Museum of Archaeology set up by the Province of Bolzano by restructuring the
austere building which housed the Bank of Italy in the same city of Bolzano, Italy. The essential core of
the project is naturally Ötzi’s room, where he will rest forever, in an environment which artificially and
precisely reproduces the microclimate which had surrounded him in the Similaun Glacier for over 5000
years.

The technology which we developed in implementing Ötzi’s preservation rooms open up to possible
uses in the field of research, both industrial and scientific, at temperatures below 0°C, in controlled
humidity conditions and in a sterile environment on materials and components, even electronics.

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 Cold technologies for industry
Energy saving in refrigeration installations

Save with Turboalgor

TURBOALGOR is an innovative start-up of the Angelantoni
Group which patented an energy efficiency system in relation to
the use of cold in refrigeration installations.
Turboalgor is the most cutting-edge solution to improve the energy
efficiency of both new and old refrigeration installations, using a
compressor turbo technology, from the automotive industry, aimed at
increasing energy recovery through heat exchangers.
A revolutionary technological innovation for energy-saving, which
marks a profound, dramatic change compared to any other energy
saving solution existing in the cold storage sector such as INVERTERS
or ECONOMIZERS. Turboalgor is ideal for cold rooms storing chemical,
pharmaceutical and food products (ice cream and frozen goods), mass
retailing, process cooling, etc.
The investment is paid back in a few years, without counting possible
energy efficiency incentives.

Energy-saving / Enhancing cooling capacity

LOW TEMP. MEDIUM TEMP. HIGH TEMP.

60%
50%
40%

30%
23% 22%
20%

10% 10% 8%
0 4%

-25°C -5°C 10°C 20°C

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Cold technologies for industry
Energy saving in refrigeration installations

The refrigerant inside a conventional steam electrical power absorbed by the system) from
compression refrigeration system shows one 30 kW to 300 kW, and in terms of evaporation
temperature, in order to supply the widest
weak spot: the expansion valve brings the
possible range of customers operating in the cold
refrigerant liquid from high to low pressure storage chain: from the food industry, to the retail
without making use of the energy potentially sector, through to the chemical, pharmaceutical
available. By inserting a heat exchanger and refrigeration transport industry, as well as
(economizer) and a turbo-compressor like the server farm industry or any other company
that used in the automotive industry, part operating
of the energy which otherwise would be in the cold
storage
lost can be recovered, thus enhancing the chain,
cooling capacity of the installation. capable of
The Turboalgor kit is therefore a combination of maximising
an economizer and a turbo-compressor inside the
a conventional steam compression refrigeration advantages
system. Turboalgor provides its customers with of the kit.
the most suitable KIT according to the technical
specifications of their refrigeration plant, so as to
maximise the advantages along the entire cold
storage chain. The technology is suitable for
industrial refrigeration systems (low temperature),
for cooling systems (medium temperature) and for
air-conditioning systems (high-temperature).
Turboalgor divided its products into different
combinations in terms of output (intended as
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 Angelantoni Life Science (ALS) is a world leader in the supply of refrigeration
equipment and in the design of technological solutions in the biomedical sector,
constantly engaged in innovation and safety, both biological and environmental.

AS brand provides for a wide range of refrigerators cabinets, ultra-low tempe-

rature freezers, blood banks refrigerators, freezers to preserve blood compo-
nents, mortuary prefabricated rooms, stability tests and plant growth cham-
bers, refrigerators and freezers for COVID-19 vaccines.

AG brand supplies standardized brine chilling units for pharmaceutical and che-
mical applications or pharma process, manual or automated solutions allow to
reach -70°C for special walk-in chambers and shelters to storage vaccines or
other farmaceutical products.

STERIL brand provides for equipment able to meet any product protection need,
as well as the product, operator and environment safety requirements, for any
level of concentration and for any kind of substance (horizontal and vertical la-
minar flow cabinets, biohazard and cytostatic safety cabinets, laminar flow pass
boxes with UV, sanitized hydrogen peroxide pass boxes, weighing, sampling and
dispensing cabinets and isolators designed in accordance with the latest inter-
national standards (GMP).

AIC brand provides Waster, and an automated treatment system for hospital and
contaminated waste.

Layout: crimic.com
Angelantoni Plants

Angelantoni Life Science S.r.l.

MASSA MARTANA HEADQUARTERS
Località Cimacolle, 464 - 06056 Massa Martana (PG) - Italy
Ph. (+39) 075.89551
[email protected]
MILAN BRANCH OFFICE
viale Monza, 291 - 20126 Milano (MI) - Italy
Ph. (+39) 02.939701.1

www.angelantonilifescience.it www.angelantoni.it

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Copyright © 2022 Angelantoni Life Science S.r.l. Illustration, description and technical data may be changed without notice. - Rev. 01/22