Leica CM1950 Brochure EN 000

CM1950_en_Brochure_Neu.qxd:CM1950_en_Brochure_Neu.qxd 28.08.
2008 13:00 Uhr Seite 1
Leica CM1950
THE Disinfecting Clinical Cryostats
CM1950_en_Brochure_Neu.qxd:CM1950_en_Brochure_Neu.qxd 28.08.2008 13:00 Uhr Seite 2
Leica CM1950 Platform

THE cryostats for high quality sectioning, user safety and efficient workflow
The Leica CM1950 platform is the latest innovation in a long line of distinguished The brightl
cryostats manufactured by Leica Microsystems. Leica designed and developed the cabinet is
new family of cryostats based upon users’ feedback and their requirements for allow effici
high quality sections, user safety, and efficient laboratory workflow. ple specim
Learn quickly and work confi-

dently using the externally loca-
ted, self-explanatory controls
with easily recognizable sym-
High Quality Sectioning bols.
•High precision microtome with stepper motor object feed

•Motorized sectioning (optional)
•New stable specimen clamp system For an extra measure of safety, the inside of
•New flat specimen discs for high specimen stability the instrument features an ozone-free UVC
disinfection system that is certified to be
•New rapid-freezing shelf design effective against most bacteria, virus, and fun-
•New effective object cooling system (optional) gi, even at cold temperatures.
User Safety
•UVC disinfection Increased safety for the user and others in the
immediate work area: Leica’s AgProtect™
•AgProtect™ antimicrobial nanosilver surface coating antimicrobial nanosilver surface coating
•New disposable blade holder CE deters the propagation of infectious agents on
•Debris-free, frost-free enclosed microtome assembly

the outside of the instrument.
•Leica’s Section Waste Removal System (optional) Protect
•Spacious cabinet with rounded edges inside and out

To protect the laboratory environment from
Efficient Workflow contamination, a multi-filter system (including
•UVC disinfection at any time and temperature HEPA filter) removes particulates and cleans
•Organized work space inside and out

the air exhausted from the optional Section
Waste Removal System
•Frost-free, encapsulated microtome assembly
•Leica’s Section Waste Removal System with easily-accessible,
concealed filter system (optional)
•Easily recognizable control symbols Liquid condensate
•Visible operating parameters at all times

collected in an eas
ble waste container
2
rightly lit, ergonomic cryo- Store tools, glass slides, stai-

et is spacious enough to ning containers, etc. in a
efficient handling of multi- recessed area on top of the
ecimens. cryostat to have these items
immediately at hand.
For extra ease of use and con-

sistent sectioning of all speci-
men types, an optional sectio-
ning motor drive is available.
nsate is safely
easily accessi-
ainer. Leica Design by Werner Hölbl
3
THE cryostats
for high quality sectioning
Obtain high quality sections through:
•NEW: CryoZone™ blade holder and anti-roll guide cooling
•Maintaining the ideal object temperature for specific specimens
•Great stability of the microtome and blade holder system
•Extreme accuracy of the stepper motor object feed
•Vacuum-assisted
Consistent, motor-driven cutting stroke (optional)
•High precision microtome
sectioning aid (optional)
• with exact stepper motor object feed.
CryoZone™ – the cool way to improve section quality

The CryoZone™ system controls a zone of uniformly cool air in the critical areas of the cryochamber. This
cool air circulates around the specimen, knife and anti-roll guide to create the optimal conditions for con-
sistent, high-quality sectioning.
4
Efficient specimen loading is achieved via single lever

operation that provides maximum clamping force indepen-
dent of individual user strength.Direct contact cooling
through the (optional) actively cooled object head facili-
tates rapid changes of specimen temperatures to provide
the best conditions for sectioning various specimen types.
High specimen stability is achieved by adherence to deeply

grooved specimen discs. Specimens freeze quickly
because the pre-cooled discs feature a large back surface
that fully contacts the freezing shelf with integrated Peltier
element.
Superior sectioning of routine, hard, and/or large samples is

achieved using a choice of knife/blade holders as well as the
new dove tail mounting system that provides increased sta-
bility and extended working distance. The new CE holder for
high and low profile disposable blades evenly distributes
clamping pressure across the entire length of the blade,
which provides vibration-free sectioning.
The new CN and CNZ knife holders are available for steel
or tungsten carbide knives (optional accessories).
The optional vacuum sectioning aid achieves time-sav-

ing section preparation and reduces section curling.
5
THE cryostats
for the highest user safety
Histology laboratorires continue to express major concerns Leica’s built-in UVC disinfection system provides
about biohazard exposure and non-ergonomic work practices. certified protection from infectious material and
As a result of their feedback, the Leica CM1950 family of minimizes the risk of contamination in the cry-
cryostats is designed to provide maximum protection from these ochamber. Scientific studies prove that surface
risks at all stages of the sectioning process. disinfection from bacteria, viruses, and fungi can
be achieved with UVC light. Certification proving the effectiveness
• Certified UVC disinfection of exposed surfaces and air
within the cryochamber at cold temperatures
of UVC disinfection against a range of microorganisms can be
downloaded from www.leica-microsystems.com/cm1950_safety,
• outside
AgProtect™ antimicrobial nanosilver coating on the
surfaces of the cryostat
which includes detailed information on the test procedure and the
efficacy of UVC disinfection.
• three filtersSection Waste Removal System with a series of
Optional
To efficiently reduce the propagation of infectious agents on
• Ergonomic exterior cabinet design with rounded edges
and comfortable working height
the outside surfaces of the cryostat, the Leica CM1950 family
features an antimicrobial nanosilver surface coating, called
• Optional ergonomic chair and foot rest AgProtect™. Silver (Ag) ions are well document-
ed for their ability to reduce bacterial growth.
Protect
Section waste is easily removed by using Leica’s optional

Section Waste Removal System during trimming with the
magnetized nozzle, or during extensive cleaning with the
flexible hose. Solid waste is collected in a concealed prima-
ry filter system and air is filtered through a HEPA filter for
added safety in the laboratory environment. Liquid conden-
sate is collected in a condensate bottle for safer disposal.
6
The new disposable blade holder CE with integrated, colored

safety guard and blade removal aid makes blade handling
safer. For users who prefer using the brush technique during
sectioning, the palm rest can be used instead of the anti-roll
guide.
The ergonomic design of the Leica CM1950 protects the user

from sharp edges and helps prevent work-related muscu-
loskeletal disorders (MSD) and repetitive strain injury (RSI).
Rounded edges allow the user to adopt a comfortable work-
ing position. Bright, glare-free illumination helps reduce eye
fatigue.
For individual user comfort, the Leica chair and height

adjustable foot rest are available as optional accessories.
7
THE cryostats
for highly efficient workflow
The best workflow for efficient operation is achieved by:
•Simple specimen identification using the optional, color-coded specimen discs

•Fast, efficient specimen orientation with clearly defined zero position
•Frost-free, enclosed
Disposable blade holder for both high and low profile blades
•Optional motor drive microtome assembly
•Certified UVC disinfection
for specimen sectioning
•contaminated waste, is effective
at low temperatures – does not produce condensation or
at low temperatures, and can be terminated at any
time to process urgent cases
Easy for the multi users: the self-

explanatory, single-function keys and
easily readable LEDs help prevent
operating errors, facilitate cryosec-
tioning, and make scrolling through
multiple menus unnecessary. The
control panels are comfortably posi-
tioned in the armrests to eliminate
the need to reach into the cold cham-
ber to use or adjust settings.
Tools, glass slides, staining contain-

ers, etc. can be stored in a recessed
area on top of the cryostat to keep
them immediately at hand.
8
Sectioning tools/aids etc. can be conveniently placed on

the optional, movable shelf.
The specimen discs can be pre-cooled in the optional

internal storage container, and then easily organized and
transported.
Optional color coded specimen discs help identify speci-

mens coming from multiple sources. The specimen disc
features a visual specimen orientation aid to enable pre-
cise orientation.
A clearly defined zero-position allows faster

specimen alignment prior to sectioning and
easy realignment if the specimen is removed
from the object head.
With the new disposable blade holder CE blade

exchange is simple and fast. The holder’s lateral
displacement function allows the use of the full
length of the blade. Small and large sections are
easily lifted from the large, horizontal pressure
plate.
9
Leica CM1950 Technical Specifications

The Leica CM1950 basic instrument is equipped with CryoZone™ technology, UVC Disinfection, specimen orientation and AgProtect™
antimicrobial nanosilver coating.
An individual, tailor-made instrument can be configured by use of the various options available:
• Actively cooled object head (double compressor)

• Vacuum Section Waste Removal System
• Motorized Sectioning
• A wide range of accessories
UVC surface disinfection: 30 or 180 minutes, user selectable
Microtome
Section thickness range: Setting values: 1 to 100 µm
1.0 µm – 5.0 µm in 0.5 µm steps
5.0 µm – 20.0 µm in 1.0 µm steps
20.0 µm – 60.0 µm in 5.0 µm steps
60.0 µm – 100.0 µm in 10.0 µm steps
Trimming range: Clinical: 10 – 40 µm
Setting values: 10 µm, 20 µm, 30 µm, 40 µm
Research: 1 – 600 µm
Setting values: 1,0 µm – 10,0 µm in 1,0 µm steps
10,0 µm – 20,0 µm in 2,0 µm steps
20,0 µm – 50,0 µm in 5,0 µm steps
50,0 µm – 100,0 µm in 10,0 µm steps
100,0 µm – 600,0 µm in 50,0 µm steps
Maximum specimen size: 50 x 80 mm
Total specimen feed: 25 mm
Vertical specimen stroke: 59 mm
Specimen retraction: 20 µm or off
Specimen orientation: 8° (x-, y-axis), 360° rotation of specimen disc
Electric coarse feed: Slow: 300 µm/s, in 20 µm steps

Fast: 900 µm/s
Cryochamber
Temperature range: 0°C to -35°C at ambient temperature of 20 °C
Specimen cooling (optional)

Temperature range: – 10 to – 50 °C
Defrosting of specimen head: manual defrost
Cryochamber defrosting
Automatic cryochamber defrosting: programmable, (hot gas defrost),
selectable time,
1 defrost in 24 h or manual hot gas defrost,
defrost time: 12 minutes
Automatic shut off defrost: at – 5 °C chamber temperature
10
Quick-freeze shelf
Minimum temperature: down to – 42 °C, at chamber temp. – 35°C
Number of freezing stations: 15 + 2
Defrost: manual hot-gas defrost
Peltier element
Number of freezing stations: 2
Maximum temperature difference: 17 K, at chamber temp. of – 35 °C
Power draw 1900 VA
General information
Operating temperature range: 18°C to 35°C
Relative humidity: max. 60%, non-condensing
Storage humidity: < 60%
Dimensions and Weights

Width (without handwheel): 700 mm
Width (with handwheel): 835 mm
Depth (cabinet only): 850 mm
Height (total): 1215 mm
Working height (armrest): 1025 mm
Weight: 165 kg
Weight (with vacuum): 183 kg
Weight (with motor): 185 kg
Weight (with motor and vacuum): 193 kg
Choice of blade or knife holders:
Stable blade holder base with segment arc for lateral displacement of the blade.
Disposable blade holder insert CE for high and low profile blades with 2 anti-roll guides with 50 and 100 µm spacer with glare
minimizing glass insert, colored safety guard and blade removal help. Palm rest for brush technique.
Stable knife holder base for knife holder CN or knife holder CNZ. Knife holder CN for reusable steel knives
Knife holder CNZ for reusable steel or tungsten carbide knives with central pressure plate for full usage of the knife.
Wide range of accessories available on request.

Technical specifications subject to change without prior notice.
As confirmed by the successful c_CSA_us certification, the Leica CM1950

has been designed and manufactured in compliance with US, Canadian and IEC
requirements.
State-of-the-art development, manufacturing and quality control procedures –

certified under DIN EN ISO 9001 – ensure highest quality and reliability.
11
“With the user, for the user”

Leica Microsystems
Leica Microsystems operates internationally in four divi- The statement by Ernst Leitz in 1907, “with the user, for the user,” describes the fruitful collaboration
sions, where we rank with the market leaders. with end users and driving force of innovation at Leica Microsystems. We have developed five
brand values to live up to this tradition: Pioneering, High-end Quality, Team Spirit, Dedication to
• Life Science Division Science, and Continuous Improvement. For us, living up to these values means: Living up to Life.
The Leica Microsystems Life Science Division supports the
imaging needs of the scientific community with advanced
Order nos. of the editions in: English 95.7826 Rev B • German 95.7827 Rev B • French 95.7828 Rev B • Spanish 95.7829 Rev B • Italian 95.7830 Rev B
innovation and technical expertise for the visualization, Active worldwide
measurement, and analysis of microstructures. Our strong
focus on understanding scientific applications puts Leica Australia: North Ryde Tel. +61 2 8870 3500 Fax +61 2 9878 1055
Microsystems’ customers at the leading edge of science. Austria: Vienna Tel. +43 1 486 80 50 0 Fax +43 1 486 80 50 30
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© Leica Microsystems GmbH • HRB 5187 • 09/2008

histology step and high-productivity workflow solutions
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The Leica Microsystems Surgical Division’s focus is to
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and representatives in more than 100 countries
tients with the highest-quality, most innovative surgical
microscope technology today and into the future.
www.leica-microsystems.com

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CM1950_en_Brochure_Neu.qxd:CM1950_en_Brochure_Neu.qxd 28.08.

2008 13:00 Uhr Seite 1

Leica CM1950 Platform

Learn quickly and work confi-

•High precision microtome with stepper motor object feed

•New disposable blade holder CE deters the propagation of infectious agents on

•Debris-free, frost-free enclosed microtome assembly

•Leica’s Section Waste Removal System (optional) Protect

•Spacious cabinet with rounded edges inside and out

•Organized work space inside and out

•Easily recognizable control symbols Liquid condensate

•Visible operating parameters at all times

rightly lit, ergonomic cryo- Store tools, glass slides, stai-

For extra ease of use and con-

CryoZone™ – the cool way to improve section quality

Efficient specimen loading is achieved via single lever

High specimen stability is achieved by adherence to deeply

Superior sectioning of routine, hard, and/or large samples is

The optional vacuum sectioning aid achieves time-sav-

Section waste is easily removed by using Leica’s optional

The new disposable blade holder CE with integrated, colored

The ergonomic design of the Leica CM1950 protects the user

For individual user comfort, the Leica chair and height

•Simple specimen identification using the optional, color-coded specimen discs

Easy for the multi users: the self-

Tools, glass slides, staining contain-

Sectioning tools/aids etc. can be conveniently placed on

The specimen discs can be pre-cooled in the optional

Optional color coded specimen discs help identify speci-

A clearly defined zero-position allows faster

With the new disposable blade holder CE blade

Leica CM1950 Technical Specifications

• Actively cooled object head (double compressor)

UVC surface disinfection: 30 or 180 minutes, user selectable

Electric coarse feed: Slow: 300 µm/s, in 20 µm steps

Specimen cooling (optional)

Defrosting of specimen head: manual defrost

Power draw 1900 VA

Dimensions and Weights

Choice of blade or knife holders:

Wide range of accessories available on request.

As confirmed by the successful c_CSA_us certification, the Leica CM1950

State-of-the-art development, manufacturing and quality control procedures –

“With the user, for the user”

© Leica Microsystems GmbH • HRB 5187 • 09/2008

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