TOPNOTCH Pharmacology

Pearls September 2018

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TOPNOTCHMEDICALBOARDPREPPHARMACOLOGYPEARLSbyM.Y.EPEREYRA-BORLONGAN,RPh,MD-MB
Forinquiriesvisttwww A
.topnotchboardprep.com.phoremailusattopnotchmedicalboardprep@gmall.com
MPORTANTNOTESONANTIPLATELETS
Whatisthetriadofaspirin SAMTERTRIAD
hypersensitivity? Asthma
ANTIMICROBIAIS-ANTIBACTERIAL,ANTIFUNGAL..
ANTIVIRAI,ANTIPROTOZOALANTIHELMINTHS
AspirinHypersensitivity
NasalPolys
WhatarethesignsofASA ASAPOISONING:C-II-A-F-S ANTIBACTERIALS
polsoning? BACTERICIDAL.ANTIBIOTICS
Coma
VeryFinelyProficientAtMurder!
Hyperventilation Vancomycin
Acidosis(MAGMA)
rever
Fluoroquinolones
Sei2uro
Penicillins
What
RespiratoryAlkalosiswith Aminoglycosides
baseabnormalityinsalicylate HAGMA Metronidazole
poisoning? BACTERIOSTATICANTIBIOTICS
WhatIsthedifference We'reECSTaTiCaboutbacteriostatics.
ADULTS
betweeninpresentationof mixecraciooDaseenisorder
Erythromycin
aspirinintoxicationin Clindamycin
RespiratoryAlkalosiswith
childrenandadults? HAGMA
Sulfamethoxazole
Trimethoprim
CHILDREN Tetracycline
[Chloramphenicol
pureacid-basedisorder
HAGMA
Whatisthedifference PENICILLINS
berweenaninhibitora INHIBITORS:completelyhalt DRUG
ndan ETC CHARACTERISTIG|SIDEEFFECT
uncouplerofoxidative UNCOUPLERS:dissipate
phosphorylation? muthivilla Narrowspectrom
Hypersensitivity,GI
protongradientwithout penicillins upset
InterruptingETC Penicillinase-
interstitial
mirillM resistantpenicillins nephritis,
ANTI-INFLAMMATORYAGENTS neutropenia
Extended-spectrum pseudomembranous
poperacillin penicillins colitis
Aspirin Irreversiblyinhibits
cyclooxygenase1and2 premille, Antipseudomonal hypertension,

Marren,Improfest,salledar ReversibleInhibitorof
cyclooxygenase1and2
arbenalis penicillins hypervolemia,
bleeding.
Celcconh. IrreversiblyInhibits
PenVIsOral,ipinapasoksaVun
cyclooxygenase2 ganga
PenGisIV:YouinGectPenG
Parauetagnel Weakandreversible
inhibitionofcyclooxygenase, Usenaf(nafcillin)forstaph.
antipyreticofchoicein
pediatricpopulation AMPicillin=AMPeduppe
Methotrexate nicilin
DMARDofchoicefor amOxicillin=greaterOralbioavaila
RheumatoldArthritis bility
Infiximab
TNE-Ablocker AmoxicillinHELPSkill
Azathloprine Enterocc
Forms6-Thiogunanine,and
suppressesBcellandT°cell Haemophilusinfluenzae
function Escherichiacoli
Cyclophosphamide Listeriamonocytogen
Formsphosphoramide es
Proteusmirabilis
mustard,whichcrosslinke
DNAtopreventcell Salmonellaspp.
Enterococci
Sulfasalazine
replication
Itsactivemetaboliteis
Sulfapyridinewhichinhibits [TCP:TakesCareofPseudom
onas
thereleaseofinflammatory Ticareillin
cytokines Carbenicillin
Colchicine Inhibitsmicrotubule Piperacillin
assemblyandLTB4
productionleadingto CEPHALOSPORINS
DRUG
decreasedmacrophage DESCRIPTION SIDEEFFECT
migrationandphagocytosis; 1sgeneration Hypersensitivity
Probenecid
SE:Aplasticanemia Cetaram cephalosporin,Highbone Keaction
Competewithuricacidfor penetration,Surgical
reabsorptionintheproximal prophylaxis,Greatest
lubules gram-positivecoverage
Allopurinol Activemetabolite Camarive 2ndgeneration SE:Disulfiram
(alloxanthine)irreversibly cephalosporin,Added
Copacaref
reaccon

inhibitsXanthineOxidase gramnegativecoverage,
enzymeandlowers 3rdgeneration Disulfiram
productionofuricacid cephalosporin, reaction
mayalavia Pseudomonascoverage
Febuxostat Nonpurine,reversible
Mostefficactouscephalosporinfor
inhtbitorofxanthineoxidase, Celteridine Pseudomonasaeruginosa.
AllopurinolIntolerance
Mepine quigenerationcephalosporin,Broadspectrum
activity(grampositiveandgramnegative)
Ceftriaxone Whichcephalosphorinhasthebest
penetrancetotheBBB?

CEPHALOSPORINS

TOPNOTCHMEDICALBOARDPREPPHARMACOLOGYPEARLSbyM.Y,E.PEREYRA-BORLONGAN,RPh,MD-MBAPage7of16
Forinquiriesvisitwww.topnotchboardprep.com.phoremallusattonnotchmedicalboardprep@gmail.com

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TOPNOTCHMEDICALBOARDPREPPHARMACOLOGYPEARLSbyM.Y.EPEREYRA-BORLONGAN,Rh,MD-MBA
Forinquiriesvisitwww.topnotchboardprep.com.phoremailusattopnotchmedicalboardprep@gmall
.com
Microbescoveredby1sgencepha PROTEINSYNTHESISINHIBITORS
losph orins
PEcKsFIRST DRUG CHARACTERISTIC SIDEEFFECT
Froreusmirabilis
escherichlacoll Kiebsienaoneum Bindsto50S aplasticanemia,
onrae
subunit graybabysyndrome
1ªgenerationCephalosphorins
FIRSTGENERATIONCEPHALOSP Bindsto30S coochenamel

FAD ORINS tebaractor

er,helpmeFAZmyPHarma subunit discoloration,
cologyboards! Photosensitivity
CeFADroxil
BindstoSOS diarrhea,cholestatic
CeFAZolin
subunit,DOCfor jaundice
CePHalothin
a
CePHapirin frantid penicillin-allergic
CePHradine patients
CePHalexin Bindsto505subunit,Highestvolumeof
distribution,Singledoseadministration
Microbescoveredby2ndgenc Bindsto505 pseudomembranous
ephalosphorins subunit,anaerobic
HENhasKEPS colitis
Haemophilusinfluenzae coverage
Enterobacteraerogenes
Neisseriaspp.
Ciwalid,Sheptes,aBindsto505subunit,Vancomycin
resistance
Klebsiellapneumoniae MNEMONIC-ProteinSynthesisIn
Escherichiacoli hibitors
Proteusmirabilis cidas-A=Aminoglycosides
Serratomor
cescens TeTetracyclines
Slabe C=Chloramphenicol
2ndgenerationcephalosphorins E=Erythromycin(Macrolides)
SECONDGENERATIONCEPHALOSP L=Lincosamides(Clindamycin)505
ORINS -L=Linezolid
InaFAMilygatheringyouseeyourFOXycou Didal S=Streptogramins
sinwearingaFUR
coatanddrinkingTEA.
CeFAMandole,CeFOXi
tin, MNEMONICS-Tetracycline
CeFURoxime,CefoTEtan
TeTeTracyclines=BlockaTTachmentofT-RNAtoaccep
Or torsite
SECONDGENERATIONCEPHALOSPORI
NS Chodarycmforanaero
FAC!LORAthePROfessionalAZhOLEIsst
illontheFONe.
bicinfectionsABOVEthe
CeFACior,LORAcarbef,CefPROzil, diaphragm.
CefmetA7.OLE,CeFONicid MahonidazaleforanaerobicInfectionsBELOWthe
diaphragm.
CEPHALOSPORINSCAUSINGDISULFIRAMREA
CTION AMINOGLYCOSIDESin)trustram,AIMAChop
Cefamandole Cefotetan
Cefmetarela DRUG REMARKS SIDEEFFECT
Cefoperazone
Bactericidal,Bindsnephrotoxicity,
30GenerationCephalosphorins Gentamicinto305subunit,ototoxicity
Treatmentof
THIRDGENERATIONCEPHALOSPORINS
endocarditis
PEngePOngPERAtoFIXmyTITTTVI Treatmentofocularinfectio
CeFEtamet CefTazidime formain ns
CefPodoxin CefoTaxime
CefoPERAzone Tuberculosisorgeribaldrafes
CeFIXime
CefTizoxime
CefTibuten
s
Treatmentofdrug-resistantgono
CefTriaxone Speckhoregein rrhea
Widestspectrumofactivity,
ANTI-PSEUDOMONALCEPHALOSPORINS Pseudomonascoverage,narro
CefTAZidime w
therapeuticwindow
CeFEPime
CeFOPerazone Neoryin Treatmentofhepaticencephalopathy

OTHERCELL.WALLSYNTHESISINHIBITORS MeanGiANTScanNOTkillanaerobes.
DRUG REMARKS Gentamicin
SIDEEFFECT Nephrotoxicity
Silverbulletagainstgramnegativebacteria, Amikacin Ototoxicity
Actreonam Nogram-positiveactivity Neomycin Teratogen
WITHANTI-PSEUDOMONALCOVERAGE Tobramycin (AminOglycosidesrequire02fortranspor
t)
Talitradam,SellutoBeta-lactamase Cholestatic Streptomycin
Cavalanieaurinhibitor jaundice
Vartengain TreatmentforMRSA RedManSyndrome SULFONAMIDES
Drugoflastresort, DRUG REMARKS
CNStoxicity SIDEEFFECT
¡magnuer-ci'last,Broads pectrumor (confusion, Sultantonardly Blocksdihydropteroatesynthase
activity encephalopathy,
Blocksdihydrofolatereductase
seizures) sinchprim
Whichantibioticsare TAMyourLastShotat Sequential hypersensitivity
considered Victory blockadeinfolate (SIS,TEN),
drugsoflastresort? Imipenem
ThP-SMx synthesis,Urinary kernicterus,
Amikacin tractinfections hemolysisin

Meropenem patientswithG6PD
Treatmentofburninfections
Linezolid Sulfadionn
Streptogramins
Vancomycin

TOPNOTCHMEDICALBOARDPREPPHARMACOLOGYPEARLSbyM.Y.E.PEREYRA-BORLONGAN,Rh,MD-MBAPage8of16
Forinquiriesvtsitwww.topnotchboardprep.com.phoremailusattopnotchmedicalboardrep@small.com

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