HEALTHY SKIN, HEALTHY LIFESTYLE:

BEAUTY COMES FROM WITHIN THROUGH

NATURAL INGREDIENTS

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
THE INCREASE OF “BEAUTY FROM WITHIN” TREND

The link between wellness and beauty is stronger than ever in consumer mind. Health is the top priority and holistic self-care
will gain greater attention, becoming the daily approach for consumers. Recently, awareness of the relationship between
dietary supplementation and skin appearance has increased significantly among consumers, as well as in the scientific
community. The concept of ingestible skincare is now firmly in the mainstream.

TOP TEN
TREND FOR
2022
PREVENTION
OVER CURE*

59% of Global consumers say that they are interested in products

that address skin health even if not suffering any specific symptoms

I am interested in products that address

skin health even if not suffering any I am interested in more information
specific symptoms. about improving skin health.

NORTH AMERICA 57% NORTH AMERICA 59%

GLOBAL 59%

GLOBAL 59%

ASIA-PACIFIC 61% ASIA-PACIFIC 60%

EUROPE 58% EUROPE 56%

SOUTH AMERICA 70% SOUTH AMERICA 56%

*Introducing FMCG Gurus Top Ten Trends for 2022

Attitudes towards skin health continue to evolve, with people adopting the notion of beauty from within and
recognizing the link between skin health and overall wellbeing. A switch from anti-ageing to healthy ageing
demonstrate an attention in the link between skin health and overall health. So, beauty and grooming routines
are not connected to the necessity to maximize physical appearance but instead, the concept of beauty from
within and the view that good skin health can boost other areas of physical and emotional wellbeing.

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
 MARKET TRENDS
Global nutricosmetics market is valued at USD 6721.4 million in 2019 and is expected
to reach USD 11,385.6 million by 2027 with a CAGR of 7.82% over the forecast period**.

NORTH AMERICA
North America is expected to dominate the nutricosmetics market in terms of market share owing to:

• The increased consumer awareness about the “beauty from within” approach;
• Changing lifestyle;
• Changing perception towards healthier alternatives for wellness and beauty.

EUROPE
Europe is expected to be the second largest revenue share
of the global nutricosmetics market, owing to:

• The increased consumer spending on beauty products;

• The number of premium products launched;
These are the major factors expected to drive growth of nutricosmetics market in Europe region

ASIA-PACIFIC
The Asia-Pacific region is expected to witness the fastest growth. This is mainly due to:

• The various product launches along with high consumers acceptance rate;
• The rising inclination towards herbal and natural products;

**Brand Essence Research, Nutricosmetics Market Size, Share & Trends Analysis Report; Published Date: Apr 2022

NATURAL SOLUTION Natural ingredients represent an interesting option for

managing beauty and for a good, safe, and environ-

FOR BEAUTY FROM WITHIN mentally friendly approach. From the Mediterranean and
Sicilian land, Bionap Srl offers two solutions for beauty from
within for skin and hair.

RED ORANGE COMPLEXTM is obtained from ACTRISAVETM is a blend of black rice seeds
the juice of three pigmented varieties of (Oryza sativa L.) and prickly pear flowers
Sicilian blood orange, Moro, Tarocco and (Opuntia ficus- indica (L.) Mill.) extracts that
Sanguinello. act synergically from inside against acne and
male alopecia.

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
WHY RED ORANGE COMPLEXTM?

NATURAL SUPPORT TO
MAINTAIN HEALTHY SKIN
WITH A BEAUTY FROM
WITHIN APPROACH
Free radicals and oxidants may give rise to health
concerns if their concentration is not maintained
under control. The oxidative stress (excess of free
radicals) can negatively affect several cellular and
molecular structures and processes being involved
in the initiation as well as in the progression of several
organism dysfunctions. Diet supplementation with
natural antioxidants helps the body reducing oxidative
stress, boosting the anti-oxidant endogenous defences
mechanisms and providing a larger protective margin
against its possible consequences linked to skin aging,
exposure to solar ultraviolet radiations, smoke and air
pollution.

as

as

as

SUGGESTED DOSAGE: 100MG/DAY

• Boosts the anti-oxidant defences and acts
The increase in solar ultraviolet radiation (UVR) that as a potent radical scavenger
reaches the Earth’s surface should make us reflect
on the need to develop new approaches to protect • Protects skin against UV-induced damage
the skin from UVR exposure. Bionap R&D has studied (cutaneous erythema) and photoaging
a global approach to fight aging and enhance
photoprotection counteracting oxidative stress and
• Controls the hyperpigmentation (melanin
inflammatory pathways to maintain skin health. The
use of food supplements with both antiaging and production)
photoprotective efficacy has increased in recent
years: eating well could be the best way to defend • Improves the homogeneous tunning and
our skin. skin brightening

• Keeps the aging skin elastic, hydrated,

radiant and reduces the wrinkle depth.

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
CLINICAL EVALUATION
OF RED ORANGE COMPLEXTM

WHAT IT DOES

Mechanism
of action

DECREASES OXIDATIVE STRESS in subjects with compromised antioxidant

defences such as athletes, scuba divers, diabetics, smokers and subject
exposed to air-pollution.

It is able to decrease oxidative stress counteracting ROS (Reactive Oxygen

Species) and other reactive free radicals, to restore glutathione levels and
thus protect against short and long-term health consequences in different
population targets with compromised antioxidant defences;

6 CLINICAL TRIALS

FIGHTS THE SKIN AGING SIGNS

IN MEN AND WOMEN

It is able to improve skin moisturization,

elasticity, distensibility and radiance;
It reduces the wrinkle depth.

1 CLINICAL TRIAL

INHIBITS SKIN DAMAGE AND HELPS TO MAINTAIN

HEALTHY SKIN IN MEN AND WOMEN

It is able to protect skin against UV-induced damage (cutaneous erythema)

and photoaging, control the hyperpigmentation (melanin production), improve
the homogeneous tunning and skin brightening.

2 CLINICAL TRIALS

RED ORANGE COMPLEXTM

is effective in Caucasian
and Asian ethnicity

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
RED ORANGE COMPLEX™ IS ABLE TO PROMOTE
THE EXTRACELLULAR MATRIX REMODELING

As reported by Freitas-Rodríguez et al. (2017) UV exposure affects the extracellular matrix (ECM) structure and organization
causing untimely skin aging. Aging and photoaging are usually considered separate but related processes, it is assumed
that around 80% of skin aging is caused by UV exposure.
Epidermis

Collagen

Elastin
Dermis

Dermal
fibroblast

Proteases

Cross-linked collagen fibers Cross-linked collagen fibers

Elastic ECD Elastic fragmentation (stiff ECD)
Function dermal fibroblasts Production degradative proteases
Maintenance of ECM homeostasis Maintenance of ECM homeostasis

The intake of 100 mg/day of the standardized RED ORANGE COMPLEX TM extract
containing anthocyanins, hydroxycinnamic acids, flavanones, and ascorbic
acid has been largely demonstrated to be effective in 8 clinical trials on anti-
oxidant activity and counteracting both the harmful effects of UVR exposure
and aging signs.

The product improves the skin reaction to UV exposure by and wrinkle depth. The activity on skin elasticity parameters
decreasing the trans-epidermal water loss, the erythema, indirectly demonstrated the effect on the extracellular matrix
and the intensity of melanin staining inside dark spots. components, and in particular on both collagen and elastic
The total skin antioxidant capacity of the stratum corneum fibers. This positive effect could be also related to the key role
as well as the UVA-induced lipid peroxidation decreases. of ascorbic acid in collagen biosynthesis and as a collagen
Moreover, the product increases skin moisturization, elasticity, structure stabilizer.
and radiance, together with the improvement of skin resilience

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
WHY ACTRISAVETM?

NATURAL PROTECTION
AGAINST HAIR LOSS
AND ACNE
Black rice is a variety of pigmented rice, rich in nutritional
and bioactive components such as anthocyanins which
are responsible for its dark color. Anthocyanins are
known as powerful antioxidants with benefic effects on
skin and hair and act synergically with prickly pear flower
flavonoids (isorhamnetin and derivatives) with anti-
inflammatory and moisturizing properties on skin and hair
scalp. Together these ingredients lead to a protective
effect in sebocytes and hair dermal papilla cells.
Hormonal changes, hereditary thinning, autoimmune
diseases, thyroid disorders, and stress are among the
known causes of hair loss in young men and women.
This condition is affecting an increasing percentage of
the population worldwide. Acne is the most common
skin disorder, that usually begins in puberty and affects
many adolescents and young adults, also it may occur
in one’s 30s and 40s. Due to frenetic lifestyles, unhealthy
diets, and hormonal factors, acne is increasing in recent
years. However, diet can strongly influence hair and skin
health and dietary supplements, formulated with natural
ingredients, can be a good solution for skin and hair, in
men and women.

ACTRISAVE ™
% (W/W)

as 4.5 - 5.5

Isorhamnetin and derivates

(quercetin-3-O-glucoside)
1.0 - 2.0

SUGGESTED DOSAGE: 250 MG/DAY

The activity of ACTRISAVETM has been evaluated in vitro
and a clinical trial is running (250mg/day). The mechanism
of action needs to be clarified, however, some literature • Counteracts acne
data suggest that the active compounds of the two
extracts have antioxidant action: androgenic alopecia, • Improves hair health in male
premature senescence of dermal papilla and acne
could occur in response to environmental stress and
with the associated overproduction of reactive oxygen
species. Moreover, the activity could also be related
to the inhibition and modulation of 5-alpha-reductase
enzyme. It is involved in testosterone metabolism
contributing to hair loss and acne. The inhibition of
5-alpha-reductase could, indirectly, stimulate the
hair anagen phase and decrease dermal papilla cell
apoptosis. In acne skin problems, the extract could
decrease sebum production and in turn acne formation.

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
 WHY CHOOSE THESE NATURAL INGREDIENTS

RED ORANGE COMPLEXTM and ACTRISAVE™ have demon- One of these, is to apply a short supply chain, choosing lo-
strated, thanks to their clinical and in vitro studies, multi-po- cal supplyers traceable and ethically managed.
tential benefits that act from the inside to make skin healthy Infact, we have a network of local certified farmlands distant
and uniformed trough dietary supplements associated to a no more than 2 hours of transport from our processing facility
healthy lifestyle. But the distinctive feature is that Bionap has to respect biodiversity, and to reduce CO2 emissions we use
invested in the quality of these ingredients , starting to adopt renawable energy.Small actions that make these unique in-
since 1997 sustanaibility practices, preserving the Mediterra- gredients enhance all the properties to the maximum.
nean natural resources thanks to green extraction practice.

01 03 05

All bionap products come from the The actual network, ever growing, We act to reduce
idea of preserving the mediterrane- consist of organic certified farm- CO2 emissions using
an natural resources and preven- lands no more distant than 2 hours renewable energy.
ting waste production, by following of transport route from our proces-
a concept of circular economy, sing facility. This helps us to reduce
that’s why we produce natural and our environmental impact.
sustainable active ingredients from
co-products, coming from agricol-
tural field.

Our production system uses only

green extraction practices (filtra-
We believe on the beauty of biodiversity, tion, squeezing, spray drying), in this
intended as respecting the natural cycle way we greatly reduce the CO2
of the nature where the man is a key ele- emissions.
ment of preserving this wonderful ecologi-
cal system

02 04

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com
REFERENCES

• Vincenzo Nobile, Andrea Burioli, Sara Yu, Shi Zhifeng, Enza Cestone, Violetta Insolia, Vincenzo Zaccaria and Giuseppe Antonio
Malfa. Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and
Caucasian Subjects: A Randomized, Double-Blind, Controlled Study.2022, Nutrients 2022, 14, 2241
• Barbara Tomasello, Giuseppe Antonio Malfa, Rosaria Acquaviva, Alfonsina La Mantia and Claudia Di Giacomo. Phytocomplex
of a Standardized Extract from Red Orange (Citrus sinensis L. Osbeck) against Photoaging. 2022. Cells 2022, 11, 1447
• Carmelo Puglia, Alessia Offerta, Antonella Saija, Domenico Trombetta, Cardile Venera. Protective effect of red orange
extract supplementation against UV-induced skin damages: photoaging and solar lentigines. 2014. J Cosmet Dermatol,2014
Jun;13(2):151-7. doi: 10.1111/jocd.12083.
• Compositions based on plant extracts for inhibition of the 5-alpha-reductase-PCT/ IB2015/051621
• Sahib S. A, et al., Oxidative stress in acne vulgaris: an important therapeutic target. J Mol Pathophysiol 2:27-21 (2103).
• Trüeb R. M, Oxidative stress in ageing of hair. Int J Tricology 1(1):6-14 (2009).
• Ruksiriwanich W, et al., 5-α-Reductase type 1 inhibition of Oryza sativa bran extract prepared mu supercritical carbon dioxide
fluid. J of Supercritical Fluids 59:61-71 (2011).
• Al-Shobaili H. A, et al., Biochemical markers of oxidative and nitrosative stress in acne vulgaris; correlation with disease activity. J
CLin Lab Anal 27:45-52 (2013).
• Sandra Freitas-Rodríguez , Alicia R Folgueras , Carlos López-Otín . The role of matrix metalloproteinases in aging: Tissue
remodeling and beyond.2017. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):2015-2025. doi: 10.1016/j.
bbamcr.2017.05.007. Epub 2017 May 9.

Contrada Fureria (Zona Industriale Ovest) 95032 Piano Tavola, Belpasso (CT) - Italy
Tel. +39 095 7086560 • [email protected] • www.bionap.com