Curriculum Vitae Name: Linda Ferrell, MD

Linda Ferrell, MD
Prepared: 10/23/2006
University of California San Francisco

CURRICULUM VITAE
Name: Linda Ferrell, MD
Position: Professor, Step V

Department of Pathology
Vice Chair of Clinical Affairs
Director of Surgical Pathology, Department of Pathology, School of Medicine
Address: Room M-590, Box 0102

University of California, San Francisco
San Francisco, CA 94143-0102
Voice: (415) 353-1090

FAX: (415) 353-1200
Email: [email protected]
www: http://www.ucsf.edu/pathol/people/ferrell2.htm
EDUCATION:
1970-74 University of Kansas, Lawrence, KS B.A. Summa cum laude,

Microbiology
1974-77 University of Kansas, Kansas City, KS M.D.
1977-79 University of Kansas, Kansas City, KS Resident Pathology
1980-81 University of California, San Francisco Chief Resident/Surgical Pathology
Pathology Fellow
LICENSES, CERTIFICATION:
1978-79 Medical Licensure, Kansas

1980-now Medical Licensure, California, G41978
1982 Board Certification, Anatomic Pathology, American Board of Pathology
PRINCIPAL POSITIONS HELD:

1981-88 Assistant Professor of Pathology, University of California, San Francisco, CA
1988-94 Associate Professor of Pathology and Surgery, University of California, San Francisco, CA
1994-now Professor of Pathology and Surgery, University of California, San Francisco, CA
1999-now Vice Chair of Clinical Affairs, Director of Surgical Pathology, University of California San
Francisco
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Linda Ferrell, MD
OTHER POSITIONS HELD CONCURRENTLY:
1982-89 Co-Director, Cytology Laboratory, Department of Pathology, University of California, San

Francisco, CA
1985-now Consultant, Anatomic Pathology, Veterans Administration Medical Center, San Francisco, CA
2001-now Member of UCSF Cancer Center, GI/Liver/Pancreas Section
HONORS AND AWARDS:
1970-74 Watkins-Berger Scholar, Univ. Kansas

1972,73 Chemistry Awards
1973 Phi Beta Kappa
1974 Outstanding Senior Woman in Academics, Dean's Award
1975-77 Robert-Wood Johnson Scholarship, Univ. Kansas
1975 Postgraduate Scholarship Award, Alpha Chi Omega
1983 Academic Senate Distinguished Teaching Award, UCSF
1984 American Roentgen Ray Executive Council Award (for hepatocryosurgery project)
1984 Nominated for Kaiser Award for Excellence in Teaching
1986 Nominated for "Excellent Small Group Teaching Award," MSII
1987 Received Kaiser Award for Excellence in Teaching, UCSF
1987 Received Distinction in Teaching, Excellent Small Group Instruction, MSII
1987 Received Distinction in Teaching, Pathology Residents
1987 Nominated for MSII "Major Contribution to Teaching" and "Stimulating Lectures"
1988 Nominated for MSII "Excellent Small Group Instructor"
1989 Nominated for MSII "Excellent Small Group Instructor" and "Stimulating Lecture Series"
1989 125th Anniversary Celebration: 1 of 125 honorees for "Exceptional Contribution"
1990 Nominated for MSII "Major Contribution in Teaching" and "Excellence in Laboratory
Instruction"
1990 Nominated for MSI "Excellent Small Group Instructor"
1990 Invited to be permanent member of the International Liver Pathology Study Group, limited to
15 pathologists
1991 Received MSII "A Major Contribution to Teaching"
1991 Nominated for MSII "A Stimulating Lecture Series", "An Outstanding Lecture" and
"Excellence in Small/Lab Instruction"
1992 Elected AOA
1992 Received MSIV award for teaching excellence
1993 Nominated for Kaiser Award for Excellence in Teaching
1993 Recognition Award, US and Canadian Academy of Pathology
1995 Nominated for MSIV teaching award
2001 Recognition Award, US and Canadian Academy of Pathology
2001-06 Listed as one of America’s Top Doctors, The Nation’s Leading Medical Specialists, Castle
Connolly Guide
2003-05 Listed in San Francisco Magazine Best Doctors
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Linda Ferrell, MD
2005-6 Listed in Best Doctors in America 2005-6 database

2006-7 Nominated for Chancellor’s Award for the Advancement of Women for a faculty member.
KEYWORDS/AREAS OF INTEREST:
Liver, liver transplantation, hepatocellular carcinoma, dysplastic nodules, liver tumors, HIV, biliary
cirrhosis, ulcerative colitis, hepatitis, steatohepatitis, diagnostic pathology, surgical pathology, surgical
pathology fellowship, anatomic pathology.
PROFESSIONAL ACTIVITIES
CLINICAL
Vice Chair of Clinical Affairs, Director of Surgical Pathology, UCSF Moffitt, Mt. Zion: I have
had this responsibility from 1999 to present, fulltime
Cytology Attending Physician 1982-89
Surgical Pathology Attending, UCSF: I attend on this service, covering internal diagnostics and
outside requests for consultation, night and weekend call including frozen section diagnoses, and
Liver Transplant.
Time on service: 1981-89 60-100% for Moffitt/Mt. Zion
1990-2000 60% for Moffitt/Mt. Zion
2000-2004 20% for Moffitt/Mt. Zion with sign-out of about 2,000 cases
per year, with consult cases at 100% time on service.
2004-now 100% on service for Liver/GI consults, 20% for transplant
and frozen sections
Director, Surgical Pathology Fellowship: I direct the selection and the training program for 7
surgical pathology fellows per year, which are all clinical service fellows
Director, Gastrointestinal/Liver Pathology Fellowship: I direct the selection and training for 1
fellow per year, which is 80% clinical service.
Director, Transplant Pathology Fellowship: I direct the selection and training for 1 fellow per
year, which is 20% clinical service.
SUMMARY OF CLINICAL ACTIVITIES
My major diagnostic role in clinical service is the consultation service for liver and GI cases,
which primarily involves rendering diagnoses on pathology slides sent to me from other
pathologists across the country and some from other countries (60%) as well as consult on
problem diagnostic cases with liver/GI problems for UCSF patients (40%). I spend at least 2-4
hours per day in this capacity. These cases are much more complex than the average samples, and
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Linda Ferrell, MD
require my expertise in these areas to render the diagnosis. I also have frozen section night and
weekend call as well as review of stat cases on the weekend equal to that of other Moffitt surgical
pathology faculty. I cover frozen section and transplant daily coverage about 1 week per month. I
also am the liver pathologist that attends, reviews, and presents current cases about 2 times per
month to the Pediatric gastroenterology service and for the biweekly Liver Transplant service.
My administrative role as Vice Chair and Director of Surgical Pathology accounts for about 50%
of my clinical service time. This also includes the Medical Director of Anatomic Pathology
laboratories for the CLIA licensures and JCAHO inspections. Quality Improvement activities,
faculty scheduling for clinical services, and relationships/service to clinical departments account
for most of this administrative work. Faculty recruitment falls under my title of Vice Chair of
Clinical Affairs. (See summary of service activities below)
As Director of Surgical Pathology, I deal daily with clinical service issues. In this role, I
coordinate the surgical pathology sign-out and call schedules, troubleshoot problems in service
coverage for attendings and residents on all surgical pathology rotations at Moffitt and Mt Zion,
deal with all problems at any time relating in any aspect to the diagnosis or performance of
surgical pathology services, set up quality improvement projects as part of the QI program, and act
as the site director for any resident or fellow problem related to surgical pathology. I have
performed as the sole Medical Director of Histology and Immunopathology labs (which includes
the primary medical director responsibility for the JCAHO inspections), roles which are currently
being taken on (as of late 2005) by other more junior faculty under my advisement. Under my
supervision, we have undergone 3 Laboratory JCAHO inspections, and received 98%, 100%, and
100% scores respectively. The Associate Director of Surgical Pathology (Grace Kim) has assisted
me in management of the gross room and histology lab since Feb 2005. I coordinate the UCSF
international consultations from Second Opinion, Ltd. for Pathology. I also coordinate our
services with clinical and basic science research efforts by meeting with and helping scientists
plan their protocols so that they can conform to the recent IRB and HIPAA requirements.
PROFESSIONAL ORGANIZATIONS
Memberships
1978-79 Kansas City Society of Pathologists

1978-80 American Society of Clinical Pathologists
1982-92 Physicians for Social Responsibility
1983 American Gastroenterology Association
1984-now Rodger Haggitt Gastrointestinal Pathology Society
1985-now US and Canadian Division of the International Academy of Pathology (USCAP)
1986-89 UCSF Women's Faculty Association
1987-89 National Foundation for Ileitis and Colitis
1987-90 American Society of Cytology
1989-93 American Society of Clinical Pathology
1989-now California Society of Pathology
1993-now Arthur Purdy Stout Society (for Academic Surgical Pathologists)
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Linda Ferrell, MD
1993-now Hans Popper Hepatopathology Society (for Liver Pathologists)

1996-2005 South Bay Pathology Society
2001-now Association of Directors of Anatomic and Surgical Pathology (for Academic Directors)
Service to Professional Organizations
1988-1989 UCSF Women’s Faculty Association Steering Committee and Co-chair

1991-present California Society of Pathologists Education Committee
1997 California Society of Pathologists Co-chair, Educational Committee
1998-2006 California Society of Pathologists Chair, Educational Committee
1996-1998 International Academy of Pathology Moderator, organizer of symposium
1991-1994 Gastrointestinal Pathology Society Fellowship Committee
1991-1994 US and Canadian Division of the Inter- Reviewer of liver abstracts, 1991-4
national Academy of Pathology (USCAP)
1998-2000 US and Canadian Division of the inter- Organized and moderated liver specialty
national Academy of Pathology (USCAP) conference for 3 years
1998-2002 US and Canadian Division of the Inter- Educational Committee for 4 years, includes
national Academy of Pathology (USCAP) review of abstracts
2002-2005 US and Canadian Division of the Inter- Council Member (Governing Board role)
2004-06 US and Canadian Divison of the Inter- Long course co-chair 2006
2005-07 US and Canadian Division of the Inter- Nominating Committee (2 year term)
2002-2008 Association of Directors of Anatomic and Council Member (Planning and Governing
Surgical Pathology Body)
2004-06 Association of Directors of Anatomic and Practice Management Committee
Surgical Pathology
2006-10 Hans Popper Hepatopathology Society Vice-President/President
2004-06 International Academy of Pathology Co-convener and organizer of 3 medical liver
disease sessions for 2006 meeting
SERVICE TO PROFESSIONAL PUBLICATIONS
1982-88 Ad hoc referee for GASTROENTEROLOGY, approximately 1 per month

1985-00 Editorial staff, MODERN PATHOLOGY, (reviews approximately 4-5 papers per year)
1992-00 Ad hoc referee for HEPATOLOGY, approximately 1 every 3 months
1995-97 Editorial Board, ADVANCES IN GASTROENTEROLOGY, HEPATOLOGY, and
CLINICAL NUTRITION, Raven Press
1995-97 Editorial Consultant, GI Pathology Section, AMERICAN JOURNAL OF SURGICAL
PATHOLOGY, Raven Press.
1996-present Editorial Board, AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Lippincott,
Wiliams & Wilkins
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Linda Ferrell, MD
1997-03 Editorial Board, LIVER, Munksgaard International Publishers

2005-present Editorial Board, HUMAN PATHOLOGY, Elsevier
INVITED PRESENTATIONS
INTERNATIONAL
University of Glasgow, Western Infirmary; Department of Pathology and Department of Medicine,

Glasgow, March, 1982 (2 lectures).
Royal Free Hospital, Department of Pathology, Department of Medicine, April 1982 (3 lectures).
FNA Symposium; Stockholm, Sweden, August, 1984 (lecturer and workshop faculty).
Medical University of Xian, Liver Pathology, Xian, China (1 week course); FNA Biopsy Techniques and
Diagnosis, Xian, China, (1 ½ week course) March-April, 1988.
International Liver Pathology Study Group; University of Amsterdam, Amsterdam, Netherlands, June,
1992 (panelist).
International Liver Pathology Study Group; Instituto di Anatomia Patologica, Universite de Verona,
Verona, Italy, September, 1994 (lecture).
International Liver Pathology Study Group; Universite Bordeaux: Cours de Pathologie Hepatique
Division, Bordeaux, France, July, 1995 (lecture).
International Academy of Pathology; Hong Kong, November 1996 (2 lectures).
International Symposium on Liver Pathology; Kanazawa University School of Medicine, Kanazawa,

Japan, September, 1997 (lecture).
International Academy of Pathology, Liver Pathology Symposium; Warsaw, Poland, June, 1998 (lecture).
International Academy of Pathology, Biannual Meeting; Nice, France, October, 1998 (co-chair of session
and lecture).
Progress in Liver Pathology; Darwin, Australia, July, 1999 (lecture).
University of Verona; Verona, Italy, October, 1999 (visiting professor and lecture).
International Symposia, Instituto Portugues Oncologia; Lisbon, Portugal, April, 2000 (visiting professor
and lecture).
Scientific Symposiums International, Hawaii, Oct 2001, (5 lectures)
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Linda Ferrell, MD
Danish Society of Pathological Anatomy and Clinical Cytology, Aalborg, Denmark, May, 2002 (5-hour
course which included many northern European attendees).
International Liver Pathology Study Group, Kings Hospital, London, England, July, 2002 (lecture).
Scientific Symposiums International, Anchorage, AL, June 2003 (5 lectures)
Update in Liver Pathology, Melbourne, Australia, September, 2003 (lecture).
Canadian Association of Pathologists, Montreal, Canada, July, 2004 (4 lectures).
International Liver Pathology Study Group, Minneapolis, MN, August, 2004 (lecture).
Laennec Society and International Liver Pathology Study Group, Bordeaux, France, June, 2005 (panelist
and lecture).
Scientific Symposiums International, Maui, HI, June 2005 (5 lectures)
International Liver Pathology Study Group, Gainesville, FL, Feb 2006 (case presentations)
Laennec Society, Thessoloniki, Greece, May 2006 (invited panelist/discussant and case presentation)
Scientific Symposiums International, South Carolina, Jul 2006 (5 lectures)
International Academy of Pathology, Montreal, Oct 2006 (organizing 2 symposia, speaker at short course)
International Liver Pathology Study Group, Dartmouth, NH, June 2007 (case presentations)
INTERNATIONAL/NATIONAL
US and Canadian Academy of Pathology, Annual Meeting
Site not available for new CV, 1988 (poster)

Site not available for new CV, 1991, (platform presentation, session chair)
Atlanta, GA, March, 1992 (platform presentation, poster, specialty conference lecturer)
New Orleans, LA, March, 1993 (platform presentation posters, specialty conference lecturer)
San Francisco, CA, March, 1994 (posters, specialty conference lecturer)
Chicago, IL, March, 1995 (platform presentation, 3-hour short course)
Washington, DC, March, 1996 (platform presentation, 3-hour short course)
Orlando, FL, March, 1997 (poster, session chair, 3-hour short course and specialty conference
lecturer)
Boston, MA, March, 1998 (session chair, 3-hour short course and moderator for liver specialty
conference)
San Francisco, CA, March, 1999 (3-hour short course, moderator for liver specialty conference
and specialty seminar)
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New Orleans, LA, March, 2000 (posters, Hans Popper Society speaker and moderator for liver
specialty conference)
Atlanta, GA, March, 2001 (posters)
Chicago, IL, March, 2002 (posters, 1.5-hour short course)
Washington, D.C., March, 2003 (posters, 1.5-hour short course)
Vancouver, Canada, March, 2004 (posters, 1.5-hour short course)
San Antonio, TX, Feb, 2005 (poster, platform and 1.5-hour short course)
Atlanta, Feb, 2006 (poster and 1.5-hour short course, Course Director for Long Course in Liver
Pathology)
San Diego, Mar, 2007 (liver specialty conference speaker)
NATIONAL
US and Canadian Academy of Pathology, Diagnostic Pathology Course

University of Michigan, Ann Arbor, MI, August, 1991 (2 lectures and discussion period)
University of Washington, Seattle, WA, August, 1992 (2 lectures)
Boston, MA, August, 1993 (2 lectures)
Philadelphia, PA, August, 2000 (2 lectures)
Monterey, CA, July, 2001 (2 lectures)
Bar Harbor, ME, July, 2002 (2 lectures)
Bar Harbor, ME, July 2003 (2 lectures)
Banff, Alberta, Canada, July 2004 (2 lectures)
Santa Barbara, CA, July 2005 (2 lectures)
US and Canadian Academy of Pathology, Weekends in Pathology

Jacksonville, FL, Mar 2006 (1.5 hr short course)
American Gastroenterology Association, Annual Meeting

San Francisco, CA, September, 1992 (case presentations)
San Francisco, CA, September, 1992 (lecture)
American Association for the Study of Liver Disease, Annual Meeting

Chicago, IL, November, 1995 (case presentation).
Chicago, IL, November, 1998 (lecture)
American Society of Clinical Pathologists

June, 1996 (lecture, teleconference).
April, 1998, Annual Meeting, Los Angeles (lecture)
College of American Pathologists

September, 2005, Annual Meeting (short course, video tutorial)
September, 2006, Annual Meeting (short course, video tutorial)
REGIONAL AND OTHER INVITED PRESENTATIONS
USCF sponsored courses
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Linda Ferrell, MD
1984, 85, 91 Bay Area Seminars in Cytopathology
1985-1997 Current Issues in Anatomic Pathology, UCSF course, annual meeting (course co-chair and
lectures)
1998-2005 Current Issues in Anatomic Pathology, UCSF/Stanford course, annual meeting (co-chair)
1999 Current Issues in Anatomic Pathology (lecture)
OTHER INVITED PRESENTATIONS
1991 Nebraska Association of Pathologists, University of Nebraska, Omaha, NE (invited

lecture)
1993 Stanford University Grand Rounds (invited lecture)
1994 Rush University, Lake Tahoe, February, 1994 (Invited lecture)
1994 Nebraska Society of Pathologists and Creighton University (invited lecture)
1994 California Society of Pathologists (invited lectures)
1995 Palm Beach Gastrointestinal Cancer Conference, Palm Beach, FL (invited lecture)
1995 The Merlin L. Trumbull Lectureship in Pathology, Memphis, TN (visiting professor and
invited lectureship)
1995 University of Kansas, Kansas City, KS (visiting professor)
1995 Colorado Society of Pathologists, Denver, CO (invited lecture)
1995 Sutherland Fellows Symposium, Scottsdale, AZ (invited lecture)
1996 University of Ohio, Department of Transplantation (visiting professor)
1996 Kaiser Permanente Gut Club (invited lectures)
1996 Kansas City Society of Pathologists (invited lectures)
1997 UC Davis The 1997 Highman Symposium (visiting professor and invited lectureship)
1997 Duke University, NC (visiting professor)
1998 Los Angeles Pathologist Society (invited lecture)
1998 UC San Diego, Department of Medicine, GI Division (visiting professor)
1999 Cleveland Clinic (visiting professor)
1999 Long Island Society of Pathologists, NY (invited lecture)
1999 Winthrop Hospital, NY (visiting professor)
2000 New York University, NY (invited lecture)
2000 Northern CA Kaiser Permanente (invited lecture)
2001 Fresno Society of Pathologists (invited lecture)
2001 University of South Florida, Tampa, FL (visiting professor)
2001 Florida West Coast Association of Pathologists, Tampa, FL (invited lecture)
2001 Harvard Hospitals Peter S. Ciano Lectureship, Boston, MA (visiting professor and invited
lectureship)
2001 Genentech, South San Francisco, CA (invited lecture)
2002 Kaiser Permanente Annual Pathology Seminar, Los Angeles, CA (invited lectures)
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Linda Ferrell, MD
2004 Yale University Department of Pathology Grand Rounds (visiting professor)

2005 Rush University, Chicago, IL (visiting professor)
2005 University of New Mexico Department of Pathology, Albuquerque, NM (visiting
professor)
2005 Ohio State University Department of Pathology, Columbus, OH (invited lectures)
2006 University of Washington, Seattle, WA, Rodger Haggitt Memorial Lectureship (visiting
professor and invited lectureship)
2006 PhenoPath, Seattle, WA (visiting professor)
2006 University of Iowa (visiting professor)
2006 Kaiser Permanente Regional Seminar, Oakland, CA
CME COURSES ATTENDED (last 5 years)
U. S. and Canadian Academy of Pathology, 2000-06

Current Issues in Anatomic Pathology, UCSF/Stanford Course, 2000-06
California Society of Pathologists, 2000-06
UCSF Department of Pathology, Mechanisms of Disease, 1999-05 approximately 28 hours/year
Pathology Coding and Claims Update, 2003, 06
Amer Assoc of the Study of Liver Diseases 2005
College of American Pathologists Annual Meeting 2005, 2006
Mechanisms of Disease Conference, Dept of pathology, 2001-06
UNIVERSITY AND PUBLIC SERVICE

UCSF CAMPUS-WIDE
1986-93 Chancellor's Committee for Personal Safety

1990-92 Academic Senate Committee on Educational Policy, San Francisco Division
1993,98 Ad hoc committee for selection of Distinction in Teaching Award
2000-02 Chancellor’s Council
SCHOOL OF MEDICINE
1981 Tissue Committee, ad hoc review

1983-87 Admissions Committee, Vice-Chair Panel 1, 1985-87
1984 Medical Student Orientation Program
1985-86 Scholarship Committee
1987-91 First Year Screening Committee, Standing Committee Member until 1991
1988-92 Medical Student Academic Standards Committee
1989-96 Director, Pathology 101-103 (MSII) Course
1997-01 Section leader, GI/liver, Pathology 102 (MSII) Course
1989-96 Second Year Course Committee
1989-present Medical Student Career Advisor
1989,91 Dinner host for Medical School Orientation Program, MSI
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Linda Ferrell, MD
1990-91 Committee on Curriculum and Educational Policy

1990 Women's Mentor Group for Students
1991,92 Committee for Faculty Development (Including faculty peer review of teaching)
1991,92 Ad Hoc Committee on Curricular Balance
1992-98 Admissions Committee, Chair Panel 1, Executive Board Member
1993-95 Committee on Curriculum and Educational Policy
1994-95 Co-Chair, CCEP ad hoc subcommittee to evaluate block teaching system for first and second
year curriculum
1994,95 Ad Hoc Committee for selection of Kaiser Teaching Awards
1994-current Ad Hoc Committees for promotions, chair of review committees
1996, 2004 Ad Hoc faculty conduct review investigations
1996-02 Faculty Council, two terms, elected member for Academic Senate
2000-2 Chair of Faculty Council and Faculty
1996-00 Surgical Case & Hospital Mortality Review Committee, Chair, 1998, 1999, 2000
1997 UC-Stanford Health Care Strategic Support Team Committee
1998 Elected member of Physicians’ Organization Board, 1998 (2 year term) for UC-Stanford Health
Care System
1998 Chair, Quality and Risk Committee, UC-Stanford Health Care System
1998-00 Chair, Academic Standards Committee, continued as member through 2002
1998 Chair, search committee for Associate Director of Graduate Medical Education
2000-03 Advisor, UCSF School of Medicine post baccalaureate program
2004-5 Search Committee, Dept of Medicine
2000-2006 Governing Board member, Continuing Medical Education
2000-present Operating room committee member
2005 Ad hoc committee, harassment review, School of Medicine
2006 Committee member for Stewardship review
DEPARTMENT OF PATHOLOGY SERVICE

1980-91 Resident Selection Committee, Director, 1984-89
1981-now Resident Evaluation Committee, Director, 1984-89
1981-84 Harassment Committee
1981-now Surgical Pathology Diagnostic Service, includes consults, on-service scheduling
1981-91 Anatomic Pathology Policies and Procedures Committee
1982-89 Cytology Diagnostic Service
1982-84 Search Committees, faculty positions
1984-89 Director of Residency in Anatomic Pathology, including Resident teaching program,
selection, and evaluations
1984-95 Supervisor of Pathology clerkship for 3rd and 4th yr students
1987-now Quality Assurance Committee, Pathology Director,'87-89
1990-now Search Committees, faculty positions
1989-2000 Director, Post-Sophomore Fellowship, including selection, program planning, and
evaluations
1987-now Co-Chair and Chair, Current Issues in Anatomic Pathology, CME Course
1989-91, Coordinator of Henry Moon Lectureship
2001, 03, 05
1990-92 Computer Teaching Committee
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Linda Ferrell, MD
1996-now Promotions committee

1998-now Search committees, Chair of Anatomic Pathology search committees for faculty clinical
positions
1998-99 Acting Director of Surgical Pathology
1998-now Resident Selection Committee
1999-2005 Director of Anatomic Pathology Histology and Immunohistochemistry Laboratories
1999-now Vice Chair of Clinical Affairs, includes duties of Director of Surgical Pathology, Director
of Surgical Pathology Fellowship, and Site-Director for Residency at Moffitt Hospital.
2005-now Director of Gastrointestinal/Liver Pathology Fellowship
2005-now Director of Transplant Pathology Fellowship
PUBLIC SERVICE
1984-90 Beideman Area Neighborhood Group
1986-90 Trained visiting community pathologists in fine needle aspiration cytology
1986-00 Expert Witness, GI, Liver, and General Pathology cases
1987 Trained Fresno pathologist on interpretation of pediatric GI biopsies, 1-day session
1987, 89 Board of Directors, Divisadero Heights Homeowner's Association; President, 1987
1988-89 National Foundation, Ileitis and Colitis, Symposium for Inflammatory Bowel Disease, Co-
Chair for course.
1990-99 Science and Health Educational Partnership Program, advise student participants on use of
pathology specimens, help in collection of specimens for the program, gave talk on careers in
medicine at Lowell High School (12/91), give occasional tours of pathology to grade school
and high school students
1992-99 Train visiting pathologists in liver transplant diagnosis, one 1-2 day sessions to one week
sessions, 2-3 times per year.
1994 Supervised visiting attending pathologist from Hong Kong in liver pathology, 3 months
1995 – now Ad hoc teaching of visiting residents, other faculty from other academic institutions in liver
pathology, 2wk to 1 month durations, approx one per year.
SUMMARY OF SERVICE ACTIVITIES
Professional Organizations: I currently serve on the Editorial Board for the Americal Journal of
Surgical Pathology and Human Pathology. I am also actively involved in several professional
organizations to a significant degree. My primary duties include service to the United States and
Canadian Academy of Pathology (USCAP), California Society of Pathologists (CSP), Association of
Directors of Anatomic and Surgical Pathology (ADASP), and Hans Popper Hepatopathology Society.
USCAP: I have served on the Educational committee, been elected and served as Council member, and
selected as one of the few members of the Nominating committee. I have also been extensively involved
in teaching for this group, as described below in the teaching narrative. CSP: I still have the key role in
the planning of their annual symposium as Chair of the Educational Committee. Since this course
supplies a large portion of the funding for the organization, the success of the course is a key element to
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Linda Ferrell, MD
the survival of the society. Hans Popper Society: I am just beginning my term as Vice-President (2
years), followed by the Presidency (2 years). ADASP: I currently am in a second term on the Executive
Council. We deal with both academic and practice-related problems for academic anatomic and surgical
pathology programs including billing/coding compliance, quality improvement issues, residency training,
faculty mentoring, subspecialty training, etc, as well as plan an annual seminar for members on topics
related to these issues.
School of Medicine: My major roles in service to the School of Medicine and the UCSF Hospital and
Clinics include Medical School Admissions Committee (10 years total) with service on the Executive
Board for 6 years, Faculty Council for 8 years, with 2 years as Chair of the Faculty, Chair of the Surgical
Case & Hospital Mortality Review Committee for 3 years, Director of the Medical School Pathology
Course in the old curriculum for 6 years, and Chair of the Academic Standards Board for 2 years.
Departmental Service: As Vice Chair, I am responsible for most of the clinical faculty searches,
recruitment, and hiring; coordination of the clinical services with advisory and supervisory roles over the
Directors of Cytology, Autopsy, and Neuropathology services as well as the Program Director for the
Anatomic Pathology Residency. I also interview and participate in the final selection all residency
applicants. I participate in and advise the Chair on most decisions regarding departmental policy and
planning. I also coordinated the relocation of residents and surgical pathology services during the recent
remodel of the new residency room and surgical pathology cutting room; supervised and coordinated all
activities of our clinical services at Moffitt during the remodels; and assisted the project manager in
completion plans and move into the new facilities. This remodel was complex and has accounted for
about 15% additional workload during that time period. I also served as major advisor on the
administration move to Mt Zion and neuropathology faculty move to 5th floor Moffitt. I also have
chaired and directed our departmental CME course (Current Issues in Anatomic Pathology) for 19 years.
My duties as Director of Surgical Pathology are noted above in the Summary of Clinical Activities.
As Director of the Surgical Pathology fellowship, I also supervise 7 senior residents each year in their
clinical duties as they function in major roles in surgical pathology services, including the vital functions
of gross room supervisor, hot seat preliminary diagnoses, kidney/transplant service, consultation services.
As the Director of the Gastrointestinal Pathology fellowship and Liver Pathology transplant fellowship, I
also supervise two other fellows on both clinical duties and clinical research projects. (See teaching
summary below for other related fellowship activities.)
Public Service: Due to my recognition as a liver pathology expert, I get numerous requests from
academic and private practice physicians to come to UCSF for informal training in liver and GI pathology
under my supervision. Because of severe space limitations, I must limit this opportunity to 2-3 visitors
for a total of approximately 4-6 weeks per year, with a few exceptions for a rare visitor for a longer 3
month visit. I try to accommodate junior faculty from other academic institutions preferentially.
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TEACHING and MENTORING

FORMAL SCHEDULED CLASSES FOR UCSF STUDENTS (since last promotion)
Quarter Course No. & Title Teaching Contribution Units Class Size
Fall, IDS 106; Medicine, Lab leader for half of block 10 Class size: 40 in
2002-05, Metabolism/Nutrition Block for New and 1-hr lecture lab; 140 in lecture
Winter 06 Curriculum
POSTGRADUATE AND OTHER COURSES
Dates Course Teaching Contribution

2002-05 Pathology residency teaching series Lecturer (7 lectures per year)
2002-06 Current Issues in Anatomic Pathology Course chair and lecturer
UCSF/Stanford CME course
2002-07 California Society of Pathologists Annual Course chair
Symposium
2002-06 US and Canadian Academy of Pathology Short course, 4 years
Faculty at Diagnostic Pathology course, 5 years
Chair to organize long course for 2006
Short course for weekends in pathology, 2006
PREDOCTORAL STUDENTS SUPERVISED OR MENTORED
Post Sophomore Fellowship--1-year work-study experience. This fellowship provides medical students
the opportunity to extend their knowledge of pathology in a working fellowship, while offering them the
opportunity to engage in research and independent study in Anatomic Pathology or Laboratory Medicine.
Academic Year Name Medical School Current Position

1988-89 Ernest Rector Class of 1991, UCSF Urology
1989-90 Kenneth Aldape Class of 1991, UCSF Neuropathology, M.D. Anderson faculty
Joan Etzell Class of 1992, UCSF Assoc Prof, Dept of Laboratory
Medicine, UCSF
Steven Long Class of 1992, UCSF Private practice, Sacramento, CA
1990-91 Arun Amar Class of 1993, UCSF Assistant Professor, Neurosurgery, Yale
Russell Bowler Class of 1993, UCSF Internal Medicine
Phillip Febbo Class of 1993, UCSF Hematology, Harvard
1991-92 Gabor Hertz Class of 1993, UCLA Private practice, CA
Kirk Jones Class of 1994, UCSF Faculty, Pathology, UCSF
Connie Teresi Class of 1994, UCSF
1992-93 Sherie Cohen Class of 1995, UCSF
Jennifer Siegel Class of 1994, UCSF Family practice
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Linda Ferrell, MD
Judy Tjoe Class of 1995, UCSF Surgery

1993-94 Timothy Kuo Class of 1995, UCSF Ears, Nose, and Throat Surgery
Jeffrey Roberts Class of 1995, UCSF Pathology, private practice
Akiko Tsuzuki Class of 1996, UCSF
Matthew Wise Class of 1996, UCSF
1994-95 Keren Ziv Class of 1997, UCSF
Theresa Burton Class of 1996, U of
MN
Maile Guerrero Class of 1996, UCSF Pathology, private practice
Shane Meehan Class of 1996, Pathology
Dartmouth
1995-96 Phillip Holsten Class of 1998, UCSF Deceased
James Hsu Class of 1997, UCSF
Stephanie Phan Class of 1997, UCSF
Hannah Vargas Class of 1997, U of VT Ears, Nose and Throat Surgery
1996-97 Bong Koh Class of 1999, UCSF Left medicine
Diego Ruiz Class of 1999, UCSF Radiology, UCSF
JenniferWu Class of 1999, UCSF Gynecology
1997-98 Teodoro Nissan Class of 2000, UCSF Orthopedic Surgery, UCSF
Blanca Ochoa Class of 2000, UCSF Family Practice
Kimberly Workman Class of 2000, UCSF Orthopedic Surgery, UCSF
1998-99 Patrick Bolton Class of 2001, UCSF
Phillip Cole Class of 2001, UCSF Pathology residency
Laura Coulson Class of 2000, UCSF
1999-2000 Kwame Denianke Class of 2001, UCSF Dermatology, NY
Rebecca Swain Class of 2002, UCSF Pathology residency, UCSF
Additional UCSF Medical Student Mentoring
Senior Year of Medical School Name

2000-04 Phillip Cole
2002-03 Maggie Lam
2003-04 John Cupp
2003-04 Lily Pang
2004-05 Scott Young
2004-05 Anne Huang
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Linda Ferrell, MD
POSTDOCTORAL FELLOW AND RESIDENTS
Surgical Pathology Fellowship—1-year fellowship in general surgical pathology for AP or AP/CP

residents to receive focused and intensive training in diagnostic surgical pathology. I have been the
Director of the fellowship from 1999-present.
Dates Name Current Position

1999-2000 James Bainton, MD Private practice, S. San Francisco, CA
Brad Butler, MD Private practice and forensics, Atlanta, GA
Russell Nash, MD Assistant Professor, University of Colorado
Thad Mully, MD Assistant Professor, New York
Ron Balassanian, MD Assistant Professor, Pittsburgh, PA
Nicole Mihok, MD Private practice, New England
2000-01 Allison Loudermilk, MD Private practice, Oregon
Kedar “Che” Prasad, MD Private practice, Marin General Hospital
Jody Burkes, MD Private practice, East Bay
Kelly Arthur, MD Private practice forensic pathology-Sonoma and
Marin County
Rick Baehner, MD Assistant Professor, UCSF
Phillip Chen, MD Private practice, CA
2001-02 Ron Rowberry, MD Private practice, Sacramento, CA
Amy Heerema, MD Assistant Professor, University of Arkansas
Jessie Xiong, MD Private practice, Fremont, CA
Lorelle Carlley, MD Private practice, East Bay
Joe Rabban, MD Assistant Professor, UCSF
Jeff Simko, MD Assistant Professor, UCSF
2002-03 Nader Shihabi, MD Private practice, East Bay
Andrew Horvai, MD Assistant Professor, UCSF
Ellen Moffat, MD Coroner’s Office, San Francisco, CA
Carol Trujillo, MD Private practice, Colorado
Shantala Bindu, MD Private practice
Ana Quiroga, MD Clinical Instructor, UCSF through 2005
Shannon Mulholland, MD Private practice, St. Mary’s, San Francisco, CA
2003-04 Emily Howard, MD Fellowship, Boston, MA
Ken Schneider, MD Private practice, East Bay
Andrew Szmit, MD Private practice, Monterey, CA
William McDonald, MD Private practice, MN
Lamia Shagrun, MD Clinical Instructor, UCSF
George Yang, MD Private Practice, CA
2004-05 Dawn Darbonne, MD Laboratory Medicine Resident
J. P. Grenert, MD Assistant Professor UCSF
Mathew Greenberg, MD Current Cytopathology Fellow
Sally Agersborg, MD Private practice, CA
Merrill Hines, MD Forensic pathology fellowship
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Linda Ferrell, MD
Amit Lamba, MD Private practice, CA

2005-6 Walden Browne, MD Current GI/Liver Pathology Fellow
Ann Buckley, MD Current Neuropathology Fellow
Nicholas Byrne, MD Current Clinical Pathology Resident
Joaquin Garcia, MD Oncology Fellow, Sloan Kettering, NY
Karuna Garg, MD Current Clinical Pathology Resident
Rebecca Spies-Swain, MD Current Clinical Pathology Resident
Dean Joelson, MD Private Practice, Atlanta, GA
Vivian Tan, MD Current Transplant Fellow
Annoel Yabes, MD Current Surgical Pathology Fellow
2006-7 Judy Doyle, MD Current Surgical Pathology Fellow
Elizabeth Hosfield, MD Current Surgical Pathology Fellow
Lorren Jackson, MD Current Surgical Pathology Fellow
Judy Pang, MD Current Surgical Pathology Fellow
Jennifer Raffel, MD Current Surgical Pathology Fellow
Annemieke Van Zante, MD Current Surgical Pathology Fellow
Tony Yang, MD Current Surgical Pathology Fellow
INFORMAL TEACHING
Quarter Academic Year Course

F, W, S, Su 1988-present Pediatric GI Pathology Conference, every week through 03, about
2x/mon currently
Su, F, W 1991-present Gross unknown sessions (1-2 per year) with pathology residents
Su, F, W, S 1996-03 Lectures to Pediatric GI staff and fellows on GI and Liver pathology,
approx. 3-4 hours per year
F, W, S 2002-present Tutorial slide sessions for medical students (1-hr session every 2-3
months
F, W, S, Su 2003-present Liver transplant service clinical case review (1 hr. every other week)
F, W, S, Su 1984-present Surgical pathology diagnosis and sign-out: Discuss cases with
students, residents, clinicians, especially GI cases (Daily)
F, W, S, Su 1994-present Discuss cases with visiting fellows or pathologists interested in liver
or liver transplant pathology (4-6 weeks per year)
S, Su 2006 Liver Pathology/Hepatology case discussion conference, 1/month
FACULTY MENTORING
As one of the senior faculty in our department, I have for many years acted in a role as an informal
advisor to younger faculty members to advise them on various academic activities, promotion
requirements, and career decisions. In more recent years, I have continued to mentor these faculty
members more regularly in my role as Vice Chair. This expanded role includes introducing young faculty
to prominent pathologists with similar clinical research interests and setting up the opportunity for them to
train with those individuals in order to establish a mentor for them in their subspecialty field outside of
17
Linda Ferrell, MD
UCSF. I have devoted more time for junior faculty (Jones, Chen, Simko, Horvai, Baehner) who did not
have the opportunity to do a subspecialty fellowships outside of UCSF.
FACULTY MENTORED
Dates Name Mentoring Role Current Position

1994-present Imok Cha, MD Career, personal, and clinical Assistant Professor, UCSF
research advisor
1992-present Henry Sanchez, MD, PhD Career, personal advisor Assistant Professor, UCSF
1999-present Kirk Jones, MD Career, personal, and clinical Associate Professor, UCSF
research advisor
2000-present Yunn-Yi Chen, MD, PhD Career, personal, and clinical Associate Professor, UCSF
research advisor
2000-present Grace Kim, MD Career, personal, and clinical Associate Professor, UCSF
research advisor
2001-present Laura Tabatabai, MD Career and clinical research Assistant Professor, UCSF
advisor
2002-present Sanjay Kakar, MD Career, personal, and clinical Assistant Professor, UCSF
research advisor
2002-present Jeff Simko, MD, PhD Career, personal, and clinical Assistant Professor, UCSF
research advisor
2003-present Rick Baehner, MD Career and personal advisor Assistant Professor, UCSF
2003-present Andrew Horvai, MD, PhD Career and clinical research Assistant Professor, UCSF
advisor
2004-present J. Rabban, MD Career advisor Assistant Professor, UCSF
2004-2005 Eric Nakakura, MD Career advisor and support Assistant Professor, UCSF
OTHER VISITING FACULTY SUPERVISED/Mentored
1994 Polly Lam, Queen Elizabeth Hospital, Hong Kong (3 months)

1995 Shari Taylor, University of Tennessee Health Science Center, Memphis, TN (1 month)
2003 Laura Davico Bonino, University of Torino, Turin, Italy (3 months)
2005 Matthew Yeh, University of Washington, Seattle, WA (2 wk)
TEACHING AIDS
Surgical Pathology Procedure Manual: For resident teaching at UCSF hospitals: Compiled, organized, edited
entire manual with annual revisions as required. 1983-91; 1999-2005. In 2006, the Associate Director of
Surgical Pathology took over the primary review of the manual under my supervision.
Liver Syllabus for new curriculum, Metabolic section, 2nd year medical students. 2002 - now
Numerous class handouts for Path 101 and 102. 1981-2001
Multiple syllabi for CME courses and invited lectures—handouts on liver and GI Pathology
18
Linda Ferrell, MD
Diagnostic Problems in Liver Pathology, a monograph for the California Society of Pathologists (Editor)
Upcoming edition of MacSween’s Pathology of the Liver 5E (Co-editor)
Numerous chapters in major Pathology textbooks
OTHER
I have been asked to do a variety of guest lectureships locally, nationally, and internationally. Most of
these required considerable effort in the preparation of the lecture and syllabus material and some also
required the selection and preparation of pathology cases and materials for the attendees to review prior to
the lecture.
Continuing Medical Education Governing Board: As a member of the UCSF CME Governing Board, I
advise and vote on policy and also serve on one of the subcommittees that review all CME applications
for accreditation. I also have assisted in the ACCME review by meeting with national inspectors, assisted
in trials of new online programs, and interviewed job applicants for the CME office.
Other Creative/Teaching activities:
I designed and for many years served as the director of a year-long fellowship (post-sophomore fellowship)
for medical students in the department of pathology which the student elects to do either after the second or
third year of medical school. The program consists of a combination of service, teaching, and research
activities for the students, and has been highly successful. This has been an exciting program for our
department as it allows students to have an in-depth experience with our department, which becomes a
home-base for them in their future endeavors. All participants to date have found this program to be
invaluable in advancing their knowledge base and improving their ability to function in their future roles in
the clinical clerkships. We hope to continue this program as long as the department can fund the positions.
Dr Henry Sanchez is currently in charge of this program, and I continue to advise him and monitor the
program. Other universities such as Stanford have recently used our program as a model to set up their own
program in response to the fact that Stanford medical students were coming to UCSF to do our fellowship.
TEACHING AWARDS AND NOMINATIONS
1983 Academic Senate Distinguished Teaching Award

1984 Nominated for Kaiser Teaching Award
1986 Nominated for "Excellent Small Group Teacher," MSII
1987 Kaiser Award for Excellence in Teaching, UCSF
1987 Distinction in Teaching, Excellent Small Group Instruction, MSII
1987 Distinction in Teaching, Pathology Residents
1987 Nominated for MSII "Major Contribution to Teaching" and "Stimulating Lectures"
1988 Nominated for MSII "Excellence in Small Group Instruction"
1989 Nominated for MSII "Excellence in Small Group Instruction" and "Stimulating Lecture Series"
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Linda Ferrell, MD
1990 Nominated for MSII "Major Contribution in Teaching" and "Excellence in Laboratory
Instruction"
1990 Nominated for MSI "Excellent Small Group Instructor"
1991 Distinction in Teaching "Major contribution to Teaching", MSII
1991 Nominated for MSII "A Stimulating Lecture Series", "An Outstanding Lecture", and
"Excellence in Small/Lab Instruction"
1992 MSIV Teaching Excellence
1993 Nominated for Kaiser Teaching Award
1995 Nominated for MSIV Teaching Award
SUMMARY OF TEACHING HOURS
2003-4 1,065 total hours of teaching (including preparation)

Formal class or course teaching hours at UCSF: 40
Informal teaching hours at UCSF: 750
Mentoring hours: 75+
Other CME courses: 200 hours (includes course organization for two major courses)
2004-5 Same as above
2005-6 Estimate same as above
TEACHING NARRATIVE
Student Teaching: My major teaching load in the past was in the Pathology 101-103 course (Sept through
May) for second year medical students as Course Director from 1989-1996. After 1996, I acted as advisor to
the course director and lieutenants, and was the section head of the GI/Liver portion of the Path 102 course.
In the new curriculum, I have served as the lab leader for the GI/endocrine section of the Metabolism block
and I give one lecture on Liver pathology. I also give 3-4 tutorials a year on liver pathology to medical
students rotating through pathology during their 3rd and 4th years, and teach these students as well as the
post-sophomore fellows (students doing an entire year in pathology between their second and third year of
medical school) on a one-on-one basis.
Residents/Fellows: I currently give seven lectures/year to pathology residents, as well as numerous sessions
on consultation slide material. I also give a case review conference for the pediatric GI service residents and
attendings about 2 times per month. I also teach residents and fellows in pathology on an individual basis
when I am on service while diagnosing cases (including consultations), working with them on techniques of
cutting, differential diagnosis, and criteria for diagnosis on their surgical pathology rotations.
UCSF courses: I serve as chair/co-chair for an annual departmental three-day course, "Current Issues in
Anatomic Pathology", and lecture on topics in this course nearly every year. This course has been well
received by the pathologists who attended each year and has grown in size from about 100 to over 250 since
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Linda Ferrell, MD
1987. At the time of the merger with Stanford, we invited their faculty to join us, and we currently maintain
this course as a joint UCSF/Stanford course. The organization of this successful course has been a
significant contribution to our department’s national reputation in surgical pathology in my opinion.
California Society of Pathologists: I have served on the educational committee for the California Society of
Pathologists since 1991, co-chair from 1997-1998, and have chaired this committee from 1999 through
2005. In 2006, I will co-chair the committee with another pathologist who will take over the chair in 2007.
This committee organizes the yearly symposium for the society that is attended by pathologists from across
the USA (more than 50% out of state attendees). This society meeting attracts more and more pathologists
each year as its reputation for excellence spreads, with current attendance around 400, which is one of the
largest state society meetings in the USA. I currently have the key role as chair to contact high quality
speakers, organize the topics for the symposium, and direct the activities during the course.
National/International Societies
US and Canadian Academy of Pathology (USCAP): This society is the largest and most respected academic
surgical pathology society in the world, and so the annual meeting routinely attracts an international
audience. I served on the Educational Committee for 4 years. I gave a half-day course from 1995-9, and
then shared another half-day course on liver tumors at the annual scientific meeting, which was presented for
4 consecutive years (through 2006). I have also lectured for 4 years at the Liver Specialty Conference, and I
organized this conference for three years (98-2000). I was also asked to lecture for 8 years in this Society’s
smaller summer course, "Diagnostic Pathology" from 1991-1993 and 2000-2004. I also co-organized the
long course for the 2006 meeting that typically has an attendance of 800-1,000 pathologists. This is a day-
long course with an organ system focus. I was selected by the Educational Committee to select my cochair
and organize this course on the subject of liver and pancreas. I now serve as a guest editor to have the
course content published in the journal Modern Pathology.
International Academy of Pathology: The USCAP is the largest division of this society. I have served as
course organizer at two IAP Congresses (1998, 2006), which are held every other year at sites around the
world.
Hans Popper Hepatopathology Society: As President, I will be responsible for 2 half-day CME courses on
liver pathology that will be presented as a companion meeting to the USCAP meeting in 2008 and 2009.
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Linda Ferrell, MD
RESEARCH AND CREATIVE ACTIVITIES

RESEARCH AWARDS AND GRANTS
CURRENT
1. U01 DK61738 (Bass) 4/1/02-03/31/07 5%

NIH NIDDK $286,140
Clinical Research Network in NASH
The major goals of this project are to establish a large Clinical Center patient database capturing the
spectrum of NAFLD/NASH and to explore the hypothesis that familial/genetic factors contribute to
the pathogenesis of NASH and its natural history
Role: Review as onsite pathologist at UCSF all liver biopsies to record histologic features, help
evaluate the features of steatohepatitis and any other features of fatty liver that may lead to
fibrosis.
2. P01 DE13904 (Kramer, R.) 6/1/2001 – 5/31/2006 2%

NIH/NIDR $762,687
Adhesion and Proliferation in Oral Cancer Progression [$4,099,905]
Core C: Tissue Bank and Pathology Core (Regezi, J.)
Research into the molecular mechanism for tumor progression
The major purpose is to define the alternations that occur during conversion of normal mucosa to oral
dysplasia, and finally to invasive squamous cell carcinoma. Project 3 will define the importance of
specific cell adhesion systems in regulating survival, apoptosis and growth in normal and malignant
oral keratinocytes. Interactive research and feasibility projects will be supported by an Administrative
Core and a Cell and Animal Model Core.
Role: To serve as the coordinator for the tissue core for collection of tissues from surgical
pathology samples.
3. U01 DK60346 (Terrault) 7/1/01 - 6/30/06 5%

NIH NIDDK $151,034
Resistance of Antiviral Therapy in Chronic Hepatitis C
The main goals of this project are to accurately define the sustained response rates with optimal anti-
viral therapy in African-Americans and provide important insights into the factors underlying
differences in response compared to non-Hispanic whites.
Role: To serve as the on site pathologist at UCSF to evaluate the liver biopsies and record
histologic findings for the database, assist in interpretation of these changes.
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Linda Ferrell, MD
4. M01 RR00079 (PI: Debas) 9/1/03 - 8/31/04 1%

UCSF, GCRE-CreFF (Project Leader: Tien)
NIH
Title: Quantification of hepatic steatosis using magnetic resonance imaging and magnetic resonance
spectroscopy compared to liver biopsy in HCV/HIV coinfected women: a pilot study
Goals: demonstrate the feasibility of using state of the art magnetic resonance imaging (MRI) and
magnetic resonance spectroscopy (MRS) to quantify hepatic steatosis.
Role: To serve as the on site pathologist at UCSF to evaluate the liver biopsies for fatty change
and other findings of possible HCV or HIV, record histologic findings, assist in interpretation of
these changes.
5. U01 AI52748 (PI: Stock, P.) 8/15/03 - 1/31/08 5%

NIH/NIAID $3,768,206
Title: Solid organ transplantation in HIV: Multi-site studies
Goals: to evaluate the safety and efficacy of solid organ transplantation in HIV disease by conducting
a prospective, multi-center cohort of HIV- positive patients.
Role: To serve as the on site and overall central-site pathologist to evaluate the liver biopsies for
findings of rejections, possible HCV, drug reactions, and record histologic findings, assist in
interpretation of these changes.
PENDING:
PI: Qayyum, A
Non-invasive evaluation of non-alcoholic fatty liver disease: Role of MR imaging and spectroscopy.
I will assist in evaluating the liver biopsies.
PAST: Data not available for new format CV
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Linda Ferrell, MD
PEER REVIEWED PUBLICATIONS
1. Lusby RJ, Woodcock JP, Machleder HI, Ferrell LD, Heans W, Skidmore R, Stedden J, Baird RN.
Transient ischemic attack: The static and dynamic morphology of the carotid artery bifurcation. Brit
J Surg, 69(suppl):41-44, 1982.
2. Lusby RJ, Ferrell LD, Stoney RJ, Ehrenfeld WK, Wylie EJ. Carotid artery atheroma: The importance
of intraplaque hemorrhage. Arch Surg, 117:1479-1487, 1982.
3. Lusby RJ, Ferrell LD, Englestad BL, Price DC, Lipton MS, Stoney RJ. Vessel wall and Indium III
labelled platelet response to carotid endarterectomy. Surgery, 93:424-432, 1983.
4. Richardson BC, Chafetz NI, Ferrell LD, Zulman JI, Genant HK. Hereditary chondrocalcinosis
(CPPD) in a Mexican-American family. Arth & Rheum, 26:1387-1396, 1983.
5. Rielly LM, Lusby RJ, Jeffrey RB, Hughes L, Ferrell DL, Stoney RJ, Ehrenfeld WK. Carotid plaque
histology using real-time ultrasound: Clinical and therapeutic implications. Am J Surg, 146:188-193,
1983.
6. Ferrell LD. Myospherulosis of the breast: Diagnosis by fine needle aspiration. Acta Cytol, 28:726-
728, 1984.
7. Bottles K, Miller TR, Ferrell LD. Tyrosine crystals in fine needle aspirates of a pleomorphic adenoma
of the parotid gland. Acta Cytol, 28:490-492, 1984.
8. Clawson GA, Moody DE, Ferrell LD, Smuckler EA. Increased nucleoside triphosphatase activity of
rat liver nuclear envelope is associated with hepatocarcinogen exposure. Lab Invest, 51:682-689,
1984.
9. Fassoulaki A, Eger EI, Johnson BH, Ferrell LD, Smuckler EA, Cahalan MK, Eger RR, Harper MH.
Isofluorane does not prevent hepatic injury produced by halothane in rats. Anesth Analg, 63:888-890,
1984.
10. Fassoulaki A, Eger EI, Johnson BH, Ferrell LD, Smuckler EA, Harper MH, Eger RR, Cahalan MK.
Brief periods of hypoxia can produce hepatic injury in rats. Anesth Analg, 63:885-887, 1984.
11. Fassoulaki A, Eger E, Johnson BM, Ferrell L, Smuckler E, Harper M, Eger R, Cahalan M. Nitrous
oxide is hepatotoxic in rats. Anesth Analg, 63:1076-1080, 1984.
12. Hohn D, Melnick J, Stagg R, Altman D, Friedman W, Ignoffo R, Ferrell L, Lerois B. Biliary sclerosis
in patients receiving hepatic arterial infusions of floxuridine. J Clin Oncol, 3.98-102, 1985.
13. Niederau C, Ferrell LD, Grendell JG. Caerulein-induced acute necrotizing pancreatitis in mice:
Protective effects of proglumide, benzotript, and secretin. Gastroenterology, 88:1192-1204, 1985.
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Linda Ferrell, MD
14. Quarfordt PG, Reilly L, Ferrell LD, Lusby R, Stony RS. Prostacyclin [PGI2] production in regions of
arterial stenosis. Surgery, 98:484-490, 1985.
15. Onik G, Gilbert J, Hoddick W, Ferrell L. Ultrasonic monitoring of hepatic cryosurgery: Preliminary
results in animal model. Amer J Roentgenol, 144:1043-1047, 1985 (Winner of American Roentgen
Ray Award).
16. Fassoulaki A, Eger E, Johnson B, Ferrell L, Smuckler E, Calahan M, Eeger R, Harper M. Nitrous
oxide does not hinder the repair of injured liver in the rat. Anest Analg, 64:465-467, 1985.
17. Shea WJ, Jr, Demas BE, Goldberg HI, Hohn DC, Ferrell LD, Kerlan RK. Sclerosing cholangitis
associated with hepatic arterial FUDR chemotherapy: Radiographic-histologic correlation. Amer J
Roentgenol, 146:717-721, 1986.
18. Eger EI, Smuckler EA, Ferrell LD, Goldsmith CH, Johnson BH. Is enflurane hepatotoxic? Anesth
Analg, 65:21-30, 1986.
19. Forwell M, Gray KG, MacSween RNM, Peel MG, Madhok R, Forbes CD, harvey JA, Roberts J,
Ferrell LD, Sandilands GP. Immunosuppression following alloantigen exposure: A role for
lymphocyte Fc gamma-receptor blocking antibodies. J Clin Lab Immunol, 19:53-57, 1986.
20. Gilbert JC, Onik GM, Hoddick WK, Rubinsky B, Ferrell LD. Ultrasound monitored hepatic
cryosurgery: Longevity study on an animal model. Cryobiology, 23:277-285, 1986.
21. Niederau C, Fiddle RA, Ferrell LD, Grendell JH. Beneficial effects of CCK-receptor blockade and
inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. J
Clin Invest, 78:1056-1063, 1986.
22. Cohen MS, Beckstead JH, Ferrell LD, Yen TSB. Enzyme histochemistry of hepatic neoplasms. Am J
Surg Pathol, 10:789-794, 1986.
23. Itzkowitz SH, Yuan M, Ferrell LD, Palekar A, Kim YS. Cancer-associated alterations of blood group
antigen expression in human colorectal polyps. Cancer Res, 46:5976-5984, 1986.
24. Niederau C, Ferrell LD, Grendell JH. Experimentelle akute pankreatitis. Der Internist, 27:681-696,
1986.
25. Messina LM, Reilly LM, Goldstone J, Ehrenfeld WK, Ferrell LD, Stoney RJ. Middle aortic
syndrome. Effectiveness and durability of complex arterial revascularization techniques. Ann Surg,
204:331-339, 1986.
26. Wisner JR, Renner IG, Grendell JH, Niederau C, Ferrell LD. Gabexate mesilate (FOY) protects
against ceruletide-induced acute pancreatitis in the rat. Pancreas, 2:181-186, 1987.
27. Tsay D, Niederau C, Schmidt H, Goldberg H, Higgins CB, Ferrell LD, Grendell JH. Experimental
acute pancreatitis: In vitro magnetic resonance characteristics. Invest Radiol, 22:556-561, 1987.
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Linda Ferrell, MD
28. Heyman MB, Perman JA, Ferrell LD, Thaler MM. Chronic non-specific inflammatory bowel disease
of the cecum and proximal colon in children with grossly normal-appearing colonic mucosa:
Diagnosis by colonoscopic biopsies. Pediatrics, 80:255-261, 1987.
29. Strum DP, Eger EI, Johnson BH, Steffey EP, Ferrell LD. Toxicity of sevofluorane in rats: Effects of
hypoxia and degradation by soda lime. Anesth Analg, 66:769-773, 1987.
30. Davis JJ, Heyman MB, Ferrell L, Kerlin R, Thaler MM. Sclerosing cholangitis caused by chronic
cryptosporidiosis in a child with congenital immunodeficiency disorder. Am J Gastroenterol,
82:1196-1202, 1987.
31. Yuan M, Itzkowitz SH, Ferrell LD, Fukushi Y, Palekar A, Hakomori S, Kim, YS. Expression of Lex
and sialylated Lex antigens in human colorectal polyps. J Natl Cancer Inst, 78:479-488, 1987.
32. Itzkowitz SH, Yuan M, Ferrell LD, Ratcliffe RM, Chung Y-S, Satale K, Umeyama K, Jones RT, Kim
YS. Cancer-associated alterations of blood group antigen expression in the human pancreas. J Natl
Cancer Inst, 79:425-434, 1987.
33. Eger EI, Johnson BH, Strum DP, Ferrell LD. Studies of the toxicity of I-653, halothane, and
isoflurane in enzyme-induced hypoxic rats. Anesth Analg, 66:1227-1229, 1987.
34. Eger EI, Johnson BH, Ferrell LD. Toxicity of I-653 versus isoflurane in rats: A test of the effect of
repeated anesthesia and the use of dry soda lime. Anesth Analg, 66:1230-1233, 1987.
35. Hales MS, Ferrell LD. Fine-needle aspiration biopsy of tibial adamantinoma: A case report. Diagn
Cytol, 4:67-70. 1988.
36. Ferrell LD, Beckstead JH. Plastic-embedded endoscopic biopsies: Diagnostic advantages. Am J
Surg Pathol, 12:547-553, 1988.
37. Neiderau C, Crass RA, Silver G, Ferrell LD, Grendell JH. Therapeutic regimens in acute
experimental hemorrhagic pancreatitis: Effects of hydration, oxygenation, peritoneal lavage, and a
potent protease inhibitor. Gastroenterology, 95:1648-1657, 1988.
38. Wisner JR, Green DW, Ferrell LD, Renner IG. Evidence for a role of oxygen-derived free radicals in
the pathogenesis of ceruletide-induced acute pancreatitis in rats. Gut, 29:1516-23, 1988.
39. O'Kuhn SP, Connelly DP, Calakos N, Ferrell L, Man-Xiang P, Goldstone J. Does compliance
mismatch alone cause neointimal hyperplasia? J Vasc Surg, 9:35-44, 1989.
40. Ferrell LD, Beckstead JH. Plastic-embedding: Use of glycol methacrylate embedded biopsy material
at the light microscopic level. Path Ann, Part 1, 1990, pp 341-360.
41. Veereman-Wauters GV, Ferrell L, Heyman MB. Trends in Campylobacter pylori in pediatric and
adult antral biopsies: A five year retrospective analysis. West J Med, 151:406-409, 1989.
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Linda Ferrell, MD
42. Longaker M, Stevens M, Ferrell DL, Lewis F. Kaposi's sarcoma presenting as acute appendicitis.
Contemp Surg, 35:18-20, 1989.
43. Ferrell LD. Hepatic granulomas: A morphologic approach to diagnosis. Surg Pathol, 3:87-106,
1990.
44. Veereman-Wauters G, Ferrell L, Ostroff J, Heyman M. Hyperplastic gastric polyps associated with
persistent Helicobacter pylori infection and active gastritis: Report of two cases. Am J Gastroenterol,
85:1395-1397, 1990.
45. Niederau C, Lüthen R, Niederau M, Strohmeyer G, Ferrell L, Grendell J. Effects of long-term CCK
stimulation and CCK blockade on pancreatic and intestinal growth, morphology, and function.
Digestion, 46(suppl 2):217-225, 1990.
46. Niederau C, Niederau M, Lüthen R, Strohmeyer G, Ferrell LD, Grendell JH. Pancreatic exocrine
secretion in acute experimental pancreatitis. Gastroenterology, 99:1120-1127, 1990.
47. Perkocha L, Geaghan S, Yen TSB, Nishimura S, Chan S, Garcia-Kennedy R, Honda G, Stoloff A,
Goldman R, VanMeter S, Ferrell L, LeBoit P. Clinical and pathological features of bacillary peliosis
hepatis in association with human immunodeficiency virus infection. New Engl J Med, 323:1581-
1586, 1990.
48. Ferrell LD. Gastrointestinal pathology of AIDS. Sem Gastroenterol, 2:37-48,1991.
49. Lavine JE, Lake JR, Ascher NL, Ferrell LD, Ganem D, Wright TL. Persistent hepatitis B virus
following -inferferon therapy and liver transplantation. Gastroenterology, 100:263-267,1991.
50. Read A, Donegan E, Lake J, Ferrell L, Galbraith C, Kuramoto IK, Zeldis JB, Ascher NL, Roberts J,
Wright TL. Hepatitis C in patients undergoing liver transplantation: Short review of data. Transplant
Proc, 23(1 Pt 2):1504-4,1991.
51. Read A, Donegan E, Lake J, Ferrell LD, Galbraith C, Kuramoto BS, Zeldis JB, Ascher NL, Roberts J,
and Wright TL. Hepatitis C in liver transplant patients. Annals Int Med, 4:282-284,1991.
52. Seeger C, Baldwin B, Hornbuckle WH, Yeager A, Tennant BC, Cote P, Ferrell L, Ganem P, Varmus
HA. Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis
virus in a common host. J Virol, 65:1673-9,1991.
53. Stempel C, Lake J, Ferrell L, Tomlanovich S, Amend W, Salvatierra O, Vincenti F. Effect of

cyclosporine on the clinical course of HBsAg-positive renal transplant patients. Transplant Proc, 23(1
Pt 2): 1251-2,1991.
54. Niederau C, Ude K, Niederau M, Reinhard L, Strohmeyer G, Ferrell LD, Grendell JH. Effects of the
seleno-organic substance ebselen in two different models of acute pancreatitis. Pancreas, 6:282-290,
1991.
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Linda Ferrell, MD
55. Roberts J, Ascher N, Lake J, Capper J, Purohit S, Garovoy M, Ferrell LD, Wright T. Graft vs. host
disease following liver transplantation in humans: A report of four cases. Hepatology, 14:274-
281,1991.
56. Ferrell LD and Beckstead JB. Paneth-like Cells in an Adenoma and Adenocarcinoma Arising in the
Ampulla of Vater. A case report. Arch Path Lab Med, 115:956-958,1991.
57. Sterneck M, Weisner R, Ascher N, Roberts J, Ferrell L, Ludwig J, Lake J. Azathioprine

Hepatotoxicity following liver transplantation: A Report of two cases and review of the literature.
Hepatology, 14: 806-10. 1991.
58. LaBerge JM, Ferrell LD, Ring EJ, Gordon RL, Lake J. Histopathology of transjugular intrahepatic
portosystemic shunts. J Vasc Intervent Radiol, 2:549-556,1991.
59. Neuschwander-Tetri B, Ferrell LD, Sukhabote RJ, Grendell JH. Glutathione Monoethyl Ester
Ameliorates Caerulein-induced pancreatitis in the mouse. J Clin Invest, 89:109-116,1992.
60. Wright T, Mamish D, Combs C, Kim M, Donegan E, Ferrell L, Lake J, Roberts J, Ascher N.
Hepatitis B virus is a common cause of apparent fulminant NANB hepatitis. Lancet, 339:952-
955,1992.
61. Martinez OM, Krams SM, Sterneck M, Villanueva J, Ferrell L, Roberts JP, Ascher NL. Intragraft
cytokine profile during human liver allograft rejection. Transplantation, 53:449-456,1992.
62. Niederau C, Luthen R, Niederau MC, Grendell JH, Ferrell LD. Acute experimental hemorrhagic
pancreatitis induced by feeding a choline-deficient, ethionine-supplemented diet: Methodology and
Standards. Eur Surg Res, 24(suppl 1):40-54, 1992.
63. Duncan BW, Adzick NS, DeLorimier A, Longaker M, Ferrell L, Zoger S, Harrison M. Necrotizing
fasciitis in two children with acute lymphoblastic leukemia. J Ped Surg, 27:668-671,1992.
64. Sterneck M, Ferrell LD, Ascher N, Roberts J, Lake J. Mycobacterial infection after liver
transplantation: A report of three cases and review of the literature. Clin Transplant, 6:55-61, 1992.
65. Wright TL, Donegan E, Hsu H, Ferrell L, Lake JR, Read A, Kim M, Fennessy S, Combs C, Ascher
NL, Roberts JP, Greenberg H. Recurrent and acquired hepatitis C viral infection in liver transplant
recipients. Gastroenterology, 103:317-322,1992.
66. Niederau C, Luthen R, Niederau M Strohmeyer G, Ferrell LD, Grendell JH. The effects of a CCK-
receptor blockade on circulating concentrations of glucose, insulin, C-peptide, and pancreatic
polypeptide after various meals in healthy human volunteers. Pancreas,7:1-10, 1992.
67. Niederau C, Niederau M, Borchard F, Ude K, Luthen R, Strohmeyer G, Ferrell L. Grendell J. Effects
of antioxidants and free redical scavengers in three different models of acute pancreatitis. Pancreas,
7:486-496, 1992.
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Linda Ferrell, MD
68. Hartshorne N, Hartman G, Markin R, Demetris AJ, Ferrell LD. Bile duct hemorrhage: A sequelae of
cholangiography or other manipulation of the biliary tract. Liver, 12:137-139, 1992.
69. Ferrell L, Schmidt K, Sheffield V, Packman S. Neonatal hemochromatosis: Genetic counseling and
retrospective diagnosis. Am J Med Genet, 44:429-433, 1992.
70. Ferrell LD, Wright TL, Roberts J, Ascher N, Lake J. Hepatitis C viral infection in liver transplant
recipients. Hepatology, 16:865-876, 1992.
71. Ferrell L, Wright T, Lake J, Roberts J, and Ascher N. Incidence and diagnostic features of
macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers. Hepatology,
16:1372-1381, 1992.
72. Ferrell L, Bass N, Roberts J, Ascher N. Lipopeliosis in the transplanted liver: A fat-induced
sinusoidal dilatation that mimics peliosis hepatitis. J Clin Pathol, 45:1109-1110, 1992.
73. Liu T, Freise CE, Ferrell LD, Ascher NL, Roberts JP. A modified vascular "sleeve" anastomosis for
rearterialization in orthotopic liver transplantation in rats. Transplantation, 54:179-180, 1992.
74. LaBerge JM, Ring EJ, Lake JF, Ferrell LD, Doherty MM, Gordon RL, Roberts JP, Peltzer MY,
Ascher NL. Transjugular intrahepatic portosystemic shunts: Preliminary results in 25 patients. J Vasc
Surg, 16:258-267, 1992.
75. Martinez OM, Krams SM, Villanueva JC, Ferrell L, Lake J, Roberts JP, Ascher NL. Intragraft
eosinophilia and interleukin-5 mRNA accompany liver allograft rejection. Transplant Proc, 25 (1 pt
1):126-127, 1993.
76. Lake J, Wright T, Ferrell L, Donegan E, Roberts J, Ascher N. Hepatitis C and B in liver
transplantation. Transplant Proc, 25:2006-2009, 1993.
77. Ferrell L. Hepatocellular carcinoma arising in multilobular adenoma of the liver: A case report. Am J
Surg Pathol, 17:525-529,1993.
78. Martinez OM, Ascher NL, Ferrell L, Villanueva J, Lake J, Roberts JP, Krams SM. Evidence for a
nonclassical pathway of graft rejection involving interleukin 5 and eosinophils. Transplantation,
55:909-918, 1993.
79. Liu T, Freise CE, Osoria R, Ferrell L, Ascher NL, Roberts JP. A reliable technique for
rearterialization in orthotopic liver transplantation in rats. Transplantation, 55 (4):960-961, 1993.
80. Greeve M, Ferrell L, Kim M, Combs C, Roberts J, Ascher N, Wright T. Cirrhosis of undefined
pathogenesis: Absence of evidence for unknown viruses or autoimmune processes. Hepatology,
17:593-598, 1993.
29
Linda Ferrell, MD
81. Ferrell L, Crawford J, Dhillon P, Scheuer P, Nakanuma Y. Proposal for standardized criteria for the
diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver
disease. Amer J Surg Pathol, 17:1113-1123, 1993.
82. LaBerge J, Ferrell L, Ring E, Gordon R. Histopathology of TIPS stenoses and occlusions. J Vascular
and Interventional Radiol, 4:779-786, 1993.
83. Roberts J, Lake J, Hebert M, Nikolai B, Ascher N, Ferrell. Reversal of chronic rejection after
treatment failure with FK506 and RS61443. Transplantation, 56:1021-3, 1993.
84. Chazouilleres O, Mamish D, Kim M, Carey K, Ferrell L, Roberts J, Ascher N, Wright T. "Occult"
hepatitis B virus as a source of infection in liver transplant recipients. Lancet, 343:142-146, 1994.
85. Jacobson M, Hanks D, Ferrell L, Ernst J. Fatal acute hepatic necrosis due to fluconazole. Amer J
Med, 96:188-190, 1994.
86. Freise CE, Liu T, Hong K, Osoria R, Papahadjopoulos D, Ferrell, L, Ascher NL, Roberts JR. The
increased efficacy and decreased nephrotoxicity of a cyclosporine liposome. Transplantation,
57(6):928-932, 1994.
87. Cha I, Bass N, Ferrell LD. Lipopeliosis: A clinical-pathologic study of 5 cases. Amer J Surg Path,
18(8):789-795, 1994.
88. Gonsowski CT, Laster MJ, Eger EI, Ferrell LD. Toxicity of Compound A in rats: Effect of a 3-hour
administration. Anesthesiology, 80:556-565, 1994.
89. Gonsowski CT, Laster MJ, Eger EI, Ferrell LD. Toxicity of Compound A in rats: Effect of increasing
duration of administration. Anesthesiology, 80:566-573, 1994.
90. Luthen R, Tetri BA, Grendell JH, Ferrell LD, Niederau C. The effect of L-buthionine-[S,R]-
sulfoximine on the pancreas in mice: A model of weakening the glutathione-based defense
mechanisms. Int J Pancreatol, 16(1): 31-6, 1994.
91. Chazouilleres O, Kim M, Combs C. Ferrell L, P Bacchetti, Ascher N, Roberts J, Neuwald P, Wilber J,
Urdea M, Quan S, Sanchez-Pescador, Wright T. Quantitation of hepatitis C RNA in liver transplant
recipients. Gastroenterology, 106(4): 994-9, 1994.
92. Wright T, Combs C, Kim M, Ferrell L, Bacchetti P, Ascher N, Roberts J, Wilber J, Sheridan P, Urdea
M. Interferon alpha therapy for hepatitis C virus infection following liver transplantation.
Hepatology, 20(4 PT 1): 773-9, 1994.
93. Erler BS, Hsu L, Truong HM, Petrovic LM, Kim SS, Huh MH, Ferrell LD, Thung SN, Geller SA,
Marchevsky AM. Image analysis and diagnostic classification of hepatocellular carcinoma using
neural networks and multivariate discriminant functions. Laboratory Investigation, 71(3):446-51,
1994.
30
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94. Working Party for World Congresses of Gastroenterology. Terminology of chronic hepatitis, hepatic
allograft rejection, and nodular lesions of the liver: Summary of recommendations developed by an
international working party, supported by the World Congresses of Gastroenterology, Los Angeles,
1994. Amer J Gastroenterol 89:S177-181, 1994.
95. Olofsson P, Rabahie GN, Matsumoto K, Ehrenfeld WK, Ferrell LD, Goldstone J, Reilly LM, Stoney
RJ. Histopathological characteristics of explanted human prosthetic arterial grafts: implications for
the prevention and management of graft infection. European Journal of Vascular and Endovascular
Surgery, 9:143-51, 1995.
96. Niederau C, Brinsa R, Niederau M, Luthen R, Strohmeyer G, Ferrell LD. Effects of C1-esterase
inhibitor in three models of acute pancreatitis. International Journal of Pancreatology, 17:189-96,
1995.
97. Theise N, Fiel IM, Hytiroglou P, Ferrell L, Schwartz M, Miller C, Thung SN. Macroregenerative
nodules in cirrhosis are not associated with serum or stainable tissue alpha-fetoprotein. Liver, 15(1):
30-34, 1995.
98. Ferrell LD. Malignant liver lesions that mimic benign lesions. Seminars in Diagnostic Pathology,
12(1): 64-76, 1995.
99. Demetris AJ, Seaberg EC, Batts KP, Ferrell L, Ludwig J, Markin R, Belle S, Detre K. Reliability and
predictive value of the NIDDK liver transplant database nomenclature and grading system for cellular
rejection of liver allografts. Hepatology, 21(2):408-416, 1995.
100. International Working Party. Terminology of hepatic allograft rejection, Hepatology, 22:548-554,
1995.
101. Venook A, Ferrell L, Roberts J, Emond J, Frye J, Ring E, Ascher N, Lake J. Liver transplantation for
hepatocellular carcinoma: Results with preoperative chemoembolization. Liver Transplantation and
Surgery, 1:242-248, 1995.
102. International Working Party, Wanless IR, Chair. Terminology of nodular lesions of the liver.
Hepatology, 25:983-993, 1995.
103. Luthen R, Grendell JH, Ferrell LD, Niederau C. Energy metabolism in mouse pancreas in response to
different dosages of CCK-analog. Pancreas, 11:141-146, 1995.
104. Luthen R, Niederau C, Niederau M, Ferrell LD, Grendell JH. Influence of ductal pressure and
infusates on activity and subcellular distribution of lysosomal enzymes in the rat pancreas.
Gastroenterology, 109:573-81, 1995.
105. Freise C, Liu T, Osoria R, Ferrell L, Ascher N, Roberts J. Increased efficacy of CSA following
rearterialization in the rat OLTX model. J Surg Res, 59:493-496, 1995.
31
Linda Ferrell, MD
106. Yamanaka S, Balestra M, Ferrell L, Fan J, Arnold K, Taylor S, Taylor J, Innerarity T. Apolipoprotein
B mRNA editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
Proceedings of the National Academy of Sciences, 92:8483-7, 1995.
107. Ferrell L, Lee R, Brixko C, Bass N, Lake J, Roberts J, Ascher N, Rabkin J. Hepatic granulomas
following liver transplantation: Clinicopathologic features in 42 patients. Transplantation, 60:926-
933, 1995.
108. Niederau C, Niederau M. Klonowski H, Luthen R, Ferrell LD. Effect of hypergastrinemia and
blockade of gastrin-receptors on pancreatic growth in the mouse. Hepato-Gastroenterology, 42:423-
31, 1995.
109. Huang E, Wright T, Combs C, Lake J, Ferrell L. Hepatitis B and C coinfections and persistent
hepatitis B infections: clinical outcome and liver pathology after transplantation. Hepatology, 23:396-
404, 1996.
110. Terrault N, Holland C, Ferrell L, Lake J, Roberts J, Hahn J, Ascher N, Wright T. Interferon alpha for
recurrent hepatitis B infection following liver transplantation. Liver Transplantation and Surgery,
2:132-138, 1996.
111. Gournay J, Ferrell L, Roberts J, Ascher N, Wright T, Lake J. Cryoglobulinemia presenting after liver
transplantation. Gastroenterology, 110:265-70, 1996.
112. Lam P, Wachs M, Somberg K, Vincenti F, Ferrell L. Fibrosing cholestatic hepatitis in renal
transplant recipients. Transplantation, 61:378-381, 1996
113. Alam I, Ferrell L, Bass N. Vanishing bile duct syndrome temporally associated with Ibuprofen use.
Amer J Gastroenterol, 91:1626-1630, 1996.
114. Roberts JP, Liu T, Freise CE, Mielczarek J, Ferrell L, Randall H, Ascher NL. Liver transplantation
improves survival of rats bearing hepatoma-3924A. J Surg Research, 65: 59-62, 1996.
115. Kuang A, Renz J, Ferrell L, Ring E, Rosenthal P, Lin R, Roberts J, Ascher N, Emond J. Failure
patterns of cryopreserved vein grafts in liver transplantation. Transplantation, 62:742-47, 1996.
116. Vandewater J, Gerson L, Ferrell L, Lake J, Coppel R, Batts K, Weisner R, Gershwin, ME.
Immunohistochemical evidence of disease recurrence following liver transplantation for primary
biliary cirrhosis. Hepatology, 24:1079-1084, 1996.
117. Zhou S, Terrault N. Ferrell L, Hahn J, Lou J, Simmonds P, Roberts J, Lake J, Ascher N, Wright T.
Severity of disease in liver transplant recipients with hepatitis C virus infection: relationship to
genotype and level of viremia. Hepatology, 24:1041-1046, 1996.
118. Theise ND, Marcelin K, Boldfischer M, Hytiroglou P, Ferrell L, Thung SN. Low proliferative
activity in macroregenerative nodules: evidence for an alternate hypothesis concerning human
hepatocarcinogenesis. Liver, 16:134-9, 1996.
32
Linda Ferrell, MD
119. Sudilovsky O, Sun M, Eshleman J, Ferrell L, Jacobs G, Tuthill R. Preneoplastic lesions of the liver:
molecular pathology and other aspects. Proceedings of 1996 Shanghai International Conference of
Gastroenterology, Ed: Xiao S-D, pages a82-7, 1996.
120. Berenguer M, Terrault N, Piatak M, Yun A, Park-Kim J, Ferrell L, Hahn J, Lau J, Lake J, Roberts J,
Ascher N, Wright T. Hepatitis G infection in patients with hepatitis C virus infection undergoing
liver transplantation. Gastroenterology 111:1569-1575, 1996.
121. Yoshida EM, McLean CA, Cheng ES, Blanc PD, Somberg KA, Ferrell LD, Lake JR. Chinese herbal
medicine, fulminant hepatitis and liver transplantation. Am J Gastroenterol, (letter) 91:2647-8, 1996.
122. Emond JC, Renz JF, Ferrell LD, Rosenthal P, Lim RC, Roberts JP,
Lake J, Ascher NL. Functional analysis of grafts from living donors: Implications for the treatment
of older recipients. Ann Surg 224:544-52, 1996.
123. Terrault NA, Dailey PJ, Ferrell L, Collins MC, Wilber JC, Urdea MS, Bhandari NB, Wright TL.
Hepatitis C virus: quantitation and distribution in liver. J Med Virol, 51:217-23, 1997.
124. Alam I, Levenson S, Ferrell L, Bass N. Diffuse intrahepatic biliary strictures in sarcoidosis resembling
sclerosing cholangitis: Case report and review of the literature. Digestive Dis and Sciences, 42:1295-
1301, 1997.
125. Reiser M, Terrault N, Nelson DR, Mizokami M, Ferrell L, Lake J, Roberts J, Ascher N, Wright TL,
Johnson YNL. Antibody to the host cellular gene derived epitope GOR in liver transplant recipients
with hepatitis C virus infection. Transplantation, 63:609-612, 1997.
126. Le Quynh-Thu, Fu KK, Kroll S, Fitts L, Massullo V, Ferrell L, Kaplan M, Phillips T. Prognostic
factors in adult soft-tissue sarcomas of the head and neck. International Journal of Radiation
Oncology. Biology and Physics, 37: 975-984, 1997.
128. International Panel: Banff schema for grading liver allograft rejection: an international consensus
document. Hepatology, 25: 658-663, 1997.
129. Pessoa M, Terrault N, Ferrell L, Kim J, Kolberg J, Lake J, Roberts J, Ascher N, Wright T.
Cryptogenic liver disease: role of hepatitis G virus (HGV) infection before and after liver
transplantation. Hepatology, 25:1266-1270, 1997.
130. Rosenthal P, Emond J, Heyman M, Snyder J, Roberts J, Ascher N, Ferrell L. Pathologic changes in
yearly protocol liver biopsies from healthy pediatric liver recipients. Liver Transplantation and
Surgery, 3:559-562, 1997.
131. An C, Petrovic L, Reyter I, Tolmachoff T, Ferrell L, Thung S, Geller S, Marchevsky A. The

application of image analysis and neural network technology to the study of premalignant and
malignant liver lesions. Hepatology, 26:1224-31, 1997.
33
Linda Ferrell, MD
132. Willenbucher RF, Zelman SJ, Ferrell LD, Moore DH II, Waldman FM. Chromosomal alterations in
ulcerative colitis-related neoplastic progression. Gastroenterology 113:791-801, 1997.
molecular pathology and other aspects. Chin J Gastroenterol, 2:254-255, 1997.
134. Demetris AJ, Seaberg EC, Batts KP, Ferrell L, Lee RG, Markin R, Detre KM. Chronic liver allograft
rejection: a National Institute of Diabetes and Digestive and Kidney Diseases interinstitutional study
analyzing the reliability of current criteria and proposal of an expanded definition. Am J Surg Pathol,
22:28-39, 1998.
135. Taga S, Washington K, Terrault, Wright T, Somberg K, Ferrell L. Cholestatic hepatitis C in liver
allografts. Liver Transplantation and Surgery, 4:1-8, 1998.
136. Jones K, Ferrell LD. Liver transplant pathology, Seminars of Diagnostic Pathology 15:306-317,
1998.
137. Pessoa MG, Terrault NA, Ferrell LD, Detmer J, Kolberg J, Collins ML, Viele M, Lake J, Roberts JR,
Ascher NL, Wright TL. Hepatitis after liver transplantation: The role of known and unknown viruses.
Liver Transplantation and Surgery, 4:461-468, 1998.
138. Kita Y, Lake JR, Ferrell LD, Mori M, Roberts JP, Kakizoe S, Kiyosawa K, Tanaka E, Shiga J,
Takikawa H, Inoue Y, Ohtake T, Ohtomo K, Yotsuyanagi H, Oka T, Harihara Y, Takayama T,
Kubota K, Kawarasaki H, Hashikura Y, Kawasaki S, Ascher NL, Makuuchi M. Possible recurrence
of primary sclerosing cholangitis following living-related liver transplantation; report of a case.
Transplantation Proceedings, 30:3321-3323, 1998.
139. Ferrell LD. Dysplastic Hepatocellular Nodules. Annals of Contemporary Diagnostic Pathology, 1998,
2:24-29, 1998.
140. Freise CE, Ferrell L, Liu T, Ascher NL, Roberts JP. Effect of systemic cyclosporine on tumor
recurrence after liver transplantation in a model of hepatocellular carcinoma. Transplantation, 67:510-
513, 1999
141. Tsui WMS, Colombari R, Bonetti F, Portmann BC, Thung SN, Ferrell LD, Nakanuma Y, Snover DC,
Bioulac-Sage P. Hepatic angiomyolipoma: delineation of unusual morphological variants. Amer J
Surg Pathol, 23:34-48, 1999.
142. Patti MG, Arcerito M, Feo CV, Worth S, DePinto M, Gibbs VC, Gantert W, Tyrrell D, Ferrell LD,
Way LW. Barrett’s esophagus: a surgical disease. Journal of Gastrointestinal Surgery, 3:397-404,
1999.
143. Kolker SE, Ferrell LD, Bollen AW, and Ursell PC. Disseminated intravascular meconium in a
newborn with meconium peritonitis. Human Pathology, 30:592-594, 1999.
34
Linda Ferrell, MD
144. Willenbucher RF, Aust DE, Chang CG, Zelman SJ, Ferrell LD, Moore DH, Waldman FM. Genomic
instability is an early event during the progression pathoway of ulcerative colitis-related neoplasia.
Amer J Pathol, 154:1825-1830, 1999.
145. Cha I, Cartwright D, Guis M, Miller TR, Ferrell LD. Angiomyolipoma of the liver in fine needle
aspiration biopsies: its distinction from hepatocellular carcinoma. Cancer Cytopathology, 87:25-
30,1999.
146. Elkayam O, Hassoba HM, Ferrell LD, Garcia-Kennedy R, Gish RG, Wright TL, Rosenthal P. GB
virus C (GBV-C/HBV) and E2 antibodies in children pre-and post-liver transplantation. Pediatric
Research, 45: 795-9, 1999.
147. Hillan KJ, Hagler KE, MacSween RNM, Ryan AM, Renz ME, Chiu HH, Ferrier RK, Dhillon AP,
Ferrell LD, Fong S. Expression of the mucosal vascular addressin, MAdCAM-1 in inflammatory liver
disease. Liver, 19: 509-18, 1999.
148. Blakolmer K, Seaberg E, Batts K, Ferrell L, Markin R, Wiesner R, Detre K, Demetris A. Analysis of
the reversibility of chronic liver allograft rejection – implications for a staging schema. Amer J Surg
Pathol, 23: 1328-39, 1999.
149. Pessoa MG, Bzowej N, Berenguer M, Phung Y, Kim M, Ferrell L, Hassoba H, Wright TL. Evolution
of hepatitis C (HCV) quasispecies in patients with severe cholestatic hepatitis following liver
transplantation. Hepatology, 30: 1513-20, 1999.
150. Kong C, Appenzeller M, Ferrell, LD. Utility of CD34 reactivity in evaluating focal nodular
hepatocellular lesions sampled by fine needle aspiration biopsy. Acta Cytologica, 44: 218-222, 2000.
151. Harmatz P, Butensky E, Quirolo K, Williams R, Ferrell L, Moyer T, Golden D, Neumayr L,

Vichinsky E. Severity of iron overload in patients with sickle cell disease receiving chronic red blood
cell transfusion therapy. Blood, 96:76-9, 2000.
152. Berenguer M, Ferrell L, Watson, J, Prieto M, Kim M, Rayon M, Cordoba J, Herola A, Ascher N, Mir
J, Berenguer J, Wright TL. HCV-related fibrosis progression following liver transplantation: increase
in recent years. J of Hepatol, 32:673-84, 2000.
153. Ferrell, LD. Short Course in Liver Pathology. Cirrhosis, Hepatitis, and Liver Tumors: Update and
Diagnostic Problems. Modern Pathology, 13: 679-704, 2000.
154. Aust DE, Willenbucher RF, Terdiman JP, Ferrell LD, Chang CG, Moore DH, Molinaro-Clark A,
Baretton GB, Loehrs U, Waldman FM Chromosomal alterations in ulcerative colitis-related and
sporadic colorectal cancers by comparative genomic hybridization. Human Pathol, 31:109-114, 2000.
155. Aust DE, Terdiman JP, Willenbucher RF, Chew K, Ferrell LD, Florendo C, Molinaro-Clark A,
Baretton GB, Loehrs U, and Waldman FM. Altered distribution of β-catenin, and its binding proteins
E-cadherin and APC, in ulcerative colitis-related colorectal cancers. Modern Pathology, 14:29-39,
2001.
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Linda Ferrell, MD
156. Enns GM, Seppala R, Musci TJ, Weisiger K, Ferrell LD, Wenger DA, Gahl WA, Packman S.
Clinical course and biochemistry of sialuria. J Inher Metab Dis, 24:328-336, 2001.
157. Yao FY, Ferrell LD, Watson JJ, Bacchetti P, Bass NM, Ascher NL, Roberts JP. Liver transplantation
for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival.
Hepatology, 33:1415-24, 2001.
158. Rabban JT, Meng MV, Yeh B, Koppie T, Ferrell L, and Stoller ML. Kidney Morcellation in
Laparoscopic Nephrectomy for Tumor: Recommendations for Specimen Sampling and Pathology
Tumor Staging. Amer Journal of Surg Pathol, 25:1158-1166, 2001.
159. Sun M, Eshleman JR, Ferrell LD, Jacobs G, Sudilovsky EC, Tuthill R, Hussein MR, Sudilovsky O.
An early lesion in hepatic carcinogenesis: loss of heterozygosity at the 1p36-p34 region in human
cirrhotic livers and dysplastic nodules. Hepatology, 33:1394-1403, 2001.
160. Wang R, Ferrell LD, Faouzi S, Maher JJ, and Bishop JM. Activation of the Met Receptor by cell
attachment induces and sustains hepatocellular carcinomas in transgenic mice. Journal of Cell
Biology, 153:1023-1033, 2001.
161. Kerlan RK, LaBerge JM, Bass NM, Ferrell LD, Wilson MW, Gordon RL. SCIR annual meeting film
panel session: Diagnosis and discussion of case 5: Pre-sinusoidal portal hypertension due to nodular
regenerative hyperplasia. J Vasc Interventional Radiol, 12:653-7, 2001.
162. Chou S-H, Chawla A, Lee T-H, Zhou Y, Busch MP, Balassanian R, Ferrell L, and Cowan MJ.
Increased engraftment and GVHD after in utero transplantation of MHC-mismatched bone marrow
cells and CD80low,CK86- dendritic cells in a fetal mouse model. Transplantation, 72:1768-76, 2001.
163. Bioulac-Sage P, Balabaud C, Ferrell L. Lipopeliosis revisited: Should we keep the term? (letter)
Amer J Surg Pathol, 26:134,2002.
164. Wang ZJ, Coakley FV, Ferrell L, Rosenthal P. CT and MRI of hepatic pseudotumor in longstanding
biliary atresia. J Computer Assisted Tomography, 26:444-447, 2002.
165. Yao FY, Ferrell L, Bass NM, Ashcer NL, Roberts JP. Liver transplantation for hepatocellular
carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh
modified TNM criteria. Liver Transplantation, 8:765-774, 2002.
166. Pott Bartsch EM, Paek BW, Yoshizawa J, Goldstein RB, Ferrell LD, Coakley FV, Harrison MR,
Albanese CT. Giant fetal hepatic hemangioma: Case report and literature review. Fetal Diagn Ther,
18:59-64, 2003.
167. Stabernack CR, Eger EI, Warnken UH, Fortser H, Hanks DK, Ferrell LD. Sevoflurane degradation by
carbon dioxide absorbents may produce more than one nephrotoxic compound in rats. Canadian J
Anesth, 50:249-252, 2003.
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Linda Ferrell, MD
168. Qayyum A, Graser A, Westphalen A, Merriman R, Ferrell L, Yeh B, Coakley F. CT of benign

hypervascular liver nodules in autoimmune hepatitis. AJR Am J Roentgenol 183:1573-6, 2004.
169. Choi S, Noh J, Hirose R, Ferrell L, Bedolli M, Roberts JP, Niemann CU. Mild hypothermia provides
significant protection against ischemia/reperfusion injury in livers of obese and lean rats. Annals of
Surg, 241:470-476, 2005.
170. Vichinsky E, Butensky E, Fung E, Hudes M, Theil E, Ferrell L, Williams R, Louie L, Lee PDK,
Harmatz P. Comparison of organ dysfunction in transfused patients with SCD or β thalassemia.
Amer J Hematol, 80:70-74, 2005.
171. Kleiner D, Brunt E, Van Natta M, Behling C, Contos M, Cummings O, Ferrell L, Liu Y, Torbenson
M, Unalp-Arida A et al. Design and validation of a histological scoring system for nonalcoholic fatty
liver disease. Hepatol, 41:1313-1321, 2005.
172. Kakar S, Burgart LJ, Batts KP, Garcia J, Jain D, Ferrell LD. Clinicopathologic features and survival
in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without
cirrhosis. Modern Pathology, 18: 1417-1423, 2005.
173. Qayyum A, Thoeni RF, Coakley FV, Lu Y, Guay JP, Ferrell LD. Detection of hepatocellular
carcinoma by ferumoxides-enhanced MR imaging in cirrhosis: incremental value of dynamic
gadoliniumpenhancement. J Magn Reson Imaging, 23:17-22, 2006.
174. Kim GE, Thung SN, Tsui WMS, Ferrell LD. Hepatic cavernous hemangioma: underrecognized
associated histologic features. Liver Int’l, 26:334-38, 2006.
175. Torbensen M, Chen YY, Brunt E, Cummings OW, Gottfried M, Jakate S, Liu YC, Yeh M, Ferrell L,
Glycogenic hepatopathy: An under-recognized hepatic complication of diabetes mellitus. American
Journal of Surgical Pathology 30(4): 508-513, 2006.
176. Kiani B, Ferrell LD, Qualman S, Frankel WL. Immunohistochemical analysis of embryonal sarcoma
of the liver. Applied Immunohistochem Mol Morphol 14:193-7, 2006.
177. Korn WM, Macal M, Christian C, Lacher M, McMillan A, Rauen KA, Warren RS, Ferrell L.
Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with
tumor differentiation (Cancer Gene Therapy, Nature Publishers, pg1-6 in online format, 2006).
178. Merriman R B, Ferrell L D, Patti M G, Weston, S R, Pabst M S, Aouizerat B E, Bass N M.

Correlation of paired biopsies in morbidly obese subjects with suspected non-alcoholic fatty liver
disease. Hepatology 44(4): 874-880, 2006.
179. Bioulac-Sage P, Balabaud C, Bedossa P, Scoazec, JY, Chiche L, Dhillon AP, Ferrell L, Paradis V,
Roskams T, Vilgrain V, Wanless IR, Zucman-Rossi J and members of the Laennec and Elves groups.
Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update. (in
press, Journal of Hepatology).
37
Linda Ferrell, MD
180. Park Y, Hirose R, Coatney JL, Ferrell L, Matthias B, Roberts JP, Serkova NJ, Niemann CU. Ischemia
reperfusion injury is more severe in older versus young rat livers. (in press, Journal of Surgical
Research).
SUBMITTED FOR PUBLICATION OR IN PREPARATION:
1. Greenberg M, Frankel W, Ferrell L. Hepatic necrosis with regenerative nodules: use of

histochemical stains to differentiate from cirrhosis (in preparation).
2. Feng S, McTaggart RA, Ferrell L, Lassman CA, Bostrom A, Roberts JP. Allograft biopsy does not
reliably differenctiate between acute rejection and recurrent Hepatitis C early after liver
transplantation. (submitted for publication, American Journal of Transplantation).
3. Yao F, Ferrell L, Roberts JP, RK Kerlan. Radiologic and pathologic response to loco-regional
therapy predict a lower risk of recurrence after liver transplantation for hepatocellular carcinoma: A
5-year prospective study. Abstract for AASLD 06
4. Noworolski SM, Merriman R, Ferrell L, Vigneron D, Qayyum A. Respiratory motion corrected

proton magnetic resonance spectroscopy in non-alcoholic fatty liver disease with coparison to
pathological finding. (in preparation).
5. Zen Y, Adsay N, Bardadin K, Romano C, Ferrell L, Haga H, Hong S, Hytiroglou P, Kloppel G,

Lauwers G, van Leeuwen D, Notohara K, Oshima K, Quaglia A, Sasaki M, Sessa F, Suriawinata A,
Tsui W, Atomi Y, Nakanuma Y. Biliary intraepithelial neoplasia: An international interobserver
agreement study and proposal of the revised diagnostic criteria. (submitted for publication, American
Journal of Surgical Pathology).
BOOKS edited (with chapter contributions):
Diagnostic Problems in Liver Pathology, L Ferrell, ed, Hanley and Belfus, Inc, Philadelphia, 1994.
MacSween’s Pathology of the Liver, Burt AD, Portmann BC and Ferrell LD (eds), 5th Ed, Elsevier,
Edinburgh, in press.
CHAPTERS IN BOOKS:
1. Lusby RJ, Ferrell LD, Wylie EJ. The significance of intraplaque hemorrhage in the pathogenesis of
carotid atherosclerosis. In: Cerebrovascular Insufficiency, Bergen JJ, Yao JST (Eds), New York:
Grune and Stratton, 1983, pp. 41-56.
2. Smuckler EA, Ferrell LD, Clawson GA. Proliferative hepatocellular lesions, benign and malignant.
In: Viral Hepatitis and Liver Disease, New York: Grune and Stratton, 1984, pp. 201-207.
38
Linda Ferrell, MD
3. Ferrell LD, Saccomono G. Practical considerations of lung cytology. In: A Textbook of Lung
Pathology, Thurlbeck WM (Ed), New York: Thieme-Stratton, Inc., 1987, pp. 105-114.
4. Saccomono G, Ferrell LD. Diagnostic cytology. In: Pathology of the Lung, Thurlbeck WM (Ed),
New York: Thieme Medical Publishers, Inc., 1988, pp. 803-822.
5. Crawford JM, Ferrell LD. The liver in transplantation. In: The Liver in Systemic Disease, Rustgi V,
Van Thiel D, (eds), Raven Press, 1993, pg 337-364.
6. Williams RA, Ferrell LD. Pediatric liver tumors. In: Topics in Pediatric Pathology, State of the Art
Reviews in Pathology, California Society of Pathology, Williams R (ed), Hanley & Belfus, Inc,
Philadelphia, 1993, pg. 23-42.
7. Ferrell, LD. Hepatocellular nodules in the cirrhotic liver: Diagnostic features and proposed
nomenclature, In: Diagnostic Problems in Liver Pathology, State of the Art Reviews in Pathology,
Ferrell L (ed), Hanley and Belfus, Inc, Philadelphia, 1994, pp. 105-118.
8. Ljung BM, Ferrell LD. Fine needle aspiration biopsy of the liver: Diagnostic problems, In:
Diagnostic Problems in Liver Pathology, State of the Art Reviews in Pathology, Ferrell L (ed), Hanley
and Belfus, Inc, Philadelphia,, 1994, pp 161-184.
9. Kelly J, Ferrell LD. Colon, appendix, and Anorectum. In: The Difficult Diagnosis in Surgical
Pathology, Weidner N, (ed), WB Saunders, 1996, pp. 217-257.
10. Ferrell LD. Liver and gallbladder pathology. In: The Difficult Diagnosis in Surgical Pathology,
Weidner N, (ed), WB Saunders, 1996, pp. 284-312.
11. Ferrell LD, Roberts JP. Liver, In: Intraoperative consultation in Surgical Pathology: State of the Art
Reviews in Pathology, Ranshod, M (ed), Hanley and Belfus, Inc, Philadelphia, 1996, pp 367-378.
12. Ljung BM, Ferrell LD. Fine needle aspiration biopsy of the liver: Diagnostic problems, In: Fine
Needle Aspiration biopsy, State of the Art Reviews in Pathology, Ljung B (ed),Hanley and Belfus, Inc,
Philadelphia, 1996, pp 365-388.
13. Ferrell L. Surgical Diseases of the Liver, In: Principles and Practice of Surgical and Cytopathology,
Silverberg S, DeLellis R, Frable W (eds) 3rd Ed, Churchill-Livingstone, 1997, pp 1997-2022.
14. Ferrell L. Nomenclature of chronic hepatitis: The new look, In: Anatomic Pathology 1997, Fechner
RE, Rosen PP (eds), American Society of Clinical Pathologists, Chicago, 1997, pp 21-34.
15. Ferrell L. Benign liver tumors, In: Clinical and Pathological Correlations in Liver Disease:
Approaching the Next Millennium. Bloomer JR, Goodman ZD, and Ishak KG (eds), Armed Forces
Institute of Pathology, Washington, DC, 1998, pp 66-75.
39
Linda Ferrell, MD
16. Ferrell LD, Scheuer PJ, and Theise N. Viral hepatitis. In, Pathology of the Liver, MacSween RNM,
Anthony PP, Scheuer PJ, Burt AD, Portmann BC (eds), 4th Ed, Churchill-Livingstone, 2002, pp 313-
362.
17. Ferrell LD. Liver, In: Modern Surgical Pathology, Weidner N, Cote RJ, Suster S (eds), WB Saunders,
Philadelphia, 2003, pp 919-979.
18. Ferrell LD. Gallbladder and Extrahepatic Biliary Tract, In: Modern Surgical Pathology, Weidner N,
Cote RJ, Suster S (eds), WB Saunders, Philadelphia, 2003, pp 980-998.
19. Ferrell LD. (contrib.), In: Q & A Color Review of Hepatobiliary Medicine, Bodenheimer HC,
Chapman R (eds), Thieme, New York 2003.
20. Ferrell LD. Benign and malignant tumors of the liver. In: Surgical Pathology of the GI Tract, Liver,
Biliary Tract, and Pancreas, Odze R, Goldblum J, and Crawford J, (eds), 1st ed, W.B.Saunders,
Philadelphia, 2004, pp.999-1024.
21. Ferrell L. and Giesinger K. Surgical Diseases of the Liver, In: Principles and Practice of Surgical
and Cytopathology, Silverberg S, DeLellis R, Frable W, Wick M, and LiVolsi V (eds) 4th Ed,
Churchill-Livingstone, 2006, pp 1527-47.
22. Ferrell LD and Kakar S. Tumors of the liver, gallbladder and biliary tree. In: Diagnostic
Histopathology of Tumors, Fletcher C (ed), 3rd Ed, Elsevier, Edinburgh, in press.
23. Theise ND, Bodenheimer H, and Ferrell LD. Viral hepatitis. In: MacSween’s Pathology of the Liver,
Burt AD, Portmann BC and Ferrell LD (eds), 5th Ed, Elsevier, Edinburgh, in press.
ABSTRACTS
1. Lusby RJ, Kerlan RK, Ferrell LD, Ehrenfeld WK, Stoney RJ, Wylie EJ: Digital subtraction and
conventional carotid angiography: Correlation with surgical pathology. San Diego Vascular
Symposium, Oct 1982.
2. Lusby RJ, Ferrell LD, Englestad BL, Price DC, Lipton MJ, Stoney RJ: Platelet imaging as a marker
of the healing response to carotid endarterectomy. San Diego Vascular Symposium, Oct 1982.
3. Lusby RJ, Ferrell LD, Reilly LM, Kersh R, Ehrenfeld WK, Stoney RJ, Wiley EJ: Stroke: The
significance of carotid plaque hemorrhage with ulceration. Eighth International Joint Conference on
Stroke and Cerebral Circulation, Feb 1983.
4. Heyman MB, Perman JA, Ferrell LD, Thaler MM: Importance of colonoscopic biopsies in diagnosis
of inflammatory bowel disease in the young patient. American Gastroenterology Association, May
1983.
40
Linda Ferrell, MD
5. Melnick J, Hohn D, Stagg R, Ignoffo R, Lewise B, Ferrell L, Altman D: Cholestasis and biliary
sclerosis in patients receiving hepatic arterial infusion of floxuridine (FUDR). American Association
for the Study of Liver Disease, Chicago, Nov 1983.
6. Onik G, Gilbert J, Hoddick WK, Filly R, Callen P, Rubinsky B, Ferrell L: Ultrasonic monitoring of
hepatic cryosurgery: Preliminary report on an animal model. Cryobiology 21:713, 1984. American
Roentgen Ray Executive Council Award.
7. Niederau C, Ferrell LD, Grendell JH: Protective effect of proglumide, benzotript, and secretin against
caerulein-induced acute necrotizing pancreatitis in mice. American Pancreatic Association, Nov
1984.
8. Crass RA, Niederau C, Ferrell LD, Grendell JH: The effects of hydration and oxygenation in
experimental acute hemorrhagic pancreatitis. American Gastroenterology Association, May 1985.
9. Niederau C, Liddle RA, Ferrell LD, Grendell JH: Proglumide and gabexate mesilate, but not secretin,
protect against diet-induced acute pancreatitis in mice. American Gastroenterology Association, May
1985.
10. Crane TB, Ferrell LD: The diagnosis of conjunctival cytologic manifestations utilizing Wright stain.
American Academy of Ophthalmology, Oct 1985.
11. Ferrell LD, Niederau C, Grendell JH: Long term effects of repeated acute episodes of diet-induced
versus cerulien-induced pancreatitis in mice. American Pancreas Association, Nov 1985.
12. Niederau C, Tsay DG, Schmidt H, Goldberg HI, Higgins C, Ferrell LD, Grendell JG: Magnetic
resonance characteristics in experimental pancreatitis. American Pancreas Association, Nov 1985.
13. Wisner JR, Renner IG, Grendell JH, Niederau C, Ferrell LD: Protective effects of FOY on cerulotide-
induced pancreatitis in rats. American Pancreas ASsociation, Nov 1985.
14. Cohen MB, Beckstead JH, Yen B, Ferrell LD: Enzyme histochemistry of hepatic neoplasms. Am J
Clin Pathol 85, 1986. ASCP meeting.
15. Yuan M, Itzkowitz SH, Ferrell LD, Chung YS, Kim YS: Peanut lectin and anti-T antibody binding in
pancreatic cancer tissues. American Gastroenterology Association, May 1986.
16. Grendell J, Niederau C, Ferrell LD, Liddle RA: Biochemical, secretory, and morphologic effects of
repetitive experimental acute pancreatitis. American Pancreatic Association, 1986.
17. Ferrell LD, Beckstead JH: Plastic embedded endoscopic biopsies. International Academy of
Pathology, 1988.
18. Wauters GV, Ferrell L, Heyman MB: Prevalence of C. pylori in children and adults at a major
medical center. XIX International Congress of Pediatrics, Paris, 1989.
41
Linda Ferrell, MD
19. Stempel C, Lake J, Ferrell L, Tomlanovich S, Melzer J, Amend W, Salvatierra O, Vincenti F: Effect
of cyclosporine on the clinical course of HBs Ag positive renal transplant patients. Congress of
Transplantation Society, 1990.
20. Read AE, Donegan E, Ferrell L, Zeldis J, Lake J, Ascher NL, Wright TL: Hepatitis C virus (HCV) in
patients undergoing liver transplantation (OLTx). 13th International Congress, Transplantation
Society, Feb 1990
21. Read AE, Donegan E, Ferrell L, Zeldis J, Lake J, Ascher NL, Wright TL: Hepatitis C virus (HCV) in
patients undergoing liver transplantation (OLTx). Am Gastro Assoc, May 1990.
22. Wright TL, Zeldis JB, Mamush D, Donegan E, Ferrell L, Ascher NL, Roberts JP, Read AE, Lake J:
Graft infection with hepatitis B (HBV) following liver transplantation (OLTx): Prognostic
importance of viral replication. American Association for the Study of Liver Diseases, Nov 1990.
23. Perkocha LP, Ferrell LD, Yen TSB, White W, McCallmont T, Hurt MA, BanksP, Leboit PE:
Extracutaneous Manifestation of Bacillary Angiomatosis. US and Canadian Academy of Pathology,
Mar 1991.
24. Freise CE, Ascher NL, Lake J, Capper J, Purohit S, Garavoy M, Ferrell L, Wright T, Roberts J: Graft
Versus Host Disease Following Liver Transplantation in Humans: Report of four cases.Western
Assoc Transplant Surgeons, Mar 1991
25. Sterneck M, Ferrell L, Read A, Wright T, Roberts J, Ascher N: Viral Co-factors in Patients with
alcoholic liver disease presenting for liver transplantation. American Gastroenterological Association,
May 1991, Gastroenterol 1991;100(Suppl):A801.
26. Sterneck M, Ferrell LD, Lake J, Wright TL. Liver disease of undefined etiology: relative roles of
hepatitis C (HCV), autoimmune (AI) disease and cryptogenic cirrhosis (CC). American
Gastroenterological Association 1991, Gastroenterol 1991;100(Suppl):A800.
27. Wright T, Ferrell L, Donegan E, Combs C, Kim M, Fennessy S, Lake J, Roberts J, Ascher N. Impact
of hepatitis C viral (HCV) infection on the allograft following liver transplantation. American
Association for the Study of Liver Disease, Nov 91, Hepatol 1991;14 (pt 2):51A.
28. Ferrell L, Wright T, Roberts J, Ascher N, Lake J. Pathology of Hepatitis C Virus Infection in Liver
Transplant Recipients. US and Canadian Academy of Pathology, Mar 92.(platform), Mod Pathol
5:96A, #567, 1992.
29. Ferrell L, Lake J, Roberts J, Ascher N. Small Hepatocellular Carcinoma and Macroregenerative
Nodules in Liver Explants with Cirrhosis. US and Canadian Academy of Pathology, Mar 92. Mod
Pathol 5:961, #566, 1992.
30. King WK, Liu H, Ferrell LD: Detection of Helicobacter pylori in human gastric carcinoma tissue by
n-pcr tests. Am Gastroenterol Assoc, May 1992.
42
Linda Ferrell, MD
31. Wright TL, Ferrell L, Lake J, Roberts J, Ascher N, Sheridan P, Detmer J, Hunt W, Chan C, Neuwald
P, Wilber J, Urdea M, Sanchez-Pescador R: Hepatitis C Viral RNA in patients on interferon (IFN)-
alpha for post-liver transplant (OLTx) hepatitis. Am Gastroenterol Assoc, May 1992.
32. Martinez O, Krams S, Villanueva J, Ferrell L, Lake J, Roberts J, Ascher N. Intragraft IL-2 and IL-5
gene expression in liver allograft recipients. American Society for Transplant Surgeons, May 1992.
33. Demetris AJ and NIDDK Liver Transplant Pathologists: Standardized nomenclature and grading
system for acute cellular rejection of liver allografts. Am Gastroenterol Assoc, May 1992.
34. Chazouilleres O, Kim M, Ferrell L, Roberts J, Ascher N, Wilber J, Chan C, Polito A, Urdea M,
Wright TL: Quantitative study of hepatitis C virus (HCV) in liver transplant (OLTX) recipients.
American Association for the Study of Liver Diseases, Transplant Section, Nov 1992.
35. Chazouilleres O, Mamish D, Carey K, Ferrell L, Roberts, Ascher N, Wright TL. Hepatitis B viral
(HBV) transmission by low level infection in liver transplant (OLTx) recipients. American Association
for the Study of Liver Diseases, Transplant Section, Nov 1992.
36. Venook AP, Lake JR, Roberts JP, Wright T, Emond J, Ferrell LD, Frye JW, Ring E, Ascher NL.
Orthotopic liver transplantation in patients with hepatocellular carcinoma: Results using preoperative
chemoembolization. American Association for the Study of Liver Disease, Transplant Section, Nov
1992.
37. Kerschmann R, Paddock C, Cregan P, Ferrell L. Oncocytic change of hepatocytes associated with
Kupffer cell infection by the human immunodeficiency virus. US and Canadian Academy of
Pathology, Mar 1993 (poster), Mod Pathol 6:111A, 1993.
38. Ferrell L, Steinkirchner T, Sterneck M, Lake J, Roberts J, Ascher N. Alpha-1-antitrypsin globules in

cirrhotic livers. US and Canadian Academy of Pathology, Mar 1993, Mod Pathol 6:110A, 1993.
39. Ferrell L, Cregan P, Wright T, Lidofsky S, Veereman-Waters G, Dimand R, Lake J, Roberts J, Ascher
N, Heyman M. Predictive value of pretransplant liver biopsy in patients with fulminant/subfulminant
hepatitis. US and Canadian Academy of Pathology, Mar 1993, Mod Pathol 6:109A, 1993.
40. Erler BS, Hsu L, Truong H, Petrovic L, Kim S, Huh M, Ferrell L, Thung S, Geller S, Marchevsky A.
Image Analysis and diagnostic classification of hepatocellular carcinoma using neural networks and
multivariate discriminant functions. US and Canadian Academy of Pathology, Mar 1993, Mod Pathol
6:109A, 1993.
41. Ferrax MLG, Greeve M, Carr K, Wright T, Ferrell L, Appelman H, Lucey M. Post-transplant
hepatitis in patients with prior autoimmune chronic active hepatitis. All due to hepatitis C? Am
Gastroenterol Assoc, May 1993.
42. Demetris AJ, Batts K, Ferrell L, Ludwig J, Marken R, Seaberg E Haber J, Belle S, and the LTD
Investigators. Intra- and interobserver reliability study of the NIDDK Transplantation Database
43
Linda Ferrell, MD
grading system for acute cellular liver allograft rejection. Amer Assoc for the Study of Liver Disease,
Hepatology 18(4,Pt 2):73A, 1993.
43. Carr K, Ferrell L, Wright T, Lucey M, Appelman H. Post-transplant liver disease in patients
transplanted for autoimmune chronic hepatitis. US and Canadian Academy of Pathology, Mar 1994.
44. Erler BS, Hsu L, Truong H, Ferrell L, Thung S, Geller S, Marchevsky A. Nuclear image analysis and
expert system diagnosis of hepatocellular carcinoma. US and Canadian Academy of Pathology, Mar
1994.
45. Erler BS, Hsu L, Truong HM, Kim SS, Huh MH, Ferrell LD, Thung SN, Geller SA, Marchevsky AM.
diagnosis of hepatocellular carcinoma using neural networks and linear discriminant functions of
nuclear image analysis data: A multicenter study. US and Canadian Academy of Pathology, Mar
1994.
46. Vartanian RK, Ferrell LD, Lake JR, Ascher NL, Roberts JP. Microvesicular vs macrovesicular fatty
change in donor livers: Relationship to preservation injury. US and Canadian Academy of Pathology,
Mar 1994.
47. Ferrell LD, Brixko C, Lake J, Bass N. The specificity of portal-based granulomas in recurrent
primary biliary cirrhosis after liver transplantation. US and Canadian Academy of Pathology, Mar
1994.
48. Cha I, Bass N, Ferrell, L. Lipopeliosis: An immunohistochemical and clinicopathological study of 5

cases. US and Canadian Academy of Pathology, Mar 1994.
49. Bhandari BN, Dailey PJ, Ferrell LD, Bacchetti P, Wright TL. HCV RNA level and histopathology is
similar in needle biopsy from different parts of liver. AGA/AASLD, New Orleans, 1994.
50. Bhandari BN, Kim M, Ferrell LD, Bacchetti P, Wright TL. Serum hepatitis C virus (HCV) levels and
alanine transaminase (ALT) do not correlate with liver histopathology. AGA/AASLD, New Orleans,
1994.
51. Luthen RE, Ferrell LD, Grendell JH, Niederau C. Morphologic damage of the pancreas induced by
total depletion of pancreatic glutathione. International Assoc of Pancreatology, Chicago, 1994.
52. Brixko C, Wall S, Ferrell L, Roberts J, Lake J. Ascher N, Bass N. Signes de recidive de las cholangite
sclerosante primitive (CSP) apres transplantation hepatique (TH). Journees Francophones de
Pathologie Digestive, Paris, 1994.
53. Brixko C, Wall S, Ferrell, L, Roberts J, Lake J, Ascher N, Bass N. Evidence for recurrence of
primary sclerosing cholangitis (PSC) after orthotopic liver transplantation (OLT). Belgian Week of
Gastroenterology, 1994. (won the prize for best presentation)
44
Linda Ferrell, MD
54. Gerson L, Van de Water J, Ferrell, L, Batts K, Weisner R, Gershwin E, Lake J. Does primary biliary
cirrhosis recur after transplantation? A study using immunohistochemical staining for the M-2
antigen. 1994.
55. Huang E, Coombs C, Wright T, and Ferrell L. HBV and HBV/HCV coinfections in orthotopic liver
transplants: detection by polymerase chain reaction and correlation with clinical outcome and liver
pathology, US and Canadian Academy of Pathology, Mar 95
56. Zhow S, Kim M, Ferrell L, Wright TL. HCV genotyping of liver transplant recipients: relation to
viremia and histology, abstract for AASLD, Nov, 94
57. Lones M, Hart J, Ferrell L, Lager D, Thung S, Weiss L, Shintaku I, Geller S. Post-transplant
lymphoproliferative disorder in liver allograft biopsies: immunohistochemical and in-situ
hybridization studies, poster for US and Canadian Academy of Pathology, Mar 95
58. Yamanaka S, Balestra M, Ferrell L, Fan J, Arnold K, Taylor S, Taylor J, Innerarity T. Apolipoprotein
B mRNA editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals, oral
presentation for RNA Processing Meeting, May 95, Proceedings of the National Academy of Science.
59. Davern J, Liao X, Ferrell L, Rockey D, Friedman S, Escabedo J, Williams L, and Scharschmidt B.
Role of platelet-derived growth factor in hepatic fibrosis: evaluation in a novel transgenic mouse
model. Amer Assoc for the Study of Liver Disease, Nov 95.
60. Le Q, Fu K, Fitts L, Massullo V, Ferrell L, Rosenau W, Kaplan M, Phillips T. Prognostic factors in

adult soft tissue sarcomas of the head and neck. American Radium Society, Mar 96
61. Taga S, Washington K, Terrault N, Wright T, Somberg K, Clavien P, Ferrell L. Cholestatic hepatitis
C in liver allografts, Platform presentation for USCAP, Mar 96, Mod Path 9:137A, 1996.
62. Marchevsky A, An C, Reyter I, Ferrell L, Thung S, Geller S. The application of image analysis and
neural network technology to the study of premalignant and malignant liver lesions, poster for
USCAP, Mar 96, Mod Pathol 9:135A,1996.
63. Pessoa M, Terrault N, Ferrell L, Kim J, Kolberg J, Lake J, Roberts J, Ascher N, Wright T.
Cryptogenic liver disease: role of hepatitis G virus (HGV) infection before and after liver
transplantation, platform presentation for Amer Gastroenterol Assoc, May 96.
64. Willenbucher R, Zelman S, Ferrell L, Waldman F. Fluorescence in situ hybridization (FISH)

detectable chromosomal abnormalities are widespread in ulcerative colitis-related neoplasia. Poster
for Amer Gastroenterol Assoc, May 96.
65. Rosenthal P, Emond J, Heyman M, Snyder J , Roberts J, Ascher N, Ferrell L. Pathologic changes in
yearly protocol liver biopsies from healthy pediatric liver recipients. Abstract for Amer Assoc for
Study of Liver disease, Nov 96
45
Linda Ferrell, MD
66. Pessoa M, Terrault N, Ferrell L, Detmer J, Kolberg J, Wright T. The search for new hepatitis viruses
in patients with post-liver transplantation hepatitis (post-OLTH) of unknown etiology. Abstract for
Amer Assoc for Study of Liver Disease, Nov 96
molecular pathology and other aspects. Proceedings of the 1996 Shanghai International Conference of
Gastroenterology, Nov 96
68. Tsui WMS, Colombari R, Bonetti F, Portmann BC, Thung SN, Ferrell LD, Nakanuma Y, Snover DC,
Bioulac-Sage P. Hepatic angiomyolipoma: delineation of unusual morphological variants. US and
Canadian Academy of Pathology, Orlando, FL, Mar 96
69. Snyder JD, Heyman MB, Elkayam O, Ferrell LD. H pylori: an uncommon cause of gastritis in young
children. Amer Gastroenterol Assoc/Amer Assoc Study of Liver Disease, May 1997
70. Narumi S, Osoria RW, Freise CL, Stock PG, Emond JC, Roberts JP, Lake J, Ferrell LD, Ascher NL.
Liver transplantation for autoimmune chronic active hepatitis. International Hepatic Transplantation
Society, Sept 97
71. Sun M, Eshleman JR, Ferrell LD, Jacobs G, Sudilovsky EC, Tuthill R, Sudilovsky O. Microsatellite
instability and allelic deletion in liver dysplastic nodules and small hepatocellular carcinomas in
humans. AASLD, Nov 97.
72. Elkayam O, Hassoba HM, Ferrell LD, Garcia-Kennedy R, Gish RG, Wright TL, Rosenthal P.
Hepatitis GBV-C infection in children pre-and post-liver transplantation. AASLD, Nov 97.
73. Elkayam O, Hassoba HM, Ferrell LD, Garcia-Kennedy R, Gish RG, Wright TL, Rosenthal P. Does
hepatitis G cause “hepatitis” in children? North Amer Soc Ped Gastroenterol & Nutrition, Nov 97.
74. Renz JF, Rosenthal P, Frankel W, Ferrell LD, Roberts JP, Ascher NL, Emond JC. Mycophenolate
mofetil, microemulsion cyslosporine, and prednisone immunotherapy reduces post-transplant
rejection in pediatric liver transplant recipients. AASLD, Nov 97.
75. Elkayam O, Heyman M, Ferrell L, Snyder J. Can upper and lower endoscopy findings predict
histologic results? What you see is not always what you get. North Amer Soc Ped Gastroenterol &
Nutrition, Nov 97.
76. Cha I, Cartwright D, Guis M, Miller TR, Ferrell LD. Angiomyolipoma of the liver in fine needle
aspiration biopsies: its distinction from hepatocellular carcinoma. American Soc of Cytopathology,
Nov, 1997.
77. Snyder JD, Elkayam O, Heyman MB, Ferrell LD. What causes gastric and duodenal ulcers in children
in the H. pylori era? Abstract for American Gastroenterological Association, May 1998.
46
Linda Ferrell, MD
78. Patti MG, Feo CV, Arcerito M, Worth S, DePinto M, Tong J, Gibbs VC, Ahmadi M, Gantert W,
Tyrrell D, Ferrell LD, Way LW. Barrett’s esophagus: a surgical disease. Society for Surgery of the
Alimentary Tract, Inc., May 1998.
79. Sun M, Ferrell LD, Jacobs G, Sudilovsky EC, Tuthill R, Sudilovsky O. Loss of heterozygosity (LOH)
and microsatellite instability (MIN) detected in liver dysplastic nodules and small and large
hepatocellular carcinomas occur also in cirrhotic nodules. 17th UICC International Cancer Congress,
1998.
80. Pessoa MG, Bzowej NH, Kim M, Phung Y, Ferrell, Ascher N, Wright TL. HCV quasispecies as a
mechanism of severe post-transplantation recurrence? International Association for the Study of Liver
Disease, Nov 1998.
81. Berenguer M, Ferrell L, Kim M, Prieto M, Rayon M, Garcia A, Ascher N, Mir J, Berenguer J, Wright
TL. Fibrosis progression in recurrent HCV disease: differences between the US And Europe.
American Association for the Study of Liver Disease, Nov 1998.
82. Blakolmer K, Seaberg EC, Batts K, Ferrell L, Markin R, Wiesner RH, Demetris AJ. Reversible and
irreversible chronic allograft rejection of the human liver. American Association for the Study of
Liver Disease, Nov 1998.
83. Boppana S, Miller WM, Mizrachi H, Park YN, Ferrell L, Tsui W, Bioulac-Sage P, Balabaud C,
Theise ND. Cytokeratin 19 expression in hepatocellular carcinoma (HCC). Mod Pathol 12:1:160A.
USCAP Annual Meeting, Boston, MA, Mar 1999.
84. Illel P, Ferrell L, Yee H, Theise ND. The role of cytokeratins 7 and 19 in the diagnosis of focal
nodular hyperplasia and adenoma of the liver. Mod Pathol 12:1:164A. USCAP Annual Meeting,
Boston, MA, Mar 1999.
85. Sun M, Ferrell LD, Jacobs G, Sudilovsky EC, Eshleman JR, Tuthill R, Sudilovsky O. Loss of
heterozygosity (LOH) of chromosone 1P36-P34 in cirrhotic nodules (CN) from human livers with
dysplastic nodules (DN) and heptocellular carcinomas (HCC). FASEB Journal 13(4),Pt.l, #176.5,
1999.
86. Sun M, Ferrell LD, Jacobs G, Sudilovsky EC, Eshleman JR, Tuthill R, Sudilovsky O. Loss of
heterozygosity (LOH) of chromosone 1P36-P34 in dysplastic nodules (DN) and hepatocellualr
carcinomas (HCC)from the same human cirrhotic livers. FASEB Journal, 13(4), Pt l,#161.7, 1999
meeting.
87. Abramson O, Fine A, Ferrell L, Heyman MB, Koerper M, Rosenthal P, Snyder JD. Natural history
and histology of untreated HCV infection in children. American Gastroenterology Association, May
1999.
88. Harmatz P, Quirolo K, Singer T, Williams R, Ferrell L, Moyer T, Hackney-Stephens E, Golden D,

Vichinsky E. Development of hemochromatosis in patients with SCD receiving chronic RBC
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Linda Ferrell, MD
transfusion therapy. National Sickle Cell Disease Meeting, 23rd Annual Program, San Francisco,
1999.
89. Harmatz P, Butensky E, Quirolo K, Williams R, Ferrell L, Moyer T, Golden D, Neumayr L,

Vichinsky E. Development of iron overload in patients with sickle cell disease receiving chronic red
blood cell transfusion therapy. Blood 1999; 94:418a.
90. Harmatz P, Butensky E, Ferrell L, Foote D, Hackney-Stephens E, Vichinsky E. Hepatic injury in

hypertransfused patients with sickle cell disease (SCD) of thalassemia. Blood 1999; 94:423a.
91. Enns G, Seppala R, Muscil TJ, Weisiger K, Ferrell LD, Wenger DA, Gahl WA, Packman S. Clinical
and molecular studies in sialuria. Pediatric Academic Societies Annual Meeting, San Francisco, 1999.
92. Harmatz P, Moyer T, Butensky E, Quirolo K, Styles L, Williams R, Ferrell L, Vichinsky E.

Variability in hepatic iron concentration from needle biopsy specimens in patients with SCD and
secondary hemochromatosis. National Sickle Cell Disease Program, 24th annual meeting,
Philadelphia, PA, 2000.
93. Harmatz P, Moyer T, Butensky E, Quirolo K, Ferrell L, Williams R, Foote D, Vichinsky E. Variation
in hepatic iron concentration from needle biopsy specimens in patients with B thalessemia and
secondary hemochromatosis. World Congress of pediatric Gastroenterology, Hepatology and
Nutrition, Boston, MA, 2000.
94. Rabban J, Heerema A, Yeh B, Ferrell L. Loss of pathologic tumor staging due to specimen
fragmentation in laparoscopic nephrectomy for renal tumor. Mod Pathol 13:1:111A. USCAP, Annual
Meeting, New Orleans, LA, Mar 2000.
95. Heerema A, Rabban J, Ferrell L, Olson J. Pre and post mortem clinicopathologic correlation of graft
versus host disease (GVHD) in allogeneic bone marrow transplant (allo-BMT) patients. Mod Path
13:1:6A. USCAP, Annual Meeting, New Orleans, LA, Mar 2000.
96. Gugig R, Elkayam O, Ferrell L, Heyman MB, Snyder JD. The role of H pylori in ulcers in children:
an important minority. World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition,
2000.
97. Chawla A, Chou SH, Zhou Y, Lee TH, Busch MP, Balassanian R, Ferrell L, Talib S, Hearst J,
Hanchett J, Cowan MJ. Impact of CD86-dendritic cell progenitors and T-cells on engraftment post in
utero transplantation in fetal mice. Amer Soc Hematol, Dec 2000.
98. Szmit A, Chen Y, Way L, Ferrell L. Cytokeratin 7 and 20 expression in ampullary adenomas and
adenocarcinomas. Mod Pathol 14:1:96A, Jan 2001. USCAP Annual Meeting, Atlanta, GA, Mar
2001.
99. Rabban J, Ferrell L. Cost effective analysis of sampling protocols for morcellated laparoscopic
nephrectomy specimens. Mod Pathol 14:1:121A, Jan 2001. USCAP Annual Meeting, Atlanta, GA,
Mar 2001.
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Linda Ferrell, MD
100. Rabban J, Mihok N, Jones K, Cha I, Sudilovsky D, Ferrell L, Treseler P. Small metastases in breast
carcinoma sentinel lymph nodes are not consistently identified without keratin stain. Mod Pathol
14:1:230A, Jan 2001. USCAP Annual Meeting, Atlanta, GA, Mar 2001.
101. Baruch-Oren T, Huston LM, Chan R, Ferrell L, Cohen C, Levin K, Brunt E, Robert M, Nichols W,
Geller S. Identification of the Wilson Disease His1069Gln gene mutation in formalin-fixed paraffin
embedded liver tissue. Mod Pathol 14:1:193A, Jan 2001. USCAP Annual Meeting, Atlanta, GA, Mar
2001.
102. Bioulac-sage P, Laurent C, Vallet A, Le Bail B, Balabaud C, Ferrell L. Massive extrahepatocytic fat
globules after implanting steatotic liver grafts. European Association for the Study of Liver Disease,
April 2001.
103. Yao FY, Ferrell L, Watson JJ, Bacchetti P, Bass NM, Venook A, Ascher NL, Roberts JP. Modest
expansion of the tumor size limits does not adversely impact survival following liver transplantation
for hepatocellular carcinoma: Proposal for a new staging criterion. Amer Gastroenterol Assoc, May
2001.
104. Morrison C, Szmit A, Ferrell LD, Suster S, Frankel WL. Gastrointestinal stromal tumors involving
the liver. Mod Path 15:1:139A, Jan 2002. USCAP, Annual Meeting, Chicago, IL, Feb 2002.
105. Pessoa MG, Alves VA, Wakamatsu A, Maertens G, van der Borght B, Guanaes J, Ferrell L, Wright T.
Post-transplant recurrent hepatitis C-immunohistochemical detection of HCV core antigen and
possible pathogenic implications. AASLD, Hepatology 2002:36(4 pt 2):181A.
106. Weston SR, Ruppert K, Ledneva T, Ferrell LD, Bell SH, Everhart JE, Charlton MR, Weisner RH,
Schafer D, Detre K, Roberts JP, Terrault NA. Are risk factors for nonalcoholic fatty liver disease
(NAFLD) important in determining hepatitis C virus (HCV) recurrence and severity in patients
undergoing liver transplantation? AASLD, Hepatology 2002:36(4 pt 2):182A.
107. Emile J, Falissard B, Azoulay D, Callea F, Ferrell L, Goodman ZD, Hayashi Y, Hsu HC, Hubscher
SG, Kojiro M, Ng IO, Paterson AC, Reynes M, Zafrani E. Multidimensional scaling analysis of the
reproducibility of histological classification of primary liver carcinomas reveals the need for better
international criteria. AASLD, Hepatology 2002:36(4 pt 2):302A.
108. Terrault N, Louie K, Weisner C, Ferrell L, Peters M. Quantity and pattern of lifetime alcohol use
predicts risk of significant fibrosis in light to moderate alcohol users with chronic hepatitis C,
AASLD. Hepatology 2002:36(4 pt 2):564A.
109. Grenert JP, Frankel W, Ferrell L. Regenerative nodules in submassive necrosis: Distinction from
hepatocellular carcinoma. Mod Pathol 16:275A, 2003. USCAP Annual Meeting, Washington, DC,
Mar 2003.
110. Frankel W, Kiani B, Ferrell L, and Qualman S. Immunohistochemical analysis of embryonal sarcoma
of the liver. Mod Pathol 16:272-273A, 2003. USCAP Annual Meeting, Washington, DC, Mar 2003.
49
Linda Ferrell, MD
111. Kim G, Thung S, Tsui W, and Ferrell L. Cavernous hemangioma, what have we been missing? Mod
Pathol 16:279A, 2003. USCAP Annual Meeting, Washington, DC, Mar 2003.
112. Greenberg M, Frankel W, Ferrell L. Hepatic necrosis with regenerative nodules: Use of
histochemical stains to differentiate from cirrhosis. Mod Pathol 16:274-275A, Jan 2003. USCAP
Annual Meeting, Washington, DC, Mar 2003.
113. Yao FY, LeBerge J, Darbonne D, Ferrell L, Bass NM, Venook A, Kerlan R, Feng S, Ascher NL,
Roberts JP. Liver transplantation for hepatocellular carcinoma: The impact of pre-operative
chemoembolization and ablation. AASLD, Digestive Disease Week, Orlando, Florida, May 2003.
Gastroenterology 2003; 124 (Suppl 1); A-708.
114. Merriman RB, Ferrell LD, Patti MG, Ostroff JW, Bagetelos K, Aouizerat BE, Bass NM. Histologic
correlation of paired right lobe and left lobe liver biopsies in morbidly obese individuals with
suspected non alcoholic fatty liver disease. AASLD Oct 2003.
115. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu Y-C,
Torbenson MS, Yeh M, McCullough AJ and Sanyal AJ for the NASH-CRN. Design and validation of
a histologic scoring system for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic
steatohepatitis (NASH), AASLD, Oct 2003.
116. Chen YY, Brunt EM, Jakate SM, Liu YC, Torbenson M, Yeh MM, Ferrell L. Glycogenic
hepatopathy: an under-recognized hepatic complication of diabetes mellitus. Mod Path, 17: (Suppl
1): 297A, Jan 2004. USCAP Annual Meeting, Vancouver, B.C., Mar 2004.
117. Kakar S, Burgart LJ, Batts KP, Jain D, Ferrell L. Survival and immunohistochemical features in
fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without
cirrhosis. Mod Path, 17: (Suppl 1): 303A, Jan 2004. USCAP Annual Meeting, Vancouver, B.C., Mar
2004.
118. McTaggart RA, Ferrell L, Lassman CR, Roberts JP, Terrault NA, Feng A. The reliability of liver
biopsy to diagnose acute rejection: the impact of recurrent hepatitis C. AASLD Annual Meeting,
Boston, MA, Oct 2004.
119. Stohr BA, Ferrell LD, Chen YY, Kim GE, Kakar S. Diagnostic concordance and role of size and site
in the identification of sessile serrated adenomas. Mod Pathol 18:119A, Jan 2005. USCAP Annual
Meeting, San Antonio, TX, Feb 2005.
120. Tabatabai ZL, Ferrell LD. Reticulin, copper, and CD34 staining in the diagnosis of focal nodular
hyperplasia. Mod Pathol 18:287A, Jan 2005. USCAP Annual Meeting, San Antonio, TX, Feb 2005.
121. Yabes A, Ferrell LD. Arterialization of central zones in alcoholic cirrhosis. Mod Pathol 18:289A, Jan
2005. USCAP Annual Meeting, San Antonio, TX, Feb 2005 (platform).
50
Linda Ferrell, MD
122. Stohr BA, Ferrell LD, Waldman FM, Mehta K, Kakar S. Use of array-based comparative genome
hybridization to distinguish hepatic adenoma from hepatocellular carcinoma. Mod Pathol 18:335A,
Jan 2005. USCAP Annual Meeting, San Antonio, TX, Feb 2005.
123. Snyder JD, Sipe W, Gugig R, Elkayam O, Heyman MB, Haas-Beckert B, Ferrell L. The nature and
location of ulcers in children in the era of H pylori. Amer Gastroenterol Assn/Digestive Disease
Week, Chicago, IL, May 2005.
124. Yao FY, Ferrell LD, Bass NM, Kerlan RK, Hirose R, Ascher NL, Roberts JP. Liver transplantation
for hepatocellular carcinoma: the impact of the degree of tumor necrosis from pre-operative loc-
regional therapy on recurrence. AASLD at Digestive Disease Week, Chicago, IL, May 2005
(Platform). Gastroenterology, 128 (Suppl 2): A-689, 2005.
125. Davern T, Bass N, Yao F, Ferrell L, Feng S. Severe liver injury from acetaminophen toxicity is not
always hyperacute. Amer Assoc for the Study of Liver Disease, Clinical Research Single Topic
Conference: Drug Induced Liver Injury, Atlanta, GA, Sep 2005 (poster).
126. Sipe W, Gugig R, Ferrell L, Elkayam O, Heyman MB, Haas-Beckert B, Snyder JD. The frequency of
diffuse inflammation in children with primary and secondary ulcers. NASPGHAN meeting, Salt Lake
City, UT, Oct 2005 (poster), J Pediatr Gastroenterol Nutr. 2005.
127. Landry G, Ferrell L, Bostrom A, Roberts J, Feng S. Chronic rejection after liver transplantation:
Incidence, risk factors and outcomes in the era of Tacrolimus/MMF, and interferon. AASLD, Hepatol
42(4), Suppl 1:328A, Oct 2005. AASLD Annual Meeting, San Francisco, CA, Nov 2005 (poster).
128. Landry G, Terrault N, Ferrell L, McTaggart R, Bacchetti P, Feng S. Interferon is associated with
chronic rejection during the first year after liver transplantation for hepatitis C. Hepatol, 42(4), Suppl
1:429A, Oct 2005. AASLD Annual Meeting, San Francisco, CA, Nov 2005 (poster).
129. Yabes A, Ferrell L. Centrizonal ductular reaction in subacute and chronic liver disease. Mod Path, 19
(Suppl 1): 238A, Jan 2006. USCAP Annual Meeting, Atlanta, GA, Feb 2006 (poster).
130. Campos GM, Tiwari U, Vittinghoff E, Ferrell L, Rogers S, Posselt A, Pabst M, Bass N, Merriman R.
A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients. WIP-
NIH Clinical Reasearch K12 annual Meeting, May 2006 (poster)
131. Yabes A, Davern T, and Ferrell L. The histologic features of prolonged hepatic acetaminophen
toxicity. International Academy of Pathology, Montreal, Canada, Sept 2006 (poster).
132. Tan V, Terrault N, E Agudelo E, Ferrell L, Roberts J, Feng S. Long-term histological outcomes after
achievement of sustained virological response in liver transplant recipients with recurrent hepatitis C
virus infection. World Transplant Congress, July 2006, Boston, MA (poster).
51
Linda Ferrell, MD
RESEARCH PROGRAM
Significant Chapters/Paper Summary
In the past few years, I have been invited to be the primary author for a liver pathology chapter in several
major textbooks in the field of pathology. This has been a major academic effort due to the
comprehensive nature of these chapters and the high standards set by the editorial staff for these
publications. The following represent the most significant of my efforts.
1. Ferrell LD, Scheuer PJ, and Theise N. Viral hepatitis. In, Pathology of the Liver, MacSween RNM,
Anthony PP, Scheuer PJ, Burt AD, Portmann BC (eds), 4th Ed, Churchill-Livingstone, 2002, pp 313-362.
2. Theise N, Bodenheimer H, and Ferrell LD. Viral hepatitis. In, MacSween’s Pathology of the Liver, Burt
AD, Portmann BC, Ferrell LD (eds),, 5th Ed, Elsevier, Edinburgh, in preparation.
Co-editor, 5th Ed, MacSween’s Pathology of the Liver, Burt AD, Portmann BC, Ferrell LD (eds), 5th Ed,
Elsevier, Edinburgh, in preparation.
This textbook has remained in the top ten pathology textbooks worldwide for the last few years; it is considered
the top liver pathology textbook available and received 1st prize at the Royal Society of Medicine awards. I
will be one of three co-editors for the next edition, due out in 2006 and coauthored the chapter on viral
hepatitis.
3. Ferrell LD. Benign and malignant tumors of the liver. In: Surgical Pathology of the GI Tract, Liver,
Biliary Tract, and Pancreas, Odze R, Goldblum J, and Crawford J, (eds), 1st ed, W.B.Saunders,
Philadelphia, 2004, pp.999-1024.
This comprehensive textbook is in the top ten for pathology textbooks in 2004.
4. Ferrell LD and Kakar S. Tumors of the Liver, Gallbladder, and Biliary Tree. In: Diagnostic
Histopathology of Tumours, Fletcher CDM (ed), 3rd ed, Elsevier, Edinburgh, in preparation.
I was the primary invited author for this chapter in the next edition to replace the previous author, with the text
due out in 2006. The comprehensive textbook has been in the top three best sellers for pathology textbooks in
2004.
5. Ferrell L. and Giesinger K. Surgical Diseases of the Liver, In: Principles and Practice of Surgical and
Cytopathology, Silverberg S, DeLellis R, Frable W, Wick M, and LiVolsi V (eds) 4th Ed, Churchill-
Livingstone, 2006, pp1527-47.
This comprehensive textbook is one of the top, two-volume, pathology textbooks for the general pathologist in
practice. In the Silverberg text, I was the primary invited author who chose my co-author for the cytopathology
portions of the chapter.
In addition, the following are a sample of peer-reviewed papers listed in those cited most frequently in
hepatopathology literature and that I consider key papers on less-commonly cited topics.
1. Ferrell L, Crawford J, Dhillon P, Scheuer P, Nakanuma Y. Proposal for standardized criteria for the
diagnosis of benign, borderline, and malignant hepatocellular lesions arising in chronic advanced liver
disease. Amer J Surg Pathol, 17:1113-1123, 1993.
I was the primary author to propose, organize, and complete this paper, which has become the single most cited
paper on the nomenclature for well-differentiated hepatocellular tumors (as documented by the reference,
Evidence-based interpretation of liver biopsies, Lab Invest 2006)
52
Linda Ferrell, MD
2. Demetris AJ, Seaberg EC, Batts KP, Ferrell L, Ludwig J, Markin R, Belle S, Detre K. Reliability and
predictive value of the NIDDK liver transplant database nomenclature and grading system for cellular
rejection of liver allografts. Hepatology, 21(2):408-416, 1995.
I was a key member of the pathology group on this study and manuscript, which is #137 on the most cited
papers in hepatopathology. This paper has provided the foundation for much of what is currently practiced in
the diagnosis of acute rejection in liver transplantation. (as documented by the reference, Evidence-based
interpretation of liver biopsies, Lab Invest 2006)
3. Demetris AJ, Seaberg EC, Batts KP, Ferrell L, Lee RG, Markin R, Detre KM. Chronic liver allograft
rejection: a National Institute of Diabetes and Digestive and Kidney Diseases interinstitutional study
analyzing the reliability of current criteria and proposal of an expanded definition. Am J Surg Pathol,
22:28-39, 1998.
As in the paper above, I was a key member of the pathology group on this study, which has become an important
standard for criteria for chronic rejection.
4. International Working Party. Terminology of hepatic allograft rejection, Hepatology, 22:548-554,1995.

Due to my key position as a liver transplant pathologist in the international setting, I was asked to be a panel
member on this study. The manuscript is #126 on the most cited papers in hepatopathology. (as documented by
the reference, Evidence-based interpretation of liver biopsies, Lab Invest 2006)
5. International Working Party, Wanless IR, Chair. Terminology of nodular lesions of the liver. Hepatology,
25:983-993, 1995.
Due to my previous key publications on this topic, I also played an important role in the terminology developed
for this manuscript.
6. Ferrell LD, Wright TL, Roberts J, Ascher N, Lake J. Hepatitis C viral infection in liver transplant
recipients. Hepatology, 16:865-876, 1992.
This was the first and the most comprehensive description and evaluation of pathology of hepatitis C following
liver transplantation, and the findings remain valid.
7. Huang E, Wright T, Combs C, Lake J, Ferrell L. Hepatitis B and C coinfections and persistent hepatitis B
infections: clinical outcome and liver pathology after transplantation. Hepatology, 23:396-404, 1996.
This manuscript was one of the key descriptions and evaluation of pathology of the co-infections for hepatitis C
and B following liver transplantation, and the findings remain valid.
8. Taga S, Washington K, Terrault, Wright T, Somberg K, Ferrell L. Cholestatic hepatitis C in liver

allografts. Liver Transplantation and Surgery, 4:1-8, 1998.
This manuscript was one of the key descriptions and evaluation of pathology of the aggressive variant of
hepatitis C following liver transplantation, and the findings remain valid. This abstract was selected as the best
hepatopathology paper presented by a resident by the Hans Popper Society at the USCAP in 1996.
9. Kleiner D, Brunt E, Van Natta M, Behling C, Contos M, Cummings O, Ferrell L, Liu Y, Torbenson M,
Unalp-Arida A et al. Design and validation of a histological scoring system for nonalcoholic fatty liver
disease. Hepatol, 41:1313-1321, 2005.
This manuscript may prove to become highly-cited over time for leading the field for the evaluation of fatty
liver disease.
53
Linda Ferrell, MD
Description of new/previously unrecognized or underrecognized entities: I personally find these types of

papers rewarding, as these involve significant diagnostic acumen and knowledge base that resulted in the
recognition and /or naming of a previously, undescribed or underrecognized entity.
Ferrell L, Bass N, Roberts J, Ascher N. Lipopeliosis in the transplanted liver: A fat-induced sinusoidal
dilatation that mimics peliosis hepatitis. J Clin Pathol, 45:1109-1110, 1992.
Cha I, Bass N, Ferrell LD. Lipopeliosis: A clinical-pathologic study of 5 cases. Amer J Surg Path,
18(8):789-795, 1994.
Hartshorne N, Hartman G, Markin R, Demetris AJ, Ferrell LD. Bile duct hemorrhage: A sequelae of
cholangiography or other manipulation of the biliary tract. Liver, 12:137-139, 1992.
Kim GE, Thung SN, Tsui WMS, Ferrell LD. Hepatic cavernous hemangioma: underrecognized associated
histologic features. Liver Int’l, 26:334-38, 2006.
Yabes A, Ferrell LD. Arterialization of central zones in alcoholic cirrhosis. Mod Pathol 18:289A, Jan 2005.
USCAP Annual Meeting, San Antonio, TX, Feb 2005 (platform presentation), manuscript in
preparation.
Torbensen M, Chen YY, Brunt E, Cummings OW, Gottfried M, Jakate S, Liu YC, Yeh M, Ferrell L,
Research Summary
In my role as a major diagnostic consultant in liver pathology, I receive unusual problem cases in liver
pathology from pathologists across the country and some from other nations as well. This has set up an
unusual setting where I can collect a larger number of rare lesions for studies. The following recently
completed and ongoing projects result directly from this situation.
1. Kim GE, Thung SN, Tsui WMS, Ferrell LD. Cavernous hemangioma, Underrecognized lesion
associated with cavernous hemangioma, Liver Int’l, 26:334-38, 2006.
This study involved collection of multiple consultation cases as well as in-house cases, and applying
immunohistochemical techniques to a unique vascular lesion noted in these samples in order to determine
their similarity to a coexisting giant hemangioma.
2. Kakar S and Ferrell LD. Examination of chromosomal abnormalities in well-differentiated

hepatocellular tumors: Utility in Differential Diagnosis and Correlation with Etiology and Prognosis,
ongoing project
I have just completed collecting cases of unusual, rare, well-differentiated hepatocellular tumors including
adenomas, well-differentiated hepatocellular carcinomas, and well-differentiated hepatocellular tumors of
uncertain classification as adenoma versus HCC. Now, in collaboration with a junior colleague in my
department, Dr. Sanjay Kakar, we have begun an analysis of chromosomal abnormalities in these tumors
using various methods including CGH and FISH technology to try to determine whether there are markers
which distinguish these lesions in a more reliable manner than routine histology and immunohistology. This
could be an important breakthrough in determining/predicting the biological outcome of these problematic
lesions.
54
Linda Ferrell, MD
3. Tabatabai L and Ferrell LD. Utility of various staining methods in the diagnosis of focal nodular
hyperplasia. (abstract published in Mod Path and presented as poster at USCAP, manuscript in
preparation)
I am currently working with a junior colleague in my department, Dr Laura Tabatabai, on techniques that
might be useful in the more successful diagnosis of this well-differentiated tumor within the liver. These
tumors are often biopsied by needle cores or fine needle aspiration cytology, which only provides small
samples, and we are trying to establish a more reliable set of criteria and use of stains that may be helpful in
distinguishing this lesion from hepatocellular carcinoma, cirrhosis, and adenoma.
4. Yabes A, Ferrell LD. Arterialization of central zones in alcoholic cirrhosis. Mod Pathol 18:289A, Jan
2005. USCAP Annual Meeting, San Antonio, TX, Feb 2005 (platform presentation by Dr Yabes, the
current liver/GI pathology fellow), manuscript in preparation.
This paper was initiated by my observation of the finding of arteries in the scarred central zones of chronic
steatohepatitis due to alcohol and nonalcoholic fatty liver disease. I presented these findings as an aspect of a
case presentation to an international liver pathology group, and was surprised to find that about half of the
experienced liver pathology experts there had not noticed this finding. This then led us to more
systematically study this finding in end-stage alcoholic liver disease, and we are continuing with the studies
in the nonalcoholic steatohepatitis patients in the NASH consortium database.
5. Torbensen M, Chen YY, Brunt E, Cummings OW, Gottfried M, Jakate S, Liu YC, Yeh M, Ferrell L,
I initiated and coordinated this multisite project to collect these very unusual rare cases, similar to what I had
rarely seen in my consultation service. The cases were initially presented as a poster at the USCAP by Dr
Chen and I. I served as senior author and wrote the first draft of the final manuscript.
Other multicenter and interdisciplinary studies
The NASH (Nonalcoholic steatohepatitis) consortium study is a multicenter study, based out of the
Johns Hopkins Center for Clinical Trials, and sponsored by the National Cancer Institute that is striving to
spend several years to evaluate many aspects of fatty liver disease. As one of the center pathologists, I have
ongoing responsibilities to evaluate the liver biopsies on the study patients and to coordinate these findings
with clinical features in order to better define fatty liver disease. I participated in the proposal for a new
scoring system for fatty liver disease developed by our pathology group.This proposal was accepted as an
abstract for plenary session presentation at the 2003 American Association for the Study of Liver Disease
(AASLD) meeting, and the manuscript published in Hepatology. Other studies are ongoing.
Kleiner D, Brunt E, vanNatta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu Y, Torbenson MS,
Yeh M, McCullough AJ, Sanyal AJ. Design and validation of a histology scoring system for nonalcoholic
fatty liver disase (NAFLD), Hepatol, 41:1313-1321, 2005.
-Numerous studies in liver and liver transplant pathology in collaboration with UCSF Liver
Transplant Service, Hepatology/GI division of the Dept of Medicine, and Radiology.
I am acting as the consultant liver pathologist for several NIH grants and other support for these projects. The
funding varies as salary support or consultant fees.
55
Linda Ferrell, MD
-Ongoing collaboration with two international groups of liver pathologists, hepatologists, and hepatic
radiologists (Laennec Society and the International Liver Pathology Study Group) on consensus terminology
and diagnostic criteria for hepatocellular carcinoma and hepatic nodules in the cirrhotic liver and well as
benign nodules in the noncirrhotic liver. I had a significant role in the preparation of the first manuscript
consensus document on benign lesions, which will be submitted for publication soon.
Specific studies:
-Solid Organ Transplantation in HIV: Multi-Site Study. I am the lead liver pathologist for all sites and
developed the data form for liver biopsy analysis. I will review all study cases as the central-review
pathologist to confirm consistency of data collection. These patients have very complex patterns of liver
injury, including mixed lesions. These include atypical patterns of viral disease, rejection, and drug reactions
to antiviral therapy that make diagnosis particularly difficult. I am one of the very few liver pathologists in
the world who has experience in this area.
-Womens Interagency HIV Study. This is also a multi-site study, and I am working with local UCSF
physicians Norah Terrault, Marion Peters, and Phyllis Tien. I am the local pathologist who evaluates and
scores the liver biopsies. These patients also have complex liver pathology that need my expertise for
interpretation.
-Vira-Hep C study. This study tries to define the response rates of anti-viral therapy in African-Americans as
compared to Caucasians. I’m working with UCSF physician Norah Terrault. I am the local pathologist who
evaluates and scores the liver biopsies.
-Natural history of HCV: living versus cadaver donor. This study is comparing the progression of HCV after
transplantation for these two donor types. I am working with UCSF physicians Chris Freise and Norah
Terrault.
-Thymoglobulin Induction therapy with a calcineurin-inhibitor sparing regimen in liver transplant patients.
This study evaluates the safety of this therapy and the outcome. Sponsored by Genzyme corporation. I am
the consultant pathologist for the UCSF trial, headed by Dr Chris Freise.
-Non-invasive evaluation of pathology and prediction of outcome in nonalcoholic fatty liver disease: role of
MR imaging and spectroscopy. Application for funding submitted by PI A Qayyum in Radiology. I will
assist in evaluating the liver biopsies.
-Outcome of hepatocellular carcinoma in the liver transplant patient. One publication has already been
completed, but further related studies are ongoing to evaluate the relationship of the degree of necrosis in
HCC that has been embolized/treated prior to transplant.
Pertinent publication: Yao FY, Ferrell L, Bass NM, Ashcer NL, Roberts JP. Liver transplantation for
hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the
Pittsburgh modified TNM criteria. Liver Transplantation, 8:765-774,2002.
-Reliability of the pathologic diagnosis of rejection versus hepatitis C in the post-transplant setting, reliability
and clinical correlation of chronic rejection, collaboration with Dr Sandy Feng at UCSF. Other related
studies are planned.
56

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Curriculum Vitae Name: Linda Ferrell, MD

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Linda Ferrell, MD

University of California San Francisco

Name: Linda Ferrell, MD

Position: Professor, Step V

Vice Chair of Clinical Affairs

Director of Surgical Pathology, Department of Pathology, School of Medicine

Address: Room M-590, Box 0102

Voice: (415) 353-1090

1970-74 University of Kansas, Lawrence, KS B.A. Summa cum laude,

1978-79 Medical Licensure, Kansas

PRINCIPAL POSITIONS HELD:

OTHER POSITIONS HELD CONCURRENTLY:

1982-89 Co-Director, Cytology Laboratory, Department of Pathology, University of California, San

HONORS AND AWARDS:

1970-74 Watkins-Berger Scholar, Univ. Kansas

2005-6 Listed in Best Doctors in America 2005-6 database

Cytology Attending Physician 1982-89

SUMMARY OF CLINICAL ACTIVITIES

1978-79 Kansas City Society of Pathologists

1993-now Hans Popper Hepatopathology Society (for Liver Pathologists)

Service to Professional Organizations

1988-1989 UCSF Women’s Faculty Association Steering Committee and Co-chair

SERVICE TO PROFESSIONAL PUBLICATIONS

1982-88 Ad hoc referee for GASTROENTEROLOGY, approximately 1 per month

1997-03 Editorial Board, LIVER, Munksgaard International Publishers

University of Glasgow, Western Infirmary; Department of Pathology and Department of Medicine,

International Academy of Pathology; Hong Kong, November 1996 (2 lectures).

International Symposium on Liver Pathology; Kanazawa University School of Medicine, Kanazawa,

Progress in Liver Pathology; Darwin, Australia, July, 1999 (lecture).

Scientific Symposiums International, Hawaii, Oct 2001, (5 lectures)

Scientific Symposiums International, Anchorage, AL, June 2003 (5 lectures)

Update in Liver Pathology, Melbourne, Australia, September, 2003 (lecture).

Canadian Association of Pathologists, Montreal, Canada, July, 2004 (4 lectures).

Scientific Symposiums International, Maui, HI, June 2005 (5 lectures)

Scientific Symposiums International, South Carolina, Jul 2006 (5 lectures)

US and Canadian Academy of Pathology, Annual Meeting

Site not available for new CV, 1988 (poster)

US and Canadian Academy of Pathology, Diagnostic Pathology Course

US and Canadian Academy of Pathology, Weekends in Pathology

American Gastroenterology Association, Annual Meeting

American Association for the Study of Liver Disease, Annual Meeting

American Society of Clinical Pathologists

College of American Pathologists

REGIONAL AND OTHER INVITED PRESENTATIONS

USCF sponsored courses

1984, 85, 91 Bay Area Seminars in Cytopathology

OTHER INVITED PRESENTATIONS

1991 Nebraska Association of Pathologists, University of Nebraska, Omaha, NE (invited

2004 Yale University Department of Pathology Grand Rounds (visiting professor)

CME COURSES ATTENDED (last 5 years)

U. S. and Canadian Academy of Pathology, 2000-06

UNIVERSITY AND PUBLIC SERVICE

1986-93 Chancellor's Committee for Personal Safety

1981 Tissue Committee, ad hoc review

1990-91 Committee on Curriculum and Educational Policy

DEPARTMENT OF PATHOLOGY SERVICE

1996-now Promotions committee

SUMMARY OF SERVICE ACTIVITIES

TEACHING and MENTORING