BRIGHTON FARAI MADZIMA

ANIMAL HEALTH – RESEARCH AND INNOVATION (ANTHELMINTICS)

2023
 ANTHELMINTIC DRUGS

• Anthelmintic Drugs are used against invasion of parasitic worms (Helminthiasis)

Roundworms, pinworms, whipworms, hookworms and tapeworms. Broad spectrum
anthelmintic drugs are effective against parasitic flat worms and nematodes. However,
the majority of drugs are more limited in their action for example- praziquantel, a drug
used in treatment of schistosomiasis and thought to act by disrupting calcium
homeostasis, has no activity against nematodes.
 CLASSES OF ANTHELMINTIC DRUGS

• Benzimidazoles
• Avermectins
• Miscellaneous
 BENZIMIDAZOLES

• Benzimidazoles:
• Albendazole – effective
against threadworms, roundworms, whipworms, tapeworms, hookworms
• Mebendazole – effective against various nematodes
• Thiabendazole – effective against various nematodes
• Fenbendazole – effective against various parasites
• Triclabendazole – effective against liver flukes
• Flubendazole – effective against most intestinal parasites
 AVERMECTINS

• Avermectins (including ivermectin) - effective against most common intestinal worms,

except tapeworms, for which praziquantel is commonly used in conjunction for mass
deworming's.
Praziquantel – effective against flatworms (e.g., tapeworms and schistosoma)
 PRODUCT RANGE

• VALBAZEN FOR CATTLE

• VALBAZEN FOR SHEEP AND GOATS
• RANOX
• DECTOMAX
• INTERMECTIN INJECTION
• INTERMECTIN SUPER
• PIPERIN
 COMPETITOR PRODUCTS

• Systamex
• Systamex +
 VALBAZEN FOR CATTLE
• For the treatment of Roundworm, Lung worm and Milk Tapeworm remedy for cattle.

• Albendazole 7.5%

Ovicidal- Prevents Roundworm eggs present in the animal at dosing from hatching.

PARASITES, VECTORS & ORGANISMS CONTROLLED

1. Wireworm

2. Bankrupt worm

3. Brown stomach worm

4. Hookworm

5. Lungworm

6. Long necked worm

7. Large mouthed worm

8. Bowel worm

9. Milk tapeworm

10. Nodular worm

APPLICATION
- Oral administration
DOSAGE RATES
- 1ml of Valbazen for cattle per 10kg body mass.
WITHDRAWAL
- Meat- 12 days
- Milk- 3 days
 VALBAZEN FOR SHEEP AND GOATS
• For the treatment of Roundworm, Lungworm, Milk Tapeworm and Liver Fluke in sheep and goats.
• Albendazole 1.9%
PARASITES VECTORS & ORGANISMS CONTROLLED
1. Wireworm
2. Brown Stomach worm
3. Bankrupt worm
4. Hookworm
5. Nodular worm
6. Lungworm
7. Long necked worm
8. Large mouthed worm
9. Bowel worm
10. Milk Tapeworm
APPLICATION RATE
Sheep and Goats Application- Oral administration
DOSE RATES
Shake before use. 2ml per 10kg body mass
-It is recommended that all animals be vaccinated against Pulpy Kidney disease before any
remedy is dosed !
WITHDRAWAL
Meat : 10 days
 RANOX
An Oral Anthelmintic effective against Liver Fluke and Wireworm in cattle and effective against Nasal worm, Liver Fluke and
Wireworm in sheep and goats.
• Rafoxanide 3.0%
PARASITES VECTORS & ORGANISMS CONTROLLED
1. Liver Fluke
2. Wireworm
3. Nasal Worm
CONTRA INDICATIONS !
-Do not overdose as this may lead to toxicity. It is recommended that all sheep be vaccinated against pulpy kidney before any
worm remedy is dosed. Do not treat lactating animals whose milk or milk products are intended for human consumption. Do
not treat animals more frequently than every 3 weeks.
APPLICATION RATE
Cattle application- Oral Administration
Sheep and Goats- Oral Administration
DOSE RATES
- Administer by mouth using standard dosing equipment.
Cattle- 12.5ml of Ranox per 50kg body mass.
Sheep & Goats- 2,5ml of Ranox per 10kg body mass.

WITHDRAWAL - Meat: 28 days

 DECTOMAX (DORAMECTIN)
A ready-to-use, colorless to pale yellow, sterile solution for the treatment and control of internal and external parasites.
Doramectin 10mg/ml
PARASITES, VECTORS & ORGANISMS CONTROLLED
1. Roundworm 6. Nodular worm 12. Grubs 18. Mites (itch)
2. Hook worm 7. Screw worm 13. False bruising
3. Lungworm 8. Large mothed worm 14. Sheep scab
4. Wireworm 9. Blue ticks 15. Nasal worm
5. Bankrupt worm 10. Lice 16. Bowfly strike
6. Brown stomach worm 11. Eyeworms 17. Mites (mange)
INDICATIONS
-Dectomax is a long-acting, injectable, broad spectrum parasiticide for cattle, sheep, goats and swine.
One low-volume injection effectively controls a wide range of Roundworm of cattle, sheep, goats and
pigs as well as arthropod parasites of cattle, sheep and pigs, which impair their health and productivity.
Dectomax injectable solution is well-tolerated, has excellent syringeability and has a long action,
making it particularly suitable for controlling parasites in cattle, sheep, goats and swine.
CONTRA INDICATIONS !
Do not use in cattle producing milk for human consumption.
Do not give to dogs (fatal)
 APPLICATION RATE
Cattle Application: subcutaneous injection in the neck or shoulder region
• Dose rates/directions for use: 200 ?g doramectin/kg : 1 ml/50kg body mass
• Note: Vaccination of cattle against broad spectrum Clostridium infections (e.g. black quarter, malignant
edema) is strongly recommended.
Sheep & Goats Application: For subcutaneous injection in the neck or shoulder region:
• Dose rates/directions for use: 200 ?g doramectin/kg : 1 ml/50kg body mass or
sheep only 300 ?g/kg doramectin : 1,5 ml/50 kg body mass.
• Note: Sheep and goats should be vaccinated against pulpy kidney (enterotoxaemia) before treatment.
Vaccination against broad spectrum Clostridium infections (e.g. black quarter, malignant edema) is also
strongly recommended.
Pigs Application: For subcutaneous injection in the neck or shoulder region:

• Dose rates/directions for use: 300 ?g doramectin/kg : 1 ml/33kg body mass .

Withdrawal- cattle, sheep & goats 35 days : Swine -28 days

 INTERMECTIN INJECTION
• Broad Spectrum
• This anthelmintic is used for the removal of gastrointestinal and lung nematodes of cattle, sheep and pigs as
well for treatment of ectoparasitic infestations caused by arthpods.
• Ivermectin 1%
• 10mg/ml
PARASITES VECTORS & ORGANISMS CONTROLLED
1. Roundworm
2. Lungworm
3. Lice
4. Oestriasis
5. Scabies
CONTRA-INDICATIONS !
-Do not administer to lactating animals.
APPLICATION RATE
Cattle Application: For subcutaneous injection.
• Dose rates/directions for use:
Cattle: 1 ml per 50 kg body weight.
Sheep & Goats Application: For subcutaneous injection.
• Dose rates/directions for use:
Goats and sheep: 1 ml per 50 kg body weight.
Pigs Application: For subcutaneous injection.
• Dose rates/directions for use:
Swine: 1 ml per 33 kg body weight.
Withdrawal- Cattle, Calves, Sheep & Goats (28 days) Swine (21 days)
 INTERMECTIN SUPER

• For the treatment and control of mixed infestation of adult Liver Fluke,
Gastrointestinal Roundworms, Lungworms, Eye Worms, Warbles, Mites and Lice in
beef-cattle and non-lactating dairy cattle.
• Ivermectin 1% & Clorsulon 10% injection.

• SIMILAR TO INTERMECTIN PLASTIC HOWEVER THIS SPECIFIC ONE

DEALS WITH LIVER FLUKE AS WELL BY THE NATURE OF IT HAVING 10%
CLORSULON AS PART OF ITS ACTIVE INGREDIENT.
 PIPERIN
• An anthelmintic with activity against nematodes. It includes a reversible flaccid paralysis in the nematode
parasites. This is provoked by hyperpolarization of the cell membrane followed by suppression of
spontaneous spike potentials. The paralysed nematodes are subsequently expelled from the gut lumen by
normal per
• Piperazine citrate 1000mg
PARASITES, VECTORS AND ORGANISMS CONTROLLED
1. Ascaris 6. Strongylus
2. Nematodirus 7. Oxyuris
3. Ostertagia 8. Trichonema
4. Cooperia 9. Oesophagostomum
5. Capillaria
CONTRA-INDICATIONS !
-Hypersensitivity to piperazine.
- Administration to animals with a seriously impaired hepatic or renal function.
- Cattle Application:
-For oral administration: Dose rates/directions for use:
Dosage: 1 - 2 g per 10 kg body mass in drinking water
Pigs Application:
-For oral administration: Dose rates/directions for use:
Dosage: 1 - 2 g per 10 kg body mass in drinking water
Poultry Application:
-For oral administration: Dose rates/directions for use:
Dosage: 1 - 2 g per 10 kg body mass in drinking water
WITHDRAWAL TIME
Meat: 2 days
Eggs: 2 days
THANKYOU
 REFERENCE LIST

• Gautier-Bouchardon AV (July 2018). "Antimicrobial Resistance in Mycoplasma

spp". Microbiology Spectrum. 6 (4): 425–446.
• Iqbal Z, Lateef M, Akhtar MS, Ghayur MN, GilaniIni
• AH., Journal of Ethno pharmacology, 2006; 106;
• FIVET ANIMAL HEALTH
• ZOETIS
• INTTERCHEMIE
• Lateef M, Iqbal Z, Khan MN, Akhtar MS, Jabbar A.
• International Journal of Agriculture and Biology