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Predictive modeling of brain tumor: a deep learning approach

Presentation · January 2020


DOI: 10.13140/RG.2.2.22911.76963

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Priyansh Saxena Saumil Maheshwari


ABV-Indian Institute of Information Technology and Management Gwalior Madhav Institute of Technology & Science Gwalior
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JANUARY 18, 2020

International Conference on
Innovations in Computational Intelligence and Computer Vision
(ICICV-2020)

PREDICTIVE MODELING OF
BRAIN TUMOR:
A DEEP LEARNING APPROACH
Priyansh Saxena, ABV-IIITM
Akshat Maheshwari, ABV-IIITM
Saumil Maheshwari, ABV-IIITM
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Presentation
Outline
Introduction
Objectives
Related Works
Research Methodology
Results & Discussion
Conclusion
References

01
Introduction

Brain tumor accounted for 85% to 90% of all primary CNS tumors.

As of 2019 statistics, the total annual number of deaths from brain


cancer across all ages, and both sexes is 247,143[1].
Recent advancements in Deep Learning, provides state of the art
solutions for detecting a brain tumor in early stages and can thus
save lives by taking preemptive measures.

02
OBJECTIVES To develop a deep learning-based model
which can classify the brain MRI scans as
cancerous or non-cancerous with zero false
negatives rate.

To further enhance the performance by using


CNN based transfer learning approach, which
not only increases accuracy but help reducing
the false negatives significantly.

03
Related Works

Emblem Ke et al. applied SVMs on perfusion MRI[2] and achieved sensitivity &
specificity of 0.76 and 0.82, respectively.

El-Dahshan et al.[3] suggested Feedback Pulse Coupling Network (FPCNN) for


image segmentation in the brain tumor diagnosis systems. It uses DWT, PCA &
ANN as feature extractor and selector and classification, respectively.

Rahmani & Akbarizadeh[4] proposed an unsupervised feature learning


technique which was related to the collaboration of spectral clustering &
sparse coding for segmentation of SAR images.

04
Related Works (Contd.)

Chang[5] devised an algorithm which contained both FCN and Conditional


Random Fields (CRF).

Lai[6] used the depth information by implementing a 3D convolution model


which utilized the correlation between slices. The 3D convolution network
requires a large number of parameters. Moreover, when a dataset with fewer
samples is used, 3D CNN often overfit.

05
RESEARCH
METHODOLOGY

Proposed methodology is organized into 3 different steps.


The models are trained & tested using Brain Tumor by
Navoneel[7].
253 samples of brain MRI images out of which, 155 samples
are of malignant tumor and 98 samples benign tumor.

06
DATA PREPROCESSING
CROP NORMALIZATION
Approach of determining of extreme points in contours.
Determines the farthest north, south, east, and west (x, y)-coordinates along a given contour.
Only the portion of the image containing the brain is cropped out [8].

RESIZING OF IMAGES
Input dataset contains images with a different dimensions and with different aspect ratio.
Images in the dataset are resized to a preset format, since the pretrained models used require the
images to be 224×224×3 dimensions.

07
ARTIFICIAL DATA
AUGMENTATION
This technique is used to artificially enhance the size of image training data by generating modified
images using the original dataset, which enhance the capability of the model to learn and generalize
better on future unseen data.
Figure shows the first image as the original image present in the dataset and the remaining images
are generated by this technique[9].

08
TRANSFER LEARNING

Uses 3 pre-trained CNN models,


Inception-V3 which acts as feature extractors.
VGG-16
Inception-V3
Resnet-50

09
VGG-16

Resnet-50
RESULTS & DISCUSSION
The dataset of 253 images is divided into-183 training images, 50 images for
the validation set, and 20 testing images.
The performance for the proposed methodology was measured in terms of
Cohen’s kappa(κ), F1-score, area under the ROC curve (AUC-ROC) and test
accuracy.

10
RESULTS & DISCUSSION (Contd.)
Resnet-50 achieved the highest F1-score, accuracy & meager false-negative
rateas zero on the test data.

Performance of Inception-V3 was very close to a random classifier since its


AUC is 0.55 as it suffered from overfitting.

11
RESULTS & DISCUSSION (Contd.)

Inception-V3 VGG-16 ResNet-50

TRAINING AND VALIDATION AC C URAC Y ANALYS IS


Inception-V3 suffers from overfitting.
VGG-16 achieves a decent accuracy.
ResNet-50 outperforms the other two.
12
RESULTS & DISCUSSION (Contd.)

Inception-V3 VGG-16 ResNet-50

TRAINING AND VALIDATION LOS S ANALYS IS


Inception-V3 suffers from high validation loss.
VGG-16 shows substantially less validation loss.
ResNet-50 shows the least validation loss out of the above two.
13
Conclusion & future scope

Resnet-50 achieved the best F1 score (0.952) and highest test accuracy (95%)
with the zero false-negative rate (primary concern in an automatic diagnostic
system and thus suitable for practical applications).
Inception-V3 suffered from overfitting and is just slightly better than a random
classifier with an accuracy 0.55.
The future possibilities for increasing the accuracy further can be done by using
new state of the art architectures by using transfer learning technique.
Extensive hyper-parameter tuning, and a better preprocessing technique can be
devised to enhance the model performance further.

14
References
1. Ritchie, Hannah. "How Many People in the World Die from Cancer?" Our World in Data, Institute for
Health Metrics and Evaluation (IHME) , 1 Feb. 2018, https://ourworldindata.org/how-many-people-in-
the-world-die-from-cancer.
2. Emblem, Kyrre E., et al. "Predictive modeling in glioma grading from MR perfusion images using
support vector machines." Magnetic Resonance in Medicine: An Official Journal of the International
Society for Magnetic Resonance in Medicine 60.4 (2008): 945-952.
3. El-Dahshan, El-Sayed A., et al. "Computer-aided diagnosis of human brain tumor through MRI: A
survey and a new algorithm." Expert systems with Applications 41.11 (2014): 5526-5545.
4. Rahmani, Masoumeh, and Gholamreza Akbarizadeh. "Unsupervised feature learning based on sparse
coding and spectral clustering for segmentation of synthetic aperture radar images." IET Computer
Vision 9.5 (2015): 629-638.
5. Chang, Peter D. "Fully convolutional deep residual neural networks for brain tumor segmentation."

15
International Workshop on Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain
Injuries. Springer, Cham, 2016.
References (Contd.)

6. Lai, Matthew. "Deep learning for medical image segmentation." arXiv preprint arXiv:1505.02000
(2015).
7. Chakrabarty, Navoneel. "Brain MRI Images for Brain Tumor Detection". Kaggle, 14 Apr. 2019,
https://www.kaggle.com/navoneel/brain-mri-images-forbrain-tumor-detection.
8. Rosebrock, Adrian. Finding Extreme Points in Contours with OpenCV.âĂİ PyImageSearch, 11 2016,
https://www.pyimagesearch.com/2016/04/11/findingextreme-points-in-contours-with-opencv/.
9. Tanner, Martin A., and Wing Hung Wong. "The calculation of posterior distributions by data
augmentation." Journal of the American statistical Association 82.398 (1987): 528-540.
10. Krizhevsky, Alex, Ilya Sutskever, and Geoffrey E. Hinton. "Imagenet classification with deep
convolutional neural networks." Advances in neural information processing systems. 2012.

16
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ICICV-2020

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