CH 08

Package Title: Pratt & Cornely Test Bank
Course Title: Pratt & Cornely

Chapter Number: 8
Question type: Multiple Choice
1) What are the characteristics of most unsaturated fatty acids found within a human cell?
A) protonated carboxylic acid and trans double bonds

B) deprotonated carboxylic acid and trans double bonds
C) protonated carboxylic acid and cis double bonds
D) deprotonated carboxylic acid and cis double bonds
E) none of the above
Answer: D
Difficulty: Easy
Section Reference: 8-1
Learning Objective: Recognize the physical characteristics of lipids
2) Which of the following is considered an omega-3 fatty acid?
A) 9,12-Octadecadienoic acid
B) 9,12,15-Octadecatrienoic acid
C) 6,9,12-Octadecatrienoic acid
D) 8,11,14-Eicosatrienoic acid
E) 5,8,11,14-Eicosatetraenoic acid
Answer: B
Difficulty: Medium
3) The major lipid component of cell membranes are _____.
A) triacylglycerols
B) cholesterol
C) glycerophospholipids
D) plasmologens
E) gangliosides
Answer: C
Difficulty: Easy
4) Which of the following alcohols is esterified to the phosphate group of glycerophospholipids?
A) choline
B) ethanolamine
C) glycerol
D) serine
E) all of the above
Answer: E
Difficulty: Medium
5) The most notable difference between _____ and other lipids is the presence of four fused
rings.
A) cholesterol
B) arachidonic acid
C) gangliosides
D) plasmologens
E) triacylglycerols
Answer: A
Difficulty: Easy
6) Which of the following terms describes all glycerophospholipid?
A) zwitterionic
B) amphipathic
C) nonpolar
D) amphoteric
Answer: B
Difficulty: Medium
7) Which of the following is the primary building block for the synthesis of molecules like
cholesterol or ubiquinone?
A) acetyl-CoA
B) palmitic acid
C) choline
D) isoprene
E) sphingosine
Answer: D
Difficulty: Medium
8) A type of lipid that commonly forms a waterproof barrier and is composed of a fatty acid and
a fatty alcohol is called a _____.
A) terpenoid
B) ganglioside
C) capsaicin
D) steroid
E) wax
Answer: E
Difficulty: Easy
9) Which of the following vitamins is derived from cholesterol?
A) vitamin A
B) vitamin D
C) vitamin E
D) vitamin K
Answer: B
Difficulty: Medium
10) What two molecules are used in the synthesis of sphingosine?
A) arachidonic acid and serine

B) stearic acid and isoprene
C) palmitic acid and choline
D) linoleic acid and isoprene
E) palmitic acid and serine
Answer: E
Difficulty: Medium
11) Which of the following explains why free fatty acids do not form bilayers?
A) the width of the polar head is greater than the nonpolar tail
B) the width of the polar head is less than the nonpolar tail
C) the width of the polar head is equal to the nonpolar tail
D) the width of the nonpolar head is greater than the polar tail
E) the width of the nonpolar head is less than the polar tail
Answer: A
Difficulty: Medium
Learning Objective: Describe the properties of the lipid bilayer
12) As temperatures grow colder with the onset of winter, animals will adapt by changing the
fatty acid composition of cell membranes. What characteristics of fatty acids will be seen?
A) longer chains with greater unsaturation

B) longer chains with greater saturation
C) shorter chains with greater unsaturation
D) shorter chains with greater saturation
E) chain length and saturation do not change in a cell membrane
Answer: C
Difficulty: Medium
13) A membrane raft is a(n) _____ in the lipid bilayer of a cell membrane.
A) transmembrane protein
B) integral membrane protein oriented to the intracellular side
C) integral membrane protein oriented to the extracellular side
D) region of high cholesterol and sphingolipid content
Answer: D
Difficulty: Medium
14) Which of the following is true regarding membrane asymmetry?
A) transverse diffusion occurs very quickly

B) lateral diffusion occurs very slowly
C) a flippase causes lateral diffusion to occur very rapidly
D) carbohydrates attached to membrane lipids are usually found on the cytosolic side of the
membrane
Answer: E
Difficulty: Medium
15) In an -helical protein that spans a cell membrane, _____ would likely be in the center of the
membrane while _____ would likely be associated with the polar head groups and _____ would
likely be associated with the aqueous environment
A) Trp; Asn; Ala

B) Leu; Gln; Asp
C) Tyr; Glu; Gly
D) Ile; Arg; Gln
E) Val; Ser; Thr
Answer: B
Difficulty: Hard
Learning Objective: Explain how proteins associate with membranes
16) Which of the following statements describes integral membrane proteins?
A) they never completely span the lipid bilayer

B) they are easily removed by changes in pH or high salt
C) amino acids that contact the core of the membrane are hydrophobic
D) they tend to be water soluble
E) their association with the membrane is through an attached fatty acyl or prenyl group
Answer: C
Difficulty: Medium
17) If a transmembrane domain of protein contains -sheet structure, the overall structure of the
transmembrane portion is likely a ____________.
A) -barrel
B) -tube
C) -turn
D) -helix
Answer: A
Difficulty: Easy
18) Which fatty acid is commonly attached to proteins to allow membrane localization?
A) eicosapentaenoic acid (EPA)

B) arachidonic acid
C) linoleic acid
D) myristic acid
E) farnesylic acid
Answer: D
Difficulty: Medium
19) If polar amino acids are found in a membrane spanning -helical region, they are most likely
_____.
A) mutations
B) modified with nonpolar groups by prenylation, methylation and/or acylation
C) hydrogen-bonded to other polar amino acids to prevent interaction with the membrane lipids
D) hydrogen-bonded with hydroxyl groups of the membrane fatty acids
Answer: C
Difficulty: Hard
20) Which of the following is a characteristic of integral membrane proteins?
A) most of their movement is by lateral diffusion

B) transverse diffusion occurs often but rather slowly
C) interactions between proteins makes the membrane highly rigid
D) all have carbohydrates attached to the extracellular domain
Answer: A
Difficulty: Medium
Learning Objective: Summarize the features of the fluid mosaic model
21) The carbohydrate portion of a membrane spanning glycoprotein is found _____.
A) spanning the membrane

B) on both the cytoplasmic and extracellular sides of the membrane
C) only on the cytoplasmic side of the membrane
D) only on the extracellular side of the membrane
E) carbohydrates are not found on membrane spanning glycoproteins
Answer: D
Difficulty: Medium
22) Which of the following aspects of membrane protein movement is explained by the fluid
mosaic model?
A) proteins that are immobile are often esterified to cholesterol via an Asp residue
B) proteins that are mobile only in a small area are sequestered by proteins attached to the
cytoskeleton
C) proteins that freely diffuse through the membrane often undergo flip-flopping
D) proteins confined to a lipid raft are linked to phosphatidylserine via and amide bond
Answer: B
Difficulty: Hard

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Package Title: Pratt & Cornely Test Bank

Course Title: Pratt & Cornely

Question type: Multiple Choice

A) protonated carboxylic acid and trans double bonds

2) Which of the following is considered an omega-3 fatty acid?

3) The major lipid component of cell membranes are _____.

4) Which of the following alcohols is esterified to the phosphate group of glycerophospholipids?

6) Which of the following terms describes all glycerophospholipid?

9) Which of the following vitamins is derived from cholesterol?

10) What two molecules are used in the synthesis of sphingosine?

A) arachidonic acid and serine

A) longer chains with greater unsaturation

14) Which of the following is true regarding membrane asymmetry?

A) transverse diffusion occurs very quickly

A) Trp; Asn; Ala

16) Which of the following statements describes integral membrane proteins?

A) they never completely span the lipid bilayer

A) eicosapentaenoic acid (EPA)

20) Which of the following is a characteristic of integral membrane proteins?

A) most of their movement is by lateral diffusion

21) The carbohydrate portion of a membrane spanning glycoprotein is found _____.

A) spanning the membrane

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