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    Nitroacetanilide

    Uploaded by

    Salah Abd El-Mageed
    The document describes the procedure to prepare p-Nitroacetanilide from acetanilide and acetic acid in the presence of a nitrating mixture. The procedure involves dissolving acetanilide in acetic acid, adding sulfuric acid, then slowly adding nitric acid while maintaining a temperature below 20 degrees Celsius. The resulting p-Nitroacetanilide crystals are filtered and washed with cold water.

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    © All Rights Reserved
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    Nitroacetanilide

    Uploaded by

    Salah Abd El-Mageed
    4 views3 pages
    The document describes the procedure to prepare p-Nitroacetanilide from acetanilide and acetic acid in the presence of a nitrating mixture. The procedure involves dissolving acetanilide in acetic acid, adding sulfuric acid, then slowly adding nitric acid while maintaining a temperature below 20 degrees Celsius. The resulting p-Nitroacetanilide crystals are filtered and washed with cold water.

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    كيمياء

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    The document describes the procedure to prepare p-Nitroacetanilide from acetanilide and acetic acid in the presence of a nitrating mixture. The procedure involves dissolving acetanilide in acetic acid, adding sulfuric acid, then slowly adding nitric acid while maintaining a temperature below 20 degrees Celsius. The resulting p-Nitroacetanilide crystals are filtered and washed with cold water.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    4 views3 pages

    Nitroacetanilide

    Uploaded by

    Salah Abd El-Mageed
    The document describes the procedure to prepare p-Nitroacetanilide from acetanilide and acetic acid in the presence of a nitrating mixture. The procedure involves dissolving acetanilide in acetic acid, adding sulfuric acid, then slowly adding nitric acid while maintaining a temperature below 20 degrees Celsius. The resulting p-Nitroacetanilide crystals are filtered and washed with cold water.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 3

    Preparation Of Nitroacetanilide

    Introduction:
    Para nitroacetanilide is also called 4-Nitroacetanilide, para nitroacetanilide is a chemical compound
    that is a nitroacetanilide derivative prepared from acetanilide and nitrating mixture. Along with para
    product a trace of ortho product is also formed.

    Aim:
    To prepare p-Nitroacetanilide from acetanilide and acetic acid in the presence of nitrating mixture.

    Equation

    Procedure :
     1-Take 3gm of finely powdered acetanilide in a clean beaker and dissolve it by adding
    glacial acetic acid by stirring the content carefully at room temperature.
     2-Gently warm the mixture to dissolve acetanilide completely.
     3-Cool the solution and add concentrated sulphuric acid slowly with constant stirring. The
    solution becomes warm, keep the mixture in ice-bath and clear solution is obtained.
     4-To the cool solution add fuming nitric acid dropwise through a dropping funnel with
    constant stirring.
     5-Maintain the temperature below 20oC during the whole process.
     6-Once the addition of nitric acid is completed, the beaker is removed from the freezing
    mixture bath and allowed to stand for half an hour at room temperature.
     7-Pour the mixture into 100gm of crushed ice in a beaker and stir well.
     8-Large crystals of p-nitroacetanilide are obtained. Filter the crystals through filter paper.
     9-The separated p-nitroacetanilide is washed with cold water in order to remove excess of
    acid.
     10-It is crystallized from ethyl alcohol. Dry the crystals in the folds of filter paper and weigh
    them to know the yield.
    Properties
    1. Physical properties :

    2.Chemical properties:
     As p-Nitroacetanilide is a compound and not found naturally, several unique
    methods and procedures are undertaken to develop the compound. Mainly, the
    p-Nitroacetanilide is prepared via nitration of acetanilide. In nitration, the
    acetanilide is processed and reacted via concentrated solutions of nitric and
    sulphuric acids.

     Moreover, the glacial acetic acid is also used during preparation, as it possesses
    the properties of a polar solvent, which regulates the acetanilide dissolving.
    Additionally, ions of acetic acid are poor nucleophiles, which ensure that there
    will be no substitution reaction during dissolving.

     In the overall process, an electrolytic substitution reaction would take place.


    Lastly, the acetanilide is purified via the process of crystallisation.

    3.Nitroacetanilide Uses:

     As discussed earlier, p-Nitroacetanilide has analgesic properties which is helpful


    to the pharmaceutical industry to prepare several medications, like paracetamol.
    Moreover, it is used to develop poultry medicines, anti-oxidants, gasoline,
    pesticides, and rubber chemicals. Apart from this, a p-Nitroacetanilide hydrolysis
    reaction is carried out, and it is synthesised to obtain the P-nitroaniline.
     It works as the reactant in a particular chemical reaction. The Reaction product is
    used further as a reactant in other Reactions to develop dyes. Lastly, p-
    Nitroacetanilide is also widely used in gum and corrosion inhibitors.

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