4. 3. 2. necessary.

1.(Figures hours Time=2

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 1 INTERNAL MBBSEXAMINATION [2022 -2023 BATCHI
DEPARTMENT OF PHYSIOLOGY
IMS & SUM HOSPITAL, BHUBANESWAR
TIME:2 hours
FULL MARK: 50

1. Enlist the coagulation factors. Explain with a flow chart the steps involved in the
mechanism of clot formation. Add a note on Haemophilia. (4+8+3)
OR

Dfaw aneat labelleddiagram of Neuromuscular junction of Skeletal Muscle. Describe

briefly the sequence of neuromuscular transmission. Write a note on Myasthenia Gravis.
(4+8+3)

2 Classify the different types of transport across the cellmembrane with examples of
each. Write a note on Na+ K+ pump. (5+5)

3. Draw a neat and labelled diagram of: T- cell activation by Antigen presenting cell. (5)

4. Short notes (5X2)

a) Pre-potential / Diastolic depolarization in pacemaker tissue of heart.
b Write the steps of fate of Haemoglobin in the body using a flow chart.
5. Objective type :(10marks).
i) Compare &contrast: Action potential & Electrotonic potential. (2)
i) Physiological reasoning. (2X3)
(a) RBC without nucleus can carry out its normal function for 120 days .
(b) Clot doesn't spread in injured vessel after blood coagulation.
(c) Long refractory period is seen in cardiac muscle.
ii) Major urinary form of bilirubin in severe obstructive jaundice is: (1)
(a) Free bilirubin.
(b) Both free & conjugated bilirubin.
(c) No bilirubin will be present in the urine.
(d) Bilirubin conjugated with glucuronic acid only.
iv) Schwann cell is not a glial cell (T/E). (1)
 1" Internal MBBS Examination 2022 - 23
BIOCHEMISTRY
Time - 2Hrs FullMarks - 50
Answer all questions

Classify Lipids, giving examples in each class. Discuss the structure and
functions of Cholesterol. Mention biomedical importance of EFA. [3+4+3]
OR.,
Define Oxidative Phosphorylation. Discuss with diagram the flow of electrons
in Electron Transport Chain. Add a brief note on inhibitors &
uncouplers. (2+5+3]
2. Write Short notes : (5
X6=30]
a. lon channels &
channelopathies. [3+2]
b. Mention the chemistry and functions of acidic
C. Define Primary structure and justify that
mucopolysaccharides. [2+3]
"primary structure" determines
the functional states of protein.
[2+31.
d. Describe the sourçes, daily requirement,
metabolËe role &deficiency states
of Vitamin A.
[1+1+2+1]
e. Name the plasma buffer. Mention the role of
Kidneý in regulation of
blood pH. [2+3]
f. Name the Nucleic acids and write the
differences between DNA & RNA.
[l+4]
3. Answer the following questions. [1X 10 =10]
a. Name the principal anion in ECF.
"ucei U ) HcO
b. What is the most common
electrolyte disorders? Hbaneta
c. Which organelle is useful for
protein trafficking?
d. ATP synthase is the marker enzyme cf
which organelle? ocnu
Antibiotic Abuse can induce deficiency of
f) Name the Purine base lipid soluble vitamin? it k
present tea.
in
(2) Electrons flow in the respiratory
chain, through a redox span of °_V.
P.T.O
h. Name the GAG responsible for charge selectivness of renal glomerulus.
Peroxidation of which type of lipids leads to generations of free radicais?PUFA
i. Name the amino acid which has maximum buffering capacity at
physiologic pH. histicie