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    Antigen

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    jesscraz25
    This document provides an overview of antigens including their definition, classification, and characteristics. It defines antigens as any substance that can stimulate an antibody response when introduced into the body. Antigens are classified as either T-dependent or T-independent based on whether they require T cell help to stimulate antibody production. The document also notes that characteristics like size, chemical nature, susceptibility to tissue enzymes, structural complexity, and foreignness to the host can impact an antigen's immunogenicity and ability to induce an immune response.

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    Antigen

    Uploaded by

    jesscraz25
    19 views11 pages
    This document provides an overview of antigens including their definition, classification, and characteristics. It defines antigens as any substance that can stimulate an antibody response when introduced into the body. Antigens are classified as either T-dependent or T-independent based on whether they require T cell help to stimulate antibody production. The document also notes that characteristics like size, chemical nature, susceptibility to tissue enzymes, structural complexity, and foreignness to the host can impact an antigen's immunogenicity and ability to induce an immune response.

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    This document provides an overview of antigens including their definition, classification, and characteristics. It defines antigens as any substance that can stimulate an antibody response when introduced into the body. Antigens are classified as either T-dependent or T-independent based on whether they require T cell help to stimulate antibody production. The document also notes that characteristics like size, chemical nature, susceptibility to tissue enzymes, structural complexity, and foreignness to the host can impact an antigen's immunogenicity and ability to induce an immune response.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    19 views11 pages

    Antigen

    Uploaded by

    jesscraz25
    This document provides an overview of antigens including their definition, classification, and characteristics. It defines antigens as any substance that can stimulate an antibody response when introduced into the body. Antigens are classified as either T-dependent or T-independent based on whether they require T cell help to stimulate antibody production. The document also notes that characteristics like size, chemical nature, susceptibility to tissue enzymes, structural complexity, and foreignness to the host can impact an antigen's immunogenicity and ability to induce an immune response.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 11

    Microbiology -

    Antigen
    Jessica I , 59
    Table of contents
    01 Definition

    02 Classification

    03 Characteristics
    Antibody Generator --Antigen

    Any substance which when


    introduced parenterally into the
    body, stimulates the production
    of an antibody with which it
    reacts specifically and in an
    observable manner
    Immunologic properties
    Immunogenicity Antigenicity
    Induce humoral and /or cell-
    mediated immune response in
    body. Combine
    specifically with
    • B cells+ antigen--> effector B
    cells (plasma cell)+memory B cells
    antibodies or T cell-
    surface receptors
    • T cells + antigen--> effector T
    cells (helper T cell or cytotoxic T
    cell) + memoryT cells
    Immunogens
    --> Substance which satisfies
    immunogenicity- IMMUNOGEN
    All immunogens are antigens
    but all antigens are not
    immunogens
    EPITOPE - small area present on
    antigen which reacts with specific site
    of T cell receptor or antibody
    Classification
    Antigens

    T - DEPENDENT T- INDEPENDENT
    ANTIGEN ANTIGEN
    Processed and presented by antigen -
    No help of T cells and
    presenting cells to T cells
    APCs

    Directly bind to Ig receptors &


    T cell activation stimulate B cells polyclonally

    Secrete cytokines- stimulate B cells - Increased secretion of


    antibodies non - specific antibodies
    T dependent antigen
    Superantigens
    --> Activate T cells directly without being
    processed by antigen - presenting cells
    --> Activate B cell pokyclonally, which leads to
    increased secretion of non- specific
    antibodies Eg - Streptococcal
    pyrogenic exotoxin(SPE) -
    A and C
    Rabies nucleocapsid
    Characteristics

    Size Larger the size, more potent is the molecule as an immunogen

    Chemical
    nature Proteins > Carbohydrates > Lipids > Nucleic acids

    Susceptibility to
    Substances susceptible to action of tissue enzymes - antigens
    tissue
    enzymes Polystytene latex - not antigenic

    Structural
    complexity Polymers with 2 or more amino acids - antigenic

    Only antigen that are 'foreign' to the individual ( non-


    Foreignness
    to host
    self) induce immune response.
    Antigenicity foreignness
    Thank you
    Any questions?

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