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    Bio Worksheet Mutations

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    Felix Robert Valenzuela
    This document discusses different types of mutations that can occur in DNA: deletions, insertions, and substitutions. Deletions and insertions cause frameshift mutations by changing the reading frame, while substitutions can result in missense mutations (amino acid change), silent mutations (no amino acid change), or nonsense mutations (premature stop codon). The document then provides examples of mutated DNA sequences and asks the reader to identify the type of mutation and whether it would cause effects. Finally, it analyzes the DNA change that causes sickle cell anemia and asks the reader to identify the specific amino acid change and type of mutation.

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    Bio Worksheet Mutations

    Uploaded by

    Felix Robert Valenzuela
    14 views2 pages
    This document discusses different types of mutations that can occur in DNA: deletions, insertions, and substitutions. Deletions and insertions cause frameshift mutations by changing the reading frame, while substitutions can result in missense mutations (amino acid change), silent mutations (no amino acid change), or nonsense mutations (premature stop codon). The document then provides examples of mutated DNA sequences and asks the reader to identify the type of mutation and whether it would cause effects. Finally, it analyzes the DNA change that causes sickle cell anemia and asks the reader to identify the specific amino acid change and type of mutation.

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    Bio-Worksheet-Mutations

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    This document discusses different types of mutations that can occur in DNA: deletions, insertions, and substitutions. Deletions and insertions cause frameshift mutations by changing the reading frame, while substitutions can result in missense mutations (amino acid change), silent mutations (no amino acid change), or nonsense mutations (premature stop codon). The document then provides examples of mutated DNA sequences and asks the reader to identify the type of mutation and whether it would cause effects. Finally, it analyzes the DNA change that causes sickle cell anemia and asks the reader to identify the specific amino acid change and type of mutation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    14 views2 pages

    Bio Worksheet Mutations

    Uploaded by

    Felix Robert Valenzuela
    This document discusses different types of mutations that can occur in DNA: deletions, insertions, and substitutions. Deletions and insertions cause frameshift mutations by changing the reading frame, while substitutions can result in missense mutations (amino acid change), silent mutations (no amino acid change), or nonsense mutations (premature stop codon). The document then provides examples of mutated DNA sequences and asks the reader to identify the type of mutation and whether it would cause effects. Finally, it analyzes the DNA change that causes sickle cell anemia and asks the reader to identify the specific amino acid change and type of mutation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    NAME __________________________________ Mutations Worksheet

    Deletion, Insertion & Substitution

    There are several types of mutation:


    ➢ DELETION (a base is lost/deleted)
    ➢ INSERTION (an extra base is added/inserted)
    --- Deletion & insertion may cause what’s called a FRAMESHIFT mutation, meaning the reading “frame"
    changes, thus changing the amino acid sequence from this point forward
    ➢ SUBSTITUTION (one base is substituted for another)
    --- If a substitution changes the amino acid, it’s called a MISSENSE mutation
    --- If a substitution does not change the amino acid, it’s called a SILENT mutation
    --- If a substitution changes the amino acid to a “stop,” it’s called a NONSENSE mutation

    Complete the boxes below. Classify each as Deletion, Insertion or Substitution AND as either
    frameshift, missense, silent or nonsense (Hint: Deletion & Insertion will always be frameshift).

    Original DNA Sequence: T A C A C C T T G G C G A C G A C T…


    mRNA Sequence:
    Amino Acid Sequence:

    Mutated DNA Sequence #1 T A C A T C T T G G C G A C G A C T…


    What’s the mRNA sequence? (Circle the change)
    amino acid sequence?
    Will there likely be effects? What type of mutation is this? ________________________________

    Mutated DNA Sequence #2 T A C G A C C T T G G C G A C G A C T…


    What’s the mRNA sequence? (Circle the change)
    amino acid sequence?
    Will there likely be effects? What type of mutation is this? ________________________________

    Mutated DNA Sequence #3 T A C A C C T T A G C G A C G A C T…


    What’s the mRNA sequence? (Circle the change)
    amino acid sequence?
    Will there likely be effects? What type of mutation is this? ________________________________

    Mutated DNA Sequence #4 T A C A C C T T G G C G A C T A C T…


    What’s the mRNA sequence? (Circle the change)
    amino acid sequence?
    Will there likely be effects? What type of mutation is this? _________________________________
    Original DNA Sequence: T A C A C C T T G G C G A C G A C T…
    mRNA Sequence:
    Amino Acid Sequence:

    Mutated DNA Sequence #5 T A C A C C T T G G G A C G A C T…


    What’s the mRNA sequence? (Circle the change)
    What will be the amino acid sequence?
    Will there likely be effects? What type of mutation is this? _________________________________

    1. Which type of mutation is responsible for new variations of a trait?


    2. Which type of mutation does not result in an abnormal amino acid sequence?
    3. Which type of mutation stops the translation of an mRNA molecule? ______________________________________

    Sickle Cell Anemia

    Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule.

    Hemoglobin carries oxygen in your red bloods cells. The mutation causes these red blood cells to become stiff &

    sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and

    increased risk of stroke, blindness, damage to the heart & lungs, and other conditions.

    --- Analyze the DNA strands below to determine what amino acid is changed AND what type of mutation occurred

    Normal hemoglobin DNA C A C G T A G A C T G A G G A C T C…

    Normal hemoglobin mRNA

    Normal hemoglobin AA sequence

    --------------------------------------------------------------------------------------------------------------------------------

    Sickle cell hemoglobin DNA C A C G T A G A C T G A G G A C A C…

    Sickle cell hemoglobin mRNA

    Sickle cell hemoglobin AA sequence

    4. What type of mutation is this? Please explain why.

    ----------------------------------------------------------------------------------------------------------------------------- -------------------------------

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