Screenshot 2024-02-07 at 10.01.54 AM
Screenshot 2024-02-07 at 10.01.54 AM
Screenshot 2024-02-07 at 10.01.54 AM
Program 2019
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Table of Contents
01 Ministry of Health Message
04 Policy
05 Procedure
05.1 Administrative Procedures
05.2 Scope of Service
05.2.1 Record-keeping
05.2.2 Medical and Occupational History
05.2.3 Occupational health services
05.2.3.1 Pre-employment Medical Examinations
05.2.3.1.1 Standard Pre-Employment examinations
05.2.3.1.2 Tuberculin skin testing
05.2.3.1.3 Interferon Gamma Release Assay Testing (IGRA)
05.2.3.2. Periodic Medical Examinations
05.2.3.3. Vaccination
05.2.3.3.1 Hepatitis B vaccine
05.2 3.3.2 Influenza vaccine
05.2.3.3.3 Measles, Mumps, Rubella (MMR)
05.2.3.3.4 Varicella
05.2.3.3.5 Tetanus/Diphtheria/Pertussis (Td/Tdap)
05.2.3.3.6 Meningococcal Vaccination
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05.2.3.4. Occupational injuries
i. Policy and procedures in case of exposure to needle stick injuries
(NSIs) & exposure to the blood or other body fluid
ii. Post-exposure management of HIV, Hepatitis B & Hepatitis C Virus
iii. Policy and procedures in case of exposure to none needle stick in-
juries (NSI) as; (musculoskeletal disorders, workplace violence & falls)
05.2.3.5. Disability evaluation and Workers’ compensation
05.2.3.6 Work restriction rules for important infectious diseases
05.2.3.7 Training
09. References
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Acronyms (Abbreviations):
ACIP: Advisory committee on Immunization Practices.
AFB: Acid Fast Bacilli.
ALT: Alanine transaminase (also, called alanine aminotransferase (ALAT) was formerly called se-
rum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase
(SGPT)).
BCG: Bacillus Calmette – Guerin.
CBC: complete blood count. CBC: Complete blood count.
CDC: Centers for Disease Control and Prevention.
CRS: Congenital Rubella Syndrome.
CXR: chest x-ray.
EIA: Enzyme immunoassay.
ELISA: enzyme-linked immunosorbent assay.
EPP: Exposure Prone Procedures.
FDA: Food and Drug Administration.
GI: Gastrointestinal.
HB: Hepatitis B.
HBIG: Hepatitis B immunoglobulin.
HBV: Hepatitis B virus.
HCP: Health care professionals / Health-Care Personnel.
HCV: Hepatitis C virus.
HCW: Healthcare Worker.
HD: Hazardous Drug.
HESN: Health Electronic Surveillance Network.
HGB: Hemoglobin.
HIV: Human Immunodeficiency Virus.
I.M: Intra muscular.
IAEA: International Atomic Energy Agency.
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ICRP: International Commission on Radiological Protection.
IG: Immunoglobulin.
IgG: Immunoglobulin G.
IGRA: Interferon-gamma release assay.
ILO: International labor of organization
IT: Information technologist.
IV: Intravenous.
KPI: Key performance indicators.
LAIV: Live attenuated influenza vaccine.
LFT: Lever function test.
LTBI: Latent Tuberculosis Infection.
MERS: Middle East Respiratory Syndrome.
MERS-CoV: Middle East Respiratory Syndrome Coronavirus.
MMR: Measles, Mumps, Rubella.
MOH: Ministry of Health.
MTB: Mycobacterium tuberculosis bacteria.
NIOSH: National institute for occupational safety and Health.
OHC: Occupational Health Clinic.
OSHA: Occupational Safety and Health Administration.
PFP: Post exposure Prophylaxis.
PPD: purified protein derivative.
PPE: Personal Protective Equipment.
RBC: Red blood cell count (RBC).
RIBA: Recombinant immunoblot assay.
RSV: Respiratory Syncytial Virus.
S.C.: Subcutaneous.
SHEA: Society for Healthcare Epidemiology of America.
Tdap: Tetanus, diphtheria & pertussis.
TNF: Tumor necrosis Factor.
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TST: Tuberculin Skin Testing.
TSTs: Tuberculin Skin Tests.
USP: United States Pharmacopeia.
VZIG: Varicella zoster immunoglobulin.
WBC: White blood cell count.
WHO: World health organization.
WPV: Workplace violence.
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01 Ministry of Health Message:
The Ministry of Health, represented by the General Directorate of Occupational
Health, works hard in all its possibilities and spare no effort through developing the oc-
cupational health clinics program in healthcare facilities, individually or in cooperation with
other parties, to maintain our employees well-being and health, to help them perform in
a safe and healthy environment, and to help them to get their best work, ability and
productivity.
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doctors trained in occupational medicine), the clinic may be managed by a specialized phy-
sicians in family medicine, community medicine, public health, or a general practitioner with
proper training in occupational health from an occupational medicine consultant. These
functions may also be performed by a qualified registered nurse, preferably an occupational
health nurse, under the direction of a suitably qualified physician who has responsibility for
the clinic.
03 Important Definitions:
1. Occupational Health (OH) is the promotion and maintenance of the highest degree of
physical, mental and social well-being of workers in all occupations and not merely the
absence of disease; by preventing departures from health, controlling risks and the ad-
aptation of work to people, and people to their jobs. (ILO / WHO 1950). Or As such,
Occupational Health deals with the impact of work on health and health on work.
2. Occupational safety is your legal right to work in conditions that are free of known
dangers. The requirements of the Occupational Safety and Health Act of 1970 helps
employers prevent the number of workplace injuries, illnesses and deaths. Or is a multi-
disciplinary field concerned with the safety, health, and welfare of people at work.
3. Occupational injury according to ILO (International Labor Organization); An occupational
injury is defined as any personal injury, disease or death resulting from an occupational
accident; an occupational injury is therefore distinct from an occupational disease, which
is a disease contracted as a result of an exposure over a period of time to risk factors
arising from work activity.
4. Occupational accident is an unexpected and unplanned occurrence, including acts of
violence, arising out of or in connection with work which results in one or more workers
incurring a personal injury, disease or death.
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5. Occupational hazard is a hazard experienced in the workplace. Occupational hazards can
encompass many types of hazards, including chemical hazards, biological hazards (bio-
hazards), psychosocial hazards, and physical hazards, mechanical hazards and ergonomics
hazards.
6. Biological hazards for healthcare workers also called occupational infections among HCW.
7. Occupational disease is an adverse health condition in human being, its occurrence or
severity is related to exposure to factors on the job or on the work environment. Or is
any disease contracted primarily as a result of an exposure to risk factors arising from
work activity.
8. Work-related diseases multi factorial diseases that occur among general population
&workers. Or have multiple causes, where factors in the work environment may play a
role, together with other risk factors, in the development of such diseases.
9. Occupational health service is a service established in or near a place of employment
for the purpose of:
• Protecting the workers against any health hazards which may arise out of the
work, or the conditions in which it is carried on.
• Contributing towards the workers physical and mental adjustment, in particular
by the adaptation of the work to the workers and their assignments to jobs for
which they are suited.
• Contributing to the establishment and maintenance of the highest possible de-
gree of physical and mental well-being of the workers. (3 June 1959 I.L.O).
10. Health-care personnel (HCP) are defined as a person (e.g., employees, students, contrac-
tors, attending clinicians, public-safety workers, or volunteers) whose activities involve
contact with patients or with blood or other body fluids from patients in a health-care,
laboratory, or public-safety setting. HCP might include (but are not limited to) physicians,
nurses, nursing assistants, therapists, technicians, emergency medical service personnel,
dental personnel, pharmacists, laboratory personnel, autopsy personnel, students and
trainees, contractual staff not employed by the health-care facility, and a person (e.g.,
clerical, dietary, housekeeping, laundry, security, maintenance, administrative, billing, and
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volunteers) not directly involved in patient care but potentially exposed to infectious
agents that can be transmitted to and from HCP and patients.
11. Exposure Prone Procedures (EPP): Any invasive procedures where there is a risk that injury
to the worker may result in exposure of the pa-taint’s open tissues to the blood of the
worker. There include procedures where the worker’s gloved hands may be in contact with
sharp instruments, needle tips or sharp tissues (e.g. specula of bone or teeth) in-side a
patient’s open body cavity, wound or confined anatomical space where the hands or fin-
gertips may not be completely visible at all times.
04 Policy:
Each healthcare facility must establish an occupational health clinic program to
ensure the wellbeing and safety of all workers in the institution and protect patients from
being exposed to any health hazard in health care facility; and aiding the workers which
suffering from occupational diseases or injuries to post-exposure management, disability
evaluation and compensation.
05 Procedure:
05.1 Administrative procedures:
a. The Occupational Health Clinic Program in each health care facility is supervised by
the occupational health department in the health affairs directorate.
b. Each healthcare facility must dedicate a suitable space for an occupational health clinic.
The clinic could be administratively under the medical director of the hospital, or the
medical director of the outpatient department, or public health unit, or the occupa-
tional health unit in the health care facility.
c. During off-duty hours, weekends and national holidays, the emergency medical ser-
vices department will be responsible for employee health matters that need urgent
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attention, e.g. post-exposure management of work related injuries (needle stick inju-
ries/ sharp injury/ blood and body fluids splashes/ falls/ and physical workplace vio-
lence).
d. Clinical staffing should be as the following:
i. Physician, preferably with experience or certification in occupational medi-
cine/ or family medicine/ or public health/ or community medicine.
ii. Nurse, preferably with experience or certification or courses in occupational
health or public health.
iii. Clerk.
e. Clinic equipment:
i. Specific space in outpatient department (OPD).
ii. Clinical examination room equipped with:
1. Examination table and chair.
2. Bedside light source.
3. Bedside table for patient equipment.
4. Ladder for the patient.
5. Examination and treatment requirements (e.g. pulse counter, medical
thermometer, sphygmomanometer for measuring blood pressure,
weight and height scales, injections, etc.).
6. Desk for the physician and chair for the patient.
7. Desktop and internet connection for data entry (e.g. occupational inju-
ries data, Health Electronic Surveillance Network (HESN), etc.).
8. Software for data entry and electronic health record access.
9. Hand washing basin and alcohol-based hand rub dispenser.
10. Cupboard for saving supplies.
11. Vaccination refrigerator.
iii. Administrative room for nurses and administrative clerk equipped with:
a. Desks for nurses and clerk.
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b. Two Desktop and internet connection for data entry (e.g. occu-
pational injuries data, Health Electronic Surveillance Network
(HESN), etc.).
c. Software for data entry and electronic health record access.
d. Printer, fax, scanner, and a photocopy machine.
e. Cupboard for keeping staff medical files.
f. Files, papers, pens and pencils, etc.
f. The clinic will generate reports of key performance indicators (KPI) monthly/ yearly as
the following:
I. Percentage of employees with files in OHC (number of employees
with files/total number of the facility employees X100).
II. Percentage of employees who completed pre-employment & periodic
medical examinations.
III. Percentage of each vaccine coverage in employees:
• HBV
• Influenza (yearly)
• MMR
• Chicken pox
• Tdap
• Meningitis
IV. Percentage of employees who received PPD skin testing:
o Number of employees with PPD conversion
o Number of employees treated for TB
V. Sero-conversion rates Hepatitis B (HB), Hepatitis C virus (HCV), Human
Immunodeficiency Virus (HIV).
VI. Total Number of occupational injuries
Needle stick/ sharp injury/ splashes numbers.
Needle stick/ sharp injury/ splashes followed up.
Needle stick/ sharp injury/ splashes treated.
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Needle stick/ sharp injury/ splashes turned positive.
Needle stick/ sharp injury/ splashes completed investigation.
PPD/IGRA conversion rates.
Fall injuries.
Cases of musculoskeletal disorders.
Cases of occupational violence.
VII. Total number of patients seen in month/ year:
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and in case of incident with potential transmission of infectious dis-
ease; the case should be referred to the infectious diseases de-
partment in the institution).
o Management and follow up cases of none needle stick injuries (NSI)
as fall injuries, cases of musculoskeletal disorders and cases of occu-
pational violence, and referral as needed.
e. Treatment, rehabilitation, disability and compensation evaluation services.
f. Applying work restriction rules according to international references.
g. Participation in the investigation of occupational health incidents.
h. Occupational health hazard risk assessment and management.
i. Referral of the common cases as chronic diseases & non -emergency
cases.
j. Training.
05.2.1 Record-keeping:
Each employee should have a medical file. The file may be as paper or
electronic. All paper files must be changed to electronic form according to the
MOH policy. The files are kept confidential in a secure place and separate from the
hospital patients’ files.
The healthcare worker (HCW) file contains the following:
a. HCW bio-data.
b. Initial medical history and examination.
c. Occupational history.
d. Vaccination record.
e. Pre-employment medical examinations.
f. Periodic medical examinations.
g. Results of all investigations.
h. Record of each OHC visit, work restrictions, and sick leaves.
i. All occupational or work-related injuries.
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j. Any unusual physical or psychological conditions should be brought to
the physician's attention.
k. Annual required investigations.
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05.2.3.1 Pre-employment Medical Examinations
Ideally, the pre-employment (pre-placement) medical examination strives to place
and maintain employees in an occupational environment adapted to their physiological
and psychological capacities. Offered to new employees to identify any health issues that
may require the provide support. There are two main purposes of pre-employment medical
examinations:
1. To provide base-line health data against which subsequent changes after
employment can be evaluated.
2. To ensure medical fitness for work.
Pre-placement (screening) examination is conducted at the time of employment and
generally consists of worker’s medical, family, occupational and social history; a thorough
physical examination and a range of laboratory/radiological examinations (such as chest
X-ray, electro-cardiogram, vision testing, urine or blood examination, and genetic screen-
ing) based on the nature of the work.
During the employment process and before starting the work at any health care
facilities (hospitals and primary care) each new employee must go through the pre-em-
ployment examination according to the following Pre-employment Examination form.
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اﺳﺗﻣﺎرة ﻓﺣص ﻣﺎ ﻗﺑل اﻟﺗوظﯾف Pre-employment examination Form /
رﻗم اﻟﻣﻠف اﻟطﺑﻲ.................................................................. Medical record No./ اﺳم اﻟﻣوظف.......................................................................................... :Name/
رﻗم اﻟﮭوﯾﺔ /اﻹﻗﺎﻣﺔ................................................................... Resident ID No:/ اﻟﺟﻧﺳﯾﺔ....................................................................................... :Nationality/
اﻟﻘﺳم.....................................................................................................Depart/ اﻟوظﯾﻔﺔ اﻟﻣرﺷﺢ ﻟﮭﺎ....................................................... The candidate's job /
اﻟﺗﺎرﯾﺦ .....................................................................................................Date/ اﻟرﻗم اﻟوظﯾﻔﻲ............................................................................. Job Number /
اﻟﻧﺗﯾﺟﺔ اﻟﻧﺗﯾﺟﺔ
Result Result
اﻟﻔﺣص اﻟﻣﺧﺑري Lab. Examination اﻟﻔﺣص اﻟﺳرﯾري Examination
ﻏﯾر ﺳﻠﯾم ﻏﯾر ﺳﻠﯾم
ﺳﻠﯾم Fit ﺳﻠﯾم Fit
Unfit Unfit
اﺷﻌﺔ اﻟﺻدرChest X-ray......................... (Rt. Eye ............... / اﻟﯾﻣﻧﻰ )
eyes
اﻟﻧظر
اﺧﺗﺑﺎر اﻟدرنManteaux Test.................... (Lt. Eye. .............. / اﻟﯾﺳرى )
ِ◌ ِ◌ ﺗﺣﻠﯾل اﻟﺑولUrine Analysis ..................... ﺗﻣﺎﯾز اﻻﻟوانColor Discrimination ...........
ﺻورة دم ﻛﺎﻣلC.B.C ............................. اﻷذن اﻟﯾﻣﻧﻰRt.Ear ................................
واﻟﻧطﻖ
اﻟﺳﻣﻊ
ﺑوﻟﯾﻧﺎ واﻣﻼحU&E .................................... اﻷذن اﻟﯾﺳرىLt.Ear ...............................
After medical examination the above mentioned is: ﺑﻌد اﻟﻛﺷف اﻟطﺑﻲ ﻋﻠﻰ اﻟﻣذﻛور اﻋﻼه اﺗﺿﺢ اﻧﮫ:
Fit ﻻﺋﻖ ﺻﺣﯾﺎ ً
Unfit ﻏﯾر ﻻﺋﻖ ﺻﺣﯾﺎ ً
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05.2.3.1.1 Standard Pre-Employment Examinations
A. Physical Exam:
A physical examination will be performed as part of the pre-employment medical screen-
ing process. Conduct a comprehensive physical examination of all body organs, focusing on
the pulmonary, cardiovascular, and musculoskeletal systems. Most physical evaluations will
generally consist of:
o Measuring blood pressure
o Measuring heights and weight
o Documenting body mass index (BMI)
o Measuring pulse rate
o Measuring respiration rate
o Reporting on existing medical illnesses
o Reporting on previous medical history
o Reporting on allergies and general social history
B. TB Screening:
ALL new HCW need to be screened for latent tuberculosis infection (LTBI) either
by:
o Interferon Gamma Release Assay (IGRA) “preferred if available” or
o If results of the chest x-ray are positive follow up with further testing is
required. Applicant cannot begin employment until documentation of fol-
low up is provided.
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C. Documentation of Immunizations:
Healthcare workers, expected to be in contact with patients directly or indirectly, are required
(as per the GCC infection control manual 3rd edition) to be immune to the following infections:
Measles, Mumps, All HCW/ pre-employment Proof of receiving at least two doses of MMR
Rubella vaccine or
Proof of immunity by lab test (IgG)
Chickenpox (Vari- All HCW/ pre-employment Proof of receiving at least two doses of Varicella
cella) vaccine or
Proof of immunity by lab test (IgG)
or
Clinically documented previous infection
Hepatitis B virus All HCW/ pre-employment Proof of receiving at least three doses of HBV
(HBV) vaccine or
Proof of immunity by lab test (HBsAb =/< 10U)
Meningococcal HCW working at Microbiology Proof of receiving at least one doses of a quad-
meningitis lab pre-employment and then rivalent Meningococcal meningitis vaccine
every 5 years
Influenza vaccine All HCW annually Proof of vaccination is required during the in-
fluenza season (usually December through the
end of April)
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D. Drug Screening:
A drug screen in urine will be performed as part of the pre-placement medical
clearance process.
E. Respirator Fitness Testing:
Respirator fit testing to an N-95 respirator will be performed as part of pre-
employment health screening visit.
F. Lab investigations: e.g.
Screening for Hepatitis B virus (HBV), Hepatitis C Virus (HCV), and Human Immu-
nodeficiency Virus (HIV).
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The procedure is as follows:
Testing for Latent TB Infection:
1. The Tuberculin Skin Test (TST) detects individuals infected with Mycobacterium tu-
berculosis. The skin test is administered intradermal using the Mantoux technique by
injecting 1.0 ml containing 5 TU of purified protein derivative (PPD) solution. If a person
is infected, a delayed-type hypersensitivity reaction is detectable 2 to 8 weeks after
infection. The reading and interpretation of TST reactions should be conducted within
48 to 72 hours of administration by trained healthcare professionals.
2. Equipment and materials 1 cc tuberculin syringe, 26- or 27-gauge needle, ½ inch
(16 mm) long, alcohol swabs and a measuring tool marked in millimeters.
3. Administration:
The Mantoux test is the recommended TST. It is administered by injecting 1.0 ml con-
taining 5 TU of purified protein derivative (PPD) solution intradermal into the volar
surface of the forearm using a 27-gauge needle with a tuberculin syringe.
a. Obtain results of all previous TSTs. Ask the patient to describe what the test
area looked like 2 to 3 days after administration; obtain documentation.
b. Avoid areas of skin with veins, rashes, or excess hair.
c. Cleanse hands with alcohol hand rub.
d. Cleanse the area with an alcohol swab, allowing the area to dry.
e. Clean the rubber top of vial before drawing up solution.
f. Inject the entire antigen just below the surface of the skin on the volar surface
of the forearm, forming a 6-10 mm wheal (a pale, raised area with distinct
edges; has orange peel-like appearance and does not disappear immediately).
g. Avoid covering the area with a bandage or applying pressure to the injection
site.
h. If minor bleeding occurs, dab the injection site with a cotton swab.
i. If no wheal forms, or if a wheal forms that is less than 6 mm, the test should
be repeated immediately, approximately 2 inches from the original site or on
the other arm.
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j. Record the date, time, and location of the TST.
k. Instruct the patient not to scratch the site but to use a cool compress to
relieve any itching or swelling.
l. Give a written appointment card for TST reading. Inform the patient of the
importance of returning for a reading of the TST within 48 to 72 hours (2 to 3
days).
m. Provide written information about the TST (a pamphlet or brochure).
NB: Consider calculate and monitor PPD conversion rates
4. Measurement:
a. Measure the induration (hard bump) rather than the erythema.
b. Palpate the area with the fingertips, measuring the diameter of induration
perpendicular to the long axis of the arm.
c. Use a ballpoint pen to mark the edges of the induration.
d. Use a tuberculin skin test ruler or a ruler with millimeter marks to measure
the distance between the two points.
5. Recording and documentation:
a. Record the date that the TST was administered.
b. Record the brand name of the PPD solution, lot number, manufacturer, and
expiration date in the patient’s records.
c. Record results in millimeters of induration (0 mm if there is no induration)
rather than as positive or negative.
d. Record the date and time of reading and the name of the person reading
the TST.
e. Provide the patient and ordering physician with written documentation.
6. Storage and handling:
a. PPD solution must be kept refrigerated at 36–46°F.
b. Avoid fluctuations in temperature; do not store in the refrigerator door.
c. Syringes must be filled immediately prior to administration.
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d. Store and transport the tuberculin in the dark as much as possible and avoid
exposure to light.
7. Notes:
a. The TST should not be performed on a person who has a documented history
of either a positive TST result or treatment for TB disease.
b. TST is contraindicated only for persons who have had a severe reaction (e.g.
necrosis, blistering, anaphylactic shock, or ulcerations) to a previous TST.
c. TST results should only be read and interpreted by a trained healthcare pro-
fessional. Patients or family members should not be relied upon to measure
TST results.
d. TB disease must be ruled out before initiating treatment for Latent Tubercu-
losis Infection (LTBI) to prevent inadequate treatment of TB disease.
Table 3: TST interpretation
TST reaction
≥15 mm indu-
induration ≥ 5mm induration ≥10 mm of induration
ration
size
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5. Those who are immuno- 5. Persons with the clinical conditions
suppressed for other rea- previously mentioned.
sons (taking an equivalent 6. Children younger than 4 years of
of ≥ 15 age.
7. Infants, children, or adolescents ex-
posed to adults at high risk for TB dis-
Mg/ day of prednisone for ease.
1 month or more or taking
TNF-α antagonists).
8- Chest Radiograph:
Chest radiographs help differentiate between LTBI and pulmonary TB disease in
individuals with positive TST results.
For TST-positive individuals:
1. Clinical evaluation to exclude active tuberculosis:
a. Order chest radiography as part of a medical evaluation for a person who has a
positive TST.
b. Determine baseline CBC and liver function test (LFT).
2. Refer to the primary care consultant for evaluation and possible prophylaxis. After
baseline testing, routine periodic retesting is recommended for persons who had ab-
normal initial results and other persons at risk for hepatic disease.
3. At any time during treatment, whether or not baseline tests were done, laboratory
testing is recommended for patients who have symptoms suggestive of hepatitis (e.g.,
fatigue, weakness, malaise, anorexia, nausea, vomiting, abdominal pain, pale stools, dark
urine, and chills) or those who have signs of jaundice. Patients should be instructed at
the start of treatment and at each monthly visit to stop taking treatment and to seek
medical attention immediately if symptoms of hepatitis develop and not to wait until a
clinic visit to stop treatment.
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9- Special Considerations during Pregnancy:
a. Consider immediate treatment for LTBI if the woman is HIV-infected or has had
recent contact with a TB case and monitor the patient.
b. In the absence of risk factors, wait until after the woman has delivered to avoid
administering unnecessary medication during pregnancy.
c. INH administered daily is the preferred regimen.
d. Supplementation with 50 mg pyridoxine (vitamin B6) is recommended.
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tests which must be interpreted within the context of the risks the individual faces of
TB infection and the risks for progression to active TB disease.
Two IGRAs Approved by the United States Food and Drug Administration (FDA):
1. QuantiFeron-TB Gold In-Tube test (QFT-GIT).
2. T-spot TB test (T-Spot).
Procedure:
1. A physician discusses IGRA recommendation with employee.
2. Health Centre/Unit provides IGRA pre-test counseling and advice the client
about the site for testing.
3. Ensure that patient has received no live vaccines in the 4 previous weeks.
If the patient has, delay testing until 4 weeks after live vaccine was re-
ceived.
4. Samples to be drawn using an incubator to transport IGRA
5. Samples must be maintained at specified temperature during transport.
6. IGRA results are recorded under the Immunization tab in the TB module
(CDC 2010 &CTC, 2010).
Interpretations of IGRA results:
1. Positive IGRA: This means that the person has been infected with Mycobacte-
rium tuberculosis bacteria (MTB).
2. Additional tests are needed to determine if the person has LTBI or MTB disease.
3. A healthcare provider will then provide treatment as needed.
4. Negative IGRA: This means that the person’s blood did not react to the test and
that LTBI of MTB disease is not likely.
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5) Clinical management will not be influenced by result. Epidemiologic evidence exists for
sequential test based on result but not for parallel testing
Indications for IGRA:
A. TST positive and BCG vaccinated and Low risk TB exposure
B. TST positive and BCG vaccinated and High risk TB exposure
C. TST negative, Immuno-compromised and High risk of TB exposure
D. Unlikely to return for TST read and High risk TB exposure
E. Specific medical conditions e.g. New dialysis clients, before renal or bone-marrow
transplants
F. Client for Tumor necrosis Factor (TNF) inhibitors
G. Previous indeterminate IGRA
H. At discretion of TB Physician
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Table 4: Tests required as periodic medical examinations:
General examination, Blood Screening for HBV, Other departments Once every 24 months
and blood tests HCV, HIV
General examination, Complete blood count Physicians and technicians working mandatory once every 12 months
and total blood (CBC)( differential platelet in radio diagnostic or radio thera-
count count; white blood cell peutic departments and Physicians
General examination, TST Two-step or IGRA HCW who are suspected to be ex- After baseline testing for infection
and TB screening posed to acquire T.B infection during with M. tuberculosis (baseline nega-
Chest X – ray Recommended for workers with pos- - HCWs with a baseline positive or
itive PPD newly positive test result
General examination, Audiogram for noise expo- Laundry workers, sterilization center, Once every 24 months
and audiometric test sure. food service area, engineering units,
etc.
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05.2.3.3 Vaccination:
Because of their contact with patients or infective material from patients, many HCW
are at risk for exposure to (and possible transmission of) vaccine-preventable diseases. Employers
and HCW have a shared responsibility to prevent occupationally acquired infections and avoid
causing harm to patients by taking reasonable precautions to prevent transmission of vaccine
preventable diseases. Vaccination programs are therefore an essential part of infection prevention
and control for HCW. Optimal use of recommended vaccines helps maintain immunity and safe-
guard HCW from infection, thereby helping protect patients from becoming infected.
Hepatitis B All health care staff 3 doses intra muscular Not recommended
(I.M)
0,1 month, 6 month
Influenza All health care staff 1 I.M dose of inacti- Vaccine repeated annu-
vated injectable vac- ally
cine annually
MMR (Measles, HCP without serologic ev- 2 doses of MMR 4 Persons vaccinated be-
Mumps, Ru- idence of immunity or weeks apart are given tween 1963 and 1967
bella) prior vaccination (Docu- Subcutaneous (S.C) with a killed measles
mented immunity) vaccine alone, killed
28
Varicella HCP who have no sero- 2 doses of varicella
(Chickenpox) logic proof of immunity, vaccine 4 weeks apart
prior vaccination or his- are given S.C
tory of varicella disease
(Documented immunity)
-Clinical research Or
-Microbiologists who are Repeated every 5 years
routinely exposed to iso- if conjugate type
lates of N. meningitides
CDC (2011)
29
of HepB vaccine on the routine schedule, followed by anti-HBs testing 1–2 months
later. A vaccine whose anti-HBs remains less than 10 mIU/ mL after 2 complete series
is considered a “non-responder.” For non-responders: HCP who are non-responders
should be considered susceptible to HBV and should be counseled regarding pre-
cautions to prevent HBV infection and the need to obtain HBIG prophylaxis for any
known or probable parenteral exposure to hepatitis B surface antigen (HBsAg)-
positive blood or blood with unknown HBsAg status.
It is also possible that non responders are people who are HBsAg positive. HBsAg
testing is recommended.
HCW found to be HBsAg positive should be counseled and medically evaluated. For
HCP with documentation of a complete 2-dose (Heplisav-B) or 3-dose (Engerix-B or
Recombivax HB) vaccine series but no documentation of anti-HBs of at least 10
mIU/mL (e.g., those vaccinated in childhood): HCW who are at risk for occupational
blood or body fluid exposure might undergo anti-HBs testing upon hire or matric-
ulation.
05.2.3. 3.2 Influenza vaccine:
All HCW, including physicians, nurses, paramedics, emergency medical technicians,
employees of nursing homes and chronic care facilities, students in these professions, and
volunteers, should receive annual vaccination against influenza. Live attenuated influenza
vaccine (LAIV) may be given only to non-pregnant healthy HCW age 49 years and younger.
Live attenuated influenza vaccine (LAIV) is preferred over LAIV for HCW who are in close
contact with severely immunosuppressed patients (e.g., stem cell transplant recipients)
when they require protective isolation.
05.2.3.3.3 Measles, Mumps, Rubella (MMR):
HCW who work in medical facilities should be immune to measles, mumps, and
rubella. HCW can be considered immune to measles, mumps, or rubella only if they have
documentation of (a) laboratory confirmation of disease or immunity or (b) appropriate
vaccination against measles, mumps, and rubella (i.e., 2 doses of live measles and mumps
vaccines given on or after. The first birthday and separated by 28 days or more, and at
30
least 1 dose of live rubella vaccine). Health care professionals (HCP) with 2 documented
doses of MMR are not recommended to be serologically tested for immunity; but if they
are tested and results are negative or equivocal for measles, mumps, and/or rubella, these
HCP should be considered to have presumptive evidence of immunity to measles, mumps,
and/or rubella and are not in need of additional MMR doses. 2 doses of MMR vaccine
should be considered for unvaccinated HCW born before 1957 that do not have laboratory
evidence of disease or immunity to measles and/or mumps. One dose of MMR vaccine
should be considered for HCP with no laboratory evidence of disease or immunity to
rubella. For these same HCP who do not have evidence of immunity, 2 doses of MMR
vaccine are recommended during an outbreak of measles or mumps and 1 dose during
an outbreak of rubella.
05.2.3.3.4 Varicella:
It is recommended that all HCP be immune to varicella Evidence of immunity in
HCW includes documentation of 2 doses of varicella vaccine given at least 28 days apart,
laboratory evidence of immunity, laboratory confirmation of disease, or diagnosis or veri-
fication of a history of varicella or herpes zoster (shingles) by a healthcare provider.
05.2.3.3.5 Tetanus/Diphtheria/Pertussis (Td/Tdap):
All HCWs who have not or are unsure if they have previously received a dose of
Tdap should receive a dose of Tdap as soon as possible, without regard to the interval
since the previous dose of Td. Pregnant HCP should be revaccinated during each preg-
nancy. All HCWs should then receive Td boosters every 10 years thereafter.
05.2.3.3.6 Meningococcal Vaccination:
With MenACWY and MenB is recommended for microbiologists who are routinely
exposed to isolates of N. meningitides. The two vaccines may be given concomitantly but
at different anatomic sites, if feasible Immunization Action Coalition 2017 CDC 2018 - IAC
2018.
31
05.2.3.4. Occupational injuries:
Statistics show that a hospital is one of the most hazardous places to work. The
following types of injuries are most prevalent among healthcare workers:
a. Needle stick injuries “NSIs” (blood borne pathogens):
o The most prevalent, least reported, and largely preventable serious risk health
care workers face comes from continuing use of inherently dangerous conven-
tional needles, such unsafe needles transmit blood borne infections to health
care workers employed in a wide variety of occupations.
o Elimination of unnecessary sharps and use of safer needles can dramatically
reduce needle stick injuries.
b. Musculoskeletal disorders:
o Rank second among all work related injuries, with the greatest number occur-
ring among the health care workers.
o Exposures include the requirements to lift, pull, slide, turn and transfer patients,
more equipment and stand for long hours.
c. Workplace violence:
o Workplace violence (WPV) is a recognized hazard in the healthcare industry.
o WPV is any act or threat of physical violence, harassment, intimidation, or other
threatening disruptive behavior that occurs at the work site.
o WPV ranges from threats and verbal abuse to physical assaults and even hom-
icide.
o According to OHSA, health care and social service workers are at high risk of
being violently assaulted at work.
o Unfortunately, many more incidents probably go unreported.
o NIOSH recommends that all hospitals develop a comprehensive violence pre-
vention program.
d. Falls, (Slip and fall from fluids spilled onto the floor):
o When water or liquids are spilled on the floor of a nursing home or hospital, a
healthcare worker can fall on the slick floor.
32
i. Policy and procedures in case of exposure to needle stick injuries (NSIs) & exposure to
the blood or other body fluid.
1. Emergency management of cases:
HCW who experience a needle stick or sharps injury or are exposed to the blood or other
body fluid of a patient during the course of work, should immediately follow these steps:
a. Do not apply pressure to the wound, or do not suck/ squeeze blood from the
injured site; allow it to bleed freely.
b. Wash the wound with a lots of soap and water. If exposure is to the eyes wash
with eyes solution or running tap water for 1 minute at least. , if such a puncture
comes through a gloves, remove gloves and wash your hands.
c. Identify the patient involved so that they can be evaluated for an infection
d. Immediately report the injury to the supervisor; do not wait until the end of the
shift or the end of the procedure
e. Immediately seek medical treatment. And get a medical assessment.
f. Follow the directions for any necessary blood tests, vaccinations, or medications
to prevent infection.
g. Notification by document the incident on the forms at the Occupational Health
Clinic (OHC) in HESN program (Occupational injury form).
h. A risk assessment should be made based on the significance of the exposure,
the HCW prior immunity to Hepatitis B and the known or likely status of the patient
for blood born viruses. This should be carried out by OHC and/or Emergency.
i. If the source patient is known, every attempt should be made to obtain a blood
specimen for testing for blood borne viruses. Check the source patient blood test-
ing status for HIV, Hep B and Hep C, if the patient have testing done in the last
two weeks, use those test results, if not, order HIV, Hep B and Hep C serology for
the source patient. All source patients should be offered tests for the three main
blood born viruses, Hepatitis B, Hepatitis C and HIV. Appropriate pre-test, counsel-
ing and informed consent is a prerequisite of testing the source; this should be
arranged by the manager.
33
j. Where the risk is high the recipient should be offered prophylaxis medication as
soon as possible; preferably within an hour of the incident.
k. Bloods from the recipient will also be required for serum save. The taking of
blood specimens and the approach to the source for permission to test should be
managed by a third party, i.e. somebody other than the recipient of the injury.
l. The exposed HCW should always get a baseline testing for HIV, Hep B (HBsAg,
HBsAb), and Hep C. Follow up testing at 4, 12, and 24 weeks should be done if the
source patient is positive for HIV, Hep B or Hep C or if the source patient is un-
known.
2. Perform follow-up anti-HBs testing in persons who receive hepatitis B vaccine.
3. Test for anti-HBs 1 – 2 months after last dose of vaccine.
4. Any positive case must be sent to the Infectious Diseases department for treatment,
and the case should be followed-up by the OHC.
5. If the case do not response to treatment and complications appear; a complete
medical report should be sent by the OHC to the disability committee for evaluations
and compensation.
ii. Post-exposure management of HIV, Hepatitis B & Hepatitis C Virus,:
34
o Provide close follow-up for exposed personnel (Box 2) that includes counseling,
baseline and follow-up HIV testing, and monitoring for drug toxicity.
o Follow-up appointments should begin within 72 hours of an HIV exposure.
o If a newer 4th generation combination HIV p24 antigen-HIV antibody test is utilized
for follow-up HIV testing of exposed HCP, HIV testing may be concluded at 4
months after exposure (Box 2).
o Expert consultation is recommended for any occupational exposures to HIV and at
a minimum for situations described in (Box 1).
o If a newer testing platform is not available, follow-up HIV, testing is typically con-
cluded at 6 months after an HIV exposure.
Table 6: HIV Post exposure Prophylaxis Regimens:
altegravir (Isentress®; RAL) 400mg PO Twice Daily PlusTruvada™,1 PO Once Daily [Tenofovir DF (Viread®; TDF)
300mg + tricitabine (Emtriva™; FTC) 200mg])
ALTERNATIVE REGIMENS
(May combine one drug or drug pair from the left column with 1 pair of nucleoside/nucleotide reverse transcrip-
tase inhibitors from the right column.
35
Atazanavir (Reyataz®; ATV) + ritonavir
(Norvir®; RTV)
(CDC, 2013)
BOX 1. Situations for Which Expert Consultation for Human Immunodeficiency Virus (HIV) Postex-
posure Prophylaxis (PEP) is Recommended
Unknown source (e.g., needle in sharps disposal container or laundry) •Use of PEP to be decided
on a case-by-case basis
•Consider severity of exposure and epidemiologic likelihood of HIV exposure
•Do not test needles or other sharp instruments for HIV
36
BOX 2. Follow-Up of Health-Care Personnel (HCP) Exposed to Known or Suspected Human
Immunodeficiency Virus (HIV)-Positive
Sources
Counseling (At the time of exposure, and at follow-up appointments) Exposed HCP should
be advised to use precautions (e.g., use of barrier contraception, avoid blood or tissue dona-
tions, pregnancy, and if possible, breastfeeding) to prevent secondary transmission, espe-
cially during the first 6–12 weeks Post exposure.
For exposures for which PEP is prescribed, HCP should be informed regarding:
•possible drug toxicities (e.g. rash and hypersensitivity reactions which could imitate acute
HIV seroconversion and the need for monitoring) •possible drug interactions, and
•the need for adherence to PEP regimens.
HIV testing results should preferably be given to the exposed healthcare provider at face to
face appointments
37
ii. Hepatitis B Virus post-exposure management:
Post-exposure prophylaxis and consultation with infectious diseases consultant
or department should be offered, and initiated as early as possible, to all individuals with
exposure that has the potential for Hepatitis B transmission.
Documented re-
sponder after com-
No action needed
plete series
(≥3 doses)
HBIG x2 sepa-
Documented non-re- Positive/
— rated — No
Unknown
sponder after 6 doses by 1 month
Positive/ <10mIU/m
Response unknown HBIG x1
Unknown L Initiate
after revac- Yes
<10mIU/m cination
3 doses Negative None
L
38
≥10mIU/m
Any result No action needed
L
Unvaccinated/incom-
pletely Positive/ Complete
— HBIG x1 Yes
vaccinated or vaccine Unknown vaccination
refusers
(CDC, 2013)
39
Source Patient:
o HCV antibody test (e.g., Enzyme immunoassay (EIA)/ enzyme-linked immuno-
sorbent assay (ELISA)), and if positive, HCV RNA test or Recombinant immunoblot
assay (RIBA)
Exposed HCW:
o Liver panel including liver enzymes
o HCV antibody, and if positive, HCV RNA test
fuses testing
Source patient is positive for both Source patient: Counsel and manage as chronic
HCV antibody and HCV RNA and hepatitis C regardless of status of exposed person
Exposed HCW is HCV-antibody Exposed HCW: Follow up as outlined in Section 2:
negative Post Exposure Follow-Up
40
a
If at any time the serum ALT level is elevated in the exposed HCW, the clinician should
test for HCV RNA to assess for acute HCV infection.
b
A single negative HCV RNA result does not exclude active infection.
SECTION 2: Post-Exposure Follow-Up for HCV
If the source patient is known to be positive for HCV antibody and/or HCV RNA, the
follow-up schedule for the exposed HCW should be as follows:
Week 4: HCV RNA and liver panel
Week 12: HCV RNA and liver panel
Week 24: Liver panel and HCV antibody
If at any time the serum Alanine transaminase Level (ALT level) is elevated, the clinician
should repeat HCV RNA testing to confirm acute HCV infection.
At any time that exposed HCWs test positive for HCV RNA, the clinician should refer for
medical management by a gastroenterologist or other clinician with experience in treating
HCV.
In the HCW exposed to a hepatitis C-infected source patient, regular follow-up with HCV
RNA testing is recommended in addition to HCV antibody testing, because HCV RNA
testing can identify acute infection within 2 weeks of exposure, whereas accuracy of the
antibody test can be delayed up to several months after acute infection (i.e., “window
period”).
iii. Policy and procedures in case of exposure to non-needle stick injuries (NSI) as; (muscu-
loskeletal disorders, workplace violence & falls).
41
3. If the case do not response to treatment and complications appear ; refereed to
disability committee for worker's compensations
Cytomegalovirus No restriction.
42
Diarrheal diseases
· Acute stage (diarrhea with Restrict from patient Until symptoms resolve.
other symptoms) contact, contact with
the patient’s environ-
ment, or food handling.
· Convalescent stage, Salmo- Restrict from care of Until symptoms resolve; consult with em-
nella spp high-risk patients, for ployee health.
example immunocom-
promized patients.
43
Herpes simplex
· Genital No restriction.
Measles
Active Exclude from duty. Until 4 days after the rash appears
Meningococcal meningitis Exclude from duty. Until 24 hours after the start of antibiotic
therapy
44
Mumps
· Active Exclude from duty. Until 9 days after onset of parotitis.
· Post exposure (susceptible Exclude from duty. From 12th day after 1st exposure through
personnel) 25th day after last exposure or until 5 days
after onset of parotitis.
Pertussis
· Active Exclude from duty. From beginning of catarrhal stage through
3rd wk after onset of paroxysms or until 5
days after start of effective antimicrobial
therapy.
· Postexposure (symptomatic Exclude from duty. Until 5 days after start effective antimicro-
personnel bial therapy.
45
Rubella
· Active Exclude from duty. Until 7 days after rash appears.
· Post exposure (susceptible Exclude from duty From 7th day after 1st exposure
personnel) through 23th day after last exposure and /
or 7 days after rash appears
46
Tuberculosis
· Active disease Exclude from duty Until proven noninfectious by
Physician
· PPD converter No restriction Treatment for latent TB infection
Varicella
· Active Exclude from duty Until all lesions dry and crust. If only le-
sions that do not crust (macules and pap-
ules), until no new lesions appears within a
24 hours period
· Post exposure (susceptible Exclude from duty From 10th day after 1st exposure
personnel through 21st day (28th day if VZIG
given) after last exposure
Zoster
·Localized, in healthy person Cover lesions; restrict Until all lesions dry and crust
from care of high-
risk patients +
·Generalized or localized in Restrict from patient Until all lesions dry and crust
immunosuppressed person contact
·Post exposure (susceptible Restrict from patient From 8th day after 1st exposure through 21st
personnel) contact day (28th day if VZIG given) after last exposure
or, if varicella occurs, until all lesions dry and
crus. If only lesions that do not crust (macules
and papules), until no new lesions appears
within a 24 hours period
47
Viral respiratory infections, Consider excluding Until acute symptoms resolve
acute febrile from the care of high
risk
patients ++ or con-
tact with their envi-
ronment during
community outbreak
of Respiratory Syn-
cytial Virus (RSV) and
influenza
MRSA (methicillin-resistant Restrict workers with wound drainage Until the infection has
Staphylococcus aureus) (pus) that cannot be covered and healed.
contained with a clean, dry bandage
or who cannot maintain good hy-
giene practices.
48
Vancomycin-resistant enterococ- Exclude from work. Until cleared on a case-by-
cus case basis by Infection Con-
(VRE) trol and Employee Health.
+ Those susceptible to varicella and those who are at increased risk of complications due to
varicella, such as neonates and immunocompromised persons of any age
++ High-risk patients as defined by the Advisory committee on Immunization Practices (ACIP) for
complications due to influenza
05.2.3.7. Training:
Training program for all employees in the facility (include new and old employees) dis-
tributed among all months of the year, includes all departments and staff members with the
following topics are included:-
A. Occupational employee clinics (importance & objectives)
B. Occupational health services.
C. Occupational diseases and work related diseases.
D. Occupational health hazards in health care facilities.
E. Vaccination of health care workers.
F. Work stress and workplace violence among health care workers.
G. Occupational injuries in health care facilities.
H. Policies and procedures in cases of sharps and needle-stick injuries, blood and body
fluid exposure incidents.
I. Policy and Procedures in cases of falls, musculoskeletal injuries, and workplace vio-
lence.
J. Personal protective equipment, indications and proper usage.
K. Standard precautions for proper infection control practices
49
06 Occupational Health Hazards among Health Care Workers
Hospital staff are exposed to a wide range of health hazards in workplace, including
biological, chemical, physical, ergonomic and psychological hazards. Theses hazards put them at
risk of different injuries and disorders.
To reduce the risk that threatens the health of this working group, it is important to
identify the hazards, and define which hazard are predominant and in priority. Training ap-
proaches should be developed and appropriate prevention strategies should be considered to
reduce the risks and minimize the hazards.
i. Biological Hazards
Human diseases caused by work associated exposure to microbial agents such as bacte-
ria, viruses and fungi. The etiology, pathogenesis, clinical findings, diagnosis and treatment of
occupational & non-occupational infections are the same but there are practical differences in
identification of source of exposure, epidemiologic controls and preventive strategies.
Biological hazards in health care industry include blood borne and air borne pathogens.
Most biologic hazards can be classified as infectious or immunologically active. As an example,
accidental injection or splash of blood borne viruses (HIV, hepatitis B, hepatitis C) is the major
hazard of needle stick injuries especially in laboratory and dialysis staff and medical trainers.
Hospital staff have two to three times the tuberculosis infection rate of non-medical
personnel. Laboratory and necropsy room staff are estimated to be between 100 and 200 times
more likely than the general public to develop tuberculosis.
Health care workers are exposed to many infections disease in workplace including: com-
mon cold, influenza, cytomegalovirus, enteric pathogens, herpes simplex virus, measles, mumps,
rubella, Varicella, pertussis, scabies, and staphylococcus. Center for disease prevention and control
recommend hepatitis B, MMR, influenza, Varicella and tetanus vaccination for hospital staff.
50
Many chemicals in hospitals are capable of producing adverse health effects through
inhalation or by absorption through the skin, which act on the hematopoietic system and damage
the lungs, skin, eyes or mucous membranes.
Chemical hazards in the workplace for health care workers include exposure to anesthetic
gases, antimicrobial drugs, antineoplastic agents, disinfectant agents, ethylene oxide, formalde-
hyde, glutaraldehyde, latex and solvents. Personnel at operating room, delivery area, recovery
units have potential exposure to anesthetic gases which have known adverse effects on repro-
ductive system. Regular maintenance and inspections of anesthesia delivery equipment, use of
scavenging systems, maintenance of room ventilation rate, and provision of training to staff mem-
bers could be effective in reduction of exposure.
Pharmacists, oncology nurses, housekeepers are at risk of exposure to hazardous drugs,
which are prone to health effects on reproductive system and pregnancy outcomes. Implementing
vertical flow biological safety cabinets and personal protective equipment are capable in control-
ling hazardous effects.
Disinfectants such as formaldehyde and glutaraldehyde are associated with irritant and
allergic effects on skin and respiratory system induced asthma.
51
Ergonomic hazards include heavy lifting, repetitive and forceful movements, and awkward
postures that arise from improper work methods and improperly designed workstations and
equipment. Some examples of task related risk factor for musculoskeletal injuries are patient
transfers, material handling, frequency of lifting, pushing/pulling of objects, and poorly designed
work area. These ergonomic hazards can lead to musculoskeletal disorders which can affect the
nerves, tendons, muscles and supporting structures of the body. Low back pain and carpal tunnel
syndrome are well recognized work related musculoskeletal disorders.
v. Psychosocial hazards
Psychosocial hazards include but aren’t limited to stress, violence and other workplace
stressors. Including negligence and carelessness of health care workers, lack of adequate protec-
tive aids and equipment, inadequate number of staff, excessive workload, failure to observe basic
safety and hygiene guidelines, and inadequate operational knowledge of modern healthcare
equipment.
Work-related mental stress has been described as the adverse reaction experienced by
workers when workplace demands and responsibilities are greater than the worker can comfort-
ably manage or are beyond the workers’ capabilities. It can affect each worker differently and
originate from different sources.
Violence by both patients and coworkers are one of the psychosocial hazards for health
care workers, all violence that hospital staffs experience isn’t physical. Verbal violence is a common
form of violence, which is due to inadequate staffing, ease of hospital entry, presence of money
& drugs, and frustrated family members.
Shift work is one the well-known and inevitable psychosocial hazards in health care set-
ting, which has different health outcomes such as sleep disturbance, psychological disorders,
gastrointestinal problems, cardiovascular diseases and aggravated the underlying diseases (epi-
lepsy, diabetes, asthma).
52
For management, treatment, and prophylaxis, consult with the infectious diseases de-
partment or the infectious diseases consultant in the hospital and refer the exposed HCW to
the infectious diseases department. OHC should continue to follow up the treatment plan
with the HCW while being treated by the infectious diseases department until resolution.
3- Period of communicability
53
Patients can shed the virus after resolution of symptoms, but the duration of
infectivity is unknown. Patients are not contagious during the incubation period.
Asymptomatic cases might not be contagious.
4- Infection control Standard, Contact and Airborne Precautions
Standard precautions assume that every person is potentially infected or colonized
with a pathogen that could be transmitted in the healthcare setting:
a- Hand Hygiene
HCP should perform hand hygiene before and after all patient contact, contact with
potentially infectious material, and before putting on and upon removal of PPE, includ-
ing gloves. Hand hygiene in healthcare settings can be performed by washing with
soap and water or using alcohol-based hand rubs. If hands are visibly soiled, use soap
and water, not alcohol-based hand rubs.
b- Personal Protective Equipment
Employers should select appropriate PPE. Workers must receive training on and
demonstrate an understanding of when to use PPE; what PPE is necessary; how to
properly use it:
Gloves
Put on clean, non-sterile gloves upon entry into the patient room or care
area. Change gloves if they become torn or heavily contaminated.
Remove and discard gloves immediately upon leaving the patient room or
care area.
Gowns
Put on a clean disposable gown upon entry into the patient room or area.
Change the gown if it becomes soiled. Remove and discard the gown im-
mediately upon leaving the patient room or care area.
Respiratory Protection
Use respiratory protection (i.e., a respirator) that is at least as protective as
a fit-tested NIOSH-certified disposable N95 filtering face piece respirator
upon entry to the patient room or care area.
54
For healthcare workers who have facial hair that comes between the sealing
surface of the face piece and the face of the wearer a Powered Air Purifying
Respirator (PAPR) should be used instead.
The respirator should be the last part of the PPE ensemble to be removed.
Staff should be medically cleared and fit-tested if using respirators with
tight-fitting face pieces (e.g., a NIOSH-certified disposable N95) and trained
in the proper use of respirators, safe removal and disposal, and medical
contraindications to respirator use.
Eye Protection
Put on eye protection (e.g., a disposable face shield) upon entry to the
patient room or care area. Remove and discard eye protection immediately
upon leaving the patient room or care area.
Using More than one Kind of Personal Protective Equipment (PPE)
The following sequence is a general approach to putting on this PPE com-
bination for respiratory pathogens: first gown; then respirator; then goggles
or face shield; then gloves.
The following sequence is a general approach to removing PPE for respira-
tory pathogens: first gloves; then goggles or face shield; then gown; then
respirator.
Except for respirator, remove PPE at doorway or in anteroom. Remove res-
pirator after leaving patient room and closing door.
Perform hand hygiene as described above immediately before putting on
and after removing all PPE.
A fit-tested
A fit-tested respirator particulate mask (N95 or higher) is required for all
HCWs who will potentially care for patients in respiratory isolation. This will
ensure the prevention of disease transmission to HCWs through the air-
borne route.
A fit test, tests the seal between the respirator’s face piece and your face. It
takes about 15 to 20 minutes to complete. After passing a fit test with a
55
respirator, you must use the exact same make, model, style, and size respi-
rator on the workplace.
5- Employee health:
a- Work restrictions :
1. Exposed:
HCP who care for patients with MERS-CoV should be monitored. They
should immediately report any signs (e.g., fever) or symptoms (e.g., cough,
shortness of breath) of acute illness to their supervisor or a facility desig-
nated person (e.g., occupational health services) for a period of 14 days
after the last known contact with a MERS CoV patient, regardless of their
use of PPE.
2. Infected:
HCP who develop any respiratory symptoms after an unprotected exposure
(i.e., not wearing recommended PPE at the time of contact) to a patient with
MERS-CoV should not report for work or should immediately stop working.
These HCP should notify their supervisor, implement respiratory hygiene
and cough etiquette, seek prompt medical evaluation, and comply with work
exclusion until they are no longer deemed infectious to others.
Asymptomatic HCP:
For asymptomatic HCP who have had an unprotected exposure (i.e., not
wearing recommended PPE at the time of contact) to a patient with MERS-
CoV, exclude from work for 14 days to monitor for signs and symptoms of
respiratory illness and fever.
Important considerations:
If necessary to ensure adequate staffing of the facility, the asympto-
matic provider could be considered for continuing patient care du-
ties after discussion with local, state, and public health authorities.
Facilities and organizations providing healthcare should:
56
Implement sick leave policies for HCP, including contract staff
and part-time personnel, that are non-punitive, flexible and
consistent with public health guidance (e.g., policies should
ensure ill HCP who may have MERS-CoV infection stay home,
unless hospital admission for isolation and treatment is rec-
ommended).
Ensure that all HCP are aware of the sick leave policies.
Provide employee health services that ensure that HCP have ready
access, including via telephone, to medical consultation and, if
needed, prompt treatment.
6- Occupational health clinic role
Occupational health clinic should perform the following duties:
Identify individuals who are vulnerable to particular exposures to pa-
tients with suspected or confirmed MERS-CoV to raise their aware-
ness and train them regarding occupational exposure to patients
with suspected or confirmed MERS-CoV
Medical evaluation for HCWs who had exposure to patients with
suspected or confirmed MERS-CoV
Follow up of HCWs who had exposure to patients with suspected or
confirmed MERS-CoV
Reporting for suspected or confirmed to MERS-Co
Implement sick leave for HCWs who may have MERS-CoV infection
to stay home, unless hospital admission for isolation and treatment
is recommended
Applying work restriction rules
Investigation or participation in the investigation of occupational in-
cidents.
Record keeping, the files are kept confidential in a secure place and
separate from the hospital patient’s files.
57
Figure (1) Management of health care workers HCWs who had exposure to patients with
suspected or confirmed MERS-CoV
58
07.1.2 MYCOBACTERIUM TUBERCULOSIS (TB):
1. Incubation period
2 to 10 weeks after exposure to detection of positive Tuberculin skin test (TST) or Inter-
feron-gamma release assay (IGRA).
Risk of developing active disease is greatest in the first 2 years after exposure.
2. Exposure criteria
Spending time in a room with a person who has active disease without properly wearing
an N95 respirator.
Packing or irrigating wounds infected with Mycobacterium Tuberculosis (MTB) without
wearing an N95 respirator.
3. Period of communicability
Persons whose smears are Acid Fast Bacilli (AFB) positive are 20 times more likely to cause
secondary infections than persons who are smear negative. Children with primary pulmo-
nary MTB are rarely contagious.
4. Employee health
Obtain baseline TST results by doing 2 step TST if these have not been performed recently
and if the HCW was previously negative; perform post-exposure TST test at 8 to 10 weeks;
if the TST test result comes out positive prescribe MTB prophylaxis. Positive IGRA result is
also an indication for MTB prophylaxis.
a. Work restrictions
1. Exposed
None, for persons whose PPD results are positive
2. Infected (HCWs with active T.B disease):
Restrict HCWs with active MTB from duty until after they have taken 2 to 3 weeks
of effective anti-tuberculosis chemotherapy and they have had 3 AFB-negative spu-
tum samples taken over 8 to 24 hours (one must be an early morning specimen).
3. HCWs with Latent T.B
No restriction.
N.B. prophylaxis for latent TB infection, with continuous follow-up.
59
b. Prophylaxis
Prescribe Isoniazid 300 mg daily for 9 months (or 12 months for HIV-infected per-
sons) and pyridoxine 20-40 mg daily. Consult with Infectious disease consultant for
verification of the most appropriate prophylaxis regimen.
(GCC, 2013)
60
61
07.1.3 MENINGOCOCCAL DISEASE EXPOSURE
1. Incubation period
Usually <4 days; range, 1-10 days.
2. Exposure criteria
Extensive contact with respiratory secretions from an infected person without wearing a
mask, particularly when suctioning, resuscitating, or intubating.
3. Period of communicability
Persons are infectious until they have taken 24 hours of effective antibiotic therapy.
4. Employee health
Prescribe prophylaxis; educate exposed HCWs about the signs and symptoms of meningi-
tis.
A. Work restrictions
Exposed:
None.
Infected:
HCW should be restricted from work until they have taken 24 hours of effective antibiotic
therapy.
B. Prophylaxis
Rifampin 600 mg every 12 hours for 2 days (contraindicated in pregnancy) or Ciprofloxacin
500 mg single dose (contraindicated in pregnancy) or Ceftriaxone 250 mg I.M single dose
(safe during pregnancy).
62
07.2. Management of Healthcare Workers infected with blood borne pathogens:
Table 11: Summary Recommendations for Managing Healthcare Providers Infected with Hep-
atitis B Virus (HBV), Hepatitis C Virus (HCV), and/or Human Immunodeficiency Virus (HIV)
(SHEA 2010).
HBV
Categories I, II, and III Twice per year
<104 GE/mL No restrictions b
Categories I and II NA
≥104 GE/mL No restrictions b
Category III NA
≥104 GE/mL Restricted c
HCV
No restrictions b
Twice per year
<104 GE/mL Categories I, II, and III
No restrictions b
NA
≥104 GE/mL Categories I and II
Restricted c NA
≥104 GE/mL Category III
HIV
No restrictions b
Twice per year
< 5×102 GE/mL Categories I, II, and III
No restrictions b
NA
≥ 5×102GE/mL Categories I and II
Restricted d
NA
≥ 5×102 GE/mL Category III
Note. These recommendations provide a framework within which to consider such cases; however, each
such case is sufficiently complex that each should be independently considered in context by the expert
review panel (see text).
GE, genome equivalents; NA, not applicable.
a) See categorization of clinical activities.
b) No restrictions recommended, so long as the infected healthcare provider
(1) Is not detected as having transmitted infection to patients;
(2) Obtains advice from an Expert Review Panel about continued practice;
(3) Undergoes follow-up routinely by Occupational Medicine staff (or an appropriate public health offi-
cial), who test the provider twice per year to demonstrate the maintenance of a viral burden of less than
the recommended threshold (see text);
63
(4) Also receives follow-up by a personal physician who has expertise in the management of her or his
infection and who is allowed by the provider to communicate with the Expert Review Panel about the
provider’s clinical status;
(5) consults with an expert about optimal infection control procedures (and strictly adheres to the
recommended procedures, including the routine use of double-gloving for Category II and Category III
procedures and frequent glove changes during procedures, particularly if performing technical tasks
known to compromise glove integrity [e.g., placing sternal wires]), and
(6) Agrees to the information in and signs a contract or letter from the Expert Review Panel that char-
acterizes her or his responsibilities.
c) These procedures permissible only when viral burden is < 10 4 GE/mL.
d) These procedures permissible only when viral burden is < 5×10 2 GE/mL.
8. Psychiatric evaluations.
64
Category II: Procedures for which blood borne virus transmission is theoretically possible
but unlikely
4. Minor oral surgical procedures (e.g., simple tooth extraction [i.e., not requiring excess
force], soft tissue flap or sectioning, minor soft tissue biopsy, or incision and drainage
of an accessible abscess).
5. Minor local procedures (e.g., skin excision, abscess drainage, biopsy, and use of laser)
under local anesthesia (often under bloodless conditions).
9. Bronchoscopy.
11. Minor gynecological procedures (e.g., dilatation and curettage, suction abortion, col-
poscopy, insertion and removal of contraceptive devices and implants, and collection
of ova).
14. Minor vascular procedures (e.g., embolectomy and vein stripping).Amputations, in-
cluding major limbs (e.g., hemipelvectomy and amputation of legs or arms) and minor
amputations (e.g., amputations of fingers, toes, hands, or feet).
16. Minimum-exposure plastic surgical procedures (e.g., liposuction, minor skin resection
for reshaping, face lift, brow lift, blepharoplasty, and otoplasty).
18. Endoscopic ear, nose, and throat surgery and simple ear and nasal procedures (e.g.,
stapedectomy or stapedotomy, and insertion of tympanostomy tubes).
65
19. Ophthalmic surgery.
26. Insertion of, maintenance of, and drug administration into arterial and central venous
lines.
28. Obtainment and use of venous and arterial access devices that occur under complete
antiseptic technique, using universal precautions, “no-sharp” technique, and newly
gloved hands.
Category III: Procedures for which there is definite risk of blood borne virus transmission
or that have been classified previously as “exposure-prone”
2. General oral surgery, including surgical extractions hard and soft tissue biopsy (if more
extensive and/or having difficult access for suturing), apicoectomy, root amputation,
gingivectomy, periodontal curettage, mucogingival and osseous surgery, alveoplasty
or alveoectomy, and endosseous implant surgery.
4. Open extensive head and neck surgery involving bones, including oncological proce-
dures.
66
6. Non elective procedures performed in the emergency department, including open
resuscitation efforts, deep suturing to arrest hemorrhage, and internal cardiac mas-
sage.
8. Orthopedic procedures, including total knee arthroplasty, total hip arthroplasty, major
joint replacement surgery, open spine surgery, and open pelvic surgery.
11. Trauma surgery, including open head injuries, facial and jaw fracture reductions, ex-
tensive soft-tissue trauma, and ophthalmic trauma.
12. Interactions with patients in situations during which the risk of the patient biting the
physician is significant; for example, interactions with violent patients or patients ex-
periencing an epileptic seizure.
13. Any open surgical procedure with a duration of more than 3 hours, probably necessi-
tating glove change.
Note.
as Category III.
c) If there is no risk present of biting or of otherwise violent patients.
d) Use of an ultrasonic device for scaling and root planing would greatly reduce or eliminate the risk for
percutaneous injury to the provider. If significant physical force with hand instrumentation is anticipated to
be necessary, scaling and root planing and other
Class II procedures could be reasonably classified as Category III.
e) Making and suturing an episiotomy is classified as Category III.
67
f) If unexpected circumstances require moving to an open procedure (eg, laparotomy or thoracotomy),
68
08. Women in health sector:
Women make up about 42% of the estimated global paid working population. A preg-
nant healthcare worker (HCW) may be at risk of occupational exposure to pathogens, radiation
and chemotherapy drugs associated with increased maternal morbidity and mortality as well as
perinatal complications.
In this guidelines; the recommendations of pregnant healthcare worker discuss toward
infectious diseases; chemotherapy drugs and radiation focusing on prevention and management
of exposures.
08.1 PREGNANT HEALTHCARE WORKERS:
06.1.1 Pregnant healthcare workers exposed to infections
06.1.2 Pregnant healthcare workers exposed to radiation
06.1.3 Pregnant healthcare workers exposed to chemotherapeutic agents
08.1.1 Table 13: Pregnant healthcare workers exposed to infections disease-causing agents
that have reproductive hazards for women in the workplace (Quoted from GCC, 2013).
Cytomegalovirus Birth defects, low birth Health care workers in Good hygienic
(CMV) weight, contact with infants practices such
developmental and children as hand washing
disorders
Human Low birth weight, Health care workers Practice universal pre-
immuno-deficiency Childhood cancer cautions
virus (HIV)
69
Human Miscarriage Health care Good hygienic
parvovirus workers, workers in practices such
B19 contact with infants as hand washing
and children
Varicella- Birth defects, low birth Health care workers, in Vaccination before
zoster virus weight contact with infants pregnancy if no prior
(chickenpox) and children immunity
Workers with immunity through vaccinations or earlier exposures are not generally at risk
from diseases such as hepatitis B, human parvovirus B19, German measles, or chicken pox. But
pregnant workers without prior immunity should avoid contact with infected children or adults.
Workers should also use good hygienic practices such as frequent hand washing to pre-
vent the spread of infectious diseases among workers in elementary schools, nursery schools, and
daycare centers. In addition, they should use universal precautions. Such as glove wearing and
safe disposal of needles.to protect against disease-causing agents found in blood.
70
08.1.2 Pregnant healthcare workers exposed to radiation
A pregnant worker can continue working in an X-ray department as long as there is
reasonable assurance that the fetal dose can be kept below 1 mGy during the pregnancy. It is
important to ensure that pregnant women are not subjected to unnecessary discrimination. Both
worker and the employer carry responsibility towards safety.
The first responsibility for the protection of the conceptus lies with the woman herself,
who should declare her pregnancy to management as soon as the condition is confirmed. The
following recommendations are taken from International Commission on Radiological Protection
(ICRP Publication 84):
Restricting dose to the conceptus does not mean that it is necessary for pregnant women
to avoid work with radiation or radioactive materials completely, or that they must be
prevented from entering or working in designated radiation areas. It does, however, imply
that the employer should carefully review the exposure conditions of pregnant women. In
particular, their working conditions should be such that the probability of high accidental
doses and radionuclide intakes is insignificant;
When a medical radiation worker is known to be pregnant, there are three options that
are often considered in medical radiation facilities: 1) no change in assigned working du-
ties; 2) change to another area where the radiation exposure may be lower; or 3) change
to a job that has essentially no radiation exposure. There is no single correct answer for
all situations, and in certain countries, there may even be specific regulations. It is desirable
to have a discussion with the employee. The worker should be informed of the potential
risks, local policies, and recommended dose limits;
Changing to a position that may have lower ambient exposure is also a possibility. In
diagnostic radiology, this may involve transferring a technician from fluoroscopy to CT
scanning or some other area where there is less scattered radiation to workers. In nuclear
medicine departments, a pregnant technician can be restricted from spending a lot of time
in the radiopharmacy or working with radioiodine solutions. In radiotherapy with sealed
sources, pregnant technicians or nurses might not participate in manual brachytherapy;
71
An ethical consideration is involved in both of these last two alternatives since another
worker will have to incur additional radiation exposure because a co-worker became preg-
nant;
There are many situations in which the worker wishes to continue doing the same job, or
the employer may depend on her to continue in the same job in order to maintain the
level of patient care that the work unit is customarily able to provide. From a radiation
protection point of view, this is perfectly acceptable providing the fetal dose can be rea-
sonably accurately estimated and falls within the recommended limit of 1 mGy fetal dose
after the pregnancy is declared. It would be reasonable to evaluate the work environment
in order to provide assurance that high-dose accidents are unlikely; (International Atomic
Energy Agency (IAEA) 2000).
Hazardous Drug (HD) Handling Activities in Healthcare Workers that can Result in
Exposure
Pharmacists, pharmacy technicians, nursing Counting out individual, uncoated oral doses from mul-
tidose bottles
Unit-dosing uncoated tablets in a unit-dose machine
Crushing tablets or opening capsules to make oral liq-
uid dose
72
Opening ampoules
Preparing topical drugs
Nursing personnel Administering antineoplastic drugs by injection (intra-
muscular, subcutaneous or intravenous (IV)), by inhala-
tion or by nasogastric tube
Spiking the IV set into an HD-containing IV bag (with-
out a closed system)
Priming the IV set with a drug-containing solution at
the administration location
Connecting and disconnecting the IV set to an IV pump
or patient
Nursing personnel, support staff, house- Handling body fluids or body-fluid-contaminated
keeping personnel, laundry personnel clothing, dressings, linens, bedpans, urinals and other
materials
Handling contaminated wastes generated at any step
of the preparation or administration process
Pharmacists, pharmacy technicians, nursing Contacting hazardous drugs present on drug vial exte-
personnel, housekeeping personnel, envi- riors, work surfaces, floors, and final drug products
(bottles, bags, cassettes, and syringes)
ronmental services personnel
Handling unused antineoplastic drugs or antineo-
plastic drug-contaminated waste
Decontaminating and cleaning drug preparation or
clinical areas
Cleaning hazardous drug spills
Physicians, nursing personnel, operating Performing certain specialized HD administration pro-
room cedures such as intraperitoneal chemotherapy (in the
operating room or other locations), bladder instillation,
isolated limb perfusion
Support staff Transporting hazardous throughout the facility
Pharmacists, pharmacy technicians, nursing Removing and disposing of personal protective equip-
personnel, housekeeping personnel ment after handling hazardous drugs or waste.
73
Recommendations
Use of Industrial Hygiene Practices to Reduce Exposure to Hazardous Drugs
1. National institute for occupational safety and Health (NIOSH) recommends that a work-
place be safe for all workers, regardless of their reproductive status
2. Several organization’s [Occupational Safety and Health Administration (OSHA) 1999;
NIOSH 2004; ASHP 2006; United States Pharmacopeia (USP) 2008; ONS 2011] recommen-
dations include:
a) The proper use of engineering controls,
b) Administrative controls, and
c) Personal protective equipment [NIOSH 2009].
d) Training of personnel and other critical work practices are instrumental in protecting work-
ers from exposure [NIOSH 2004, 2013].
Additional information on adverse reproductive effects of these drugs can be found in the
drug package inserts and in the Safety Data Sheets (SDS for the drugs.
74
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